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Operator
We'll be right back. At this time, I'd like to introduce Skylar Bloom, Senior Director of Business Development and Corporate Strategy at ADMA Biologics. Please go ahead.
Skylar Bloom
Welcome, everyone, and thank you for joining us this afternoon to discuss ADMA Biologics financial results for the fourth quarter and full year 2021. In recent corporate updates, I'm joined today by Adam Grossman, President and Chief Executive Officer, and Brian Lenz, Executive Vice President, Chief Financial Officer, and General Manager of ADMA Biocenters. During today's call, Adam will provide some introductory comments and provide an update on corporate progress, and Brian will provide an overview of the company's fourth quarter and full year 2021 financial results. Finally, Adam will then provide some brief summary remarks before opening the call up for questions. Earlier today, we issued a press release detailing the fourth quarter and full year 2021 financial results and summarized certain fourth quarter achievements in recent corporate updates including $175 million debt refinance with Hathen Capital. The release is available on our website at www.admobiologics.com. Before we begin our formal comments, I'll remind you that we will be making forward-looking assertions during today's call that represent the company's intentions, expectations, or beliefs concerning future events, which constitute forward-looking statements for the purposes of the Safe Harbor provisions under the Private Securities Litigation Reform Act of 1995. All forward-looking statements are subject to factors, risks, and uncertainties such as those detailed in today's press release announcing this call and in our filings with the SEC, which may cause actual results to differ materially from the results expressed or implied by such statements. In addition, any forward-looking statements represent our views only as of the date of this call and should not be relied upon as representing our views as of any subsequent date. we specifically disclaim any obligations to update such statements, except as required by the federal securities laws. We refer you to the disclosure notice section in our earnings release we issued today in the risk factors section of our 2021 annual report on Form 10-K for the year ended December 31st, 2021, for discussion of important factors that could cause actual results to differ materially from these forward-looking statements. With that, I would now like to turn the call over to Adam Grossman. Adam?
Adam Grossman
Thank you, Skylar. Good afternoon, everyone, and thank you for joining us on today's call. We hope you all remain healthy and safe. Our 2021 operating and financial achievements mark a pivotal point in the business's evolution towards a profit-oriented growth organization. During the year, we delivered on our financial objectives, including 92% year-over-year revenue growth, and importantly, took assertive measures to shore up our financing and cash positions, notably with today's announced $175 million debt refinancing with AFIN, which we will address in more detail during this call. The year was capped by delivering fourth quarter revenues of $26.4 million, consistent with our previously disclosed expectation of annualizing at a rate of more than $100 million. The generation of first-time gross profitability for the full year 2021 driven by outsized assentive adoption in our overall product mix, the growth of our plasma collection center network, and the successful conclusion of the supply chain robustness initiatives undertaken at the Boca Raton, Florida, manufacturing facility. Of particular note, we are encouraged by the recent and continued utilization uptick for assentive, We believe our marketing, sales, and medical education efforts are effectively catalyzing adoption, and the product's unique manufacturing methods, antibody profile, and commercial value proposition are resonating well with physicians, providers, and patients. Brian will discuss the gross profitability implications resulting from the increasing adoption of Ascendant. But from our vantage point, we are seeing signals that the product may potentially exceed our previous expectations. Moving on to the supply chain, ADMA's investments towards securing raw material plasma supply and expanding its biocenters plasma collection center network enabled the company to maintain its production plans and grow its customer base throughout the pandemic and 2021. We are proud to have delivered on our promise of continuity of patient care during this period of plasma supply dislocation, impacting the broader immunoglobulin market. And we believe in doing so, we have solidified ADMA's emerging reputation as a reliable and growing immune globulin supplier in the United States. The recent approval of ADMA's fifth plasma collection center advances the company towards its goal of having 10 FDA-approved centers before the end of next year. which we believe will allow the company to potentially reach plasma supply self-sufficiency by year-end 2023. ADMA's growing internal plasma collections are currently being supplemented by third-party supply contracts, as well as the yield enhancements resulting from the implementation of the Humanetics Nexus Persona system. The successful expansion and operating results of ADMA's plasma collection network further solidifies our company's pathway towards profitability. Looking to the remainder of 2022, and based upon current data, we now anticipate total annual revenues to exceed $125 million, representing more than a 50 percent year-over-year growth rate compared to 2021. From a margin perspective, we anticipate gross profits will continue to increase and net losses will narrow as costs and operating efficiencies begin materializing as a result of our supply chain enhancement initiatives. We believe the commercial, regulatory, and operational milestones achieved during 2021 will serve as a strong foundation for ADMA to advance towards anticipated profitability no later than the first quarter of 2024. We expect the substantial vertical integration achieved to date will position our company to execute through even the most challenging operating backdrops. and excel even further in a more normalized environment. We thank the entire ADMA Biologics and ADMA BioCenters teams for their extraordinary efforts in keeping true to our mission of providing quality products to patients. Finally, we'd like to thank the HAFEM team for their hard work in completing their robust diligence process and closing on the debt refinancing with