AbCellera Biologics Inc.

Good afternoon and welcome to AppSolaris full year 2022 Business Update conference call. My name is Donyell and I will facilitate the audio portion of today's interactive broadcast. All lines will be muted during the presentation portion of the call with an opportunity for questions and answers at the end. If you would like to ask a question, please press star followed by one on your telephone keypad. At this time, I would like to turn the call over to Trinh Steinmart, Abcelera's Chief Legal and Compliance Officer. Please proceed. Thank you.

Good afternoon and welcome to Abcelera's full year and fourth quarter 2022 business update. We are pleased to have you with us today as we discuss the results announced in our press release issued after the market closed today, which you can find on our investor relations website. With me on the call today are Dr. Carl Hansen, Abcela's Chief Executive Officer and President, and Andrew Booth, Abcela's Chief Financial Officer. The webcast portion of this call contains a slide presentation that we will refer to during the call. If you are following along on the phone and wish to access the slide portion of this presentation, you may do so on the investor relations section of our website. For those of you who have accessed the streaming portion of the webcast, please be aware that there may be a delay and that you will not be able to post questions via the web. This presentation may contain forward-looking statements pursuant to the safe harbor provisions of the Private Securities Litigation Act of 1995. Any forward-looking statements are based on management's current expectations and are subject to certain risks and uncertainties. Please review our SEC filings for risk factors that could impact our future performance. Our presentation and SEC filings are available on our investor relations website. Note that all dollars referred to during our call today are U.S. dollars. Now I am pleased to turn the call over to Dr. Carl Hansen.

