Compugen Ltd.

Ladies and gentlemen, thank you for joining us today. Welcome to Compugen's second quarter 2026 results conference call. At this time, all participants are in list and only mode. An audio webcast of this call is available in the investor section of Compugen's website at www.cgen.com. As a reminder, today's call is being recorded. I will now hand the call over to Lindsay Trickett, Head of Investor Relations and Corporate Communications to begin. Lindsay, please go ahead.

Thank you, Operator. Good morning and good afternoon, everyone, and welcome to CONFIGEN's second quarter 2026 Financial Results Conference Call. With us today are Dr. Eran Ophir, President and Chief Executive Officer, and David Silberman, Chief Financial Officer. Dr. Michelle Mahler, Chief Medical Officer, will join us for the Q&A portion of the call. Before we begin, I'd like to remind you that during this call, the company may make projections or forward-looking statements regarding future events, business outlook, development efforts, and their potential outcomes. The company's discovery platform, anticipated progress and plans, results and timelines for our programs, including disclosure of clinical data, financial and accounting-related matters, as well as statements regarding our cash position and cash runway. We wish to caution you that such statements reflect only the company's current beliefs, expectations, and assumptions, and that actual results, performance, or achievements of the company may differ materially. These statements are subject to known and unknown risks and uncertainties, and we refer you to our SEC filings for more details on these risks, including the company's most recent annual report on Form 20-F. The company undertakes no obligation to update projections and forward-looking statements in the future. With that, I'll now turn the call over to Eran.