us. The plasma industry is global, and we believe Hathen's XUS operations and asset base makes for an ideal partner to enable ADMA's continued exploration of strategic alternatives and evaluation of creating business development opportunities. Brian will discuss the use of proceeds in more detail, but we are pleased to be able to extend the interest-only period by three years to March of 2027, significantly increase non-diluted funding for our business, and reduce ADMA's overall cost of capital. We believe the improved liquidity position resulting from the debt refinancing will enable the company to execute on its operating strategy while continuing to explore strategic alternatives with our advisors, Morgan Stanley. We believe this is an important step towards unlocking shareholder value. We'd also like to thank the Perceptive Advisors credit team for their support these past few years and the equity team for their continued investment and confidence in ADMA's forward-looking outlook. All of our organization's accomplishments across our business segments could not have been possible without the dedication and focus of ADMA staff, leadership, and advisors. We commend the entire team for their remarkable efforts focused on the continuity of care for patients who we know are counting on us. With that said, I'd now like to turn the call over to Brian for a review of fourth quarter and full year 2021 financials.
Brian
Thank you, Adam. Since we issued a press release earlier today, outlining our fourth quarter and full year 2021 financial results, I'll just review some of the highlights. As Adam mentioned earlier, for the fourth quarter of 2021, total revenues were $26.4 million compared to $14 million for the quarter ended December 31st, 2020. And this represents an increase of approximately $12.4 million or 89%. The revenue growth for the fourth quarter of 2021 compared to the fourth quarter of 2020 was favorably impacted by the continued commercial ramp-up of our IVIG product portfolio. Additionally, total revenues of $80.9 million were recorded during the year-ended December 31, 2021, as compared to $42.2 million during the year-ended December 31, 2020, and this represents an increase of $38.7 million, or approximately 92%. The year-over-year increase is mainly due to greater sales of our immunoglobulin products and intermediate fractions generated by our Boca Raton manufacturing segment operations in 2021, totaling $38.1 million, as we concluded our second full year of commercial sales of Bibigam and Ascetic. One of the notable highlights in what we believe to be an otherwise very strong set of financial results was the continued expansion of the company's consolidated gross profits. For the fourth quarter of 2021, ADMA generated a gross profit of approximately 13%, which further enabled the company to report gross profitability for the full year ended 2021. This key financial milestone was primarily attributable to the favorable product mix achieved during the fourth quarter where we sold more of our higher-margin products compared to the previous quarter's results. Our unique, patented IG Ascentive and hyperimmune Dobby HB yields higher gross margins than our standard IG product, Vivigam, and we are encouraged by the market penetration of Ascentive, which continues to establish commercial traction. As a result of the greater-than-expected adoption of Ascentive observed over recent periods, we have increased incentives production from our original 2022 production plan at the plant to support continued upside for the product in 2022 and beyond. In addition to a favorable product mix, we anticipate the trend of positive gross profit and narrowing net losses to continue to improve during 2022 as efficiencies continue to be realized from the FDA approvals received in 2021 for both the 4,400-liter expanded production scale as well as our in-house fill finish capabilities. As Adam mentioned earlier, ADMA significantly strengthened its balance sheet during the fourth quarter and subsequent periods. Earlier this afternoon, we announced a $175 million debt refinancing with AFIN. The new loan agreement will provide for, among other things, a five-year interest-only period which is the duration of the credit facility maturing in March of 2027. Borrowings under the HAFN credit agreement bear interest at a rate per annum equal to 8.25 percent with an accumulating 2.5 percent paid in kind or PIP component. The first tranche of $150 million from HAFN was fully drawn and used to completely discharge the obligations under the previously held perceptive senior secured notes, including all associated prepayment fees, which totaled $102 million. With this new credit facility, we also have the ability to access an additional $25 million under the second tranche, which is tied to revenue milestones, and if drawn, will be used to support continuing operations and to fund the company's ongoing growth. All told, we have taken assertive measures over recent periods to ensure ADMA is well capitalized as we embark on the growth and profit-oriented phase of our business cycle. As Adam previously mentioned, we believe our improved liquidity position will enable us to continue to explore strategic alternatives with our advisor, Morgan Stanley. During the year ended December 31st, 2021, ADMA grew its total asset value to $276 million, which includes $125 million in inventories. ADMA expects the robust inventories, which are recorded at our cost, to support continued revenue growth throughout 2022 and beyond. Our consolidated net loss was $16.6 million for the three months ended December 31, 2021. as compared to $19.4 million for the three months ended December 31st, 2020. The $2.8 million decrease in net loss compared to the prior year period was primarily attributable to a gross profit contribution of $3.5 million for the fourth quarter of 2021 compared to a gross loss of $5.2 million during the fourth quarter of 2020. The decrease in net loss was partially offset by an increase in selling general and administrative expenses of $2.4 million related to employee compensation, new hires, along with other costs to support the commercialization efforts for BIVGAM and Ascentive. Additionally, we recorded a $2.5 million increase in Plasma Center operating expenses related to the company's Plasma Center build-up and expansion activities to support our target of having 10 plasma centers open and FDA approved by year end 2023, of which two additional centers have already received FDA approval during this first quarter of 2022. With that, I will now turn the call back over to Adam for closing remarks.
