Incyte Corporation

If anyone should require operator assistance, please press star zero on your telephone keypad. A question and answer session will follow the formal presentation and you may be placed into question queue at any time by pressing star one on your telephone keypad. We ask you please ask one question and one follow-up, then return to the queue. As a reminder, this conference is being recorded. It's now my pleasure to turn the call over to Greg Furtzer, Senior Director of Investor Relations. Please go ahead.

Thank you, Kevin. Good morning and welcome to Insight's second quarter 2025 earnings conference call. Before we begin, I'd encourage everyone to go to the Investor section of our website to find the press release, related financial tables, and slides that follow today's discussion. On today's call, I am joined by Bill, Christiana, and Pablo, who will deliver our prepared remarks. Mateo, Mohammed, and Stephen will also be available for the Q&A. I would like to point out that we will be making forward-looking statements, which are based on our current expectations and beliefs. These statements are subject to certain risks and uncertainties, and our actual results may differ materially. I encourage you to consult the risk factors discussed in our SEC filings for additional detail. I will now hand the call over to Bill.

Thanks, Greg, and good morning, everyone. Before I get started, and on behalf of the Insight management team and the employees, I'd like to thank and recognize Hervé Openo for his leadership and commitment to Insight over 10 years. His contributions to this company were invaluable and greatly appreciated, and we wish him the best in his retirement. As you know, I started at Insight very recently, roughly 30 days ago, and so before jumping into the quarterly results, I'd like to touch on two fundamental questions I've been asked since joining Insight. The first one is, what specifically attracted me to the company? And second, what are my initial thoughts on strategic priorities? In response to the first question, I naturally studied the company and the business in great detail and spoke to many different stakeholders, including physicians, patients, and investors before joining. And my initial impression is that Insight has all the intrinsic characteristics of a high-quality growth business. That is the potential for new, meaningful product flow, attractive markets, R&D and commercial capabilities, and a strong balance sheet. I believe there's a foundation in place and a path to value creation, but time is of the essence. The non-trivial challenge Insight faces is navigating the company through 2029 and transitioning to a new set of durable product growth drivers. On the potential for meaningful new product flow, Insight has several important product launches between now and 2030. These products, of course, will vary in size. Some will contribute substantially and others incrementally to growth. But either way, there is substrate here. Marketed products, Opsalora, Nectimvo, Monjuvi, and pipeline compounds like 989, our mutant Cal-R monoclonal antibody, and Pobacitinib, our JAK-1 specific inhibitor, have the potential to drive future sales growth and form the company's core. More work remains, of course, but we've made progress with these compounds scientifically and commercially. Opsalora is showing strong broad-based growth today across AD and vitiligo, has close to 20,000 prescribers, and has the potential for new indications in the coming years. Nectimvo is off to a very strong start. Phase 1 results with 989 and ET are promising, and we will share data on MF at the end of the year. And finally, Pobacitinib could support at least three different indications. Next, InSight operates in two of the most structurally attractive markets in the industry, hematology, oncology, and immunology. They're built on solid foundations of science, need, and opportunity, and we have differentiated knowledge and capabilities in these areas, and we'll focus on them. And finally, InSight has well-developed high-quality R&D and commercial capabilities. Yes, there have been R&D setbacks, and we need to convert science into regulatory approvals and business results, but I believe our discovery and development capabilities in our core areas are a competitive advantage. Now, regarding our strategic priorities, here's my initial thinking, and I will come back to you in the coming months with more specifics on the direction we plan to take the company strategically, operationally, and financially. We intend to build a comprehensive plan for acceleration that goes beyond just filling a revenue gap. We'll take a fresh look at this business, including our R&D productivity, operating expenses and capital allocation, and dedicate resources to accelerating product flow and growth. My framework for the business will likely have the following set of priorities. First, take care of the core. That's straightforward. Driving utilization of our major products in the short term is necessary for long-term success. Second, accelerate product development. Pablo and I have spent many hours on this topic. It's almost all we talk about. Our mid- to late-stage pipeline has the potential to unlock the next phase of growth for InSight, but there are still unanswered questions, which is not uncommon. 989 is arguably the most scientifically promising asset in the MPN space as a targeted mutation-specific approach. Our success will depend on translating early Phase I data into a regulatory approval and a marketed product. The medical need and the market potential for 989 is significant. If we're successful, 989 should trigger a fundamental shift in the treatment of MPNs like we've seen in other cancers. For Povacitinib, we have a clear and credible path to turning this into a major product for InSight. Its success will be predicated on execution in areas where Povacitinib can have differentiation such as HS, PN, and vitiligo. In HS, Povacitinib could be the first oral option, which is perhaps the most challenging disease in dermatology. It's not like -3-mediated psoriasis or -13-mediated AD. It's more complex, involves more pathways, treatment success is variable, and so a new treatment option like Povacitinib should be very marketable. As it relates to our early stage pipeline, the scientific rationale behind CDK2, G12D, TGF-Beta, BiPD-1 for select solid tumors, among others, is strong. But as you know, early stage projects inherently involve uncertainties. We will be continuously assessing these and other programs. They'll be put through a framework to be scored and compared to other programs based on strategic importance, PTRS, commercial potential, and return on investment. And I recognize that every use of capital, R&D capital, is an opportunity cost for other uses. Third, capital allocation. We're generating significant cash flow and have a growing balance sheet. The first call on capital will be the core business, our marketed products. The second is the late stage pipeline, and the third is business development. Sometimes our best investments will be inside the company, and other times the reverse will be true. We'll have a governance mechanism for allocating capital internally and externally to ensure long-term growth and maximize shareholder value. Regarding business development, we'll look hard at finding de-risked, pre-revenue, or revenue stage opportunities. As you know, there are very few positive asymmetrical opportunities out there, and it's easy to mistakenly turn a dollar into 50 cents. We'll be careful about where and how much capital we put to work. But when strategically sourced, appropriately priced, and well executed, BD can create a lot of value. We will have a well-defined framework for BD, and we will look for opportunities that fit that framework. Finally, it's important to keep a close eye on execution. Converting science and strategic plans to results is the job. We'll run the business at a detailed level, enhance the quality and speed of decision making inside the company and manage our expenses in a disciplined way, which means focusing on doing more with less versus more with more. I look forward to sharing more details on our strategic framework later this year. Now, moving to our second quarter results, which Christiana will review next, Jackify demand remains very strong across three indications. Opsalora growth was exceptional across two indications, and the NICTimvo launch is exceeding expectations with rapid adoption among BMT centers, reinforcing its commercial potential. The growth prospects for these products are excellent if we continue to execute. On the R&D front, we made excellent progress. We released phase one data on 989 and MF at the end of the year to supplement the data we presented at EHA and NET. We expect an FDA approval for Opsalora and pediatric patients 2 to 11 years of age with mild to moderate AD in September. Importantly, the pivotal trials for Povacitinib and Vitiligo and PN and combination trials with Axotillumab and GVHD are enrolling on track. With that, I'd like to turn the call over to Christiana, who will provide the second quarter commercial and financial update.

