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spk09: Good morning and welcome to the OmniAB Inc's First Quarter 2023 Financial Results and Business Update conference call. At this time, all participants are in a listen-only mode. Following the presentation, we will conduct a question and answer session. As a reminder, this conference is being recorded. I would now like to turn the call over to Kurt Gustafson, OmniAB Inc's Chief Financial Officer. Please go ahead.
spk08: Thank you, Operator. and good morning everyone thank you all for joining our first quarter 2023 financial results conference call there are slides to accompany today's remarks and they are available in the investors section of our website at omniab.com before we begin i would like to remind listeners that comments made during this call will include forward-looking statements within the meaning of federal securities laws these forward-looking statements involve risks and uncertainties that could cause actual results to be materially different from any anticipated results. These forward looking statements are qualified by the cautionary statements contained in today's press release and our SEC filing. Importantly, this conference call contains time sensitive information that is accurate only as of the date of this live broadcast today, May 11th, 2023. That is required by law. OmniAd undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call. Joining me on the call today is Matt Foer, President and CEO. During today's call, Matt and I will provide highlights on the company's operations, partner and technology updates, and our recent financial results. At the conclusion of the prepared remarks, we'll open the call to questions. With that, let me turn the call over to Matt Foer.
spk01: Thanks, Kurt. Good morning, everyone, and thanks for joining our first quarter 2023 financial results conference call. Omniab has been an independent publicly traded company for just about six months now. So I'd like to start off this morning by taking a quick moment to welcome our new investors and new analysts who are joining today and to just briefly describe a bit of what we do. OmniApp's business model is focused on licensing our proprietary discovery platform to enable our partners to rapidly discover innovative therapeutics. We generate revenue from upfront payments for access to our technology stack, from collaboration or service revenue when a partner asks us to do work for and with them, from milestone payments related to advancement of clinical phases, regulatory or commercial achievement, and from royalties on net sales of our partner's products. We believe OmniAb has the most diverse host systems for fully human and bispecific antibody discovery with the industry's only four species platform. Our technology stack is driven at its core by the biological intelligence of our engineered transgenic animals paired with our high throughput screening technologies to enable the discovery of high quality, fully human antibody therapeutic candidates for a wide range of diseases. Our robust base of experience coupled with our close collaborations with partners gives us critical insight into the industry, and creates a positive feedback loop to advance and expand our proprietary platform. We strive to keep our technology offerings at the forefront of our industry. And in a few slides, I'll discuss our branded OmniDeep offering, which leverages in silico capabilities, such as structural modeling, artificial intelligence, and machine learning across our technology platforms in order to further enable our partners' work. OmniDeep is the first of our technology launches this year, as we also plan to launch our novel heavy-chain-only chicken in the fourth quarter. Leveraging our highly scalable business model, the number of programs underway by partners continues to grow, and that provides significant validation of the value our technology brings to our partners. And we continue to drive business development efforts. to attract additional partners as we participate in this large and growing market, which is projected to reach about $279 billion in 2025. With our current resources and our dedicated staff of over 100 employees and a proven technology platform, we believe we're positioned for growth to address major unmet medical needs for novel therapeutics. We continue to expand partner relationships, which totaled 70 partners at the end of the first quarter, with the addition of a new license with the Scripps Research Institute related to assets now being developed by Cessation Therapeutics. Subsequent to quarter end, we also signed a new platform license agreement with Neurocrine Biosciences. Our partners represent a wide range of pharma companies, and we continue to attract high-quality partners that are seeking our discovery platform and our team's scientific collaboration services. Approximately 20% of our partners are among the world's top 20 pharmaceutical companies as measured by global revenue. I'll also highlight here that this industry is constantly expanding and consolidating with new companies being formed and companies being acquired, and that dynamic will sometimes impact the number of partners that we report. That's expected to be the case with Cgen and Pfizer, given their previously announced and planned consolidation. I note here, too, that our agreements are generally all structured so that the economics to OmniAB are tied and maintained to the program, even in instances where there are changes in ownership. As I mentioned, our portfolio continues to grow and reached over 300 programs with 27 programs in the clinic or approved for commercialization at the end of Q1. During the quarter, we added a net of 10 new programs to our portfolio. The pie chart on this slide breaks out our 301 programs by stage of development. The discovery phase