Adam Grossman
Thank you, Brian. ADMA's assertive financial and operating measures enacted at the board and C-suite level over recent periods, we believe will enable the company to continue to execute and deliver on commitments to stockholders while providing for optionality as we continue to explore strategic business opportunities with our advisors, Morgan Stanley. We look forward to executing on all previously stated operating targets, including the newly issued 2022 revenue guidance calling for total annual revenues in excess of of $125 million. In closing, I'd like to thank you, our stockholders, for your continued support as your investment in ADMA helps to advance our mission to save lives and make high-quality, safe, and efficacious products that help our friends, family, and neighbors. Please donate plasma, donate blood, help save lives. And with that, I'll now open up the call for your questions. Thanks, Operator.
Operator
Certainly. Ladies and gentlemen, if you have a question at this time, please press star then 1 on your touchtone telephone. If your question has been answered and you'd like to remove yourself from the queue, please press the pound key. Our first question comes from the line of Elliot Wilber from Raymond James. Your question, please.
Elliot Wilber
Thanks. Good afternoon. Congratulations on all the progress made in business over the course of the year and continuation of strong underlying fundamental trends.
Adam Grossman
Thank you.
Elliot Wilber
First question for Adam. I think I asked this last call, but just wanted to try to get a little bit more insight and color into the continued favorable mix shift toward incentive vis-a-vis Bibigam, obviously significant uptick in incidence of RSV this year. I assume that had something to do with the favorable mix shift, but just trying to understand You know, how much of it was just driven by increased RSV, tightness in overall IVIG supply, or specific aspects tied to a sentence profile that you think are driving increased share in the market?
Adam Grossman
Sure. Thanks, Elliot. Good question. You know, the product is indicated for the prevention of serious infections in patients with primary to moral immune deficiency. And as you know, with our patented methods, and if you look at the Ascentive.com website, it is the only Ig produced and available in the United States that is manufactured by blending normal source plasma and RSC high-titer plasma. So when you look at that and you look at the published data, you know, our antibody profile is unique. If you start with plasma that has higher levels of antibodies to certain pathogens, the resulting Ig, in theory, should have higher levels of antibodies to this panel of pathogens. You know, I don't believe that the tightness in the IG market is driving utilization. I mean, Ascentive is a unique product, and I think if you spend some time on the Ascentive.com website and you look at the types of patients, the risk factors that we're calling out, not all PI patients are created equal. Some have a more severe form of PI than others. There are over 400 different classifications of disorders that make up primary immune deficiency. Some affect T and D cells, and some patients have just had a bad course throughout their life, even while they're on immunoglobulin therapy, standard IG therapy. So we really look at the product as this is a product for problematic patients. This is a product that clinicians are trying, that payers are reimbursing for, who don't have the best outcomes on regular IG. And medical letters of justification, Again, certain risk factors, comorbidities, socioeconomic factors, all of this plays into a potential prescriber and payer's decision to allow or prescribe incentive to these patients. So really what I think is driving increased utilization is the product's been on the market now for a couple of years. It was launched in the second half of 19. Obviously the beginning part of COVID was tough for us in the 2020 timeframe engaging with clinicians, but For the back half of 21, we were front and center at medical conferences. We've been really hitting the pavement from a medical education standpoint. And I think that it's a combination of just what's going on in the world today with COVID and Omicron and respiratory viruses. I think patients are doing more diligence and research about their quality of care and what kind of options they have available to them. But I really think it's a culmination, as I said in