Thank you, Bill, and good morning, everyone. In Q2, we delivered strong financial results with total product revenues of $1.06 billion, representing an increase of 17% year over year, driven by continued demand growth for JAKAFI and Opsalora, as well as a contribution from the ongoing commercial launch of Nick Timbos. Total revenues were $1.22 billion, up 16% versus the same period last year. Turning to JAKAFI on slide nine, JAKAFI net product revenue was $764 million for the second quarter, representing an 8% growth year over year, driven by paid demand, which also increased 8% versus the prior year period. Demand for JAKAFI continued to grow across all indications. Channel inventory levels ended the quarter with a normal range. As a result of the strong demand seen in the first half of the year, we are raising our revenue guidance for JAKAFI to a new range of $3 to $3.05 billion. Turning now to Opsalora on slide 10, total net product revenue for the second quarter was $164 million, representing a 35% increase year over year. U.S. net product revenue of $132 million was up 19% year over year, driven by increased patient demand and refills in both atopic dermatitis and vitiligo. Channel inventory levels ended the quarter with a normal range. -U.S. net product revenues of $32 million last year were driven by continued uptake in France and Germany, as well as the recent launches in Italy, Spain and Canada. In France and Italy, Opsalora has seen very rapid adoption. Turning to slide 11 in the Nctivo launch, Nctivo net product revenues in the second quarter were $36 million, driven by high patient need and strong commercial execution. We continue to see positive launch metrics with widespread product awareness and interest. We have achieved roughly 82% account penetration with rapid and broad uptake in BMT centers across the U.S. Since the beginning of the launch, over 4,000 infusions have been administered to an estimated 700 patients, representing approximately 10% of the third-line plus GVHD market. Of all the patients that went on Nctivo, approximately 80 to 90% remain on therapy today. Turning now to other amatology oncology products on slide 12, net product revenues for the second quarter were $131 million, representing a 66% -over-year increase. This is primarily driven by the commercial launch of Nctivo, as well as increased contribution from Zainiz following the approval in ACAC. As a result of the strength of the Nctivo launch, higher demand for Zainiz, and the earlier than anticipated approval for Monjuvi in FL, we are raising our full-year revenue guidance for other oncology products to a new range of $500 to $520 million. Moving on to slide 13 and our operating expenses, during the second quarter, we recorded a benefit of $242 million from the contract dispute settlement with Novartis relating to JAKA-5 royalty payments through the first quarter of 2025. The settlement also resulted in a reduction in COGS, driven by an ongoing 50% reduction in the royalty rate payable to Novartis. As a result, we are reducing the lower end of our COGS guidance. The revised guidance range is now 8 to 9% of net product revenues. Shifting now to R&D, total R&D expenses on a gap basis were $495 million for the second quarter. Excluding the one-time Asian cost in 2024, and other one-time expenses in both years, R&D expenses increased 8% -over-year, driven by continued investment in our late-stage development assets. In the first half of the year, we entered into two new development collaborations with Genesis and Biotherics. As a result of the upfront and ongoing expenses related to these new collaborations, we are increasing our full-year guidance for R&D by $35 million to a new range of $1.965 to $1.995 billion. Moving to SG&A, total gap SG&A expenses were $331 million for the second quarter. Excluding the one-time cost for the prior year, gap SG&A expenses increased 16% -over-year, primarily driven by increased legal costs related to the Novartis contracts dispute settlement and other matters, and timing of certain consumer marketing activities. Finally, we continued to execute on our commitment to grow operating expenses at a slower pace than revenues. Ongoing operating expenses in the second quarter of 2025 increased 13% -over-year compared to a 16% increase in revenues during the same period, leading to continued increase in operating leverage and margins. Given the very strong performance of our commercial portfolio in the first half of the year, and based on our updated guidance for the year, we expect net product revenues for the full year to grow at a rate of 14% to 17% -over-year, and ongoing operating expenses to grow at a rate of 5% to 7%, leading to further expansion in operating margins. I'll now turn the call over to Pablo for an R&D update.