Thanks, Trent, and thanks, everyone, for joining us today. It's my pleasure to provide an update on our business and the strong progress we made in 2022. 2022 marked Epsilor's 10th anniversary, and in the year, we hit a symbolic milestone in starting our 100th partnered antibody discovery program. Much has changed since we founded the company in 2012. We have grown from six founders to over 500 employees. We have opened facilities in four countries and have developed systems and processes to support our operations that have grown in size and in complexity. Throughout, we have continued to develop and integrate technologies as we build an engine for antibody discovery and development that we believe now stands at the forefront of the industry. And along the way, we have expanded our business and evolved the ways in which we bring our growing capabilities to our partners. Two years ago, we embraced more change as we made the transition to a publicly traded company and accelerated our growth. As we enter 2023, I believe we are now at an inflection point. and are entering a new phase of transformation and growth of our capabilities, expanding our engine with translational science, manufacturing, and regulatory matters to create a unified path from idea to the clinic, and demonstrating our capabilities in solving some of the most difficult discovery problems in the industry. Over the past decade, Abcelera has been a company of continual improvement and change. However, Throughout all this change, our strategy and the core beliefs that underpin it have remained constant. Every business is built on a hypothesis. Ours is that sustained investments in technology can move the needle in drug development and make our industry more productive. Every business also reflects a way of seeing the world, a philosophy. Ours is that the surest path to success is through building strength and using it to create value for others. That is why our primary focus is not on developing a new drug, but rather on building a company that works with others to find many drugs. Our belief in technology and our philosophy on how we create value is captured in our strategy. Our strategy is simply this. First, to build an engine that is best in world at going from an idea to a drug, and second, to use our engine with partners to build a large and diversified portfolio of stakes in future antibody therapies. The first part of our strategy to build an engine for antibody discovery and development is an ambitious and long-term technology project that encapsulates nearly everything we do as a company. The problem we're working to solve is to take a partner's specification for a new therapeutic antibody and turn this into a treatment that is ready for clinical testing. Our engine creates value for the industry by speeding up discovery and development, unlocking new areas for antibody drugs, and by leveling the playing field to make antibody discovery more accessible to drug developers of all sizes. Drug discovery is not done in a single step and our engine is not built on a single instrument or technology. It is a centralized solution that integrates expertise, technology, data, know-how, and infrastructure to enable us to respond to any problem that partners may have and to do so with precision and with speed. The challenges of building such an engine are formidable. It takes time, technology, expertise, capital, and mastery of the complexity that is inherent in doing antibody discovery at scale. The second part of our strategy is to build a large and diversified portfolio of stakes in future therapies. Over the years, our partnerships have evolved to include three different program types. The first two types are partner-initiated programs, which include discovery programs and co-development programs. The third program type, known as pre-partnered programs, arises from long-range R&D projects that seek to unlock high value areas of antibody therapeutics. When successful, these efforts have the potential to generate wholly owned assets for partnering. Partner-initiated discovery programs are the largest component of our portfolio and have deal terms that include near-term upfront and research payments, downstream milestones, and royalties on success and the sale of products. Because near-term payments typically cover our costs of doing the work, the return on marginal investment for these programs is high. the largest fraction of the value of these programs is associated with future royalty streams from approved drugs. Royalty rates for these programs are typically in low to mid single-digit range and have increased as the capabilities of our engine have grown. Partner-initiated discovery programs represent a large number of programs in which we have a small royalty position. It is the aggregate of these positions that has the potential to create significant long-term value in a way that is predictable and does not depend on the success of any one specific program. Noteworthy partnerships for us in 2022 include agreements with premier venture capital groups, Versant Ventures and Atlas Venture. These relationships are valuable for connecting our engine to early stage innovation. In 2022, we also entered into a new partnership with AbbVie, highlighting the value we can bring to large and well-enabled partners. Similarly, we announced our partnership with Regeneron last year and the advancement of our first program with them towards late-stage preclinical development. Although partner-initiated discovery programs have a high return on investment, the bulk of the returns will not be realized until therapies reach the market, which has historically taken an average of more than 10 years. Due to the confidential nature of discovery programs, we are able to provide only limited information about this part of our portfolio with details on any specific program only disclosed once it reaches the clinic. Because of the limited disclosure and the long timelines, we believe this large and important component of our portfolio may have been underappreciated, but should be of interest to those investors who look for efficient capital allocation with a long-term view. Our second type of partner initiative programs are co-developments. Although there are fewer of these programs in our portfolio, any one of them has the potential to meaningfully impact our business. Co-development programs give us the option, but not the obligation, to co-invest in the sequential stages of program development. We begin discovery with a 50% stake in the program and have the option to invest on a stage by stage basis to retain this position. This also gives us visibility on the data and the progress of each program. We announced our first co-development partnership in 2021, and to date, we have started work on six co-development programs. We expect to select final candidates, final clinical candidates for one or more of these programs in the next 12 to 18 months, which will allow them to advance into CMC and IND enabling studies. In 2022, we announced a new co-development partnership with RallyBio to bring treatments to patients with rare diseases. Finally, We have been working on long range technology development projects that seek to open up areas of therapeutic discovery where we believe there is not just one target or one opportunity, but a whole family of opportunities that could be prosecuted. While the primary objective of our pre-partnered work is to expand the capabilities of our engine in high value areas, these efforts may produce wholly owned assets with the potential to become first in class antibody therapies that address large areas of unmet medical need. Our pre-partner programs are focused on three areas, including T-cell engagers, GPCRs and ion channels, and pandemic response. To date, we've started five programs directed against well-known solid tumor targets using our T-cell engager platform. We expect the first of these programs to advance to development candidates within the next 12 to 18 months. In GPCRs and ion channels, we've initiated preparatory work on about a dozen targets, have now progressed to program starts. While technical risk remains, we anticipate sharing data on the first clinical candidate resulting from this work in 2023. Finally, our most advanced pre-partner program is, of course, COVID-19, where antibody assets emerged from our efforts to develop a pandemic response platform. We partnered these assets with Lilly to bring our first two COVID-19 antibodies, banlanivimab and beptilovimab, that helped approximately 2 million patients in the US and worldwide. As mentioned on our previous earnings call, we have a third COVID-19 antibody that we believe will be effective against all known variants of concern, including the recent BQ1, BQ1.1, and XBB variants. This antibody continues to progress through preclinical development with Lilly. If a clear path for clinical development and patient access can be established, we stand ready, together with Lilly, to move this program forward quickly. Looking forward into 2023 and beyond, we will continue to allocate our resources to build the pillars of our strategy. First, building technology and infrastructure to create a centralized engine for the discovery and development of antibody therapies at scale. Here, our near to medium term focus is on building out our capabilities for forward integration, including translational science, manufacturing and regulatory capabilities to enable full preclinical antibody discovery and development. Second, continuing technology development to unlock new target classes and to enable new modalities, including our work in TCEs and GPCRs and ion channels. We are excited to see these efforts advancing and look forward to demonstrating our capability in bringing new clinical candidates forward for development. And third, executing on partnered programs to build a diversified portfolio of stakes in next generation therapeutic antibodies. Our business development efforts remain focused on connecting with the highest value programs, both with new and existing partners. And as our capabilities grow, we anticipate building deeper relationships that take our partners faster and further towards the clinic. As we execute on this strategy, we are defining an exciting new category of company called tech-enabled biotech or TechBio. We believe companies in this space, including our own, must ultimately be evaluated not on the promise of their technology, but on the output of their platforms. We demonstrate this by solving discovery problems that are recognized as difficult across the industry, by signing new and expanded partnerships with top-tier drug developers, and when the molecules that we discover are advancing towards and through the clinic. And in the end, our success will come down to the people. I am fiercely proud of the team that we've built and what we've accomplished over the first 10 years of the business. We have momentum. We are at an inflection point. And in the next two years, as a team, we will show what our engine can really do. And with that, I'll now hand it over to Andrew Booth, our CFO, to provide an overview of our full year 2022 financials. Andrew? Thanks, Carl.

