Evotec SE

Good morning, good afternoon to all of you in this call. We have a lot to cover today and I'll keep my part very short. So let's move on to cover the housekeeping items on page two. We share the cautionary language here as usual and some statements will be future looking based on information available today and they might be subject to change in future. But now let me hand over to our CEO, Dr. Christian Wojciechowski. Christian, please.

Thank you, Volker. Good morning and good afternoon to everyone. It's a pleasure to welcome you all to this call. I'm looking forward to taking you through the progress we've made over the past six months of transition since the announcement of our new strategy. Very pleased with the momentum and high speed of our transformation toward better monetizing our technology leadership. The steps we've taken in the past couple of quarters are a strong fundament for our value creation path and for the execution of our midterm outlook. I'm confident that this will become more visible to you while we lead you through this presentation. Let us now take a closer look at the year-to-date performance. In the first nine months, group revenues landed at 535.1 million euros, which is a 7% decline versus the previous year. This is driven by our DMPD business where we face continued softness in the early drug discovery market, leading to 12% revenue decline. In contrast, our biologics business, JAB, remains on a strong growth path, with plus 11% growth in the first nine months. As mentioned in the last call, we expect the trend in DMPD to continue in the second half of 2025, while for just Avotech Biologics, we anticipate revenue growth to further accelerate. Taking a closer look into the DNPD business, we see several main elements driving past and future performance. Talking about the early drug discovery market environment, the VC funding for Biotech is certainly not yet favorable, affecting the business development activities of the transactional service business. However, Over the last two quarters, the number and value of proposals going out from Avotech to customers is clearly trending upward, indicating that the business is stabilizing. Also, the level of negative change order volumes in Q3 has substantially improved versus first two quarters. In the meanwhile, we've taken appropriate actions to adjust our cost base. We've introduced a new organization structure And we're strengthening our commercial and operational capabilities. 12 months ago, we were targeting 30 million of cost out in 2025. We raised the bar over the course of the year. And during the last call, we committed to 60 million of cost out. And we will stay ahead of plan. As announced last call, we're working on delivering additional 50 million of cost out and productivity measures in future. you should expect a full update on the initiatives we're working on during our next call. The business momentum with strategic partnerships remains healthy, ensuring continued mid-term revenue streams. Those strategic partnerships are expected to also result in meaningful progression of our asset portfolio over the next six to nine months. several catalysts lie ahead of us, leading to the transition of molecules from the early drug discovery stage into preclinical and from preclinical into clinic. And I'm pleased to announce today that we're expecting up to four molecules from our partnered acid pipeline to be in phase two clinical studies in 2026. This is exciting news for Evertech, as it demonstrates the scientific strength and the outstanding capability of our technology. And it underpins our plan to generate meaningful upside through milestone and royalty payments in future. More about this a bit later. At Just Evotech Biologics, we're making great progress in our efforts to diversify and broaden our customer portfolio. Business development with a non-Sandoz and non-DOD business is moving fast. The momentum for this part of the business has further accelerated versus half-year results to now over 100% growth after nine months. Moreover, we signed a transformational deal between Just Evotech Biologics and Sandoz just hours ago. This landmark transaction is a strong testament to our cutting edge technology and capabilities in the fast growing biologics business. It will unlock payments of more than $650 million over the next years. In addition, we expect to generate sizable revenues from royalty streams related to 10 biosimilars. We're extremely excited and proud to have been selected as partner by Sandoz on their path to shaping the biosimilars market. In a nutshell, we're well on track with our strategy, driving both scientific and operational excellence. Since the VC funding for biotech customers is relevant for approximately 30% to 40% of our revenue base in DNPD, let me share some further background information about the market trend. Updated data on total venture capital funding environment shows no material change compared to the analysis we shared in August. The absolute funding level has not grown over the past two quarters. The share related to discovery and preclinical stage companies remains well below pre-pandemic levels. suggesting a continuing short-term investment focus on companies with clinical stage assets. We spoke about the temporary deprioritization of early discovery and development activities and funding. It needs to be overcome before we see a forceful recovery of the early drug discovery market. That said, we do see some encouraging developments. Negative change orders are normalizing and customer activities are increasing. In the first half of 2025, the balance between positive and negative change orders was impacted by higher than expected cancellation volume, contributing to a weaker sales performance in DMPD. This effect was related to a small number of contracts which were canceled by customers either for strategic or scientific reasons. In Q3, we're back to normal levels. The development of our change order balance is shown in the upper graph. In contrast to the comparably low funding activities for early stage biotech, the business activity level at Evotech has picked up. The number of proposals issued to our customers has grown 20% over the past two quarters, and this is also in line with a growth in total value of proposals. Even though those early indicators are promising, we're not yet indicating a change of trends. We remain vigilant in monitoring market developments and continue to adopt to our customers' evolving needs in a more agile way. In parallel, We are building a more targeted go-to-market approach. And as mentioned last time, we're strengthening our commercial organization. I'd like to now hand over to Paul, who will guide you through our financial results.