Thank you, Cristiana. Good morning, everyone. As we highlighted a year ago when we summarized on this slide, our portfolio remains on track to deliver more than 10 launches by 2030. Moving to slide 16, the phase one data in essential thrombocytemia for INCA-0339A9, our mutant-colored monoclonal antibody, was presented at EHA 2025. 9A9 is the first truly targeted therapy for a subset of patients with MPNs that includes 25% of patients with essential thrombocytemia and 35% of patients with myelofibrosis. Importantly, this data set demonstrated the normalization of plate accounts in patients with ET, which is consistent with the mechanism of action of 9A9 and a key point of differentiation from seroductive therapies. 9A9 was very well tolerated with only one out of 49 patients discontinuing therapy. It is very reassuring that at this point in the development of 9A9, it appears to have an excellent safety profile. We also observe rapid and sustained reductions in VIF in most patients despite the short follow-up for patients in the highest host cohorts. We believe this data will continue to improve as it matures, delivering an important outcome for patients. Treatment with 9A9 also resulted in a reduction in mutant-colored positive mega-carotides in the bone marrow as well as a reduction in mutant-colored positive CD34 positive stem and progenitor cells in peripheral blood, confirming the potential of 9A9 to be a disease-modifying therapy that offers a potential path to a cure. On slide 17, let me summarize the key steps for the 9A9 development plan. We will advance this program with great urgency with the goal of starting pivotal trials in ET by early 2026. We continue to gather data and have expanded certain dose cohorts to better understand what the optimal dose is for further development. We are committed to presenting data in MF as monotherapy and in combination with Rux litinib by the end of the year. Additionally, we have established a collaboration with Kyogen to develop a co-diagnostic across MPNs with an initial focus in color mutations. Importantly, we continue to develop a subcutaneous formulation and that work is ongoing. We believe that initially the IV formulation every two weeks is acceptable, but we will work to advance the sub-Q in parallel. Turning to our dermatology portfolio starting on slide 18. I'm pleased to share an important update on Rux litinib cream. As you know, Opsilura is currently approved in the U.S. for the treatment of adult and adolescent patients with mild to moderate atopic dermatitis and vitiligo and in Europe for the treatment of vitiligo. Today we announced the top line results from the pivotal phase three through AD4 study which evaluated Rux litinib cream in adult patients with moderate atopic dermatitis with extensive by the surface area involvement of 10 to 20% and significantly impaired quality of life with a DLQI greater than 10. I'm happy to report that the true AD4 study met its co-primer endpoints at week eight with statistically significantly larger proportion of patients receiving .5% Rux cream compared to vehicle achieving both IGA-TS and EC75. At week eight, Rux cream demonstrated a vehicle adjusted difference in IGA-TS of .6% and a vehicle adjusted difference in EC75 of 51.4%, both highly statistically significant. In addition, the study met all key secondary endpoints, further reinforcing the efficacy profile of Rux litinib cream in this patient population. Importantly, the safety profile observed in true AD4 was consistent with previously reported data in atopic dermatitis. Rux litinib cream was well tolerated. No new safety signals were observed. This result confirmed that Rux litinib cream is a highly effective treatment option for patients with moderate AD who are eligible for systemic therapies. Based on the results of the study, plans are underway to submit a type two variation for obsolescent in Europe where there's a strong demand for innovative topical therapies in patients who have failed topical corticosteroids or topical calcineurin inhibitors. Looking ahead, we plan to present a full phase three top line results at an upcoming medical meeting and we look forward to engaging with regulators to discuss next steps for potential label expansion. Moving to slide 19 and the near term opportunities for poversitinib. We're advancing poversitinib in three indications and believe this represents significant opportunities for near term revenue and long term value creation. The positive phase three data in patients with moderate to severe HS, which affects over 300,000 patients in the US will be our first submission for poversitinib and will support worldwide regulatory filings in 2026. The phase three studies in patients with vitiligo and prurigo nodularis are progressing well and we anticipate presenting data in 2026 with potential approvals in 2027. 2025 is a pivotal year for insight with over 18 key milestones including four new product launches, four pivotal trial readouts, at least three phase three study initiations, and seven proof of concept study results. As shown on slide 20, we have already achieved several of these milestones with multiple important catalysts still to come. I would like to note that the initiation of our bed phase three studies now planned for the second half of the year pending regulatory feedback and the release of V617 phase one data has shifted from the second half of 2025 to the first half of 2026. We look forward to sharing additional updates on this milestone in the second half of 2025. I will now turn it back over to Bill for his closing remarks.

Thanks, Pablo. To summarize the key takeaways before we open the line for Q&A, our second quarter sales and growth for our key products were strong, resulting in revenue guidance being increased for the full year. Next, we are making excellent progress with our R&D pipeline both for hematology as well as for I&I. Lastly, our focus is converting science and strategic plans into product flow and generating durable revenue and cash

flow. That concludes our

prepared remarks. Kevin, please open up the line and give your instructions for Q&A.

Certainly. We will now be conducting a question and answer session. If you would like to be placed into question Q, please press star one on your telephone keypad. As a reminder, we ask that you please ask one question and one follow-up to return to the queue. That star one be placed into queue and star two if you would like to remove yourself from the queue. Our first question today is coming from Jay Holson from Oppenheimer. Your line is now live.

Oh, hey. Congrats on the quarter and welcome to Bill. It's a pleasure to reconnect with you, especially after having had the pleasure of working with you in the past. Thank you so much for outlining your strategic vision and the rigorous prioritization process that you that you're planning. Can you just share with us your thoughts on the relative importance of the three therapeutic areas at Insight, oncology, hematology, immunology? Do any of those get prioritized in your strategic plan or are you agnostic to therapeutic area? Thank you.