Carl provided an overview of the engine that we have built over the past decade. We estimate that we have invested over $500 million to build that engine, which spans approximately 500 team members and is on track to include over 650,000 square feet of lab and office space, including CMC and GMP capabilities by 2024. To fund our growth, we have raised approximately $800 million in equity since 2012. We have also access substantial non-dilutive funding, predominantly in the form of royalties from our COVID-19 response, where we have generated approximately $1 billion in revenue cumulatively. In addition, we have also secured over $150 million in government grants and contracts. We prioritize investments with scalability, broad applicability, and high expected rates of return when we allocate capital. Since 2012, we have accumulated earnings of approximately $430 million. From the combination of strong operational execution and financing, we are in a strong liquidity position with approximately $900 million in cash, cash equivalents, and marketable securities. Our key business metrics speak to the strong momentum in our business. In 2022, we started work on 23 new discovery programs with partners. Of these, nine starts were in the fourth quarter. taking us to a cumulative total of 101 partnered program starts. The 23 programs we started in the year represent approximately a quarter of all programs that we have ever started with partners and reflect an almost 30% increase in cumulative starts compared to the end of 2021. All starts in the fourth quarter included downstream participation. We ended 2022 with 174 programs under contract with 40 unique partners. In 2022, our partners also advanced three more molecules into the clinic, bringing our total molecules in the clinic to eight at the end of 2022. Our portfolio is diversified across partner types and therapeutic indications. The capabilities of our engine are broadly applicable to antibody-based drug development, so we can access a broad selection of programs in the industry by partnering. Of our 148 partner-initiated programs with downstreams, 90% are in human health. The majority of our partner programs are in oncology, neurology, and immunology, broadly reflecting the activity in the industry. Possessing a diverse portfolio of programs ameliorates certain risks associated with individual drug development programs, and we believe diversification across partner type and indication makes our portfolio potentially more robust relative to portfolios with a more limited focus. Our portfolio is also diversified across program types. Our three program types provide flexibility in how we create and capture value. They allow us to enhance our platform and our economics, where the value we add to the programs is particularly large. Partner-initiated discovery was our first type of program. Out of a total of 131 partner-initiated programs under contract with downstream participation, we have started work on 69 programs. We continue to add programs to this portfolio and their large volume speaks to our portfolio diversification. The potential return we can earn on our incremental investment in these programs is very high. We announced our first co-development program in 2021. Out of 17 such programs in our portfolio, we have started work on six. These programs enhance our portfolio economics by giving us 50-50 co-ownership and the option but not the obligation to co-invest to maintain our ownership of these programs. We announced our pre-partnered program category in 2022. These efforts in technology development have the potential to produce wholly owned assets. To date, we have started 12 of these pre-partnered programs. Success in partnering these assets could drive meaningful value in deeper royalty stakes in each program. They also have the potential for large upfront payments which could bring significant cash flows forward. The value we add to programs is reflected largely in the royalty rates that we negotiate. We continue to prioritize more valuable programs instead of maximizing the number of programs under contract. As a result, the range in average negotiated royalty rates in our portfolio is shifting favorably. As we reported last year, our mean royalty rate was 2.4% across 37 partner initiated discovery programs with downstream participation that were contracted between 2015 and 2019. Between 2020 and 2022, the mean royalty rate has increased to 4.1% across the 112 programs with downstream participation that we have signed during that period. A quarter of the programs with downstream participation that we've signed between 2020 and 2022 have the potential to achieve royalty rates above 5%. We continue to view our growing list of molecules in the clinic as specific examples of our near and mid-term potential revenue from downstream milestone fees and long-term royalty payments. During the year, we saw three additional molecules enter the clinic. We can now disclose that one molecule, DNL919, was discovered by us in our discovery partnership with Denali. Denali has advanced the molecule into a phase one clinical trial with an indication in Alzheimer's disease. The other two molecules were discovered and developed by partners, one of them undisclosed, using our Triani humanized rodent platform under license. We congratulate NovaRock on advancing NBL020 with an indication in oncology as their third Triani-derived molecule into the clinic and welcome the phase one start of NBL015. Turning to revenue, our revenue for the year was approximately $485 million. Our 2022 revenues were dominated by the $443 million of royalties that we earned from shipments of Bamlanivimab and Bepthelovimab during the year. This was up from $375 million in 2021. We realized approximately $1 million in milestone payments and approximately $1 million in licensing fee revenue in 2022. Finally, We earned approximately $48 million in research fees in connection with our partner-initiated discovery programs. This is up from $19 million in 2021. We have always viewed the royalties earned from our sales of COVID-19 antibodies as a source of non-dilutive funding. As Carl mentioned earlier in the call, if a practical regulatory path is established, we are ready to go ahead with a third COVID antibody together with our partner Lilly. As it stands, we do not expect to receive further royalties from our COVID-19 program and expect our revenues to be correspondingly lower in 2023. With or without these royalties from the sale of COVID antibodies, we will continue to support investments in expanding the capabilities of our engine, including our forward integration into translational sciences, CMC, and GMP, which we expect to be operational in 2025. Turning to operating expenses. Our research and development expenses for the year were nearly $108 million compared to $62 million in 2021. This 75% increase reflects our continuing investments in our business as we expand the capacity of our teams and the capabilities of our engine to deliver on a growing number of discovery programs. Notably, our build out of the teams for CMC and GMP manufacturing is now gathering pace heading into 2023. Approximately two thirds of our R&D efforts continue to be directed at enhancing the capabilities of our engine, with the remaining one third relating to execution on our partner initiated programs. Sales and marketing expenses for the year were approximately $11 million compared to nearly $7 million in 2021. This approximately 60% increase reflects our continuing investments in business development. General and administration expenses for the year were approximately $55 million, compared to almost 42 million in 2021. This approximately 30% increase was driven by the need to support the growing business overall. We were profitable for the full year of 2022 and are reporting earnings of approximately $158 million for the year. This compares to earnings of approximately $153 million in 2021. This result reflects the recognition of royalties on Bamlanivimab and Bethelivimab offsetting investments to expand the capabilities of our engine and running discovery efforts for our partners. As discussed earlier, we do not expect to receive further royalties from our COVID-19 program and therefore do not expect to be profitable in 2023. In terms of earnings per share, our result for 2022 works out to a profit of 56 cents per share on a basic and 50 cents per share on a diluted basis. Looking at cash flows, Our operating activities for 2022 contributed approximately $270 million to our cash flow. This includes the strong royalties earned from our COVID antibodies in the first three quarters of the year and the collection of accrued accounts receivable from royalties on sales of Bamlanivimab in 2021. As a part of our treasury strategy, we keep around $500 million invested in short-term marketable securities. and our investment activities for the year include an approximately $250 million net increase in these holdings. Also included in our investment activities for the year is an approximately $70 million investment in property and equipment, as well as payments connected with our facilities expansion, including our future GMP facility in Vancouver. Having broken ground for that facility, as well as on a new headquarters building in 2022, We are set to continue these investments into 2023 and 2024. As a reminder, our GMP facility is co-funded by the Government of Canada's Strategic Innovation Fund. As a result, we finished the year with over $880 million of unrestricted cash, cash equivalents, and marketable securities. We remain in a strong liquidity position that allows us to fully execute on our strategy, to continue to expand the capabilities of our engine, and to do so with excellent visibility and runway. We continue to believe that we have sufficient liquidity to fund well beyond the next three years of investment in the growth of our business. With that, we'd be happy to take your questions. Operator?

