Evogene Ltd.

Welcome to Evogen third quarter 2025 results conference call. All participants are at present in listen-only mode. Following management's formal presentation, we will open the question and answer session. You may send questions via chat. Please type your name and company before your question. As a reminder, this conference is being recorded November 20, 2025. Before we begin, I would like to caution that certain statements made during this Earnings Conference call by Evogen's management will constitute forward-looking statements that relate to future events. This presentation contains forward-looking statements relating to future events, and Avagen Ltd., the company, may from time to time make other statements regarding our outlook or expectation for future financial or operating results and or other matters regarding or affecting us that are considered forward-looking statements as defined in the U.S. Private Securities Litigation Reform Act of 1995, the PSLRA, and other securities laws as demand. Statements that are not statements or historical facts may be deemed to be forward-looking statements. Such forward-looking statements may be identified by the use of such words as believe, expect, anticipate, should, planned, estimate, intent and potential, or words of similar meaning. We are using forward-looking statements in this presentation when we discussed our value drivers, commercialization efforts and timing, product development and launches, estimate market sizes and milestones, pipeline, as well as our capabilities and technology. Such statements are based on current expectations, estimates, projections and assumptions, describe opinions about future events, involve certain risks and uncertainties, which are difficult to predict and are not guaranteed of future performance. We deserve caution that certain important factors may affect the company's actual results and could cause such results to differ materially from any forward-looking statement that may be made in this presentation. Therefore, actual future results, performance or achievements, and trends in the future may differ materially from what is expressed or implied by such forward-looking statements due to a variety of factors, many of which are beyond their control, including, without limitation, the current war between Israel and Hamas and any other adverse impact that it may have on economic activity in Israel due to the calling up of a large number of reserve soldiers or the incurrence of debt to pay for the high cost of the war and any accompanying future uncertainties for the security of the company's operations in southern Israel. as well as those additional factors describing in greater detailing Evogen's annual report on Form 20F and in other reports Evogen files with and furnishes to the Israel Securities Authorities and the U.S. Securities and Exchange Commission, including those factors under the head and risk factors. expect as required by applicable securities law we disclaim any obligation or commitment to update any information contained in this presentation or to publicly release the results of any revisions to any statement that may be made to reflect future events and developments or changes in expectation estimates projections and assumptions The information contained herein does not constitute a prospectus or other offering document, nor does it constitute or form part of any invitation or offer to sell, or any solicitation of any invitation or offer to purchase or subscribe for. Any securities of the company, nor shall the information or any part of it, or the fact of its distribution from the basis of, or be relied on in connection with any action, contract or commitment relating thereto or to securities of the company. The trademarks include herein are the property of the owners thereof and are used for reference purposes only. Such use should not be construed as an endorsement of a product or services. With us on the line will be Ofer Haviv, President and CEO of Evergen and Yaron Heldad, CFO of Evergen. Now I will turn the call over to Ofer Haviv. Mr. Haviv, please go ahead.

Thank you for joining Avogen's third quarter 2025 analyst call. In today's call, I'd like to focus on the company's new strategy, which I partly shared at our previous quarterly calls, and its current implementation. I will also provide an update on our expectation to start reaping the business benefits of this strategic shift over the coming year. Following my remarks, our CFO, Yaron Eldad, will present the financial results, and we will then open the call for questions. But as usual, I will start with the financial highlights. During the first nine months ending September 30, 2025, Evogen advanced its strategic transition toward establishing itself as a leader in computational chemistry with a focus on the generative design of small molecules for the pharmaceutical and agriculture industries. As part of this new strategy, the company executed an organizational change and cost reduction plan, most of which was completed by the end of the second quarter. The impact of these measures is reflected in the third quarter results with total operating expenses net of approximately $2.9 million compared to $6.6 million in the same period of 2024. This new expense level is expected to be maintained going forward. The financial results of LaviBio Evogenz subsidiary for the nine and three months ending September 30, 2025 are presented as a single line item in Evogenz consolidated P&L statement for 2025. Its results are including under the line titled income or loss from discontinued operations net This accounting presentation includes the sale of