Thank you, Christian, and a warm welcome from my side. Let me guide you through our year-to-date results in a little more detail. Our first nine months' group revenues reached 535 million euros. 7% decline versus the same period in 2024 and is aligned with our expectations. Firstly, our D&PD revenues declined by 12% to 391.9 million euros in a persisting soft market in early drug discovery, as Christian commented on in his introduction. Also, as mentioned last time, included in this result is the expected temporary decline in the BMS revenues. Our JustEvaTech biologics business continues to grow strongly in the first nine months of the year and is on track for a very strong 2025. For the first nine months of 2025, revenues reached 143.2 million euros, which is up 11% versus the first half of 2024. As we mentioned last time, we continue to see a broadening of our customer base with non-Sandoz and non-DOD customers growing 105% in the first nine months versus last year. During the first nine months of 2025, our Sandos business grew low single digits. Although, as we look forward, we expect meaningful full-year growth following the completion of the recently announced transaction, which will include multi-year consideration for technology access, development revenues, and product royalties. Our R&D spending remains on the trajectory shared last time and is reduced by 33% versus prior year period, from 41.1 million euros in the first nine months of 2024 to 27.7 million euros in the first nine months of 2025 as we direct our investments to those most relevant for our partners. Adjusted group EBITDA reached negative 16.9 million euros driven by the weaker than expected DMPD revenues and our fixed cost base. We are well on track with our cost-out initiatives to deliver the 60 million euros of in-year structural cost reduction in 2025 that we communicated in our last call. We also remain focused on delivering the additional mid-term cost and productivity actions that we discussed in our April update. Our JustEvaTech biologics business remains ahead of expectations, helped by positive operating leverage despite the planned JPOD build-out. Bridging to our full-year outlook, we expect our fourth quarter profile to reflect the higher revenue contribution weighting that we have seen in prior years. In addition, our recent guidance update in July reflected lower full-year DMPD revenues with an overall improved business mix, including the effects of the events announced last night. Now continuing with cash flow. Our year-to-date free cash flow has improved by 14% versus the same period last year. This is despite our third quarter operating cash flow having a tough comparable to last year when we received $125 million of BMS payments, whilst the recently announced BMS Neuro payments has only been received in the fourth quarter of this year. However, in line with our expectations, our investing cash flow continued to see sequential improvements as we drive more rigor in our capex investment processes whilst also completing the JPOD build-out. Our net debt levels grew versus the second quarter of 2025, which also reflected the higher lease obligations following the adoption of a long-term lease agreement in our Hamburg facility. Following the completion of our transaction with Sandoz, planned in the fourth quarter of this year, we expect our liquidity to be in a significantly stronger position with a residual long-term debt portfolio. With that, I hand over to Cord.