If you would like to ask a question, please press star followed by one on your telephone keypad. If for any reason you would like to remove that question, please press star followed by two. Again, to ask a question, please press star one. As a reminder, if you are using a speakerphone, please remember to pick up your handset before asking your question. We will pause here briefly as questions are registered. The first question comes from the line of Tiago Falf of Credit Suisse. Please proceed.

Hey, great. Thanks for taking the questions and congrats on the progress. Just a couple for me. One is on the pre-partner program. So again, you had a lot of program starts in that category. How should we think about the ideal timing in general to search for partners for those programs? I know that's probably going to be a case-by-case basis, but curious what the potential monetization partnership of those programs.

Hey, Tiago. Carl here. Thank you for the question. So the punchline is I think you're right. We're going to look at every one of these opportunities as they mature, and it's likely that timing could be different. Our strategy is to advance these to the point where we have established that we have high likelihood or have actually achieved clinical candidates, and then to make that data available, probably in a publication or certainly when strategic at a meeting. That effort, we anticipate, given the nature of these targets. So these are typically programs that are directed towards targets that are widely sought after and are recognized as being of high value. So we believe that that disclosure is likely to kick off discussions with partners. And then, of course, we'll have to enter into those discussions and see what is the best path for each particular asset.

Thank you.

The next question comes from the line of Andrea Tan of Goldman Sachs. Please proceed.

Hi, everyone. Thanks for taking my question. Maybe on the GPCR and ion channel work that you're planning on highlighting this year, just curious if you can provide a bit more color on the nature of those data disclosures. And then maybe given that this will fall on the back of your work with T-cell engagers that you shared last year, how much read-through do you think there is to your broader platform and your ability to discover antibodies against these types of targets?