is large and growing, with a base totaling 260 programs, in addition to 14 programs in the preclinical stage. In the clinic, our partners have 20 programs in phase one, two in phase two, and two in phase three. There are three approved drugs utilizing OmniAb-derived antibodies, and we're recognizing royalty revenue from commercial sales of Zimbarilumab and melamab in China, both of which are also being pursued in other markets. In the first quarter, we had a new program enter the clinic with Segen, who initiated a Phase I clinical trial of SGN-BB228, which is a CD228 and 4,1-BB bispecific molecule that's in clinical development for advanced melanoma and other solid tumors. As I mentioned on our last quarterly call, based on discussions with partners, we see potential for three to five new omniab-derived antibodies to enter the clinic in 2023. We strive to provide utmost flexibility to meet our partners' evolving scientific needs, as we believe generating large and diverse repertoires of high-quality antibodies increases the likelihood of success in optimizing desired therapeutic characteristics. The science behind individual programs drives our partners' use of our different engineered animals, and in many cases, they use more than one source for a program. Partners currently have antibodies in clinical trials that are rat-derived, that are mouse-derived, and are chicken-derived, and we continue to see the versatility of our platform showing in the number of modalities and formats being employed by our partners both preclinically and clinically. Our partners made a number of public announcements about their clinical and commercial progress during the first quarter and in recent weeks. Notably, in January, we received $35 million in milestone payments from Janssen related to Tecvali, which Kurt will discuss. Regarding other progress, I'll start with Batoclumab. Batoclumab is in clinical development by Hanol, by Harbor Biomed, and by ImmunoVan. Harbor Biomed announced positive top-line results from its Phase III clinical trial in China for the treatment of generalized myasthenia gravis. The panel has announced that they're making progress on plans to initiate a Phase III in Japan later this year, also for the treatment of generalized myasthenia gravis. In addition, Immunivan announced that it expects to report initial results from its Phase II clinical trial in Graves' disease in the second half of this year. Immunovant is also running clinical trials in generalized myasthenia gravis, thyroid eye disease, and chronic inflammatory demyelinating polyneuropathy. And for the next generation anti-FCRN IMVT-1402, which was discovered using our OmniRAT technology, Immunovant announced plans to initiate a Phase I clinical trial for autoimmune disease. I want to make one clarifying note regarding the economics for both beta-climaz and the 1402 programs, which is that these molecules were originally discovered by Hanol using OmniRAT, and any payments that we receive will come from Hanol through defined sharing economics that are built into our agreement with them. As I mentioned, CGEN recently initiated a Phase I clinical trial of SGM-BB228, a CD228 and 41BB bispecific molecule in advanced melanoma and other solid tumors. And a comment also here on ASCO. I'll note that based on the titles and presentations that have been disclosed, we expect a number of our partners will present new clinical data for OmniAB-derived programs at the ASCO annual meeting that is taking place coming up here in June. As mentioned in our press release this morning, we'll be launching our OmniDeep platform at next week's PEGS meeting in Boston. Our head of systems engineering, Bob Chen, will be presenting case studies highlighting OmniDeep. OmniDeep is a suite of in silico tools for therapeutic discovery and optimization that have been woven throughout OmniAB's various technologies and capabilities. These tools include structural modeling, molecular dynamic simulations, large proprietary multi-species antibody databases, AI and machine and deep learning sequence models, and additional features. Leveraged with the biological intelligence of our engineered animals and our screening technologies, such as exploration, OmniDeep allows for rapid identification of candidates with the right affinity, specificity, and developability profiles to lead to more effective and efficient drug development. These proprietary capabilities have been part of our internal research efforts for many years, and we've recently expanded them, especially for programs with some of our larger partners. Our extensive capabilities centered around ion channels and transporters also leverage OmniDeep, which we view as a differentiated tool for viable target-to-lead delivery. We have capabilities that are particularly effective for difficult and high-value ion channel targets. capabilities were originally established and built around small molecules and are now being applied to multiple formats and modalities for our partners. Not only do we value the relationships we have with our partners, we also help to create value through their feedback on the discovery process and areas that they find of interest to their pipeline expansion plans. We utilize this input to further enhance and innovate our technology platform to maintain what we see as a leading position within the industry. We have a highly scalable business model, and we're poised to facilitate the development of therapeutic candidates into the clinic by our partners, as well as to continue to do new deals with structures that create value for all stakeholders, and also that expand our portfolio with new partners. And we look forward to keeping you updated as we execute on this strategy. So with that, let me now turn the call back over to Kurt for a discussion of the first quarter financials. Kurt? Thanks, Matt.