the prepared remarks, of the marketing, the sales force, the medical education strategy. Our AMCT dossier is available publicly, which supports a wide array of different applications. But the majority of the use of Ascendant is still coming from the outpatient setting. You know, these are patients that are receiving IG every three to four weeks, like they would standard IG. Same thing for Bivigan. You know, our Bivigan numbers are also increasing in the pull through there. um, is, is very favorable and positive. So, um, we feel that all of our IT products are really being viewed favorably. They're, they're of a high quality. Um, and, um, we're just very proud of the fact that the message is resonating. Um, so I'm, I'm, uh, I can't comment per se on, is it the uptick in RSV? I mean, I've seen the same data you have on the CDC website, Elliot, that I'm sure you're referring to. And, and, um, There were some peaks of RSV throughout the year last year, and that could be driving clinicians to maybe consider the product. But, again, it is not indicated for it. And what I'll tell you is that the utilization we're seeing is sticky business. It's patients that are being prescribed incentive and they're having favorable outcomes. They're seeing improved quality of life measures. Their chronic persistent infections are declining. The use of antibiotics and other drugs, Concomitant therapies are being reduced. And, you know, I can tell you when a doctor sees a favorable outcome in one of their PI patients on the drug, that makes them want to try it in others. Once they get reimbursement approved for one patient, you know, the daunting task of getting reimbursement is something that they can manage. And I think all of this is evidence of our team executing in the right way. a product that is, you know, it's certainly not a mature product, but it is maturing in the market. And, um, as I said in the prepared remarks, I really feel very strongly that, um, uh, the product is going to exceed, um, even my expectations. And, um, you know, that that was, this is the original reason why Admiral was founded and, and it's been an interesting history, but we're very proud of this product. Again, it is a higher margin product, um, compared to our standard IG products. And, um, we really believe that that medical education messaging is starting to resonate.
Elliot Wilber
Okay, thanks. Maybe I can follow up that question with one directed to Brian that ties into the expectation for increased volume of incentive over the course of 2022. Anything, Brian, that you can say about expectations for revenue progression and gross margin progression over the course of the year, and specifically just thinking about sequential trends in each of those as you dedicate more capacity towards Ascentive versus original expectations?
Brian
Sure, absolutely, Elliot. So about a few years ago, upon the launch of Bibigam and Ascentive, we were looking at a product mix of around 90% 90% are Bibigam product and about 10% for our higher gross margin products, Ascentiv and Navi. Now we're seeing a mix closer to 80-20, 75-25 because of that patient adoption by providers. When you're looking at gross margin, we really set the company up for success. Back in 2019, getting the FDA approvals. 2020, the conformance batches. bringing the plant to a 4,400-liter process capacity, as well as fill finish, bringing that in-house, will all contribute to positive gross margins throughout 2022 and beyond, leading up to a 40% to 50% gross margin sometime in that end of 2023, 2024 timeframe. And as we said previously, incentives gross margins are in that 75-85% range, BIVIGAM, and 20% NAVI-HB, 70% plus, and then we have our intermediates in sales of normal source plasma. So blended, all in, 40-50% by the end of 2023-2024.
Elliot Wilber
Okay, thanks. Last question for me, directed back to Adam. With the recent announcement of the FDA approval of your fifth collection center, Could you just maybe talk a little bit about trends in collection volumes, how they're performing versus expectations? I know some of the bigger players in the space, even though they've been able to experience some recovery in volume, have really had to ratchet up incentives in order to be able to drive their volume recovery. So just curious what you're seeing in terms of collection volume levels versus expectations, price per liter, and, you know, what – you may be offsetting, uh, incentives with in, in terms of realizing the efficiencies.