Thanks, Andrea. So I'll start by talking about the GPCR9 channel work. As mentioned in the prepared remarks, these programs have been launched not as standalone programs but in connection with long-range R&D activities that seek to unlock the entire class. So within the class of ion channels and GPCRs, there's a large number of targets that are validated. Perhaps there are small molecules that have worked, but there are problems with toxicity or specificity that would make antibodies an ideal solution. For these targets that are generally out in the open, the problem has been in identifying antibodies with the right properties to make them into drugs. So we've been working on several of these programs. As I mentioned, there is still risk and I would certainly say that we're not at the point where any of these targets can be addressed successfully, but we do expect that we'll get there. That work is now gathering speed and there's enough success that we expect this year we'll be able to bring forward at least the first example of a clinical candidate. So the data that we would share on a molecule like that would, of course, include all the characterization that shows that it hits the target, that it has the desired functional properties, and that it has the right biophysical properties to make it developable as a drug. So we're expecting or certainly aiming to have the first of those show up this year. And as you mentioned, that success in itself will be seen as valuable because these have the potential to be developed as first in class or best in class assets. But even more important for us is that it demonstrates that the strategy of investing in solving these problems is paying off. And once you solve one, there's a higher likelihood you'll be able to get the next one. And so we believe there's a lot of read through into the platform by showing examples of solving problems that have remained outstanding in the industry for a decade. The same is true, of course, in the T-cell engager space. That effort is not as advanced, but we do expect to get to the point of development candidates for the first program this year. And in our view, layering on successes over the last few years in CD3, in COVID-19, in moving forward programs for partners, layering on top success in GPCRs and ion channels, and ultimately in T-cell engagers, all of that reinforces our thesis that sustained investments in technology can move the needle and make it more accessible and practical to get antibodies forward for these problems.

Thanks, Carl. And then maybe just one last question. Could you just remind us what in your mind is the right mix of partner-initiated co-development and pre-partnered programs?

Yeah, so I wouldn't say that we're thinking about it as the right mix. Our main line of business is to generate a large and diversified stake in programs that are being advanced by partners. And so partner-initiated programs are one element of that. And of course, there's the discovery partnerships and co-development partnerships. Pre-partnered programs, as I mentioned, come out of our technology development work. We have been investing to build capacity to make sure that we are able to respond to all the high-quality partner-initiated programs that we can find. And so we're continuing to grow that business. Of course, if we see opportunities that are connected with our technology development, we will invest in those as well. And we see that as anticipating the needs and finding another way to bring high-quality assets into the hands of partners for clinical development.

Great. Thanks so much. Thank you.

Next question comes from the line of Gary Nakum of BMO. Please proceed.

Hi, guys. Good afternoon. Just following on that last question, Carl, so on the different strategies of creating value with both partnered and pre-partnered programs, are those moving completely in parallel, or do you expect to focus a lot more on the pre-partnered programs going forward? So another way of asking it is, do you think it'll be harder to accelerate the level of your partner programs? Is there a point where it just gets a little bit more mature, that part of the business? And then how do things change for you when you have CMC and GMP capabilities in 2025? How will that change how you think about both the partnered and the pre-partnered programs, and maybe how you're going to structure economics around those programs with those capabilities.

Thanks, Gary. So first, the partner-initiated programs that we do are the bread and butter of the business, and so we are continuing to move that forward. Now, as we've said on previous calls, Our business development strategy is not to optimize volume in terms of the number of programs, but rather to make decisions that we believe will optimize the value that they represent in the portfolio. So that will be a combination of finding partners that we believe have great ideas and are well enabled to bring them forward. It'll be being able to negotiate terms that give us a deeper economic stake in those. And connected with that is our ability to demonstrate and to perform activities that add more value to those programs. So certainly as we begin to move towards forward integration with translational science, with manufacturing, even building out regulatory capabilities to help the smaller and less enabled partners, we're adding more value and we would expect to participate more in the success of those programs. So that's how we see partner-initiated programs is Volume, I do believe it will increase, but much more, I think, the way in which we select opportunities, the likelihood of them moving forward, the speed at which they move forward, and our economic participation are some of the big levers that we think about in terms of maximizing value. From that perspective, the work on pre-partnered programs, which is about taking the initiative to demonstrate capabilities that unlock new areas, we see as completely synergistic with that. It drives business towards us because we develop and demonstrate capabilities. And in many instances, particularly with the larger companies, we will have, you know, move forward programs where there is an interest. And that has also generated value by saving time and de-risking those programs. And so we really see those two parts of the business as one, really, or at least walking arm in arm.

Okay, that's helpful. And then maybe you could just run through a little bit on the last couple of partnered programs, AVI and RallyBio. You know, it seems they're a little bit on opposite ends of the spectrum in terms of the size of the company and how they're structured in terms of, you know, AVI being responsible for the targets and RallyBio that's really shared in a co-development arrangement. I'm just curious, if you see in terms of the opportunities out there, is it, um, are there a lot for both of those types of, of partnerships and how long did it take for those to really to, to consummate? Um, you know, just so we get a sense of maybe what goes a little bit behind the scenes, uh, just with two recent examples. Thanks.

