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Operator
Good evening and welcome to Diatics International's second quarter 2021 financial results conference call. Currently, all participants are in a listen-only mode. Following management's prepared remarks, there will be a brief question and answer session. As a reminder, this conference call is being recorded today, August 12, 2021. I'd now like to turn the call over to Ms. Ping Rawson, Diatics Chief Financial Officer. Please go ahead.
Ping Rawson
Thank you. Good evening and welcome everyone to Dyadic International's second quarter 2021 financial results conference call. I hope you've had an opportunity to review Dyadic's press release announcing financial results for the second quarter ended June 30, 2021, and the recent company highlights. You may access our release and Form 10-Q under the Investors section of the company's website at dyadic.com. On today's call, our president and CEO, Mark Emelfarb, will give a review of our business and corporate accomplishments for the second quarter of 2021, including a brief summary of our research and business development efforts. I will follow with a review of our financial results in more detail. We'll then hold a brief Q&A session. Our senior management team, Matthew Jones and Rona Shalette, will join Mark and I for the Q&A. At this time, I'd like to inform you that certain commentary made in this conference call may be considered forward-looking statements, which involve risks and uncertainties and other factors that could cause dyadic's actual results, performance, scientific or otherwise, or achievements to be materially different from those expressed or implied by these forward-looking statements. DIADX expressly disclaims any duty to provide updates to its forward-looking statements, whether as a result of new information, future events, or otherwise. Participants are directed to the risk factors set forth in DIADX reports filed with the SEC. It is now my pleasure to pass the call to our CEO, Mark Unifar. Mark?
Mark Unifar
Thank you, Ping. Welcome, everyone, and thank you for joining us as we move into the back half of Fiscal 2021. We continue to make significant progress in our science and across our corporate and strategic development goals of delivering the benefits of Dyadic's C1 protein production platform to life science, biologics, and vaccine production space. Since the sale of Dyadic's industrial biotech business to DuPont for $75 million in 2015, we have focused our efforts on using synthetic biology to re-engineer our versatile, industrially proven C1 protein production platform to address biologic vaccine and drug production in the animal and human health markets. Our research and development continues to advance. including having manufactured a C1-produced protein under CGMP manufacturing conditions. Demonstrating that C1 proteins can be manufactured in a CGMP facility, coupled with the successful completion of an interim toxicology study, puts us a step closer in advancing our DYI-100 COVID-19 vaccine candidate towards a Phase I human clinical trial. Since March, we entered into four collaborations, including the recently announced binding term sheet with Sorrento Therapeutics, a NASDAQ-listed clinical stage antibody-centric biopharmaceutical company developing new treatments for COVID-19, cancer, and pain. The Sorrento license agreement, when executed, will mark a significant milestone in our corporate development efforts. as we will have begun to monetize our COVID-19 development efforts through licensing our C1 technology for the development and commercialization of vaccines, therapeutic antibodies, protein diagnostics solely for coronaviruses, including DYAI-100, Diatics' lead COVID-19 vaccine candidate, to a drug development partner that has the resources and the expertise to advance coronavirus vaccines, therapeutics, and diagnostics, both clinically and commercially. Due to confidentiality agreements, we are often unable to publicly announce certain ongoing collaborations. Over the past six months, as noted by Sorrento's chairman and CEO, Dr. Henry Gee, Sorrento carried out several promising preclinical animal studies using the C1-produced RBD antigen. and Dyadic's lead COVID-19 vaccine candidate, DYAI-100. Sorrento extensively studied Dyadic's lead COVID-19 vaccine, which utilizes the SARS-CoV-2 spike protein receptor binding domain, RBD antigen, in vitro and in vivo, for its induction of high titer neutralization activities in vaccinated animals against the SARS-CoV-2 virus and its major variants of concern. The goal, or their goal, is to manufacture a COVID-19 vaccine that will provide protection across the variants of concern, including Delta. And in addition, apply to C1 protein production platform broadly across their current and future coronavirus programs. Our mutual goal, as highlighted in yesterday's press