Adam Grossman
So, um, maybe I'll just touch on some of the, some of the macro topics and, and, and Brian, um, as you're much more intimately familiar with the, uh, uh, donor fee rationale these days. Um, I'll let you handle that one, but you know, Elliot, from a, from a industry perspective, collections are still being pressured. Um, You know, AdMob, we've always said this throughout the pandemic. We have certainly had impacts, but our recovery has been fantastic. We've got a great team out there. We've got great donor recruitment efforts that are really driving folks to our centers. Social media campaigns, the whole nine, we're doing everything we can to attract donors. And again, I think the awareness coming post-COVID, the fact that more localities are open, people are traveling about, we're certainly seeing an uptick in donors. But With respect to the industry, some of our larger competitors, they are still experiencing some impacts. I know that the border continues to plague some of the larger players. It's a problem. I think that overall, you're going to see some tightness ultimately in the global stage for IG products. It's just happening. You know, I can't tell you how severe it's going to get, but I do think that this is going to continue to persist. If nothing else, the border, when you look at the, you know, tens of centers or so that are along the border, these centers represent, you know, a couple million liters of plasma that we collect annually. And, you know, at an admi-biologics yield of, you know, call it roughly four grams per liter, that's, you know, tens of millions of grams of IG that the world may not have available. It's not just the U.S. that gets product made from U.S. plasma. It's on a global stage. So, you know, ADMA's perspective, we are recovering. I mean, I just saw an internal graph that I probably can't talk about on this call, but it looks great. You know, Q1 is looking very strong from a collection standpoint. And, again, as you get the centers approved and we're opening up more centers, certainly, you know, I think we say for the first time in the prepared remarks that we are forecasting plasma supply self-sufficiency by year end next year. So we feel very confident about our position. But I do think that the lingering impacts from COVID as well as the border are going to plague the broader industry for the period ahead. Brian, you want to comment on the donor fees and some of the other programs?
Brian
Sure, absolutely. So we're very pleased, as you can imagine, with the acceleration of how we've built out our 10 centers. We currently have 10 under our corporate umbrella. six collecting, so certainly made a lot of progress over the past year. And then you can see we already received two additional FDA approvals this year already. Regarding opening up new centers, plasma collections, plasma donors, our collections for 2022, as Adam just highlighted, they're ahead of our schedule, so we're pleased how we're instituting special programs. When we open up a center, we'll have certain incentives for donors to come into the center And then we'll run programs throughout the year. But to offset those costs, last year we implemented the persona software technology from the humanetics program. And we're seeing anywhere from 7% to 10% increased yield from donors that we're collecting plasma from. So we're certainly very proud of our achievements of quickly bringing 10 centers online under our corporate umbrella. and the FDA approvals being received in half the time. So we're accelerating the openings of our centers and we're instituting programs that really have brought donors in and we're pleased with our numbers so far.
Operator
Thank you. Our next question comes to the line of Christian Kleska from Cantor Fitzgerald. Your question please.
Elliot
Hi, good afternoon, everybody. Thanks for taking the questions and congrats on a strong start of the year that you've had. Thank you. I wanted to see if you could comment on what the reimbursement landscape has been, particularly on incentive in light of your positive comments here around usage. And then maybe are you able to comment a bit about the specific profiles of usage here? Are you seeing that these are PI patients that weren't perhaps having as strong of a response with the standard IVIG products? Or perhaps are these some of those patients off some of your comments earlier that not all are the same and perhaps they have a more severe type of disease to begin with? Or is it a mix that you're seeing?
Adam Grossman
Both great questions. Maybe I'll just touch on the reimbursement piece first. So again, all all. 70% or so, 80% of all IG requires prior authorization, whether it's Ascentive, Bibigam, or any of our competitors' products. So no matter what, you need to go through the rigmarole of getting a patient approved, whether they have documented primary immune deficiency or they're on the borderline with some rare type of immune disorder. So no matter what, the physician community is used to having to, if you will, fight for reimbursement for any IG product. So this is not something that's unique to us and our drugs or Ascentive. It's just the nature of the beast. What I can say is that we're seeing reimbursement because of Ascentive's approval, because of the approval in primary immune deficiency. That's why, you know, I think even earlier to Elliot's question, It's not so much about RSV or the respiratory viruses. This is a product that has documented efficacy in patients with primary immune deficiency. Now because of its cost, and it is more costly than other IGs in the market, we believe that there's an appropriate patient profile that you want to look for in order to prescribe a product like this. And I think that the payers understand it. They understand that the product is manufactured differently. Some of the private payers have even published in their IG reimbursement guidelines that, you know, if you can demonstrate a documented need for a product manufactured from this type of plasma, they will approve it. And, you know, these patients, it's very hard to tell specifically every patient that we have going on the product, Kristen, but what I can tell you is that these are patients, most of