spk08: As a reminder, the financial results reported from the prior year period are prepared on a carve-out basis, which were derived from Ligand's historical accounting records as if OmniApp were an independent company. This makes certain comparisons difficult, primarily for operating expenses, given the differences in the methodologies for reporting. Now let's walk through a few of the highlights for the quarter. Total revenue for the first quarter of 2023 was $16.9 million, compared to $9.6 million in the prior year quarter. The revenue increase was primarily due to the recognition of the remaining $10 million milestone payment for the first commercial sale of TechValley in the EU. I mentioned on our last conference call that we received a $35 million payment from Janssen and that $25 million was recognized as revenue in the fourth quarter for the first commercial sale in the US. I also stated that we would likely recognize the remaining $10 million milestone payment later in the year. However, in April, we received information from Janssen that met the criteria for recognizing the EU portion of this milestone revenue in the first quarter. Like last quarter, our service revenue is down slightly as a result of less work being performed for some of our ION channel partners based on stage and status of these exclusively licensed programs. Turning to operating expense, our R&D expense for the first quarter was $13.8 million compared to $10.8 million in the prior year quarter. The increase was primarily due to higher personnel costs and higher costs associated with our new facilities. DNA expense was $8.2 million compared to $4.1 million in the prior year quarter as we staffed up these functions and incurred other costs associated with being a public company. The net loss for the first quarter was $6.1 million, or $0.06 per share, versus a net loss of $6.3 million, or $0.08 per share, in the prior year period. One additional comment about shares used for our earnings per share calculations. The number of shares of $99.2 million for Q1 is based on our basic shares outstanding and should be a good number to be using for the EPS calculations going forward. We ended the first quarter with $113.6 million in cash, cash equivalents, and short-term investments. The increase in the quarter was primarily driven by the receipt of the $35 million milestone payment for Tech Valley. Other than the associated decrease in accounts receivable for the milestone that I just mentioned, there were no significant changes to our balance sheet. The only other change that I'll mention is that we paid approximately $2 million in the first quarter on our CVR obligation, most of which was related to various Omnitour programs that recently started. We continue to expect that our cash balance at the end of 2023 slightly higher than the balance at the end of 2022, and that this balance provides sufficient runway to fund our operations for the foreseeable future. On our fourth quarter earnings call, I indicated that our Q4 2022 R&D expense is a good base off of which we would be growing. Q1 2023 actual results are in line with that expectation, and we continue to expect to see this trend going forward. On the G&A side of things, I previously indicated that our fourth quarter 2022 G&A expenses included approximately $2 million of one-time expenses and indicated that if you pulled out that $2 million, we expected that our G&A expense would grow slightly off this adjusted Q4 figure. As you can see, our Q1 2023 results are consistent with that guidance, and we also expect to see this similar trend going forward. And with that, I'd like to open up the call for questions. Operator?