Thank you, Paul, and good morning and good afternoon to everybody on the call, also from my side. As you know, at Evotech, we strive for technology and science leadership on our mission to pioneer drug discovery and development. Our ambition is to accelerate the journey from concept to cure in partnership with our customers. Today, we are pleased to talk about considerable achievements we have made along the strategy in both segments. Let me start with a look at the DMPD segment first. We are seeing great scientific progress with our strategic partnerships. Based on these achievements, we continue to feed and expand our strategic partnerships and are confident that our Co-Owned Asset Pipeline will show substantial progress not only in 2025, but also during the next six to nine months. So what is our approach? Christian already mentioned that we offer end-to-end discovery services, including development, and also highly innovative drug discovery technology platforms. We strive to combine both offerings to create superior customer value. Our core service offering spans the entire value chain from target identification to IND. When we combine those individual services, we can seamlessly run integrated research projects using highly automated workflows. This train of services shown in blue on this chart is the backbone of our operations. Within our strategic partnerships, we are then adding proprietary AI-enabled technology platforms on top of this. These are shown here in pink. These platforms elevate our drug discovery platforms to the next level. Our AI driven platforms are targeting in particular four goals. We create a much deeper understanding of disease biology and therefore patient stratification through our proprietary molecular patient database. We improve our target ID and validation efforts as well as hit identification through superior in vitro disease models. by our IPSC platform. We enhance and accelerate hit-to-lead and lead-up processes through in silico profiling and an eye-supported molecular design. We reduce the risk of failures due to industry-leading toxin safety predictive tools. So this means that AI, for us, is not a standalone feature. we have embedded AI deeply into our toolbox, enhancing the performance of each and every platform in the value chain. Based on these, we not only shorten timelines, but we also improve outcomes. Let me briefly take you through the individual elements. Our proprietary molecular patient database consists not only of highest quality and comprehensive clinical data, but also of deep multiomics data based on corresponding patient samples. This database is invaluable when it comes to target ID and validation and is supported by AI machine learning algorithms. Our e-invent platform is a highly comprehensive suite of AI machine learning supported molecular design tools predicting everything from solubility, admi-tox parameters, affinities to targets, but most importantly, it supports and accelerates our molecular design cycles. Our e-safety platform is a suite of NAMs consisting of gold standard in vitro models which are combining with high content omics and or high content imaging data to predict the safety and tox profiles of drug candidates. We are doing this with extremely high accuracies and I will come to this in more detail later. Furthermore, We have an extremely versatile IPSC drug screening platform, which in combination with omics and high content imaging data is able to profile disease relevance, as well as efficacy and safety of drug candidates throughout the drug discovery process with higher granularity and therefore higher accuracy than standard in vitro models. All of these platforms are underpinned by our seamless, high-performance omics platforms, which can generate, in particular, transcriptome, proteome, and metabolome data at highest quality and with unmatched throughput. I will come to the details here later as well. Finally, we are able to bring all of these data together in our data analysis tool called Penhunter. This tool facilitates the handling and the analysis of high-dimensional data sets and is in many areas AI machine learning support. On the next page, I will show you selected examples of significant scientific achievements in 2025 and also talk about how they translate into commercial results with our strategic partners. And thereafter, I will show you how those partnerships are associated with highly attractive long-term financial upside. But let me take you through a few selected highlights. I have mentioned the importance of our Evotek molecular patient database as a foundation for a better understanding of disease processes and therefore also target ID and validation. And in 2025, we have significantly expanded the database through the addition of new cohorts, in particular in kidney diseases, obesity, but also immunological diseases. This database continues to support strategic partnerships while also generating