release, is to continue to work together to develop and commercialize a protein-based COVID-19 vaccine that can be rapidly manufactured in very large quantities in Sorrento's existing CGMP and other CGMP facilities and stored and transported at either room temperature or two to eight degrees in order to increase access and affordability to underserved populations globally. Sorrento reported that a multivalent COVID-19 vaccine is under development using the SARS-CoV-2 RBDs for the variants of concern, such as Delta, Alpha, Beta, Gamma, and Lambda, and is being designed to cover all known and emerging variants of concern. This is a significant event for Dyadic. Having achieved our goal of creating a pathway that addresses the COVID-19 production and commercialization, and distribution gap for mass-scale immunizations across the globe quickly and efficiently. The Sorrento license fills the gap for the remaining potential COVID-19 immunization production and distribution across all other territories, not already covered by Diatics' existing agreements with Meditox, Syngene, and the Rubic Consortium. The Sorrento license agreement, when executed, will grant Sorrento exclusive rights for human health and non-excluder rights for animal health in their territory to utilize dyadic C1 technology for the development and commercialization of vaccines, therapeutic antibodies, protein therapeutics, and diagnostics solely for coronaviruses, including DYAI-100, dyadic's lead COVID-19 vaccine candidate, and will include upfront payments of $10 million in cash and stock up to $4 million in reimbursements for DYAI 100's preclinical and clinical development milestones and development costs incurred by Dyadic, up to $33 million of potential milestone payments for the successful developments of vaccines, therapeutics in humans and animals, as well as additional royalty payments based on net sales. All future development costs related to this license will be incurred by Sorrento. The following is a brief overview of our other strategic T1 COVID-19 collaborations that could potentially reach upwards of an additional 3.7 billion people. The Rubik Consortium. This collaboration with South Africa's Rubik Consortium is intended to reduce Africa's dependence on foreign vaccine suppliers. Africa represents 14% of the world's population. However, remarkably less than one-tenth of 1% of the world's vaccines are produced there. Rubric intends to develop novel vaccines and in addition to a COVID-19 vaccine using RC1 technology. They also intend to build manufacturing capacity in South Africa to manufacture vaccines for distribution in Africa to improve both access and affordability. Less than 2% of Africans are currently vaccinated against COVID-19 and the potential need for boosters may further push back COVID-19 vaccine availability and affordability on the African continent, which is estimated at 1.3 billion people. Syngene. International. This collaboration is with an integrated research development and manufacturing services company in India to develop a COVID-19 vaccine candidate using Dyadic's proprietary C1 cell protein production platform. In just a few short weeks of receiving the C1 cell line used to develop and produce a DYAI-100 vaccine candidate, Syngin has already successfully demonstrated their capability to adopt and produce the Seaman Express SARS-CoV-2 RBD antigen at high levels. The population of the Indian subcontinent is estimated at 1.7 billion people. Meditox. This is a co-development program with South Korea's Meditox to enable COVID-19 vaccines and or boosters which will immunize people against two or more of the current and future COVID-19 variants. For example, tetravalent or possibly even quadrivalent COVID-19 vaccines. Meditox has begun engineering CM1 cells to express COVID-19 variants of concern antigens. Meditox's territory covers the Republic of Korea and multiple Southeast Asian countries. The population of Korea and the countries covered under this collaboration is estimated to be over 700 million people. We believe that this is just the beginning of a new phase in dietetics transformation. As you know, the C1 production platform is the culmination of more than 20 years of ongoing research, development, evolution, and ultimately cross-application of proven industrial scale enzyme and protein production in broad-ranging industries. such as enzyme manufacturing used in the production of renewable biofuels. Our technology was used to manufacture and sell Diatics' own enzyme products in more than 30 countries. And our C1 technology was licensed for industrial uses non-exclusively to Codexis and Shell, BASF, and Abengoa until our industrial biotech business was sold to DuPont in 2015. These non-exclusive license fees generated more than $110 million in non-dilutive revenue for the company. Currently, we see our healthcare opportunities in animal