Sure. So, um, Obviously, those are two deals with companies that have a very different profile. I would say that the new partnership with AbbVie, which we're very excited about, is representative of much of our work with the larger, very enabled partners that have a real track record and capabilities in antibody therapeutics. So those engagements tend to be driven by their teams finding problems where they need an extra lever or an extra advantage in technology to get those programs over the hump and start to move them towards the clinic. And there are no shortage of programs like that. So there's a lot of potential market opportunity amongst the big and most enabled players, like the Avis, like the Regenerons, where they are actively interested in moving antibody therapeutics into areas where it has been either difficult or impossible. So that, you know, that... That deal, I think finding alignment early on in the capabilities is very straightforward. Of course, it does take time to contract, but that's part of doing business in this space. On the Rallye Bio side, that's another great example of how our platform can deliver value to partners. So here we have a company that is based on insight into the targets that is experienced, that has developed drugs before. but that has not yet built internal capabilities for antibody discovery. And there we can save them the need to reassemble those capabilities or build them from scratch and allow them to focus on where they're really strong while we take on the discovery and preclinical development of those assets. And that we see as a way to really strip out redundancy in the industry. I mentioned also in the prepared remarks that a couple engagements that we have made with premier venture capital groups. And I think that's another example where you've got innovation, you've got capital, you've got executives, a business idea. And from our perspective, there's no need for these companies to need to reinvent all the substructure of innovation. They should be focused on where they can really deliver value. And of course, that's what a centralized engine is supposed to do. And that's part of our mission.

Okay. That color was really helpful. Thank you. Thank you.

The next question comes from Robin Karnatsuka from Truist. Please proceed.

Good try. It's difficult. Thanks for taking my question. So, I just had a few. Just one, does the new NovaRock molecule that's entering the clinic, can you talk about whether it has downstream participation in it? And my second question is on deal terms. So the contract you signed the last two years probably have a lower royalty structure. And as you're building out your capabilities and given how long sometimes it can take pharma to move to the clinic, Is there a way for you or the partner to amend the terms of the partnership to get more involved or to receive higher royalty rates? Is that something that you think might happen at all? And then my last question is, how has it changed since the IRA and the big focus on biologics, your interactions with? your partners as far as the need to develop new molecules fast that are best in class. I'm just curious if you've seen a shift since the IRA was announced. Thanks.

Hey, Robin. Andrew here. Yeah, I'll take each of those in turn. So the new Noviraka molecule, yes, it does indeed have downstream participation and a royalty associated with it. That's why we do include it on that chart. With regards to the deal terms that we have with our partners, in each of these arrangements, we have an understood scope of work that we're doing and the agreed economics and terms associated with that scope of work. It's not contemplated that we would change that materially throughout the execution of the program, and certainly not with an intent to come to a renegotiation at some point later in the partnership. I think those terms or those contracts kind of stand on their own with a set scope of work with the intent for us to do our activity and then deliver back to the partner what is promised for them to continue on the development. You mentioned a comment as well that I just want to clarify. It sounded as though you indicate that the royalty rates had decreased in the recent past, but that's not the case. The royalty rates have been increasing.

The old ones. Yeah, the old ones, I was asking about the old contracts, because I would assume the old programs were lower royalty rates. But like, do you have, would you negotiate, be able to negotiate higher royalty rates as these companies see that you're more capable, you have greater capabilities? No. And that they may need that because pharma is moving faster.

Actually, it's a great question. And this is in between 2021 and 2022. We made a definite change in the nature of the contracts we were negotiating. In 2021, you'll see we negotiated several multi-year, multi-target deals for even eight or ten targets at a time. We've since indicated on calls that we've moved away from locking ourselves into the economics on multiple targets, even when we are adding capabilities. So what we're tending to do more and more, and you see it in our results, is negotiate smaller contracts for programs under contract with certain economics, because there really isn't the opportunity to go back to the partner and renegotiate the economics once they're agreed to at the signing of the contract. The opportunity we have is to have a renewal or repeat engagement with an existing partner once they've seen our capabilities, and then we have the opportunity on the subsequent programs to negotiate, again, the royalty rates given the increased capabilities and whatever the increased value is that we would be doing, we would be bringing to that partner. That's more our posturing today than it had been some years ago. And so we don't see the opportunity to reopen those older negotiations from 2019 and previously to change the economics in those contracts. Hopefully that answers the question more completely.

Yes. Exactly. And then just the question on the IRA, I'm just curious if you're seeing, we're definitely hearing a shift in big pharma world and biotech world about what they're prioritizing. And so I'm just curious if you're seeing a shift in what types of programs people are leveraging your technology for.