them, they've been on IG for years, some of them even decades. They've had multiple bouts of bacterial pneumonia throughout their life while on standard IgE therapy. And what the data suggests now and what payers really frown upon is, oh, I want to increase the dose. I want to go from 500 mg per kg to 600 mg per kg to 700 mg per kg. And what the payers are starting to frown upon now is that increasing the dose doesn't necessarily translate into better outcomes, better efficacy, better quality of life. Physicians already know that they can't go and they can switch brands, but they can't go and ask for more products. So now with Ascended, they have an alternative. They have a new option for these problematic patients. And, again, these are patients that have lots of comorbidities. They may have bronchiectasis. They've had multiple bouts of bacterial pneumonia, and they have scarring of the bronchioles and the alveoli and the lung tissue. They may have chronic persistent otitis, sinusitis, bronchitis. They're on antibiotics for three, six, nine, 12 months out of a year. They've been on antibiotics for two years in a row. They take Tamiflu prophylactically. These are the kind of stories that I hear coming back in from our KOLs and our Speakers Bureau and our medical affairs team that these are really problematic patients, and it's probably, call it 10%, of the PI population that really experiences these comorbidities. It's been a couple of weeks since I've looked at our corporate slide deck, but I want to say roughly about 30% of PI patients have experienced or currently experience some type of chronic lung condition. So I think that when you put all these factors together, these are the problematic patients that our sales force is targeting, our medical affairs and medical education efforts are targeting. And these are the patients that clinicians are saying, you know, I want to do better for this patient. Let me try this product that's out there. And from a reimbursement standpoint, CMS is continuing to reimburse at our ASP plus 6%. I'd like to say that our ASP has been stable for Ascentive and Vivigam since their launch, which also makes payers happy as well as makes the prescribers and the infusion clinics happy. So I think we've got a stable process. stable ASP. I think that we've got a reimbursement pathway that is well defined since receiving the J code last year. And we're really pleased with the utilization in these, you know, high risk and more at risk patients for chronic and persistent infectious diseases.
Elliot
Okay, thanks. I appreciate that color. And Maybe just because it sounds like Ascentive has been exceeding some of your own internal projections, just in light of all these positive signals, how are you considering also the longer-term horizon if this adoption continues to grow and you continue to receive this great feedback? Are you also considering avenues to maybe collect more plasma from those donors who have the sufficient levels of the naturally occurring neutralizing antibody titers to RSV?
Adam Grossman
You know, I can tell you it's – were you in the halls of ADMA over the past few weeks? I mean, we are very, very encouraged by the performance of the product throughout the tail end of last year and the beginning part of this year. We've been collecting plasma for a long time, I will say, Kristen. You know, a portion of the raw material inventory that we have on the books is plasma that we've collected from RSV donors for the past, you know, three, four, five years. Plasma has a 10-year shelf life when used for the U.S. market. So the U.S. FDA has a 10-year shelf life. Some other regions around the world have a shorter shelf life, but plasma for the U.S. is 10 years. So we like all the RSV plasma we can get, and when we identify donors, we certainly do what we can to ensure that they continue to come back in. Some projects that we don't really talk about per se, but, you know, our analytical development team here in Boca Raton is working to transfer part of the RSV detection assay that we use to identify plasma donors in-house. We think that can improve turnaround times for donor collections. And when we improve turnaround times, we've got a better chance of telling that donor, hey, you've got something special in you. Please donate it. Come back. We do pay these donors sometimes slightly higher donor fees to come back more frequently. But we are using all measures possible to continue to increase donor collections from an RSV standpoint. We do have long-term supply contracts for RSV plasma. So while I've mentioned that our normal source plasma supply contract will end with griffles at the end of 2022, again, we're augmenting that with collections from our internal expanded network. Our RSV plasma collection contract with Griffles runs through June of 2027. So we still have more time, and we are able to augment our RSV plasma supply from collections from third parties. And we're also signing, I think we spoke about it last quarter, we've been signing some additional agreements with some new and emerging collectors in the market who we have relationships with. But we feel very, very good about our position to collect. the high-titer RSV plasma that we use to make a sentence. I think, as we've mentioned, roughly about 5%, 10% of plasma donors have the antibody profile that we're looking for. And we are able to easily identify these donors. And, you know, we are looking at our inventories, and we certainly feel good for the, you know, next, you know, 12, 24 months that we've got the plasma that we need in order to meet the market demand. We've been increasing our production of Ascentive early in the beginning part of 2022 to meet the forecasted growth in demand throughout the year. But we feel very, very good about our ability to continue to supply the market. Again, it's a product that the clinicians understand. It's not for everyone. It's a product that is used in patients that are costly to the payers. There's a pharmacoeconomic value proposition here with the drug that certainly makes sense. And I think if you stay tuned for the next couple of quarters, I think you'll be very, very pleased with the uptick of the higher margin products in the revenue mix for ADMA.