and human health markets as much larger and potentially far more valuable. We've done it before, and we are laser-focused on doing it again. Across these industries, dyadic development advances have transformed the scalability, production, efficiency, as well as manufacturing footprint needed for those industries to reliably produce enzymes and proteins at industrial scale. It has been our goal to disrupt the biomanufacturing of biologics for use in the animal and human pharmaceutical markets. We are proud to say that in five years, Diatics has pivoted the utility of the C1 platform to transform the biologic and vaccine production process in life sciences. To be frank, what we're trying to accomplish is a massive undertaking, and we remain very enthusiastic by the progress that we have made in such a short time, as well as what we believe we can achieve in the future. The license agreement with Sorrento, once executed, further validates Dyadic's business model and is in the first licensing agreement, which includes a cash upfront payment for the development of a vaccine intended for human or animal health. We are creating multiple shots on goals for our technology to be recognized for its utility, and application in healthcare, especially when vaccine access across the globe is terribly unequal from one population to the next. We now have agreements that serve as a framework for the potential to support vaccine development of COVID-19 and other vaccines and production for up to 100% of the world's population. While we truly believe that the versatility and benefits of our C1 platform technology go beyond the COVID-19 program. In tackling the current world problem, we continue to validate the utility of dyadic C1 expression systems. To talk about our DYA100 COVID vaccine candidate, the C1 technology platform has the potential to rapidly develop new, highly productive cell lines to produce the SARS-CoV-2 RVD receptor binding domain variant antigens. Our goal is to demonstrate The recombinant protein vaccines of all types produced from C1 cells can be manufactured rapidly under CGMP conditions in large amounts using standard microbial bioreactors at low cost, which can gain regulatory approval by showing safety and efficacy for their use in humans. This data is anticipated to further accelerate the adoption of use of our C1 production platform broadly to support rapid development and manufacturing of future vaccines, drugs, including vaccines for pandemics. We and our collaborators continue to advance DYAI 100 towards initiation of a phase one clinical study. An interim analysis of toxicology study conducted by INVIGO has demonstrated preliminary safety. Final toxicology results are expected by October 2021. CGMP production is in progress, and once completed, we expect it to put us a step closer in advancing our DYAI-100 COVID-19 vaccine candidate towards a Phase I human clinical trial. Later this month, we anticipate meeting for a second time with the Paul Ehrlich Institute, PEI, a German federal agency medical regulatory body and research institution for vaccines and biomedicines to discuss the regulatory requirements, yet again, that will be needed for switching between different COVID-19 variant antigens following the initial phase one study. The C1 technology platform has the potential to rapidly develop new, highly productive C1 cell lines, producing receptor binding domain variant antigens. Our goal here is to ensure that the regulatory approval process can support such rapid development. Part of the understanding with Sorrento is that they will share phase one data with us to fulfill our previous contract commitments, such as with Rubik. We will also share clinical data with Sorrento whenever possible under the terms and conditions allowed under our contracts with our other collaborators. Once the Sorrento license agreement is executed, this is expected to allow us to greatly reduce our expenses related to our ongoing efforts to advance our DYAI-100 vaccine candidate towards a Phase I clinical trial. Once we have validated that the C1-produced proteins are safe in humans, we will then have the potential to accelerate C1's adoption and use for several biologic drug and vaccine opportunities. On July 27, 2021, the company sold its equity interest in BDI Holdings and VLP Bio, realizing 1.3 million euros in cash and approximately a 30% return on investment. The related gain will be recorded in the third quarter of 2021. However, just as importantly, BDI remains a valuable resource to perform contract research for us in the future as needed. In regards to the ZAPI Zoonosis Anticipation Preparedness Initiative, a peer-reviewed study, the development of a modular vaccine platform for multimeric antigen display using an orthobunovirus model, demonstrated the successful use of Diatics' patented and proprietary C1 protein production platform to