Yeah, look, it's a good question, Jay. It should be pretty clear to everybody that MPNs is our most important therapeutic area right now. I think we have as a company an asymmetrical advantage in that space. I believe there's a window of opportunity here to completely transform the treatment of that group of blood cancers. As you know, targeting driver mutations in MPNs is the holy grail. And if you talk to a hematologist and ask, would you rather use a targeted monoclonal antibody versus a pathway approach, they'll select the target approach every time. We have potentially the ability to create a series of innovations, obviously starting with 989, we have 617, we have a bispecific, we also have compounds in discovery. And when you have an opportunity to sort of dominate and control and never see the market, you got to take advantage of it. And so strategically speaking, that is our number one priority. And I think we can set a new standard of care in MPNs, set what I would describe as a new high watermark. Now look, no one should take my word for it. We have to convert, as I said, science into results. And of course, the progress that we're making with 989 has been incredibly important. I think in I&I, I do believe that there's a credible path to building a large product. We're not, for example, with poversitinib, copying all the indications for RENVOKE. And I do believe we have differentiated knowledge and capabilities in the three immune mediated skin conditions that we're targeting. And we do have a franchise strategy with Opsilor and poversitinib, which other companies don't have. The product has the potential to be first in HS, first in vitiligo. And I think, you know, paragonodulorus was a disease made for JAKS. And so I like the potential there. And as it relates to our oncology business, Jay, you know, there are certain principles that you have to apply. Find the right product first, pick a winning market, and make sure that you can defend that position. And we will apply those principles and make sure we make good decisions as it relates to the other programs that we're developing for solid tumors. Beyond those three areas, look, the pressure to fill a pipeline in biopharma, this is true not just at Insight, but it's true at every company, is pretty unforgiving. We're focused on these areas right now. If we were to look at other areas, it would have to make sense strategically and operationally. And I would never stretch the capabilities of the company. But at the end of the day, what we're solving for is new product flow and the knowledge and skills we have in those three areas can be transferable. Thanks, Jay.

Thank you, Bill. Thank you. Next question is coming from Tasheen Amad from Bank of America. Your line is now live. Hi,

guys. Good morning. Thanks for taking my question. I just wanted to get a sense, maybe this is for Pablo, on the read-through from the CalR data that you saw from ET and what to maybe expect to see for MF. And then related to that, you're going to show monotherapy as well as combo. But is there a minimal threshold that you're looking for for activity on monotherapy if you could just help set expectations for that? We'd appreciate it. Thanks.

Good morning, Tasheen. Thank you for the question. Look, let me make a couple comments here. The important thing to remember is mechanistically, the mutant color antibody 989 would work the same way in MF that it does in ET. So whatever one's preconception on the probability of success was before the ET data, it certainly has to increase with the ET date in hand, A, because of the safety that was so clean, and B, because the efficacy, not only the clear normalization of playlist reduction in VAF and reduction in mutant color positive megas was so clear in the ET data, but because those were our fundamental based on the mechanism of action of the mutant color antibody. So when you have that mechanistic clarity in a set of patients, the probability that it will work on a different disease with the same molecular basis is certainly high. The reason why we decided to shift the release of the data in MF to later this year is, as you pointed out, because we want to have combination data with Rux litinib. As we all know, Rux litinib increases survival in first line patients and patients with MF. And so we believe that the development of 989 in MF will be at least in part in combination with Rux, which is why we wanted to have a more comprehensive data set when we present the data later this year. In terms of specific numbers, what I would say is we would expect to see improvement in MF in all the basic endpoints that we've discussed over the years in MF patients, obviously. Spleen size reduction, spleen volume reductions, improvement in symptoms, improvement in hemoglobin perhaps, and we expect to see a component of that in their data released later this year.

Thank you. Next question is coming from Salveon Richter from Goldman Sachs.

Your line is now live.

Good morning. Thank you for taking my question. Just a follow-up to two comments that were mentioned earlier. One is, initial data for 617F is now expected in the first half of 26, and should we read anything into this delay? And then secondly, you talked about the enthusiasm for POVO in the HS market and its competitive differentiation. Maybe just walk us through that, particularly when you look at the context of secure efficacy that we've seen for some of the currently approved therapies such as Binslex. Thank you.

Great, Salveon. I'll answer the second question, and Pablo wants to take the first question.

Certainly. So, this is simply related to the fact that this is a phase one dose escalation study. And you make projections when you start this study about what dose will give you a certain exposure that will be sufficient in this case to reach the IC35, which we've been talking about over the years about inhibiting the mutated cells. It turns out we need higher doses than we expected. You always need a certain amount of follow-up in these patients. As you know, in MF, data needs to mature a little bit. Because of those two reasons, the data has moved to the first half of 2026. Importantly, we have opened the study also now to patients with ET and PV. So, the study is progressing well. We simply need higher dose levels with a longer follow-up to get the kind of data that we're willing to release. Our conviction, the mechanism on this program continues to be strong, and this is simply a matter of escalating a little bit further.

And then Salveon, on HS and POVR-CITNIB, and if Mohamed has, excuse me, Mohamed, Matea has any comments he can add. First of all, as you know, it's one of the most challenging conditions in dermatology. Ask any dermatologist that. IL-17s don't work almost half the time. One dermatologist described high score 50 or even 75 as a beauty contest. It's very hard to compare high score rates from one study to the next. The condition, as you know, is fundamentally different than IL-23 mediated psoriasis or IL-413 mediated AD. That is to say it's inflammation soup. There are multiple pathways involved. If you ask a dermatologist what's most important, they'll first say make the patient feel better and then make them look better, meaning clearance. And this is a quality of life condition. If you look at the data from POVR-CITNIB and you look at the effect that the drug has on pain and flare control, it's pretty remarkable and it's a very competitive data set. It also does, you get out past week 12 at week 16 or 18, those clearance rates are in the 50 percent range. And if you look at the effect of the drug across all those endpoints, clearance, pain, flare control, half the effect is in the first three weeks. So I believe that a systemic option like POVR-CITNIB is going to have a place in the treatment paradigm for HS, whether they're starting with POVR-CITNIB and then going to a biologic or they go to a biologic and then to POVR-CITNIB. I don't think anyone has a clear view on the future, but this is a condition that there's a lack of treatment options. We have good data and when you look at the totality of the evidence, there's going to be a place for POVR-CITNIB as well as the IL-17s.