Thank you, Lindsay, and good morning, everyone. Q2 was a quarter of steady advancement, and I am pleased with the progress they have made across every part of the company. Our science continues to advance in the clinic, and our partnerships are advancing on strong footing. Our myovarant trial in platinum-sensitive ovarian cancer is progressing as in on track for the interim analysis by Q1 2027. We were encouraged to see AstraZeneca continue to build momentum behind rilvogostomib by initiating a new phase three trial in urothelial carcinoma and with new data at ASCO from the Gemini study in hepatobiliary cancer and the investigator-initiated i-SPI trial in breast cancer. Lastly, our collaboration with Gilead on GS0321 continued to progress as planned And underpinning all of this is the same disciplined, data-driven approach that has always defined COMPOGEN. Now let me take each program one by one, starting with our only home program, COM701, a potential first-class antipyvergy antibody. We continue to make good progress with myOvarian, our sponsored randomized placebo-controlled adaptive platform trial, evaluating COM701, its maintenance monotherapy, in patients with second- and third-line relapsed platinum-sensitive ovarian cancer in a setting with no approved maintenance treatment option and significant unmet needs. We anticipate interim analysis with median progression-free survival data by the first quarter of 2027. During this quarter, we were pleased to present a trial-in-progress poster on myovarian at the Esmogen Ecological Cancers Congress in Copenhagen. The poster underscored the strong biological and clinical rationale for evaluating COM7-1 in this population, including the differentiated biology of the PBRG pathway versus other checkpoints like PD-1 and digits, its high expression in ovarian cancer, and the durable responses previously observed with COM7-1 in mono and combination therapy in heavily pretreated platinum-resistant patients. As we prepare for the myovarian interim analysis, we have been keeping close tabs on the emerging external data to keep our own expectations anchored in the current clinical context. Two recent clinical trials in relapsed platinum-sensitive ovarian cancer, that include in patients who have been pre-treated with spalpinibutols or bevacizumab or both, have shown median progression-free survival for the control arm of less than three months. While the patient population of these two trials is not identical and more heavily protruded than the Maya trial population, based on these data, we estimate the median PSS of the placebo control group in our trial to be approximately four months. As a reminder, patients with ovarian cancer are divided into either platinum sensitive or platinum resistant categories, with the difference being the duration of their platinum free interval. If a patient relapses in less than six months following platinum-based chemotherapy, they move into platinum-resistant category, where further platinum therapy is generally no longer considered effective and treatment shifts to non-platinum options. For the interim analysis, we define clinically meaningful success as COM701 helping patients remain progression-free for at least six months after platinum-based chemotherapy. Achieving these thresholds maintains patients as platinum-sensitive for longer, delays their transition to platinum-resistant disease, and gives patients a valuable recovery break for the intensity of chemotherapy, thereby improving quality of life while preserving additional treatment options and potentially changing their disease course. Overall, we believe COM701's anti-tumor activity will be best assessed by the totality of the data comparing the treatment effects against our blinded randomized control arm. MYA is an exploratory trial designed to evaluate COM7-1 monotherapy and the magnitude of its effects. It is not a registration trial powered to demonstrate a statistical difference between the treatment groups. Nevertheless, we believe that comparing COM7-1 as a monotherapy against a placebo control We allow us to draw clear conclusions about the clinical activity. Looking ahead, we believe that clear prolongation of PFS in these patients could inform a registration path for COM701 and establish it as a potential backbone for drug combinations in this population, while also enabling a potential broader clinical development plan across earlier and later lines of ovarian cancer treatment, as well as in other indications where clinical signals were previously seen for COM701. Turning to Rivagostamine, the PD-1-tigit bispecific antibody being advanced by our partner, AstraZeneca, the tigit component of which is derived from our fully-owned COM902 program. In the last week, AZ has added a 12-phase free trial to the overall real vet program in participants with high-risk muscle-invasive urothelial carcinoma. In this trial, will be combined with DAPRO-A, their approved TROP2 ADC, and tested in adjuvant settings against TANATOF-KER. This new phase three trial, Tropion-Ureterial O4, follows the phase two Tropion-Pentumal O3 study in which RILVE plus DATOCOMBO showed an encouraging efficacy and a manageable safety profile in a metastatic ureterial carcinoma. We also encouraged but the addition of RILVE data AstraZeneca presented at 2026 ASCO Annual Meeting which we believe continues to support the differentiated profile of this bispecific and its potential as an immuno-oncology backbone across multiple tumor types. In advanced biliary tract cancer, AstraZeneca presented an updated analysis from the Gemini Hepatovolibularis study of RILVE in combination with chemotherapy in the first line setting. This was the first overall survival data result from RILVE, and as AstraZeneca highlights in their ASCO investor call, the 16.8 months of overall survival was a clear example of prolonged stabilization of responses seen with RILVE across clinical trials, and the profile continues to support RILVE combination potential. In comparison, Historical trials for first-line BTC showed overall survival duration of less than 13 months. The data showed encouraging efficacy together with manageable safety profile, both of which we view as promising signals in a setting of high animate needs, while recognizing that longer follow-up and randomized data from the ongoing phase three trial in this setting will ultimately be needed to validate these findings. As AstraZeneca continues to advance revigostomy, across its broad late-stage program, we believe this sustained investment reflects ongoing confidence in Rilke Kostami. As a reminder, AZ has previously guided that Rilke has a non-risk-adjusted peak-year revenue potential of over $5 billion, and you remain eligible for future milestones of $195 million and up to mid-single-digit territories tied to Rilke Kostami progress and success. Moving to GS0321, formerly known as COM503, our potential first-in-class anti-IL-18 binding protein antibody licensed to Gilead. GS0321 represents a novel antibody approach to harness cytokine biology for the treatment of cancer, potentially overcoming the limitations of direct cytokine administration. The ongoing Phase I dose escalation trial continues to progress as planned. As a reminder, We have received $90 million so far from Gilead on this asset, and we are eligible to receive up to $768 million in additional milestones payments, plus single-digit to low double-digit tiered royalties. Now moving to our early pipeline, Fueled by Unigen, our AI machine learning powered computational discovery platform, which has been developed and refined for more than a decade to identify novel drug targets and biological pathways grounded in human disease biology. As we have said before, our focus is not on using AI to optimize known biology, but on uncovering innovative opportunities to activate the immune system against cancer. UNIGINE has already discovered the targets of COM701, COM902, NGS0321, and we remain committed to identifying and advancing the next generation of immuno-oncology innovation. With that, I will turn the call over to David to review the financials.