spk09: Thank you. Ladies and gentlemen, we will now begin the question and answer session. Should you have a question, please press star 1. If you want to withdraw your question, please press star 2. Your questions will be pulled in the order they are received. If you are using a speakerphone, please lift the handset before pressing any keys. One moment, please, for your first question. Your first question comes from Robin Karnauskas from Tourist Securities. Please go ahead.
spk03: Hi, this is Nishant. I'm one for Robin. Thanks for taking our questions, and congrats on all the process. So one question on OmniDeep. I know you still believe that biological intelligence is a better way to produce But just wondering, if you're willing to leverage the OmniDeep platform to kind of create novel antibodies just in silico, is that something like a plan for the future?
spk01: Thanks, Nishant. Yeah, good question. And I'll first talk a little bit about the, quote, branding of OmniDeep, and it's really to the term deep, and Omnideep is really a nod towards deep repertoires, right, that the biological intelligence of our animals produce, to deep screening in terms of our screening capabilities with exploration and other proprietary capabilities, to deep sequencing and ultimately to deep learning as well. And we'd already been leveraging in silico tools and AI in our downstream work. especially on the screening side and in some of the work around ion channels and transporters really for some time. And I'd be remiss if I didn't note that we have some really fantastic in silico experts on our team who are really impressive and important teammates and have been for a long time. We actually announced the deal a couple of summers ago with Landing AI. And talked a bit about it then, and that work expanded considerably over the last 12 or 18 months or so. That work was centered around our exploration screening platform. And kind of as you're generally referencing, there are obviously some public and sporadic examples of concordance of predicted structures with actual crystal structures, right? So this is a you know, a scientific resource that's available to us and really to everyone else in the drug discovery space. But that, I'll say that area of work really is not perfect. There are many, many classes of proteins where it's not so good at all for a variety of reasons. And similarly, designing antibodies based on predicted antibody structure from sequence has a lot of very well-known limitations. And the uncertainties are really compounded in that quite a bit. when using a predicted but not verified antigen structure, which creates almost like a house of cards type scenario, as some have described it, when using only in silico or AI-only approaches. And still, while that sort of approach may bear bits of fruit in specific instances, it will lead only to a subset of all solutions, and it'll never change the fact that an in silico solution or enhancement will need to be tested for expression and binding, both in vitro and eventually in vivo, and will also need to be evaluated for off-target binding to a large number of irrelevant proteins. But the point I really want to highlight here is carefully engineered transgenic animal systems have many of these tests inherently built in as natural checkpoints. So our systems can essentially try and test many different antibody sequence possibilities directed at the actual protein structure rather than just a predicted model. And then it can weed out antibodies that don't express well or that bind promiscuously. And then it can further and refine and edit, if you will, for high affinity. And that's why, you know, kind of a long lead up, but that's why we and our partners see so much power in pairing our biological intelligence of our highly engineered transgenic animals with the Insilico tool. that we brand and call OmniDeep. So those are the sorts of reasons why we're excited about it, and I think our partners are. But really, it remains our core foundation, the biological intelligence, but obviously we're leading into the OmniDeep element as we expand our technology as well.
spk03: Great. Thanks. And in terms of the economics of the use, as you do more deals for difficult targets using your new advanced technologies. Is there variability in terms of economics? Like do you negotiate higher economics for this type of deals versus the others which are like more simpler targets?
spk01: Yeah, you know in general we've obviously got a core commitment as part of our strategy. to continue to innovate around the platform, to really continue to keep it cutting edge, right? And that takes a variety of forms. That's not only workflow enhancement. It's also, you know, continued genetic engineering. As I said, we're going to be launching a heavy chain only chicken in the fourth quarter. And it's really leveraging the positive feedback loop that we have from our partners and really understanding not only where they are today, but where they are headed. Generally, when it comes to deal structures, maybe I'll let Kurt comment a little bit on kind of the elements of economics of our deals. But it's really an interchange of kind of the work that we're doing, the technology that partners are leveraging. And then that kind of is reflected in the structure of a deal. But, Kurt, maybe you want to comment there. Yeah.