Thank you. Our next question today is coming from Salim Sayed from ZOO Security. Your line is now live.

Great. First of all, my welcome to Bill and thanks for the question. I guess maybe one for us on NIC-TIMVA. So you had a good beat again on the quarter and obviously the J-code went into effect here around April, April 1st, I believe. Can you maybe comment some of the interquarter dynamics there that you saw from the J-code going into effect or do you describe the strength of the quarter to any other particular part of the launch? And I don't think you guys mentioned the inventory impact there for the quarter for me. Maybe just remind us what the inventory impact was for the quarter. Thank you.

Yeah, thanks for the question. I'll give you my overall assessment and either Mohammed or Christiana can fill in some of the details. As Christiana said, we're five months in and we're at a 10% penetration of that third, fourth line market. And what we watch on a weekly basis and what is important for any new product launch is what do your new patient starts look like? Every pharmaceutical product is like a leaky bucket and you have to maintain, the same is true with Opsalora, you have to maintain new patient starts. So when I look at the dynamics underneath NIC-TIMVA, that's what I'm focused on. This product over the next five, six, seven months, say the balance of the year has the potential to reach over a thousand patients. That would be a very, very good first year. If you take a look at the adoption curve, for example, of Sanofi's Resaroc and you look at the adoption curve right now for NIC-TIMVA, they're both in the same zip code. Now, new product launches are very unpredictable. They can be fickle and there can be a lot of choppiness from quarter to quarter. But I like the momentum, the underlying momentum of the business right now. As you heard, over 80% of EMT centers in the United States are using the TIMVO. That's also important because you need a large group of users, prescribers, or in this case, accounts. The other thing that is reassuring to me is we have 4,500 infusions and roughly 700 patients, which means the large majority of patients, my estimate could be 90% of patients are still on the product. When you have a chronic disease like this, duration of therapy isn't necessarily measured in months. It can be measured much longer than that. I don't think we could have gotten off to a better start, but I'm very paranoid. We're in the middle of the first year of launch. You have to really manage the details very carefully. Of course, the Ops designation makes this feasible for institutions. Do you want to cover anything I missed?

You didn't miss much. It's important to underscore that we're pleased with the performance so far. You heard earlier about 10% penetration in that third line plus setting. Also important to note that there's about 3,500 patients that are in play at any given time in the third line plus setting. That means these are the patients that are up for grabs, that are changing therapy in some capacity. We're either at 10% of the third line plus setting in total or we're 20% of that in play opportunity, which again is a testament of commercial execution. You heard some of the metrics around infusions and penetration from Bill. I think the last thing maybe I'd say is that we know prescribers are seeing real world results very similar to what they saw in our clinical trials, which is not always the case in this disease. This is going to naturally encourage providers not only to use Nectimvo more often, but perhaps also consider Nectimvo earlier in their treatment paradigm for more patients.

Thanks for the question. Just an inventory. Sorry.

The inventory, just to put that in perspective, inventory accounted for less than 5% of Q2 sales so far and that's stabilizing in that expected range. The performance that you're seeing and the volume is driven primarily by demand.

Thank you.

Next question is coming from Kelly Shi from Jefferies. Your line is now live.

Hi. Good morning. This is Clara Ahn for Kelly. Thanks for taking our question and congrats on the quarter. You have the initial G12D and bispecific data representing an asthma. I'm wondering whether you can provide more granularity on the scope of proof concept data and maybe help us understand what would be the key metrics you're looking for to define a success and move the program forward. Thank you.

Great. Pablo,

you want to take that?

Certainly. So what we should expect, what you should expect for this two presentations at ASMO in a way is consistent what we did last year with CDK2. As we've made, we try to be consistent about presenting data. We want to present substantial data sets that give you clarity on how well these compounds work in terms of both efficacy and safety and to be able to have with you a discussion about next steps for the programs. That's exactly what you should expect here. We're going to have a substantial number of patients for both our KRSG12D program and our TGF beta receptor by PD-1 bispecific. And we believe that both demonstrate proof of concept in a range of tumor types and the amount of data we'll be able to use that to have a discussion with you on the next steps for these two programs, which we expect to do at ASMO in the next couple of months.

Thank you.

Thank you. Next question today is coming from Brian Abrams from RBC Capital Marketer Line

is now live. Hey, good morning. Congrats on all the progress and welcome to Bill. Look forward to working with you again. Hey Brian. Hey. So a question on Opsalora. I know your guidance was unchanged, but I wanted to unpack the dynamics underlying that. And I'm curious the degree to which pediatric indication is embedded there and then maybe how we should be thinking about the XUS cadence going forward. I know you saw a big uptick, but international can be a bit lumpy. And then maybe longer term, the degree to which the moderate AD data from true AD4 might expand the market opportunity down the road.