the majority of LaviBio's activities to ICL, which was completed in July, 2025, and together with the sales of MicroBoost for Ag generated income of approximately $7.9 million in the third quarter of 2025. In the nine months ending September 30, 2025, revenues amounted to approximately $3.5 million, compared to $4 million in the same period last year. The decrease was primarily driven by lower revenue from ACT Planus activity. which included a one-time payment from buyer during the first quarter of 2024, partially offset by an increase in seed sales generated by Castera. Total research and development expenses in the nine months ending September 30, 2025, were approximately $5.9 million, compared to approximately $9.8 million in the same period of 2024. The decrease is primarily attributed to a reduction in Biomica's and Avogen R&D activities and the discontinuation of Canonix operations. Certain marketing expenses in the nine months ending September 30, 2025 totalled approximately 1.1 million compared to approximately 1.6 million in the same period of 2024. The decrease is mainly due to reduction in headcounts across the subsidiaries. In the nine months ending September 30, 2025, Total operating loss was approximately 8.8 million compared to approximately 15.3 million in the same period of 2024. This decrease is mainly due to the decrease in the subsidiaries and evidence activity. As of the end of the third quarter of 2025, the company's cash and short-term bank deposit balance was approximately $16 million This cash balance reflects the proceeds from the sale of LaviBio's assets and the MicroBoost AI for AgTech engine to ICL. The following are the business highlights of our subsidiary and related parties in the past quarter. LaviBio completed the transfer of its team and the majority of its activity to ICL. Its collaboration agreement with an existing partner continues with positive results. The distribution of funds to its shareholders with Avogen as the majority holder is advancing. No additional activities are expected. Biomica's clinical trial continues according to plan and is expected to be completed in early 2026. Currently, only one patient is in the trial, and the efforts to secure partners to lead Biomica's current development program continue. No additional activity are expected. Last week, Castella partnered with Fantini to advance agricultural mechanizations for scalable commercial castor farming. The collaboration focus on integrating high yield castor varieties with advanced mechanized solutions, including harvesting and threshing technologies. In addition, the company is investing efforts in strengthening its position in Brazil's castor farming ecosystem. Agplanus underwent organizational restructuring including the completion of workforce reductions. Evogen's related party, Finally Food, which grows the casein protein in potatoes, announced raising $1.2 million, led by CBC Group, and signed a commercial agreement with it. Now, I would like to continue with Evogen's new strategy and its implementation which include Ag Planus activity for the agriculture industry. The following slides reflect Evogen's new messaging and appearance supporting its new strategy. At Evogen, we are on an ongoing mission to redefine the future of science and business. By harnessing the power of our proprietary generative AI tech engine, Campus AI, we design novel groundbreaking small molecules, highly potent and precisely optimized across multiple parameters to transform the pharmaceutical and chemical industries. Our goal is not just innovation, but meaningful, beneficial impact for our world. Headlining this slide is the phrase real world innovation. What do we mean by it? One of the greatest challenges in developing product in life sciences from pharmaceuticals to chemicals is the gap between real world challenges and innovative scientific discovery. Anyone involved in life science product development knows this challenge well. It's reflected in the high failure rate of product that start full of innovative promise, but ultimately fall short of one or more critical criteria that often emerge only in later stage of development. We believe now is the time for change, for bridging the gap between innovation and real-world impact. The key lies in harnessing the possibilities of the computational revolution, transforming our world, and above all, in unlocking the power of AI. Today's computational capabilities allow for simultaneous analysis of countless parameters, achieving a level of scientific depth that was once behind reach. They empower us to design solutions that integrate scientific innovation with commercial viabilities pushing beyond the limits of traditional trial and error product development. Computational technology serves as the bridge connecting scientific discovery to commercial success. And this is exactly what we focus on. We call our approach real-world innovation. Evogen is structured on three interconnected pillars. Our groundbreaking gene AI best technology, campus AI, which serve as the competitive advantage for our offering in the pharmaceutical and agriculture industries. Second, our established activity in agriculture through our subsidiary, AgPlanus, where we have already achieved results and collaboration with leading global companies in the development of ag-chemical product, and our recent expansion into the pharma industry, where campus AI significantly increased the likelihood of the discovery of novel molecules with the highest potential to become breakthrough commercial drugs. I will begin with a brief introduction to Campus AI, which is at the core of our operations. To understand the unique