facilitate a fast, coordinated, and practical response to new infectious diseases as soon as they emerge. This was published in the peer-reviewed journal, Vaccines. Through ZAPI, we have validated that the C1-produced antigens can be used to develop vaccines that are safe, effective, and protective in animals, such as cattle and sheep. As mentioned in our Q1 conference call, we are continuing to work with a global animal health company that is continuing to conduct poultry animal trials using C1-produced antigens. They continue to report that the C1 express antigens show promising efficacy in their initial animal study. They have additional animal trials ongoing, and we've begun a fully funded phase two portion of this project to work on further increasing productivity of one or more of these antigens. Based on the encouraging results to date, we've begun initial discussions on how to expand our collaboration to develop a number of additional antigens for farm animals. Last but not least, there are several ongoing fully funded research projects with C1 is being used to explore the expression of a number of different proteins, including antibodies and bispecifics with registrational potential in oncology, autoimmune disease, and COVID-19. We anticipate that we'll be able to share with you additional details related to one or more of these C1 human health programs before the end of the year. Suffice it to say, we are very pleased with the company's scientific progress and our operational and corporate progress as we move into the back half of fiscal 2021 and as we look forward to 2022 and beyond. And with this, I will turn the call over to Ping for a financial update.
Ping Rawson
Thank you, Mark. In addition to the financial results I'll be discussing now, you can find additional information in our Form 10-Q, which we filed earlier today. Our cash, cash equivalents, and the current value of our investment-grade securities, including interest, were $25.8 million as of June 30, 2021, compared to $27.4 million as of March 31, 2021. Research and development revenue for the quarter ended June 30, 2021 increased to approximately $937,000 compared to $524,000 for the same period a year ago. Costs of research and development revenue for the quarter ended June 30, 2021 increased to approximately $830,000 compared to $624,000 for the same period a year ago. The increase in revenue and cost of revenue for the quarter reflected and increased the number of ongoing research collaborations to 11 compared to nine collaborations for the same period a year ago. There was no provision for contract losses in 2021. R&D expenses for the quarter increased to approximately $2.2 million, comparing to $1.1 million for the same period a year ago. The increase primarily reflected Phase I clinical trial costs of DYA-100, our lead COVID-19 vaccine candidate, in the amount of $1.5 million, offset by a decrease of $415,000 related to our other internal research projects. DNA expenses for the quarter increased 18.5 percent to approximately $1.7 million, compared to $1.5 million for the same period a year ago. The increase principally reflected increases in legal expenses of $117,000. Business development and investor relations costs of $65,000, executive and the board of director compensation costs of $41,000, insurance expenses of $24,000, and other increases of $26,000. Interest income for the quarter was approximately $21,000 compared to $147,000 for the same period a year ago. The decrease was primarily due to the lower balance of hold-to-maturity securities and the less reinvestment because of the decrease in interest rate. Net loss for the quarter was approximately $3.8 million or $0.14 per share, comparing to $2.7 million or $0.10 per share for the same period a year ago. As Mark mentioned earlier, on July 26, we sold our equity interest in BDI Holdings and the BLP Bio, resulting approximately a 30 percent return on investment and a cash of approximately 1.3 million euros. The related gain will be subsequently recorded in the third quarter of 2021. Based on amended service framework agreements with BDI Farmer, we will remain the right to engage BDI to provide R&D services until June 30, 2025. Looking forward, our previously provided cash burn guidance for 2021, which was in the range of 10 to 12 million U.S. dollars, will be significantly changed once the Sorento License Agreement is executed. We expected to receive the 10 million upfront cash and stock from Sorrento in the fourth quarter of 2021. With that, I will now ask the operator to begin our Q&A session. Dr. Roland Chalet and Matthew Jones will be joining Mark and I to answer your questions. Each caller will be allowed one question and one follow-up question to provide all callers an opportunity to participate. If time permits, the operator will allow additional questions from those who have already spoken. Operator?