Thanks. Yeah, Brian, good question. You know, I'll give you my initial observations after the first 30 days. Obviously 60% of the business is AD and 40% is Vitelligo. That AD business is growing at plus 20% and the Vitelligo business is growing at plus 10%. Our penetration of this market, if you just think about the AD market as systemic and topicals, is still relatively modest. 7% of the overall AD market is systemic and about 17% of the topical market. Markets growing at 20% year over year because of migration from topical corticosteroids to a non-steroidal option, topical or systemic. And that TCS market in the United States at branded pricing is about $15 billion. Now it's moving at a modest rate, but that's what's fueling the growth of the market that they're in. And as I said, I see this as a double digit kegger business, both US and of course internationally over the next several years, just with AD and with Vitelligo. As it relates to pediatric, I would think about it as an incremental growth in the US. I think the core business right now is what's going to drive growth over the next several years. The product's got 20,000 users in the United States, prescribers, which is second to only to PICS and AD. And so there's a large prescriber base here and when you're thinking about a large prescriber base, you're thinking about a large prescriber base. And so I think the long-term growth potential of any product, that's important. And then as you know, the coverage, both commercial, Medicaid and Medicare, is solid. It's not cheap, but it's solid coverage. And so I like the way it looks. As it relates to the international business, I just spoke with the person who runs our international business the other day about this, France, Italy, Germany, and Canada. We had a good first or second year. It's gone from 60 million to roughly $120 million in sales. We'll get the AD indicator. That was just in Vitelligo. And the indication for AD has the potential to keep that business growing and maybe you too exit over several years.

Teo, anything you want to add? No, you covered it all. And on the PICS side, we see the same way. It's a great tailwind to sustain the growth of our already strong budget proposition in that disease. Great. Thanks, Brian.

Thank you. Thank you. Next question today is coming from Jessica Pye from JP Morgan. Your line is now live.

Great. Good morning. Thanks for taking my questions. A couple more for Bill. I'm curious how you plan to balance investment in pipeline advancement relative to external opportunities, relative to the need for investment to support kind of near-term commercial performance. I guess if we think about kind of looking out five years from now, how do you see insight? Is this going to be mainly organically grown, transformed through M&A, some kind of combination? Thank you.

Yeah, it's a really good question. I think there's a lot in that. Look, the job here, it's not just mine. It's Pablo and Steven and Christiana and the people who run the commercial business. It's about, forgive the baseball metaphor, it's about calling balls and strikes. And you have to look at internal investments and external investments the exact same way. There are no sacred cows inside the company. It's also not true that everything outside the company is a shiny penny. And I've been here 30 days, but I will tell you all we think about is capital allocation, both internally and externally. In terms of a balance between the two, I don't like to force any ratio. I think we have to just look at facts, details, and analysis and make our calls. As it relates to where I want to see the company in five years, it'd be nice to exit. But I think what we want to do is to, and I mentioned this earlier, set a new high watermark for this company. We have to get through 2029, but set new highs for the company. And that means getting our growth portfolio right. And I include that Opsil or Nectimvo and then 989 and POVO. And I know there's no guarantee there. We have to manage those programs. Next, get R&D priorities right, which is what every company has to do. Then get the cost base right. That's just good corporate hygiene. Get BD right. And build a business for the long term so that we really never see the end of the road. And as I mentioned earlier, I do believe we have a win of opportunity in MPNs where we have differentiated knowledge capabilities to build a really great business there. Thanks for the question.

Next question today is coming from Mark from TD Cal, and your line is now live.

Thanks for taking my questions. Maybe one quick one clarifying an earlier answer just on the thresholds in MF for meeting Cal-R. Even if maybe the best path forward is combinations, do you need to see convincing monotherapy activity that if that was all you had would have justified moving forward as well in order to move the program forward either as a monotherapy or as a combo? Or is just convincing combo data enough? And then similar to that, maybe Bill, when you were talking through the way to think about prioritizing financial resources, you can't put solid tumor oncology or oncology outside PMONC as maybe the third priority. When you think about the G12D data coming, you guys are not first in class there necessarily. And the next steps are likely some combinations in addition to monotherapy work where this program really starts to blossom. Does it need to be convincing best in class agent in order to justify the investment? Or is it over time competing in various combinations but with a more similar asset enough to justify investment?

Good, Mark. Thanks for the question. I'll turn over the first question to Pablo, and then probably Pablo and I will take the second question together. Go ahead, Pablo.

So let me address the 999. And the short answer, Mark, is we absolutely have to have single agent activity in MF. I think it's an expectation based on the mechanism of action of 999 that it will have single agent activity in patients with myelofibrosis. The question here is, as we build a comprehensive plan to basically cover the needs of every single patient with a myoperiflorene meoplasm, we want to make sure we can address early MF, first line MF, and patients with MF that failed on JAKFI either for intolerance or progression on JAKFI. And to do that, we need a comprehensive data set to show you single agent and combination data with JAKFI. But it's an expectation based on the mechanism of action of 999 that it will have single agent activity in myelofibrosis.

Great. Thanks, Paul. And as it relates to G12D and Pablo will also comment, the first thing I said is we're very clear-eyed about this. There are dozens in development and in the hands of big companies, the hurdle here is high, and we'll be clear-eyed about making a decision. If you're not first, you better be early. And most importantly, the position has to be defensible. And when we get that data, we're going to have to make that decision. We do believe that the properties of G12D could be differentiating, and we believe that it will have a place in the treatment paradigm. And I'll let Pablo talk a little bit about that.

So to complement what Bill said, this is, as you know, Mark, a very competitive space, G12D, and there's some excellent programs advancing in this setting. But we think we have our G12D program, and we look forward to sharing the data so we can discuss this in more detail with data in hand. It's a component that not only might be competitive in terms of single agent activity, but the combinability might be better than some of our competitors. And when you think about the really, really big opportunity here, which is first-line pancreatic cancer, that's going to require more likely than not a combination therapy with intensive chemotherapy. In that context, we think we have a path to compete with some of the other programs. So as Bill said, we may not be first in class, but we're certainly in the front of the pack when it comes to positioning. And if the combinability of our G12D inhibitor is better than some of our competitors, perhaps there is a way to accelerate the development in early lines of therapy in pancreatic cancer. That's the way we're seeing the program. As Bill said in his introductory remarks, we will have a very high bar to continue to advance this program forward once we share all the data and we'll make those decisions later this year.