Elliot
Okay, thank you. And then the last question I have for you is, you know, you noted in the release that your total revenues for this year are expected to exceed 125 million. Obviously, a majority of that is coming from your approved product revenue line. But, you know, just thinking about the other important lines here, your plasma collection centers, you've publicly stated in the press releases that some of these approvals came ahead of your own guidance. And then, you know, intermediate byproduct revenues, thinking about all the implementations that you took last year in terms of manufacturing. So just, you know, simply wanted to ask how we should be thinking about these two avenues moving forward as well in light of some of these implementations that took place. Thank you again.
Adam Grossman
Sure. So, you know, our growth is really going to be driven by finished good product revenue. I mean, that's where we're going to see growth. I know that with our intermediate fractions agreement that we announced a couple years ago. Brian, I don't want to misspeak because everybody then chews me out. We say it's $10 to $15 million a year we can generate intermediate fractions?
Brian
That's correct. $10 to $15 growing closer to $20 to $25 as we're looking in 2024 and beyond.
Adam Grossman
Correct. So that revenue line item is going to grow exponentially as we increased throughput at the facility. Again, the intermediate fractions, we get more intermediate fractions from a batch of 4,400 liter Bibigan than we would from, say, a batch of 2,200 liter Ascentive. But a batch of 2,200 liter Ascentive is going to, you know, at a $900 per gram price, you know, roughly it's 8,000 grams at a $900 per gram price. You're looking at $6, $7 million net of fees on a batch of Ascentive where Bivigam at 133 is certainly less, even at double the scale. We'll trade a batch of Ascentive at an 80 plus percent margin any day of the week for our Bivigam product manufacturing opportunity. But you're really going to see the growth coming from the finished goods line. And again, I think Ascentive is going to take a larger a larger portion of that as we continue to matriculate throughout this year. But, you know, from a plasma supply, excuse me, a plasma, source plasma revenue standpoint, you know, we've got a great contract in place with our friends at Takeda and they keep paying us on time and we thank them very much for their business. But we're not really looking at signing new agreements right now. I'm going to reiterate that we We are forecasting to be plasma supply self-sufficient from a normal source perspective by year end next year. So it's hard to do that when you – it's hard to increase your revenue when you need the plasma. But we feel very, very good about the way that the market is currently set up. We feel very good about being opportunistic right now. due to some of the tightness that we're seeing in the market from some of the competitors that have had some voluntary market withdrawals with their products. And we certainly feel very, very proud of our ability to capitalize on some of this dislocation out there that we're seeing in the market, and that's what's ultimately going to drive revenue and take us to profitability. We're seeing shorter turnaround times now that we're filling in-house contracts You know, I think there are going to be some pretty unique and interesting updates that we can talk to investors about as we finish up the first quarter here. But we're really starting to see and unlock the efficiencies from our supply chain robustness initiatives. And, you know, we continue to win sticky books of business, and we continue to have patients who perform well on our products, both Vivigam and Ascentive. And that's what's ultimately going to win here. What wins is you make a good product that helps people and they keep ordering. And you grow and you penetrate. And if there is a downturn in supply, we've got the ability to fill it. We've got more product in our, I mean, Brian, you said $125 million in inventory. I don't lend it, call it 40%, 50% gross margin. You know, that's a lot of revenue. It's much more revenue than what we're forecasting for the year or so. I think that there is some upside there, but as you know, it's an interesting and precarious time for the supply chain, so I want to caveat that with please read our risk factors, but we do feel very, very good about capitalizing on the dislocation and penetrating the market more broadly with it again and finding the right patients with arsenic.
Elliot
Okay, great. Thank you so much again.
Operator
Thank you, Kristen.
Brian
Thank you.
Operator
Thank you. Our next question comes from the line of Zach Weiner from Jefferies. Your question, please.
Adam
Hey, thanks for taking the questions. Just a few from us. First, if you give some color on the end users of Ascentive, if it's new users or recurring users just using more product, just some color there on the customer base.