multimillion-dollar success-based payments. As far as our IPSC drug discovery platform is concerned, We continue to upgrade our disease models into more complex organoid-type in vitro models. We have done this particularly successful in the kidney disease space. We continue to also make progress in our AI-supported small molecular design platform, eInvent. Here we continue to build models that support specifically the design of certain compound classes, as we believe that there are no one-size-fits-all models that are suitable for every compound class. We mentioned previously that we continue to invest in new approach methodologies to predict safety and toxicology of drug candidates. Also, here we continue to make very significant progress by continuously improving our existing models while also adding further models. For example, our drug-induced liver injury tox prediction tool continues to improve as now we have reached a predictive accuracy of more than 90%. Similarly, we have developed a highly predictive cardio tox prediction tool, which also has a predictive accuracy of about 90%. A further example is a new model in a teratogenicity prediction tool, where we are currently approaching 80% of predictive accuracy. To our knowledge, these omics and image-based AI-supported safety tox prediction tools are absolutely industry-leading when it comes to their predictive accuracies. Finally, I would like to briefly talk about scientific progress in our Pronomics platform. our high-performance pronomics platform continues to evolve. In 2025, we reached two landmark achievements. With our high-throughput transcriptomics platform called ScreenSec, we conducted a high-throughput compound screen screening over 250,000 compounds using transcriptomics as the primary readout. To our knowledge, this is an industry first and has never been done before. Similarly, we keep improving our proteomics platform. We have improved efficiency, automation and throughput of our platform significantly and expect to profile over 100,000 compounds in 2026 using proteomics as the primary reader. To our knowledge, there is no other company generating as many proteomic compound profiles in the industry or processing as many samples using proteomics. So it is great to see that we continue to make this much progress on our AI-supported proprietary platform. Just as important is, however, that these platforms continue to support the business financially. The combined order value directly tied to these AI-empowered platforms is currently north of 200 million already. Beyond this, it is important to keep in mind that these platforms are not only supporting the business through research payments, they enable us to build strategic partnerships which fuel our partnered asset pipeline with very substantial financial upside. And this is shown in more detail on the next slide. Today, Evotech has a pipeline of more than 100 projects. Over 60% of these projects are part of strategic partnership and therefore fully supported by these. All of the more advanced assets, in particular those in clinical and preclinical stages, are supported by partnerships and therefore represent pure financial upside for Evotech. Collectively, this portfolio represents a non-risk adjusted value of over 16 billion euros just in milestones. In 2025, the pipeline progressed significantly, which means that the total milestone potential of more than 16 billion as well as significant royalties is becoming increasingly tangible. Accumulated returns up to 2028 could total on the order of 500 million euros. In April, we gave you a status update on our asset portfolio. At that time, in total, we had 12 projects of our 100 projects were beyond the discovery stages. Six of these were in preclinical stages and six in clinical phase one. In 2025, two assets have progressed from phase one to phase two of clinical development. Furthermore, we expect that one asset will move from the preclinic into the clinic. And moreover, we anticipate further progress over the course of the next six to nine months with two further molecules expected to move to clinical phase two. This means that there's a high likelihood that our asset pipeline will have in total four molecules in clinical phase two, each of them with a different partner in different indication areas. Overall, we are clearly pleased with a lot of progress on multiple fronts. First of all, we have very significant scientific progress on AI-supported platforms. We have been able to show very significant progress in our clinical and preclinical portfolio of assets, with two new assets in Phase 2 and additional assets expected to come to the clinic soon. And finally, our discovery stage pipeline also continues to expand and is expected to continue to fuel our pre-clinic stage portfolio going forward. So a lot more exciting news is to come here within the next six to nine months. This is where I hand over and back to Christian.