Thank you. Next question today is coming from Evan Seigerman from BMO Capital Marketer. The true line is now live.

Hi there. This is Connor McKay on for Evan. Thanks for taking our question and congrats on the quarter. This is the second quarter in a row that Nick Timvo has come in ahead of consensus expectations. And you shared a little bit today about kind of the dynamics in the early days of the launch. But I'm curious, maybe can you remind us how you're thinking about sort of the peak opportunity for this product and kind of has the launch trajectory in the early days changed that at all? And then I guess maybe just one quick follow-up for Bill as well. You know, we discussed a little bit about business development and how you're prioritizing that versus the internal pipeline. I guess, are there any therapeutic areas that you'd be most focused on sort of as it relates to business development? Thank you.

Great. I'll take a shot at the first question and then let Muhammad fill in. And then I'll come back to the second question. You know, as it relates to the peak potential of Nick Timvo, it's really hard to figure out what's going to happen in five years. I'm pretty modest about the accuracy of my future predictions, but I will tell you that it's only two quarters. And I've been on both sides of this, positive and negative. I'm reassured by what I see. I think the potential of this product in part is going to trade on, can we get it into combination with Jackify and with steroids? And those studies are ongoing. That's number one. We also have a team working on a sub-q formulation, which I think is very important. And that's going to get you into front line, whether you're a monotherapy or whether you're a combination therapy. Now, we have to take care of the short term and build a real solid business in the indication that we have today. And all estimates are that we're doing that. Things can sort of wobble around quarter to quarter. But since your question was about the long term, my expectations are, you know, when you look at a product like Resarock at Sanofi, you know, that could be the low watermark for us. And I think if you get these additional indications, then you're going to travel north of that.

Mohammed? Yeah, maybe just to quickly compliment there. I think, look, in the first five months we mentioned, we've been able to capture 20 percent of that in-play segment. If by the end of the year we can capture, to Bill's point earlier, a thousand patients, so let's call it 30 percent of that in-play market, we'd be ahead of GVHD analogs and overcome any entry, order of entry discounts. So if you consider those same analogs, then I think it'll be conceivable for just our indication that we have today to deliver several hundred million dollars of annual sales by, you know, working ahead and performing ahead of analogs in the space. And I think we're performing to an extent where we're going to mute, I think, order of entry analogs to a certain extent. And I think you can put projections based on some of those.

Yeah, and as it relates to this second question, you know, if you study companies that have great businesses, there are a couple criteria that are common in terms of new therapeutic areas. And I'll just say up front, we'd never go into a new therapeutic area that would stretch our capabilities, or we would go beyond our competencies, because I do believe right now we're into excellent areas with excellent prospects for growth. But you look, first of all, chronic disease management is, has a lot of sort of attributes to it. You look for a fairly sizable population, unmet need, the potential to have a standard of care approach, and where duration of therapy is measured in years, not months. And there are some logical extensions of our current business in hemonk and immune mediated skin conditions, or I&I. And we'll continue to look at it. But my focus right now is on what we have. And if there's an opportunity to enter another therapeutic area that makes sense strategically, operationally, financially, we'll explain it and do it. But the focus right now is what's inside the company.

Thank you. Our next question today is coming from Srikripat Devarkanda from Truer Security. Your line is now live.

Thank you so much for taking my question. And Bill, let me extend my welcome. Looking forward to working with you. I have a question on Jackify in PV. You know, you've showed continued growth in PV. It continues to be, Jackify continues to be a key growth driver here. Can you talk about the patient population where you're seeing increased uptake? And also, given the footprint you have established here, any thoughts on life cycle management beyond the XR and V617F, which we're going to see data hopefully next year, would be helpful? And also, one follow-up question. Monjuvi was approved for relapsed refractory FL in June. Just any thoughts on expectations there for the remainder of the year? Thank you.

Yeah, thanks for the question. I'll just go ahead and turn it over to Mohammed to address the question on Jackify.

Yeah, maybe let me take a stab on Jackify and Monjuvi, and then Bill, I'll give it back to you for any added remarks. Look, PV is the least penetrated indication for Jackify when compared to the other two indications, thus being our biggest growth driver. Our team is doing a very effective job in educating the market on the importance of treating PV earlier with Jackify and its benefits of thrombosis-free survival. As a result, you continue to see strong double-digit growth in Q2, and we're confident in that momentum going forward. So there, the patient population is simply more than enough to provide a good amount of support to patients on an earlier line therapy that are experiencing symptoms and or need an intervention, and when using Jackify for those patients, they benefit from thrombosis-free survival. If I can just quickly touch on Monjuvi, and then Bill, I'll give it back to you. Look, I think it's important to note Monjuvi showed a 59% risk reduction disease progression or death versus what is currently the standard of care. So we believe naturally Monjuvi has the potential to be the new standard of care for patients living with FL, and we expect the growth ramp, though, here to be reflective of the indolent nature of the disease, and our expectations for the balance of the year are captured in the guidance that Christiana provided for the other HEMON portfolio. With really good execution, Monjuvi and FL alone, excluding any other indication, can be one of those incremental growth drivers and deliver, you know, 200, you know, $1 million or so in annual revenue by 2028.

