Amarin Corporation plc

Welcome to Ameren Corporation's conference call to discuss its fourth quarter 2025 financial results. At this time, all participants are in a listen-only mode. A question and answer session will follow the formal presentation. If anyone should require operator assistance during the conference, please press star zero on your telephone keypad. Please note this conference is being recorded. I would now like to turn the conference call over to Devin Sullivan, Investor Relations for Ameren.

Thank you for your time and attention this morning as we discuss Ameren's 2025 fourth quarter and full year financial results. On the call today are Aaron Berg, President and Chief Executive Officer, and Pete Fishman, Chief Financial Officer. Other members of the senior management team will be available as needed during the Q&A session that will follow these prepared comments. Turning to today's agenda, Aaron will provide a state of the company and Pete will walk through the numbers. Before we begin, I'd like to remind everyone that today's press release is available on the investor relations section of the company's website, www.amroncorp.com, as will a replay of this call shortly after its completion. Our annual report on Form 10-K will also be available in the investor relations section of the website in the coming days. Please be aware that during this call we may make certain statements related to our business that are deemed forward-looking statements under federal securities laws. These statements are not guarantees of future performance, but rather are subject to a variety of risks and uncertainties. Our actual results could differ materially from expectations reflected in any forward-looking statements. Additionally, we assume no obligation to update these statements as circumstances change. For a discussion of the material risks and important factors that could affect our actual results, please refer to our SEC filings, which are available either on our company website or the Securities and Exchange Commission's EDGAR system. With that said, I'd now like to turn the call over to Ameren's President and CEO, Aaron Berg. Aaron, please go ahead.