value of Campus AI, it is essential to consider the background of the product development process and its inherent challenges. Here is a simplified overview of how a small molecule product such as drug or pesticides is developed. It started with identifying the target protein we aim to inhibit, followed by searching for a chemical molecule capable of binding to it from an almost infinite number of possibilities. During the discovery and optimization phase, The objective is to design the most promising candidate for advancement into the next stage of development. These later stages are time consuming and costly, so choosing wisely early on is crucial. It's also worth noting that once these advanced stages are reached, the chemical structure of the molecules is basically set. This is the version that hopefully will eventually make it all the way to market. Therefore, Very early in the process, right after optimization, we commit to the molecule we believe has the highest probability of becoming the final product. The outcome of this process is often frustrating. Statistically, only a small fraction of promising molecules that make it into advanced development actually reach the market. success rate are usually somewhere between 3% and 10%, depending on the industry. This naturally raised the question, what caused the success rate to be so low? A major reasons for low success rate is that a product must meet many often conflicting parameters to reach commercializations. Traditional methods for selecting molecules and addressing multiple parameters are very limited. As a result, early development usually optimize only a few parameters, one parameter at a time, creating a major bottleneck to commercial success. Overcoming this challenge presents a significant strategic opportunity. Today, advance in computational technologies allows for the simultaneous optimization of multiple parameters with the potential to greatly improve development efficiency and success rate. That brings us to Campus AI, the cutting edge tech engine developed here at Avogen. built to transform the way we design small molecules that are precisely tailored to specific target proteins. What makes our approach truly unique is not just the molecules we design, but the intelligence behind them. Each molecule must overcome a complex web of scientific, regulatory and commercial challenges. To become real product, a molecule has to do more than just work. It must excel across multiple dimensions simultaneously. And that's exactly what Campus AI was built to achieve. Our engine designs molecules that meet three critical requirements. High potency, molecules that strongly and effectively modulate their target protein. Novelty, expanding into novel chemical space, ensuring the creation of strong, defensible intellectual property. And multi-parameter excellence, molecules that perform across the many requirements needed for the real world commercial success. With Campus AI, we are not just designing molecules, we are designing the next generation of breakthrough products, closing the gap between innovation and market impact. That's the power and the promise of Campus AI. We are advancing a multi-year development program, continuously adding new capabilities to our generative AI tech engine. As a result, the number of parameters we can address keeps growing and the precision of the molecules designed to meet the required criteria continues to improve. The more the system is used, the smarter and more accurate it becomes. To accelerate campus AI development process, we are collaborating with major technology companies such as Google Cloud, as disclosed in May this year, and we intend to continue doing so. Additionally, we intend to explore the possibility of making certain parts of our technology accessible to researchers through such companies which have a broad market reach. Of course, we will be happy to update you on these developments in the future. Our vision comes to life through the technology we have developed. Now, I'd like to present the implementation of our technology through our agriculture and pharma activities. Starting with agriculture, a field we entered back in 2018 through the establishment of our subsidiary, Agplanus. Since then, Agplanus has achieved significant milestones, including strategic collaborations with leading industries players, such as Bayer and Corteva. Agriculture is a huge global market valued in 2024 at $79 billion including three main segments, herbicides, insecticides, and fungicides. A single product in this space can generate anywhere from hundreds of millions to billions of dollars in sales annually. The industry is in great need of new products, yet developing them comes with significant challenges. an increase in pest resistance and regulatory requirements, an urgent need for new mode of action, and the decreased rate in discovery of new pesticides due to lack of innovation. To address the challenges of developing new products in ag chemistry, revolutionary technologies are needed. Computational chemistry can drive real world impact in agriculture. And this is the mission of Agplanus, Evogen's wholly owned subsidiary. Agplanus discovered and optimized candidates for crop protection products and has a robust product development pipeline through collaborations with leading global agriculture companies, as well as internally founded programs. We are very proud of Agplanu's achievements reflected in its strategic collaboration with two world leading companies, Bayer and Corteva. Both collaborations focus on developing new herbicides, each targeting a different protein that represent a novel mode of action. This