Yeah, I think Mohamed said it well, very focused on the growth of Jackify over the next several years. Obviously, our penetration in MF is high, and as Mohamed said, in GVHD, I would describe it as medium, and then in PV, it's low, which is why you're seeing double-digit growth with that product right now, or with that indication right now, I think we'll continue to see that, and the MAGIC PV study is only a couple years old, so thanks for the question.

Thank

you. Next question today is coming from Stephen Willey from Steeple. Your line is not live.

Yeah, good morning. Thanks for taking the questions. Just a couple on -8-9. Can you say anything about the characteristics of those, the MF patients enrolled into the phase one with respect to just baseline cytopenias, hemoglobin? Were there any restrictions placed on eligibility criteria, or should we expect that this is going to look like a typical Jack experience patient population? And then just wondering how we should also be thinking about the duration of follow-up we'll have relative to what was just presented in ET. Thanks.

Thanks for the question. Pablo,

take it. So the population is, as you call it, typical of patients that have been exposed to Jackify. There are patients that are intolerant or progressed on Jackify, so it's a pretty representative population in MF. We were not very restrictive in terms of enrollment criteria, so I think it would be very informative in order to discuss next steps for -8-9 in patients with MF. Follow-up is going to be variable. This has been a dose escalation study, as you know, so the early dose cohorts will have longer follow-up than the later higher dose cohorts, but all in all, we'll have patients with pretty substantial follow-up because the studies are enrolling patients at low doses more than a year ago, so we'll have a fair amount of follow

-up. Thanks for the question. Thank you. Next question today is coming from David Lebowitz from City Your Line is Now Live. Hello,

thanks for taking my question, and Bill, welcome to the team. I guess on Jackify in the current quarter, what were the particular drivers, which side of the, you know, which indication drove the therapy the most, and curious as to what IRA and the -of-pocket changes might have had an impact in the quarter, and how we should see that impacting going forward.

Yeah, good question. I'll give you some initial comments, and then Hamid can take over. I think the most important point about the quarter is that there was growth in all three indications, and I think you can, I would view MF and GVHD as, you know, mid-single digit grower, growing indications, and I think this is true over the longer term, and PV as a double-digit growing indication. We saw that last quarter, we saw it again this quarter, and I think given where the product sits in each one of those markets or those indications, that's what the growth profile or the mix is going to look like for the next, you know, three-plus years. And then as relates to the IRA, Mohamed.

Yeah, nothing to add on the growth drivers. On IRA, the simple answer is that it had no impact on our performance in Q2. As you remember, the IRA dynamics had a favorable GTN impact in Q1, but that was a one-time effect as we communicated there, and in Q2, the demand really drove the growth, and that's where you see the performance for Jackify in the quarter.

Thank you. Our next question is coming from Michael Schmidt from Grubenheim. Your line is now

live. Oh, hey, guys. Good morning. I just had another bigger picture question for Bill. So in terms of capital allocation and sort of reading between the lines and prior comments, it sounds like there may be opportunity to perhaps optimize the earlier stage R&D portfolio. So longer term, as you think about potentially increasing R&D productivity for the company, are there specific areas where you think insight is under-invested, you know, be it in terms of targets, modalities, or disease areas within the broader framework of oncology and I&I? And then just a quick one for Pablo on Sydney. Could you just help us understand the importance of the upcoming Phase 2 data in ASTMA in the second half of the year? I know you've noted in the past that the bar is high to advancing this, but yeah, I'm just curious what we should expect there. Thanks so much.

Yeah, Michael, good question. Listen, Pablo and I speak a lot about the first question that you just asked regarding specific areas. Putting external opportunities aside, as soon as I make a comment about an area, the prices of all those companies would go up, but why don't you just talk about how we're thinking about internal R&D and oncology?

So if I understand your question, Michael, it's more specifically related to the early preclinical pipeline and what we've been doing there, a lot of which is honestly not visible because we don't disclose -R&D programs, but we have over the past couple of years increasingly tightened our focus around novel biology and applying novel platforms to novel biology. So our goal over time is to truly focus on trying to be first in class applying novel platforms. And that was the impetus behind the collaboration we established with Genesis to take advantage of the capabilities on AI, machine learning, drug discovery, the collaboration that we put in, we expanded with biotherics to give access to molecular glucose library. And we will continue to do those because we believe, fundamentally, in order to win in the next 10 years, we need to focus on novel areas, novel targets by applying novel platforms. So that's a lot of the emphasis when it comes to the preclinical pipeline.

Thanks for the question.

There was a question on asthma. So this remains a really important potential indication for POVO. We think there's a type of patients, particularly those with non-type 2 asthma, where there remains a need to reduce exacerbations and deliver substantial improvements in FEV1. And I'm talking about over 100 to 150 mls. So we are really excited about having this data later this year. It's been a program that has not received a lot of attention. So we look forward to deliver results before the end of the year. And depending on those results, obviously, discuss next steps.

Thank you, Erf. Our final question today is coming from Gavin Clark-Cartner from Iroquois ISI. Your line is now live.

Hey, guys. Very quick one. For 989, should we expect updated ET data alongside the MS data later this year? Thanks.

Yes, Gavin. There will be an update on ET data as well later this year. Absolutely. We are, as I mentioned in my remarks, we're moving as quickly as we can in ET. We will obtain later this year regulatory feedback with the goal of starting pivotal trials early 2026. So we will provide an update on the ET data that will be sent out to EHA later this year.

Thank you. We've reached the end of our question and answer session. I'd like to turn the floor back over for any further closing comments.

Thank you all for participating in the call today and for your questions. The IR team will be available for the rest of the day for follow-up. Thank you and goodbye.

Thank you. That does conclude today's teleconference and webcast. You may disconnect your line at this time and have a wonderful day. We thank you for your participation today.