Thanks, Devin. 2025 was a year of substantial achievement for Ameren. The strategy we've been developing to transform our business model and expand the global market for our Vesepa Veskepa franchise took shape and began producing measurable results. Mid-year, we established our exclusive long-term partnership with Recordati to commercialize Veskepa across Europe with the overarching goal of better capitalizing on the untapped potential of Veskepa to tackle the growing challenge of cardiovascular risk worldwide. This strategy was the catalyst for us to examine the entirety of our operations and identify areas where we could realize significant and durable efficiencies that would support this strategic pivot. Our expectation is that this combination of a refined strategy via our relationship with Record Audi and enterprise-wide operating efficiencies generated by our global restructuring will result in a whole that is greater than the sum of its parts. allowing us to efficiently generate revenue and cash flow globally and position us to be a stronger, leaner operation. We are very pleased with the progress to date. For full year 2025, we achieved a significant reduction in our operating expenses, generated positive cash flow earlier than anticipated, and maintained a debt-free balance sheet and ample cash balance. As of December 31st, 2025, we realized approximately half of the estimated $70 million in total operating expense savings associated with our global restructuring plan and expect to achieve the full savings benefit from these initiatives by June 30, 2026 as planned. While there's still work to be done, we are operating from a much stronger position due to the hard work and dedication of our exceptional team. The operational progress we made this year reflects their shared commitment to enhancing long-term shareholder value. Everything we do as a company is driven by our commitment to reduce cardiovascular disease as a leading cause of death. With approximately 30 million total prescriptions written since the launch of the SEPA in 2013, and a large and growing library of validating studies, analyses, and scientific evidence, that support Vesipa's ability to reduce cardiovascular events by 25% when added to a statin. We remain confident in the durability of our core franchise and its global growth potential. In the US, Vesipa has retained clear market leadership across all available icosapent ethyl products, branded and generic, a remarkable achievement five years since the first generic product was introduced. We maintained all major managed care exclusives through 2025 and successfully regained exclusive status mid-year with a large national PBM. Our continued revenue generation reflects the effectiveness of our commercial strategy, as well as our success in maintaining market share leadership due to both accessibility and affordability. We know from our experience with ASEPA in the U.S. that Europe offers a significant growth opportunity because of the growing awareness about lipid management protocols and the need for therapies that address cardiovascular disease, which is the number one killer globally and on the rise across the world. While our team in Europe made very good progress in various markets, as we considered our options to address this promising opportunity for the future, it became clear that the best way to accelerate and maximize access to this large, untapped market, where we have IP protection through 2039, was via a partnership with an established leader in cardiovascular disease in Europe. Our exclusive long-term license and supply agreement with Recordati, which commenced in Q3 2025, includes commercializing Veskepa across 59 countries with a focus in Europe. This agreement has significantly transformed our international commercial strategy into a fully partnered model comprised of seven parties in close to 100 countries. This approach is designed to generate substantial economies of scale and offer significant revenue opportunities while providing extensive infrastructure and commercial experience. Recordati is now fully managing European promotional activities for Mesquepa, As a result, we're providing this therapy with greater effectiveness and efficiency to an expanded international patient population. I'd like to share with you some of the initial highlights from this agreement. Delivered immediate, meaningful financial value, including a $25 million upfront cash payment for Rekordati with eligible future milestone payments totaling up to $150 million, with the first milestone payment contingent upon Recordati achieving annual net sales of $100 million. Commercial momentum continues, with both volume and in-market demand growing across all large markets. Commercialization was advanced in Italy, a key market, initiating sales efforts and building on Ameren's strong pre-deal groundwork for pricing and reimbursement. Expanded patient access, including securing pricing and reimbursement in two additional countries, Austria and Slovenia. The position for further European expansion with Recordati actively evaluating additional launch opportunities and timing broadly across the full 59 country territory. Outside of Europe, our partners continue to make progress in their respective regions. Of note, Together with our partner, Lotus, we secured two regulatory approvals in 2025, South Korea and Singapore, and are preparing to launch in these countries in the future. We expect the regulatory reviews of previously submitted applications in Thailand and the Philippines will be significantly advanced by the respective local authorities across 2026, with new regulatory filings to be made in Vietnam and Malaysia this year. Overall, the success of our partners is fundamental to our global strategy of making the SEPA available to the millions of patients in need of cardiovascular risk reduction today. Supported by more than 500 peer-reviewed publications, science is the foundation of everything we do, providing both us and our partners with robust, credible evidence to support confident decision-making and long-term patient impact. It guides our decisions and underpins our continued investment in analyses that further explore and validate Bacipa's ability to reduce major adverse cardiovascular events across diverse patient populations, further strengthening its established therapeutic value. We ended 2025 having supported a total of 45 abstracts, posters, and papers that further expanded the body of knowledge for our product. Our most recent publications in late 2025 and 2026 include three reduced post hoc analyses that were previously presented at major medical congresses. We had two papers published online in the American Journal of Preventive Cardiology, or the AJPC. The first demonstrated that icosapenafil reduced cardiovascular risk in patients with baseline characteristics cardiovascular, kidney, metabolic, or CKM syndrome. The second showed that icosapen ethyl reduced the rate of cardiovascular events across the range of standard modifiable cardiovascular risk factors that included hypertension, diabetes, smoking, and hypercholesterolemia at baseline for established cardiovascular disease patients. A third paper published online in the European Journal of Preventive Cardiology, or EJPC, demonstrated that icospinethyl treatment in the REDUCE-IT study was associated with fewer total hospitalizations and increased the chances of an individual living without hospitalization. We look forward to sharing more about this paper soon, which provides additional insights on the effects of icospinethyl on patient-centered measures of total disease burden. In addition, we're preparing to attend the American College of Cardiology Scientific Sessions in New Orleans from March 28th to 30th, where we and our collaborators will present a new, reduced patient subgroup analysis and additional mechanistic data on EPA's multifactorial biologic activities. We expect to share more details as we approach the ACC conference. Building on the substantial body of evidence we've generated and supported this year, we're also encouraged by the ongoing progress across the complex lipid and lipoprotein research landscape. Recent FDA breakthrough therapy designations highlight the growing recognition of the risks associated with elevated triglycerides and the need to address them. Innovation is reshaping the future of cardiovascular care. With promising research into multiple pathways, And as this landscape evolves, we believe the SEPA remains uniquely positioned for sustained relevance and growth. While multiple forces are shaping today's treatment environment, our perspective is straightforward. Currently available, proven, safe, and evidence-backed therapies are often overlooked as attention shifts to new innovations. But it should not change the reality that some of the most effective treatment options are those that have consistently delivered meaningful outcomes over many years, including the SEPA. Such conviction is supported by two key factors. Firstly, the FDA's recent update to phenofibrate labeling marks a meaningful turning point in regulatory clarity. While phenofibrates remain approved to lower triglycerides in patients with severe hypertriglyceridemia, The updated label reflects what decades of outcomes data have shown. Fibrates do not reduce cardiovascular events, even when added to statins. While fibrates continue to be prescribed frequently for patients in conjunction with statins to reduce cardiovascular events, this clarification is helping reset expectations across the healthcare system and reinforcing a shift toward therapies supported by proven clinical outcomes, not simply biomarker changes. Against this backdrop, the SEPA stands apart as the only FDA-approved oral therapy with indications for both severe hypertriglyceridemia and cardiovascular risk reduction, with it demonstrating its ability to reduce the risk of major cardiovascular events by 25% when added to statin therapy in appropriate patients as shown in the REDUCE-IT cardiovascular outcomes trial. As prescribers and payers increasingly align decisions with evidence-based medicine, this differentiation becomes even more important, especially with nearly half of all U.S. adults affected by cardiovascular disease. Secondly, as research activity across lipids and lipoproteins expands, we believe it continues to highlight the role of established, proven options such as Vesepa. As we mentioned previously, we're closely monitoring payer-driven step therapy dynamics as premium-priced injectable triglyceride lowering therapies enter the market. In many cases, payers are already requiring patients to step through approved, established, lower-cost options before accessing newer agents. Historically, this type of formulary design has driven broader use of proven oral therapies, and we believe a similar dynamic is likely to emerge in severe hypertriglyceridemia. Taken together, these developments reinforce our confidence in the global opportunity for the BESIPA franchise, grounded in outcomes-based evidence. All that said, we've entered 2026 with an established U.S. therapeutic franchise that continues to deliver life-saving results supported by industry tailwinds emphasizing widely available cost-effective treatments such as the CIPA as a crucial part of preventing cardiovascular disease in patients with elevated triglycerides. We have what we view as a significant growth driver via our relationship with Recordati that has strengthened our presence in Europe and helped define our fully partnered international commercial strategy. We significantly lowered our corporate expense base and enjoy a financial position that ranks among the strongest in our recent history. At the same time, the board and management, with the assistance of our exclusive advisor, Barclays, will continue to explore value-enhancing strategic opportunities. We've come a long way over the past year, addressing challenges and meeting opportunities head-on and emerging stronger. But I'll say it again, we still have much work to do. 2026 will be a pivotal year for Ameren. working to defend our U.S. franchise, working efficiently and effectively to expand our global presence through our international partnership model, and working to stay the course to unlock sustainable long-term value for shareholders. I'm confident that we have the right product, strategy, and team in place to meet these objectives and position the company for long-term success. As the year progresses, we expect to be able to provide greater insight to our progress and look forward to sharing that with you. With that, I'll now turn the call over to Pete to take us through the numbers.