innovation is essential to addressing the growing resistance of pests to existing solutions. The plant images shown in this slide clearly demonstrate the effect of the small molecules being advanced through those collaborations. Agplanus is also advancing independent projects within its internal pipeline. Its main focus today is on developing fungicide candidates against septoria, a fungus causing major damage to field crops, especially wheat. Agplanus already has several small molecules showing very promising results in lab tests. which are now moving to greenhouse trial to test their performance on plants. Looking ahead, Actplanus plans to further strengthen and expand its collaboration with existing partners, establish new partnerships leveraging Actplanus pipeline innovations, and broaden the scope of programs within its internal development portfolio. These initiatives are expected to generate cash inflows for the company through upfront payment, R&D reimbursement, and as our products advance through development, milestone payment, and potential royalties. We look forward to providing further update on both collaborative efforts and internal pipeline progress. Now, I will continue with our efforts to capture the value of our tech engine, Campus AI, in the pharma industry, focusing on the market segment of drugs based on small molecules. Why are small molecules-based drugs such a lucrative opportunity? And why do we believe now is the right time to leverage our technology for it? Small molecule-based drugs represent nearly 60% of the global pharmaceutical market, valued at approximately $780 billion. Even more exciting is the current momentum of AI-designed small molecules that are advancing through various companies' pipelines. more than 60 new candidates with an expected annual growth rate exceeding 150%. This rapid expansion is expected to drive the AI drug discovery market to nearly $190 billion by 2034. As I previously mentioned, The traditional process of developing drug based on a small molecule is expensive, lengthy, and has a low success rate. This slide illustrates the high numbers of failure that occur during the transition from one stage of clinical trial to the next. We expect that the smart use of our tech engines, campus AI, will lead to the initiation of clinical trials for highly active, innovative, small molecules, which most importantly meet the maximum number of the defined drug's key parameters. As a result, we expect the probability of successfully progressing from one development stage to the next to improve and the number of candidates that complete the development process and become successful commercial product will increase significantly. To capture the value of campus AI offering in pharma, our business strategy is designed to maximize potential while minimizing risk. We hope to partner with leaders in pharma, biotech companies, and academia that bring domain specific knowledge, forming collaboration agreements. Through this strategic alliance, we aim to co-develop innovative products. The expected upside for Evogen stems from R&D fees, milestone payment, and revenue sharing mechanism of the end product. In August, Our farmer division announced a collaboration with Professor Ehud Gazit of Tel Aviv University to develop new therapeutics for metabolic disease linked to the self-assembly of small metabolites such as tyrosinemia and gout. The partnership combines Evogen Campus AI generative design platform with Professor Gazit expertise in molecular self-assembly to discover and optimize novel small molecules that can inhibit harmful metabolite aggregation. This collaboration aims to accelerate the development of first in class therapies that addresses the underlying molecular causes of accumulated metabolic disease, offering new hope to patients worldwide. This collaboration exemplifies the type of strategic partnership we are pursuing, leveraging Evogen's advanced computational capabilities alongside existing scientific knowledge to create meaningful synergies that can drive breakthrough discoveries in drug development. Over the coming year, we expect to announce additional collaborations of this nature, further strengthening Avogen's position in this field and enhancing recognition of our unique technological edge. We believe such partnership will provide the validation and visibility needed to enable broader and more complex collaborations with leading biotech and pharmaceutical companies, opening new growth opportunities for Evogen. We look forward to providing future updates on our collaborative efforts. To summarize Abogen's strategy, we are using campus AI, which is at the core of our offering and our main competitive advantage to drive real world innovation for two strategic markets. Pharma for the development of small molecule based drugs, agriculture for the development of crop protections, chemicals. To realize this vision, we operate through pharma division focused on pharmaceutical applications. And so our wholly owned subsidiaries Act Planus focused on our chemical solutions. Each develops its products either in collaboration with leading global companies or independently. In the near future, we expect the following. continuing to strengthen and expand campus AI and maintaining our technological edge, signing additional collaboration agreement with biotech and later on with pharma partners for small molecules drug development, and expanding collaborations with existing and new leading ad chem companies while growing ACK Planus internal crop protection pipeline. With this, I conclude my part and I will now hand the call to our CFO, Yaron Eldad, to present the financial results.