Thanks, Eran, and thank you all for joining us today. We finished the first half of 2026 with a solid balance sheet and financial flexibility. Cash Runway, assuming no further cash inflows, is expected to fund our operating plans into 2029. We anticipate using this runway to continue advancing our COM71 platinum-sensitive ovarian cancer trial, MyOvarian, and to support the progression of GS0320 in the clinic together with continuous investment in our early stage pipeline. Going into the details, I will start with our cash balance. As of June 30th, 2026, we had approximately $125.3 million in cash, cash equivalents, short-term bank deposits, and investment in marketable securities. Revenues for the second quarter of 2026 were approximately $2.6 million compared to approximately $1.3 million of revenue for the comparable period in 2025. The revenues in the second quarters of 2026 and 2025 reflect the recognition of portions of both the upfront payment and AI and demand front payment from the License Agreement with Gilead. Expenses for the second quarter of 2026 were in line with our plans. R&D expenses for the second quarter of 2026 were approximately $6.3 million compared to approximately $5.6 million in the second quarter of 2025. Our G&A expenses were approximately $2.3 million for the second quarter of 2026, compared to $2.2 million for the second quarter of 2025. For the second quarter of 2026, our net loss was approximately $7 million or $0.07 per basic and diluted share, compared to a net loss of approximately $7.3 million or $0.08 per basic and diluted share in the second quarter of 2025. With that, I will hand over to the operator to open the call for questions.

Thank you. Ladies and gentlemen, at this time we will begin the question and answer session. If you have a question, please press star 1. If you wish to decline from the polling process, please press star 2. If you are using speaker equipment, kindly lift the hands and before pressing the numbers. Please stand by while we poll for your questions. The first question is from Steven Wiley of CISO. Please go ahead.

Yeah, good morning. Thanks for taking the questions. I was just curious, so it sounds like you've taken down your control arm assumption in the MIAA trial by maybe about a month and a half. What do you know about the Haitian population from these two trials that you cited with respect to things like liver metastasis and . I guess just general patient eligibility criteria and would just be curious to get a better understanding as to your level of confidence now around this revised form of number.

Thank you. Michelle, do you want to take this?

Yeah, I'm happy to take it.

Hi, Steve.

How are you doing? So the two trials that we are referring to are European studies. One is TODOVA recently presented. and the other trial is a trial called OREO. Both trials are run in Europe and had similar patient populations because they enrolled patients with platinum sensitive ovarian cancer and were treated in the maintenance setting. However, the patient population was not identical because the trials did not cap the prior lines of treatment. They included patients that had stable disease as well, which we don't. They also included patients who have liver metastases. And so they also could have had multiple attempts of being treated with both bevacizumab or POP inhibitors. So due to this, these patients were actually more heavily pretreated than our myovarian trial. and their placebo control arms had a medium PFS of 2.8 months. We anticipate that the actual benchmark is somewhere in between the historical data sets, which we took from the original registration trials for the POMP inhibitors, which was approximately five and a half months, and these new updated trials who have a similar patient population, and therefore we've adjusted it to approximately four months. As such, we currently don't know who is allocated to which arm because our trial is blinded, so we're making these adjustments based on emerging data.

And maybe I could add that eventually the approximation is roughly around four months, but I think eventually what is most important for this trial is that that's why we have an internal randomized controlled placebo arm and eventually we are comparing COM701 for T patients treated in monotherapy versus placebo arm of 20 patients. Whatever antitumor activity you see in the treatment arm is COM701 driven. It's not a combination study and the assumptions for the placebo controller are important but eventually the critical is the actual data on the trial comparing placebo to COM701 treatment.