Adam Grossman
Yes and yes, Zach. I think that certainly you've got the clinicians who were early adopters and who began using the product. They are certainly adding to their patient rosters. Many of these physicians who we're calling on, they have practices where they see 50, 100, 200, sometimes 300 or more PI patients in their private practices. And as I'm saying, about 10% of the population have these comorbidities or, you know, a higher susceptibility and risk for other types of infectious diseases, especially respiratory viral infections. And I think that once the docs see that they can get reimbursement, once they see that the drug is providing some clinical benefits in their assessment in these patients, they're putting more patients on. with medical education symposium, with publications that have been given out there by clinicians on individual case presentations about actual real-life patients, I think that it's really turning other doctors who may have been on the fence on to, well, let me try this in my patient. I want to do something. The clinical immunologist is a really kind-hearted type of clinician. They're seeing many of these patients for decades, and they want to do better. They develop real relationships with these patients, and we certainly are seeing word of mouth, grassroots efforts. You know, doctors are calling our medical affairs team, and they're saying, you know, I'd like to organize a roundtable in my region of my friends across the city, and You know, it's really something, it's the first really differentiated opportunity for the clinical immunology setting in years. And, you know, we're not just talking about expiration dating or subcutaneous administration or, you know, room temperature storage. We're sitting here talking about a differentiated antibody profile and a unique way of blending normal and RSV high-titer plasma. So we're seeing utilization and we're seeing penetration from existing accounts, but we are adding new accounts every single week, every single month.
Adam
That's helpful. And then just on the balance sheet and cash usage, 2021, you guys spent a fair bit on manufacturing updates, the 440-watt capacity and the fill finish. I guess my question would be, you know, what is the expectation? Are there manufacturing upgrades, supply chain upgrades that are, you know, expected through 2022, or is the focus more on plasma center growth and, you know, just continuing growth in the business?
Brian
Sure, I can take this one. It's predominantly focused on building up the remaining plasma centers. As I said, we have six currently collecting plasma. So we have another four to go in various stages. And then obviously we're going to continue to build that inventory balance. We feel very pleased where we're at now with $125 million as we look forward to 2023 and 2024 revenues. But ideally it's going to be, there's no major projects at the plant. The projects, the CapEx projects are really just concluding the tent center build out, which we have four to go.
Adam
All right, and then thanks. And then my last one just on the refinancing and then the strategic alternatives, if you can just give some color on both those, it would be helpful. Thanks.
Adam Grossman
Well, I'll say the refinancing we're really very proud of. I mean, Haston is a top-tier shop. And, you know, they came in robust due diligence, extensive and robust due diligence. And, you know, I think in light of the state of the global affairs, they really did not leave a stone unturned. We're really very proud of that. I'll let Brian comment on the cost of capital, but I'll tell you from my perspective, we have a lot more money at our disposal. We've got a lot of cash available to us, and it's cheaper, plain and simple. We think that they're a great partner. They're a They've loaned on the global stage. You know, they've diligent a number of other companies in our space and complementary companies. We think that they also can be helpful to us now that they're sitting alongside us here. They can be helpful to us evaluating strategic opportunities. And, you know, they're a $25 or so billion fund, I believe. I mean, they certainly have the capacity that if we see some interesting opportunities in and need some financing help, they could be there for us. To take the capital, I will say, was a business decision. It's something that we promised investors during our financing in the fourth quarter of last year. We look at this as it's all part of the opportunity here. We've now got all the cash we need, we believe, to get to the promised land of profitability. And we really feel that that's the right way to approach a strategic alternatives process. And that process continues and is progressing. And I think it just really strengthens ADMA's position of looking across the table to maximize value for shareholders here, showing that we've now got a fully financed organization.
Brian
Sure, I'll just add a couple more things to that regarding the debt process. Zach, with regards to, as Adam mentioned, it was a very robust process, thorough due diligence. It was a competitive process, multiple parties expressing interest. The cash carry interest at 8.25% on $150 million is essentially the same cash interest that we were paying at $100 million. So the overall effective rate is lower than we've previously seen. The interest-only period is a five-year interest-only period, which matures in March of 2027. And then we have another $25 million available to us based on future revenue milestones. So certainly very encouraged, very thankful for the Hafen team providing us this capital to continue to grow the business.
Adam
Thanks for taking the questions. Appreciate it. Congrats on the quarter.
Operator
Thank you, Zach. This does conclude the question and answer session of today's program. I'd like to hand the program back to Adam Grossman for any further remarks.
Adam Grossman
So thank you, everybody. Thank you for your interest and attention and time. We do appreciate you, our shareholders, for helping us to make good, high-quality products that help save the lives of our friends, family, and neighbors. And please donate plasma. You can visit admabiocenters.com, where we've got a number of new centers that are opening. And go visit. Go donate plasma. Donate blood. Save some lives. And thank you. We will keep you posted on our progress throughout the year. Thank you again. Have a good afternoon.
Operator
Thank you, ladies and gentlemen, for your participation in today's conference. This does conclude the program. You may now disconnect. Good day.
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