I'd say just generally the IRA and certainly how biologics are more favorably treated in that document or in that regulation It definitely is a tailwind for us in the business with more people shifting towards antibody, potential antibody treatments. I think that bodes well for us over the longer term. You know, in the very recent past, I'm not sure we've quite seen the giant uptick, but I think it would only be a tailwind for us in our business going forward.

Great. Thanks a lot. Thank you.

The next question comes from Puneet Sauda of SVP Securities. Please proceed.

Hi, you have Michael Lanz for Puneet. Congrats on 4Q and a strong 2022. So now that COVID is starting to normalize, I was wondering if you could provide any guardrails for perhaps program starts or potential new ads Michael Bresalier, Under contract for the year, so it seems in 2022 and 2023 had roughly similar program start that occasion that we should expect going forward, or do you see it lifting from this year into 2023.

Michael Bresalier, hey thanks, thanks for the question Michael so first of all, on the coven revenues yeah we do, as we mentioned in the prepared remarks. We are not forecasting any future revenue from COVID molecules. Of course, we stand at the ready with our partner Lilly if a regulatory path opens up with a molecule that we've discovered with them. We see that really as upside to 2023 and beyond. In terms of program starts, as I think you know, we haven't provided guidance in the past on program starts. We have been saying it's, you know, we've had a very strong quarter in Q4 with nine program starts. And I think that generally reflects just the momentum we have and our focus on the execution and the business of working on these with our partners. And in addition, of course, we have the program starts related to the pre-partner programs. Our key metric is really for only partner initiated program starts. And we continue to see, you know, great momentum there as well as, and that we do see that continuing into 2023. but we still do not plan to give any specific guidance with regards to program starts for 2023. I would point to, and I'm sure you noticed, the performance on research fees year over year. This again points to the fact that we're doing more per program, and that is directly reflected in the research fee revenue that we are earning on the execution of each of those programs. That's where we're really focused rather than on specifically the number of program starts. It's how are we adding more and more value to each program that we're working on, advancing those discovery efforts through to molecules that eventually can get to patients in the clinic.

Okay, great.

That's really helpful. And then one thing we're also wondering, so we've heard a little bit about increased I guess, scrutiny on capital deployment. And we were wondering if this has reflected favorably for the business, given your, I guess, more capital-efficient offering, or if that's having any bearings on, I guess, your trajectory for a program start.

Yeah. I'll do my best to answer that question. As you know, we're in a very strong liquidity position, and we have big investments, which I think we've been communicating consistently, this forward integration into translational sciences, CMC, GMP. It does require absolutely some allocation of capital to build up those capabilities. We, of course, are doing that very capital-efficient way with the co-funding from the Government of Canada, and we have, in general, taken advantage of... government programs that are out there in the past, and we'll continue to do that for any available government programs in the future to really make sure we're investing in a very efficient way the capital that we have. I don't think we've seen any, I think the words you used were increased scrutiny on the deployment of that capital. I think we've been quite transparent in what our plans are.

Just to expand. Just to clarify, this is for customers. So we've been hearing some biopharma have been focusing on making their cash runway extend. So this is not about accelerated capital deployment, but rather accelerated customers if their decisions about how to proceed with capital, that sort of question. Yes.

Okay, if this is a macro question about many of our customers and their ability to deploy capital, I think that the fact that the market is down at the moment really plays to our strengths, where companies can come to us and we can, in a very capital-efficient way, where we are deferring the lion's share of the economics to the downstream participation through milestones and royalties, they can quickly get up and running and have us put best of world capabilities on discovering antibody for them in the shortest amount of time. That's a great value proposition overall, and especially in a tight macro market. So I think that that plays to our strengths and can help us get them to a value inflection point maybe more quickly than their alternative.

So I think that is a tailwind for us at the moment.

Great. Thank you very much. Thank you. Next question comes from .

Please proceed.

Hi, guys. This is . I just have a quick question regarding pre-partnered T-cell engager program. So I'm wondering, like, how differentiated your selected T-cell engagers should be in order to guarantee, you know, potential partnering. But on the flip side, like, if you can't find a partnering, like, how far in the clinic, I guess, like, would you be able to, like, advance these selected T cell engagers in the clinic, you know, by yourself? Like, how far can you advance it in the clinic? So, thank you.