Thank you, Cord. Let us now switch gears from monetizing technology leadership in BNPD over to doing the same for Just Evotech Biologics. As you will have noted, last night we announced the successful signing of the sale of the Just Evotech Biologics Toulouse site to Sandoz. Under this transaction, Sandoz will acquire Just Evotech Biologics EU plus a technology license to our continuous manufacturing platform. The agreement includes additional license fees and development revenues. This marks a pivotal milestone in the journey of just Iberdeck Biologics and underscores the successful execution of our strategy. We aim to close the transaction together in 2025, subject to meeting customary closing conditions, including foreign direct investment clearance by the French authorities. With the transaction, we are reconfiguring our successful partnership with Sundoz which started back in 2023 with the intent to support the expansion of Sandow's biosimilar pipeline and was extended in July last year. We are now converting a collaboration that was based on a long-term manufacturing arrangement into a new partnership centered around technology transfer and enabling our partners. The rationale for the deal is clear and compelling, and it follows the strategy we outlined for the whole company. Number one, we will focus on our core competencies. This is making business by leveraging our technology leadership. Our intent is not to run a fleet of manufacturing sites as a classic CDMO player. Number two, we're entering a new episode of growth. our commercial approach will pivot towards an asset lighter, higher margin business model. One that leverages best our technology, scales to partnerships, avoids the need for large upfront capacity investments and delivers superior returns. Number three, we remain fully equipped to serve all our customers through our center of excellence in Redmond and Seattle. Operationally, we have no limitations to support the growth plans of our partners. Number four, this deal is financially highly attractive for Evotech, as it provides us with short, medium, and long-term economic benefits. On this page, you see a summary of the financial parameters of the deal. We've agreed on an initial consideration of about $350 million for the site transfer and upfront technology license payments, which will be effective short term. Over the midterm, Evotech has the potential to generate revenues from licenses and development services plus milestones of over $300 million. Those payments are related to enabling our partner to manufacture biosimilars. In the time period thereafter and starting with commercial success, Evotac is eligible to royalty payments for up to 10 molecules. These three phases, starting with a handover, create sustained cash flows over an extended period. At the same time, we improve our revenue mix, reduce capex intensity, and unlock high margin IP and technology streams. As part of the deal, up to 10 molecules developed with the Evotech continuous manufacturing technology are eligible for royalties. As recently published by Sandoz, the Evotech partnered molecules in development are targeting a fairly large share of the originator biologics market. For example, the six most advanced molecules address a combined net sales of approximately 92 billion dollars. Another four molecules are currently not disclosed. Looking ahead to the future of just Evotech Biologics beyond our great collaboration with Sandoz, our US operations will remain a center of excellence for biologics discovery, process development, and manufacturing. A hub of innovation fully aligned with our mission to discover, develop, and deliver the next generation of medicines faster, smarter, and more sustainably. Given the strong momentum of our US business with over 50 ongoing customer projects, we've expanded P&PD in Redmond and are contemplating further expansion in manufacturing selectively. Going forward, we will provide additional commercial routes for our customers to use our proprietary technology. With a transaction announced last night, we've validated the value of the technology and we demonstrated the IP licensing model for our continuous manufacturing platform is a very attractive path for our partners. We're now adding further optionality, including licensing of our cell lines, the fusion media, and a launchpad concept to enable alternative manufacturing platforms via our J-POD design. In very simple terms, our job is to drive the innovation forward and to enable our partners to successfully launch and manufacture Biologics products. Just Avotech Biologics has four main compelling modules to offer on this page in blue. J-HAL for molecule discovery, GMD, our machine learning enabled molecular development technology, JP3 for complex biologics process development, and the J-POD for continuous manufacturing. Until now, we have deployed this technology as part of an overall plan to manufacture biologics. This would have required Evotech to continue to invest in the expansion of a manufacturing footprint. The transformation towards the next generation CDMO model allows us to now deploy the technology without having to make those investments. All components are already in place such as JCHO, JMEDIA, JTRAIN, and JPOD here in pink. The performance of our proprietary cells and cell culture media customized for the perfusion-based continuous manufacturing process is industry leading. Today, we are only using them for in-house development. For tomorrow, we see the potential to leverage these assets along a product commercialization path. On the path to enable our customers, there are multiple options to ramp up manufacturing capacity using our technology without us directly investing, such as integrating a J train into a customer's facility or providing turnkey solutions at the customer's premises. Over to guidance and outlook. Our midterm outlook, shared in April, is based on the ambition to better leverage technology and science leadership, the foundation of our strategy. It is therefore encouraging to see that the endorsement of an important customer of just Evotech Biologics, such as Standoz, translates into tangible results only a few months later. Furthermore, our asset portfolio in DMPD has substantially progressed. The visibility towards our midterm goals has improved substantially. You heard the detailed financial analysis from Paul earlier. Hence, I keep it short here on this page. Despite the headwinds in the early drug discovery market, we have full confidence and confirm our guidance for 2025 with a targeted revenue of 760 to 800 million and an expected adjusted EBITDA in the range of 30 to 50 million euros. We also see Evotech on track to reach its mid-term outlook at 8% to 12% top line growth at ABDA margins greater than 20%. With the actions in place, we gain visibility and increased confidence in delivering our ABDA margin. Let me conclude by making reference to what we discussed on 17th of April this year with you. Only half a year later, we see three out of four levers of our mid-term value creation unfolding their impacts. While it is too early to call the challenges in the DMPD market mastered, we see green shoots and continue to prepare our organization to be more competitive in this environment. Our cost-out program is ahead of plan We fast-tracked the execution of our new strategy at just Evotech Biologics and the asset pipeline is progressing well. For now, I would like to say thank you. We're now happy to answer your questions. Back to Lorenzo.