Operator
Thank you. Ladies and gentlemen, the floor is now open for questions. If you have any questions or comments, please indicate so by pressing star 1. Pressing star 2 will remove you from the queue should your question be answered. And lastly, while posing your question, please pick up your handset if listening on speakerphone to provide optimum sound quality. Once again, that's star 1 if you have a question or a comment. Okay, and the first question is coming from John Evander-Mostrin from Zacks SCR. John, your line is live. John Evander- Hey, good afternoon.
John
Congratulations on this rental agreement. That's nice to see up front. We've been looking for that, and it's finally here. That $4 million that was cited, is that for past expenditures or is that for future expenditures?
Mark Unifar
John Evander- Yeah, that's for past and current expenditures. that are ongoing as we continue to move the TYAI-100 vaccine candidate towards the first phase one clinical trial.
John
Okay, great. And then... Oh, I'm sorry, go ahead.
Mark Unifar
Up to $4 million.
John
Okay, great. And do you think you'll get that whole $4 million, or will it just be a portion of that?
Mark Unifar
Well, you know, we'll see. I'd rather not say, but obviously it'll be exactly what it is in the bills that we have to submit for all the different things, but it'll probably be close to that number.
John
Okay, great. Yeah, I mean, I guess you break that out internally on all the COVID-specific R&D expenditures.
Mark Unifar
Yeah, there's different vendors specifically for DYAI 100. Got it, got it.
John
And then on Rubik in South Africa, I mean, that's a great deal that you have with them as well. I guess, is that more for a long-term objective to build up, I guess, an opportunity for biosimilars to be developed in the country? I guess I'm trying to think of that longer term, how the work now could be set up for something bigger in the future.
Mark Unifar
Yeah, no, I think it's a good point. I think there's today, there's tomorrow, and there's the future. And I think they can address all those things because, number one, the consortium consists of research, immunologists, virologists, people that are going to develop not just COVID-19 vaccine, but potential therapeutics, but also it could be malaria, it could be HIV, it could be a variety of different diseases. And so they're carrying on research and development. And so the problem there, as I mentioned, What I said, less than one-tenth and one percent of the vaccines in the whole world are actually for Africa, yet it's, what, 14 percent of the world population. It's not sustainable. It hasn't been sustainable. And they view that the technology fits like a glove. high quantities, low cost, rapid production, ease of use, all the things that you would think you would need in an environment like the African continent as well as other continents all over the globe that have underserved needs. So what we're doing here is we're together putting the infrastructure in place today for the research and development. They have very good clinical trial experience. In fact, the researcher that's involved Javert Mahdi is running some of the J&J and Novavax clinical trials. So South Africa is well known for their phase one, phase two, phase three clinical trial capabilities. So for their COVID-19, DYA 100, either that product and or a variant thereof, they're well skilled in taking that through rapidly and quickly, and they're motivated to get that out as fast as possible. So that's today. Tomorrow is new developments. And in the future is, of course, a biomanufacturing facility that can satisfy a nice portion of the African continent. And all that brings low-cost health care, revenues, profits, you know, for Dyadic and for Rubic.
John
And just a clarification on my question. Will this be for off-patent products in the future? Sure. Or new developed products. I get the sense that the target will be off-patent products, vaccines that have already been proven. It's just going to be done using C1 in Africa.
Mark Unifar
I think it will be for both.
John
Okay. Great. Thank you, Mark.
Operator
Once again, if there are any remaining questions or comments, please indicate so by pressing star 1 on your touchtone phone. The next question is coming from Dick Williams from Williams Resource Group. Dick, your line is live. Hi, Mark.
Mark
Mark?
Mark Unifar
Yeah, hi, Dick.