Thanks, Kuli. This is Carl taking the question. So just as a backdrop, the T-cell work is an effort we started a little bit over a year ago, first working to build out what we believe is now the broadest and highest quality panel of anti-CD3 antibodies, which we can then combine with our bispecific platform, Orthomab, and using automation and high-throughput functional characterization select antibodies that have, the bispecific antibodies that have potent tumor killing, even against targets with low surface density, and that simultaneously have desirable profiles in terms of cytokine release, which has been one of the main issues limiting these therapies. So we have now initiated five programs as part of that effort to demonstrate that capability. You know, we still will need to do the preclinical work to show that these work in animal models and ultimately this needs to be tested in the clinic. But it's worth highlighting that, you know, in the field, a large majority of the T cell engagers that have been brought forward have been brought forward on either the same or a very close variant of the same CD3 molecule that people have been using for over a decade. So we've got a scenario where just based on the scarcity of available molecules The same experiment has been run again and again and again, although with some changes in format and, of course, indication. So our hypothesis is that that's not the way to solve the problem. Solving the problem requires new innovation, and we are confident that we'll be able to demonstrate that. In terms of the partnering, we have been engaged with a number of conversations with some of the very large players in the space. that are aware now that this is going to be an important class for oncology. Those conversations are going very well, and we are optimistic that we'll be able to find a partner for one or more of those relatively soon. But of course, that work is still ongoing. What we're not going to do is take our foot off the brake. So we are equipped in order to bring these forward, and we will continue to move them forward so that we're not losing time on those. And in the background, we do anticipate we may start some other programs to demonstrate this in the near term.

Thank you. Thank you.

The next question comes from Gaurav Gopraju of Barenburg. Please proceed.

And nothing more for me, guys. Really congratulate on the year and the quarter, and talk soon.

Thanks, Yara.

Thank you. The next question comes from Antonio, or Antonia Borovino of Bloom Burton. Please proceed.

Great. Thanks, and congrats on a solid quarter. My first question is just with regards to the pre-partner programs. I'm just wondering, you know, what could that look like? Would it likely just be a single antibody candidate that you would partner, or would a deal likely involve some backup candidates with slightly different properties? And then my second question is with regards to you know, the macro environment. And I'm just wondering if the broader sector downturn has impacted the types of deals partners want to pursue. Like I'm thinking specifically with regards to the smaller players and whether they're more interested in pursuing co-development deals with you to offload some of the development costs.

Sure. So this is Carl again. So, in terms of pre-partner programs, we are advancing these programs primarily in connection with technology development, and we believe that bringing forward ready clinical candidates is the strongest proof that the platform is working and that we're actually solving the problems. We would expect that when we do that, we would have a lead clinical candidate that would be the focal point of any discussion. But of course, on a case-by-case basis, if there are backups and if that's appropriate, that could easily be part of a deal. So I don't think I would speculate on that unless we had a particular case that we were discussing. In terms of the market condition and what we are perceiving from partners, As Andrew briefly touched on it, it is a difficult market, but in many ways, our business is quite robust to this. So from our view, there's a foundation of a lot of terrific science and innovation still in the industry. There's a lot of capital in the private sector and new companies being formed. And our business model allows those companies to move forward more quickly and with lower investment. And so we believe that that smaller company or early innovation sector of the market is one where we are becoming more attractive, at least on a relative basis, in the current conditions. I don't think that we've seen an increased activity or interest in co-development. And co-development opportunities more often happen when we happen to meet a group where there's a really great synergy and capability and where we become, you know, convinced that there is an interesting opportunity to go forward and then that conversation proceeds. But to date, we haven't seen that. But, of course, it's still early.

Okay. Thank you. Thank you.

And the last question comes from Du Kim of Piper Sandler. Please proceed.

Hi. This is Skylar on for Doe. Thanks for taking my question. For your partner-initiated programs, what is the variation of how well-defined the partner's discovery plan is when the collaboration begins? And does that vary significantly among your big pharma customers? and how much does the initial discovery plan impact your decision both to choose partners and the deal terms? Thanks.

Hey, Skylar, great question. I think there is definitely variability in how well-defined the program is or the statement of work, and that is something that normally our R&D team will work with the R&D team of our partner. to further define even before a contract gets finalized. So I think it's, you know, when that statement of work gets completed for the target of interest, you know, we have to have a very clear understanding of what is getting delivered. And this is somewhere where actually Abcelera can bring a lot of value in even defining what exactly is the output that the partner is looking for, really focused on the years of experience and 100 programs that we've worked on to work towards that clinical candidate that can actually move forward into translational sciences, CMC, and GMP manufacturing, and then ultimately to patients. There is some variability, and I think we're becoming more and more experts in really understanding how to define that program from the start.

Got it. Thank you, and congrats on the quarter.

Thank you.

And with that, we will conclude our question and answer portion of today's call. I would now like to pass the call back over to Carl for closing remarks.

Great. Thank you all for joining us today. This remains an exciting time for Accelera, and we're looking forward to keeping you updated on our progress on future calls. Thanks so much.

And with that, we will conclude today's conference call. Thank you for participating. You may now disconnect your line.