The first question comes from the line of Charles Weston from RBC. Please go ahead, sir.

Hello, thank you for taking the questions. They're kind of sequential in nature, so I'll just ask them one at a time, please. Firstly, just factually, how much were Sando revenues in the first nine months and what would the division have looked like without the Sando revenues and the associated costs in Toulouse?

Are you going to... Okay, so you want me to answer right away, right?

Yes, please. That's okay.

I'll hand this over to Paul.

Yeah. Hey, Charles. Good afternoon. So I would answer your question as non-Sandoz revenue in our year-to-date was more than 50% of the overall year-to-date revenue. Also, your question was around, I think, earnings contribution within that. So what I think about that is within the just profile that you see on a year-to-date basis, that includes a Toulouse build-out cost of around $20 million. So it gives you a little bit of a normalized view of share and profitability looks like. I hope.

Okay, thank you, thank you. And then associated with that, therefore, how much of the 30 to 50 million EBITDA guide for this year is the expected upfront recognition from the Sando deal?

Yeah, just to give a little bit more colour on the full year bridge. So first of all, on the DMPD segment, just to reiterate what we said last time, we've seen a similar trajectory on full year revenues for DMPD. We do see some potential mix improvements from milestones as we get into the fourth quarter. On the JustEvaTech biologics side of the business, again, a couple of things. Continued outperformance and operating leverage as we go into the end of the year. Some impact of lower cost to lose, depending upon the completion timing once approvals are met. And indeed, there's a license recognition element from Sandals.

Sorry, I missed that last bit that you said around just after operating leverage.

So lower cost base in Toulouse, depending upon completion timing. And then, yes, there is a license recognition from Sandoz, the split of which is included or the value of which is included within the initial consideration that is shown on the presentation, Charles. And at this stage, we're not actually splitting out the license component within that initial $350 million of upfront payment.

Okay, and thank you. That just leads me on to the last one, please, for now, which is around the category from 2025 to 2028. You've given us that revenue CAGR range, the margin guidance sort of implies 140 to 180 million EBITDA in 2028 off a number that excluding the Sando deal is there about zero this year. So can you just help us understand what the trajectory is of that in terms of what we might expect as the sort of year on year progression over the next few years and how lumpy it might be depending on those milestones that you've talked about?

Yeah, Charles, let me have a go. So on the midterm outlook, you said we announced 8% to 12% in the revenue CAGR growing with EBITDA margin 20% by 2028. Following the transaction and also the events that occurred so far this year in the DMPD business, I would say the revenue CAGR is on the lower end of that revenue range. However, we do see stronger potential on the EBITDA margin rate. versus our initial funding assumptions. As it pertains to milestones, obviously, as you know, those are quite lumpy in both sides of the business, whether it's on DMPD or the JustEva Technologies business. When you think about the transaction with Sandoz that we disclosed, where there is consideration between 2026 and 2028, um what you should think about is around two-thirds of that is is product development type activity um and about one-third is licenses milestones which are subject to certain meeting criteria so it gives you a little bit of flavor of what that may look like over that period of time over the next three years okay thank you uh thanks very much for your help thanks charles

The next question comes from the line of Brandon Smith from TD. Please go ahead.