And then maybe just quickly on GSO321, I guess you've been dose escalating now for, I guess, around 18 months or so. Have you had a conversation with Gilead about presenting some of the dose escalation data before you move into dose expansion? And is it safe to assume that you are now dose escalating both in combination with the PD-1 inhibitor and, I guess, monotherapy as well?

Yes, so typically with this kind of regimens of pharma companies, we cannot say much. I would just remind that, as you said, we have dose escalation in mono and in combination with PD-1. We also have backfill course in the monotherapy, meaning more patients in the higher doses, and then the expansion phase. So we're looking at benchmark studies in this stage. I think it's reasonable to assume that everything is moving forward as planned. That means that probably we are already doing combinations and other expansions, or showing the backfield course, I would say. But you cannot say precisely where we are and in which days we'll disclose data. I think it's still early. I mean, if you look at other benchmark studies, phase one studies, 18 months into the study, it's a bit early for reporting data.

The next question is from William Gershel of Oppenheimer. Please go ahead.

Hi. Good morning. Thanks, Eran and the team. Just two questions for me. Just wondering, you know, with respect to the mild variant on the guidance for the data, just wondering given the nature of the kind of, you know, changing assumptions and event-driven nature, could you see to the extent possible a readout that might come before the end of the year? and also want to ask, are there any particular biomarkers that you'll be looking at alongside the clinical PFS?

Thanks, Eran, future studies. Thank you.

Thank you.

Thanks, Eran. So for the first question, we are, yes, the status of the placebo is now a bit shorter, but we are not changing our guidelines, and eventually, that's why we say the results will be by 2127. It is depending on the actual data on the study, and obviously we will report it when the data is mature enough. Michelle, do you want to add something for the second question about the biomarkers and other readouts to look at the study?

Sure. So our primary readout is progression-free survival. We don't have a specific biomarker selection strategy other than patient characteristics where we have excluded patients with liver metastases. And the other thing to note is that In our earlier data, we did see activity in patients who were both PD-L1 positive and PD-L1 negative. So other than trying to enrich for more clinical attributes, we don't have a specific biomarker, and we do have an exploratory plan that we will analyze when we unblind the data.

The next question is from RK of HC Wainwright. Please go ahead.

Thank you. Good afternoon, Eran and team. This is RK from HC Wainwright. One quick question. Have you had any interactions with the FDA to see if the myovarian Thank you. Okay, sure. So at this point in time we have not had a meeting with the FDA. Once the trial reads out we will follow all the appropriate regulatory steps.

What I will say to you is we incorporated a lot of the guidelines from the FDA in designing the trial and it's definitely in line with their guidance on Project Frontrunner which is one of the reasons why we did go into an earlier line of treatment as well as using the Bayesian trial design which is again part of the FDA and the guidelines that have recently come out. So we are confident that with robust data we will be able to have good engagements with the FDA.

Thanks. Is it possible for me to ask another question? Sure. On the partnership with AstraZeneca and now that they have 12 clinical studies going on and 12 phase 3 studies going on. Do you have an idea of what we should expect in terms of the earliest phase 3 readout that we could see? And also does this inclusion of the new trial, does it change either the schedule or composition of the 95 million milestone outstanding?

Well, we'll start with the second question.

This doesn't change.

I mean, just another short-term goal and a new indication in combination with ADC, which is, again, very promising, also based on what you've seen from the Phase II study. So this goes for the agreement terms. Promote the first question, please. Okay.

You know, do you have any idea of, you know, which of the Phase II studies we could see data from and, you know, anything on? and others, either the timing or what data we could be seeing or from which study we could be seeing data.

So we could refer only to what AstraZeneca are saying and while they are reporting continuously data on Phase 2 studies in ASCO and in conferences, the Phase 3 results according to their guidelines is after 27, meaning 28. It doesn't mean that it couldn't be earlier analysis and other options, but the actual formal guidelines, are after 27 for the phase 3 studies.

Thank you. Thanks for taking all my questions.

This concludes the Q&A session and Compugens Investor Conference Call. Thank you for your participation. You may go ahead and discuss.