Mark
Oh, hi. I missed you for a second. Sorry. Congratulations on a tremendous deal that you've made. I don't think the breadth and size of that deal is understood totally yet by our stockholders and the street. But I have a clarification question, in essence, In terms of the deal with these guys at this company, they were working initially on mRNA vaccine. They had made several announcements in the past months on it. And it seems as though they also were working during that same period on animal studies with the Dio 100 with your product. And it seems obvious to me that somewhere along the line, they determined that the way to go and the home run for them was with the DIO 100 product. And obviously, that's why they've signed this deal with you, which is a much larger deal and something that's developed sooner rather than later because they've been working on this. And the other part of that same question, essentially, is that the remuneration of the funds and everything to you one additional factor there is that this only pertains in terms of the royalty etc and so forth to everything connected to coronaviruses so whatever is developed beyond the coronaviruses in the future obviously you would then renegotiate a compensation deal including a royalty for that is that not correct
Mark Unifar
Yes. So this particular license agreement is solely for coronaviruses. I can't speak as to their other development efforts, but it's obvious that based on their press release yesterday, and I would suggest everyone not just reading ours, but reading Sorrento's press release, as I mentioned in today's call, they got very high neutralizing antibody titers. They're very excited about it. I think they have very similar goals and objectives, which we are virtually able to fulfill together in a much more efficient way. Large volume, low cost, safe, effective, protective vaccines for prime and boost as well as potentially boosters. And so the answer is they're excited about what they're doing. Obviously, they're going to write a check. But more importantly, these people are teed up With the right regulatory expertise, the infrastructure, I believe there's about 800 people that work in that company, and they have a variety of products already in the clinic, in COVID and otherwise, and we expect them to bring this to market in a more efficient way with a higher probability than we can do it on our own, with obviously a much lower cost to us, with a high upside potential for both companies.
Mark
Okay, one thing in terms of the potential for both companies. It was mentioned in the release, and the way I interpreted everything, and I did some back-of-the-envelope numbers here, and I just want to make sure I'm in the right ballpark, so I'll mention them here to you, that the royalties, typically a royalty for situations like this, in my experience, has been about a 5% number. It goes up to 10 and 12, but I think I'm using a lower, probably be a lower number of a 5% royalty. And according to the numbers of how many vaccines would be made, Pfizer was charging 30 cents a vaccine for their products.
Mark Unifar
I mean 30. I use 15 to be conservative.
Mark
And that translated to a revenue stream on that royalty basis of $75 million. And of course, 100 million of these to equate to that would be a small number. When everybody is talking of billions required throughout the world, and especially the market that these guys have as an exclusive, assuming they meet the criteria you've set it, we would be far north of that. But Is that reasonable in terms of the numbers that I've come up with from the back of the envelope?
Mark Unifar
Well, I can't share with you what Sorrento's terms and conditions are, but obviously based on your math, if you had 100 million doses at $15, which is approximately half the price per dose, and you had, I think you said 5%, that I believe equals $75 million. And if we have an epidemic, not just a pandemic, which some people think this is going to be a sustainable market for years to come, just at 100 million doses, no matter what the number is, there's a lot of potential for Sorrento and a great potential for Dyadic. It's a win-win situation. Actually, win-win-win. Patients first, low-cost access to a vaccine that can save lives and reduce pain and suffering, and we can make profits both at Sorrento and Dyadic, and everybody wins.
Mark
Thank you for your presentation today. It was very, very comprehensive and answered some of the questions that I had. Thanks a lot.
Operator
Thank you. Okay, the next question is coming from Luis Garcia, private investor. Luis, your line is live.
Luis
How are you doing, Mark? I missed a little earlier on just a question about the patent life on this product. When we come out with a new, say someone uses a C1 for the vaccine, is that the new date for that product? Are we issuing different patents for different variances and things like that?
Mark Unifar
Yeah, I mean, obviously patent lights vary depending on when it starts and what you do to change and modify something, what improvements you make, what advances, what's innovative. But we believe, and we have patent applications that I would say are provisional, so they're very new in some cases, and we believe that the cell line that's being used in this case is just at the beginning of its life, not its end. So it's got many years to run.
Luis
So I was just going to say we expect the long run with many, many, many hopefully different opportunities. Another question, I believe you said or it's been said that we can use this for insulin. Is that correct?