Great. Thanks for taking the questions guys. Actually, I really appreciate all the color on the AI capabilities internally, so I actually wanted to ask just a bit more about this. And really, I guess, to what extent the NAMs capabilities actually come up in your conversations with partners and customers thus far this year, if you've seen any material shift in that kind of tone? I mean, we get a lot of questions about whether pharma is kind of increasing investments in AI internally on their side is impacting their engagement with external partners, offering those kinds of capabilities. So just wondering if you're seeing any demonstrative shift in where they're engaging on that set of things, or if NAM's offerings are actually increasing that, and how you might expect that to kind of help grow revenues over the next, let's say, 12 to 18 months. Thanks.

Thanks, Brandon. I'll hand this over to Cord, and I'm really pleased to see also these questions. We recognize that we've maybe talked a little bit less in the past about those topics, but rest assured there's quite some activity at the Evotech side. Cord, please.

So the NAMs are definitely getting more attention, and also from the pharma side particularly. Nevertheless, it's still sort of a muted growth in the area at this point in time, but we do see real signs of acceleration because people, a lot of projects are integrating these norms at an earlier stage. You can imagine if you sort of have a predictive tool for drug-induced liver injury, If you introduce this late in the process, you essentially have to profile a handful of compounds maybe. But if you introduce it early in the process, you are continuously profiling potentially hundreds of compounds. And here, this is why we keep talking about industrialization of these platforms and making them high throughput feasible, because this sort of opens up the funnel to really bring this into the, on the critical path of the drug discovery value chain and incorporating these kind of assets at an earlier stage. So basically, Right after hit finding, essentially, you can start incorporating this. So I think with this sort of seeing that people are getting more and more interested in incorporating these NAMs early, I would expect to see the revenues vastly accelerate on this fund. If it's within the next six months, I would say that would be very ambitious. But within the next 12 to 24 months, certainly.

Got it. Thank you. That's very helpful.

As a reminder, if you wish to register for a question, please press star and 1 on your telephone. The next question comes from the line of Finn Schartzer from Deutsche Bank. Please go ahead.

Hi, and thanks for taking my questions. So the first one I would like to ask them one by one. It's on your drug discovery and preclinical development segment. and whether you are able to give any sort of glimpse on what you expect into 2026. Some of your US peers sort of gave an early indication. I think consensus sits at around 5% growth for next year. Do you consider this a sensible starting point for the year? As of now, would you point us to take a more cautious stance? I understood you spoke of green shoots and so on, but not really of an inflection yet. This would be very helpful.

Thanks, Finn, for the question. Obviously, our visibility at this point in time is not all the way through 2026. And keep in mind, collectively, the industry, since quite a bit, was actually looking at when exactly the tipping point is happening. So I'm a bit cautious with making statements about when exactly the market is coming back. And as I said earlier, when you look at the individual bits and pieces here, you've seen on one slide, the change order pattern It wasn't favorable in the first and second quarter, the negative change orders, but it was also related to a few individual wins. Q3 looks much better. Then you've seen the number of prospects going out, right? Plus 20%. You can draw conclusions out of that, but I'm not doing it at this point in time because there's prospects need to convert into sales orders. So um at uh at this point in time given that we have probably visibility into the next couple of months uh i would i would not make a statement around plus five percent for the market next year okay that's helpful um if i can maybe follow up with two shorter ones um so on the profitability and the discovery and pre-clinical development segment uh

I think it was surprisingly weak this quarter, but the revenues were sequentially actually about stable. So could you maybe help explain that?

Say that again, please. I'm not sure why.

No, sorry. I was just saying that I think the revenue in the discovery segment was pretty much flat sequentially, but the profitability was much worse than probably expected. What was the explanation for that?