Thank you, Ofer. The financial results for the first nine months of 2025 and the capital gain of LaviBio, a subsidiary of Evogen, are presented as a single line item in Evogen's consolidated P&L statement for the first nine months of 2025. Its results are included under the line titled, income or loss from discontinued operations. This accounting treatment reflects the classification of LaviBio's operations and its capital gain as discontinued following the sale of the majority of its activities to ICL, which was completed in July, 2025. During the first half of 2025, Evergen implemented a cost reduction plan, most of which was completed by the end of the second quarter. The impact of these reductions is reflected in the first nine months results. As of September 30, 2025, Evergen held cash, cash equivalents, and short-term bank deposits of approximately $16 million. The consolidated cash usage during the third quarter of 2025, excluding the cash generated from the sale of the majority of LevyBio's assets and the sale of MicroBoost AI for Ag to ICL, was approximately $3.5 million. Excluding LevyBio and Biomica, Evogen and its other subsidiaries used approximately $2.3 million in cash during the third quarter of 2025. Revenues for the nine months of 2025 were approximately $3.5 million compared to approximately $4 million on the same period the previous year, reflecting a decrease of approximately half a million dollars The decrease was primarily driven by lower revenue recognized from AgPlanes' activity, which included one-time payment from Bayer during the first quarter of 2024, and revenues recognized from the collaboration agreement with Corteva, partially offset by an increase in seed sales generated by Castera during the first quarter of 2025. revenues for the third quarter of 2025 were approximately $300,000, a decrease compared to approximately $1.7 billion in the same period last year. The decrease was mainly due to reduced seed sales generated by Castera during the third quarter of 2025. Research and development expenses net of non-refundable grants for the nine months of 2025 were approximately $6.2 million, a decrease of approximately $3.6 million compared to $9.8 million in the nine months of 2024. The decrease was primarily due to reduced R&D expenses in Biomeka and the cessation of Canonics operation at the beginning of 2024. In the third quarter of 2025, R&D expenses were approximately $1.4 million, down from approximately $3.3 million in the same period of 2024. This decrease is mainly attributed to decreased expenses in Biomica. Sales and marketing expenses for the nine months of 2025 were approximately $1.2 million, a decrease of approximately $400,000 compared to approximately $1.6 million in the same period last year. The decrease was mainly due to reduction in Evogen, Agplanus, and Biomica personnel costs. Sales and marketing expenses for the third quarter of 2025 were approximately $400,000, reflecting a slight decrease of approximately $100,000 compared to approximately $500,000 in the third quarter of 2024. General and administrative expenses for the nine months of 2025 decreased to approximately $3.4 million from approximately $5.7 million in the same period last year. This decrease is mainly attributable to expenses recorded during the nine-month period of 2024 related to a provision for doubtful debt for one of Castera's seed suppliers, as well as transaction costs associated with Evergen's fundraising in August 2024. General and administrative expenses for the third quarter of 2025 decreased to approximately $1.1 million compared to approximately $2.8 million in the same period of the previous year, primarily due to decreased expenses in Castera and Evogen, as mentioned above. Other income of approximately $200,000 was recorded in the first quarter of 2025 as part of the accounting treatment related to a sub-lease agreement. The decision to cease Canonix operation in the first half of 2024 resulted in other expenses of approximately $500,000, primarily due to impairment of fixed assets recorded in the first quarter of 2024. The operating loss for the nine months of 2025 was approximately $8.8 million, a significant decrease from approximately $15.3 million in the same period of the previous year, mainly due to the decreased operating expenses, partially offset by the decreased revenues as mentioned above. The operating loss for the third quarter of 2025 was approximately $2.7 million, a decrease from approximately $5.9 million in the same period of the previous year, primarily due to the decreased operating expenses partially offset by decreased revenues as mentioned above. Financing income net for the nine months of 2025 was approximately $744,000 compared to financing expenses net of $448,000 in the same period of the previous year. The increase in financing income is mainly associated with accounting treatment of pre-funded warrants and warrants issued in August 2024 fundraising. As a result, during the nine months of 2025, the company recorded financial income net related to pre-funded warrants and warrants of approximately $674,000 as compared to financing expenses net of approximately $881,000 in the same period of 2024. Financing income net for the third quarter of 2025 was approximately $12,000 compared to financing expenses net of approximately $821,000 in the same period of the previous year. The increase in financing income is mainly associated with accounting treatment of pre-funded warrants and warrants issued in August 24, fundraising as mentioned above. Income from discontinued operations net for the nine months of 2025 was approximately $5.7 million, compared to a loss of approximately $2.2 million in the same period of 2024. For the third quarter of 2025, income from discontinued operations net was approximately $7.9 million, compared to a loss of approximately $1.5 million in the quarter of the previous year. These amounts primarily reflect the financial results of LaviBio and expenses related to the development and maintenance of MicroBoost AI for Ag, which are presented as a single line item in the consolidated statement of profit and loss. Following the sale of the majority of LaviBio's assets, as well as Evergen's MicroBoost AI for Ag to ICL, the company recognized a gain on sale of approximately $6.4 million, which is also included in the income or loss from discontinued operations net for the nine months and three months period ended September 2025. All prior period amounts have been reclassified to confirm to this presentation. The net loss for the nine months of 2025 was approximately $2.5 million compared to approximately $18 million in the same period last year. The $15.5 million decrease in net loss was primarily due to decreased operating expenses, income derived from discontinued operations due to the asset sale to ICL net, an increased financial income net partially offset by reduced revenues. The net income for the third quarter of 2025 was approximately $5.2 million compared to a net loss of approximately $8.2 million in the same period last year. This improvement was primarily due to income derived from discontinued operations net due to the asset sale to ICL, decreased operating expenses and increased financing income net, partially offset by reduced revenues net, as mentioned above. Operator,