Mark Unifar
Well, we can produce virtually any protein from any gene, but not every system will make every protein, okay? So, you know, and some are very easy to make, some are more difficult to make, some are mediocre in terms of how much time and effort, but there's a good possibility that we could express insulin, antibody. We've already expressed antibodies with bispecifics, trispecifics, fabs, virus-like particles. I'm just going by memory. You know, different classes and types of proteins for different uses, whether it be oncology or potential rheumatoid arthritis. For Alzheimer's, potentially we worked on insulin. So, you know, we haven't reported specific projects, but we've worked on a number of different types and classes of proteins of multibillion-dollar targets.
Luis
Okay, very good. Do you think that many of these big pharmaceutical companies don't really want to do business with us right out of the gate because it's less money for them and they don't care. They're just getting the top dollar for product.
Mark Unifar
I can't predict or think about what the big pharma companies will or won't do. But if you remember, we went through this experience in the industrial biotech business. But we did a non-exclusive license with Abengoa Bioenergy. And then we did a non-exclusive license with BASF. And then we did a non-exclusive license with Shell Oil and Codexis. And then DuPont came and purchased the industrial biotech business. And so that was $110 million combined. And this is a far greater, larger market that's much more valuable. So we've already done this once, and we expect to do it again. We developed our own products in addition to that and sold them in 30 countries around the world. So I think the opportunity for us here is Just to continue making this technology more robust, more versatile in the applications, proving it out in human beings, safe, effective, protective, first in the vaccine space, which is what we're doing now, ultimately then moving into therapeutics and antibodies. And then, of course, you have the whole animal health side, where you have companion animals and farm animals. And then you have a whole bunch of other biologic projects and products and opportunities that were being sort of, I don't know, inbounded with opportunities that are broad and diverse. So we're not at loss of opportunity. We want to focus right now on making sure that we succeed in producing large volumes of low-cost, safe, effective vaccines for COVID-19 and other vaccines because that platform is up and running and looks to be, we believe, the most productive, simplest, easiest way to make a vaccine for more common and protein production.
Luis
All right. One more. Speaking of the biofuels, anything from stopping you to getting involved with that again since it's already a proven market?
Mark Unifar
Well, there are obviously certain patents out there, but we think that there's a possibility for a variety of different products and opportunities to get back into that space. Our non-compete ended on December 31st of last year, and so we are evaluating that, and we're being approached by a variety of different people, and we're sorting through that. But to be honest with you, that's moving at a slower pace because we're focused on making sure we don't drop the ball.
Luis
Great. Okay. Well, thanks for all the information. Have a great night, everyone. Thank you.
Operator
Thank you. Thanks, Liz. There are no further questions. I will now turn the call over to Diatics CEO, Mr. Amilcar.
Mark Unifar
So one of the things I just wanted to clarify is that these opportunities that we have today are proof of concept, not only for COVID-19, but potentially for new novel proteins biosimilars, biobetters. So the people that we're involved with, for example, Syngene, who's owned 70% by Biocon in India, are quite large. Meditox is the fourth largest producer of Botox. Rubic is smaller but nimble and have wide connections in the African continent. And of course, Sorrento is a proven biotech, very aggressive company. So we believe that we have the opportunity to expand those license agreements to even broader, deeper, and wider areas, whether it be rheumatoid arthritis, oncology, or insulin, or diabetes, or who knows what. So once they get used to using the technology, see the power of it, the speed at which it can be programmed, the protein yields that can be produced, the simple ease, the low-cost media, safety in humans, I think the sky's the limit. So I want to thank, again, everybody here as we go forward as a small biotech company, growing, expanding, ultimately benefiting populations that are disenfranchised or otherwise lack access to immunization and vaccine programs and treatments for infectious and other diseases due to inaccessibility and or prohibitive costs. We look forward to keeping you updated on our progress along the way and we'll see you on our next call. Thank you and good night.
Operator
The conference has now concluded. Thank you for attending today's presentation. You may now disconnect your lines at this time.
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