Yeah, Paul again. When you look at the year-to-date profile of the D&PD business and then compared to third quarter, you are correct that it appears to take a step down. We did actually in the first half have better mix and then also a license benefit in the first half that impacted positively. It didn't repeat in the third quarter. As I said in my comments, however, we do see further opportunities around milestones for the fourth quarter for DMPD, and that volatility, if you like, on milestone recognition will continue in this segment. But that explains the delta there.

Okay, helpful. One last one on the Sandor deal. I'm not sure if you sort of compare the revenues that investors and the sell side had expected from sort of your CDMO income stream that is now falling away. How does this compare to what you will get now in terms of licensing revenue and so on and so forth? So sort of the 300 million package you described, What I'm trying to understand is consensus sits at around 420 million for the JAB business in 2028. Does that then look completely off from your point of view, or is this still sort of the right ballpark, or are people totally misunderstanding this at the moment?

I think a couple of points here. First of all, I try to explain that there is the Sundance deal, And that's a fantastic opportunity to partner with Sandoz, and it will continue to generate revenues and profit for the company. Then there is another 50 customer projects that we're serving out of the US. Don't forget to keep that in consideration. And then what we said is we're basically pivoting to a different model, right? the way that we look at it is a much more capital effective way of doing business. So moving from a manufacturing view to a license model allows us to generate revenues in our view at a higher margin rate and much more capital efficient. And that's the driver why we've concluded that this is a great deal for the company. And as we said also last time, from an NPV perspective, for us, this is a positive contribution.

Yeah, so there is some level of reduction on revenues. But as Christian rightly says, significant improvement in the gross margin, driven by that higher quality revenue mix, whether it's tech licenses, royalties, consumable sales that we talked about, as well and that lower capital intensity. So we're trading to higher quality mix of business.

Okay, that's very helpful. Thank you.

The next question comes from the line of Michael Riskin from Bank of America. Please go ahead.

Hi, thank you for taking the question. This is Aaron on for Mike. You called out the soft early drug development market environment and VC biotech funding. Given the current market environment, can you talk a little bit about what you're hearing from customers and related to that a little bit more about the implications for the overall pricing environment?

So I think there's still uncertainty in the market, especially in biotech. And I've also mentioned that our DMPD business, 30 to 40% of the revenues is related to biotech. So there's quite some exposure here. That's number one. Number two, as we also mentioned throughout the course of the year, while conversations continue, There's more slicing happening than what we've seen in the past. So more cautious spending, less larger projects, more smaller projects, and decision making is slower. So that's a little bit the environment that I have the picture I've painted already in Q1 and Q2. And we see this continuing with maybe the difference that, as I said, the number of prospects have come up quite a bit over the course of the last month and quarters, which shows that there's more activity and hopefully also more prospects for 2026. Pricing obviously is a function of also capacity in the market. It's clear that there has been overcapacity across the market in drug discovery, but it's also clear that most players are right now adjusting like we're doing it. So I see this actually also starting to normalize when demand and capacity is coming more into balance again.

Great, thank you. And then just a quick follow-up. I wanted to actually ask about the prospects. I'm wondering if you're seeing the prospects of green shoots within similar geographic regions, if there's any geography that's performing better than expected, worse than expected, if you could provide a little bit of color there. Thank you.

That is actually the case, but it depends a little bit on the subsegment. And as you know, we're less penetrating the Asian market. So we've seen a little bit less dynamic in the US market earlier this year, and that has flipped more to the European market. So not very consistent and conclusive at this point in time, but there is variation.

Great, thank you.

The next question comes from the line of Charles Weston from RBC. Please go ahead. Charles? Mr. Weston, your line is open. Please go ahead. Ladies and gentlemen, we lost the line with the questioner. So there are no more questions at this time. I would now like to turn the conference back over to Volker Braun for any closing remarks.

Thank you, Lorenzo. And thanks to all in the call for the engaged discussion. In case you feel not all of your questions were addressed, please feel free to reach out to me anytime. We are looking forward to meeting many of you at the upcoming investor conferences in November and December. And with that, we wish you a good rest of the day. Thank you and goodbye.