spk08: I mean, for the most part, the economics of all of our partnership deals are established and set at the time that we sign those deals. So they're sort of fixed in nature in terms of what milestones and royalties will be. That being said, to the extent that we're performing additional work, we, or partners, we would earn additional service revenue for those types of things.
spk03: Just the last one. I mean, I know you provide guidance for a number of new clinical molecules that will enter clinic in this year. Just wondering, I mean, you're seeing a nice consistent trend of around like 10 new project starts every quarter. Do you plan to provide guidance for new project starts for the year?
spk08: In terms of guidance for, you know, the only guidance we're providing is really just sort of this guidance on the number of clinical starts. And the reason for that is it's sort of a number where we do have some visibility in terms of discussions and insight from partners. As it relates to kind of program starts, it's a really difficult thing for us to project, given the way partners start new programs. So I would doubt that we would ever provide guidance on that number. But, you know, to the extent where we do have visibility, like I said, on kind of clinical starts, that's where we've tried to provide a little bit more guidance here.
spk03: Great. Thank you. Thanks for taking your question.
spk08: Sure.
spk09: Thank you. Your next question comes from Stephen Wiley from CFO. Please go ahead.
spk02: Yeah, good morning. Thanks for taking the questions. Maybe just a follow-up on... On the OmniDeep, is that technology that a partner with just a broader platform license would have access to, or is that technology that a partner who comes to you looking for a full end-to-end solution would benefit from, given the way that it's kind of woven into the tech stack?
spk01: Yeah, thanks, Steve. This is Matt. Yeah, it really is woven throughout our tech stack, right? And there are elements of this that we're now branding as OmniDeep that we've been leveraging for years. And so it's been an important part of it. We've expanded it over the last 12 to 18 months. And we are employing these techniques for partners, especially some of our larger partners, To answer your question, it's part of the benefit, if you will, that partners get when they partner with us. They know they're coming to us. They get cutting-edge technology. They get continued innovation and a commitment to continued investment around the platform. I think that's what drives our partners' use of the platform. That's one of the reasons I think they're excited. about the things that we do and why our science team is excited about as well. So hopefully that gives you a little perspective there.
spk02: Okay. And then you talked about launching the heavy chain chicken species in I think the fourth quarter of this year. I guess how do you think about what the demand for that will look like? Right. And I guess I asked the question, I know that you guys launched on the tour, I think back in 2020. And I think kind of per one of the slides you have on the deck, I think 2% of demand looks to be centered around that technology. Would you expect the heavy chain chicken to, uh, to, uh,
spk01: to improve upon i guess kind of that two percent omni tour demand metric yeah thanks steve i you know i'll say for omni tour uh we actually are seeing an increase in in starts there and that percentage is going up uh obviously when you have over 300 programs uh it can be you know the percentages are going to shift around uh the edges but omni tour is an area of of growing and increased interest and we have had new new starts there On the heavy chain antibody side, that's an area of growing interest in the industry. Domain antibodies, heavy chain antibodies, nanobodies, picobodies, that sort of thing. So we do see a demand there. In fact, we do have partners who are already inquiring and lining up for use and access to the heavy chain chicken when it becomes available in December. We'll probably talk more about where we see it fitting in to the overall landscape at the time we launch it, but hopefully that gives you a little bit of color.
spk02: Okay. And then maybe just lastly, you can kind of speak to the average royalty rate on the royalty bearing assets across the portfolio right now. where you think that metric can kind of realistically expand to over the next three to five years? And then maybe, you know, what are the key levers that allow for that expansion to occur? Thanks.
spk08: Yeah, Steve, so I guess the way that I would sort of frame that question is there are two products that are approved right now where we're receiving royalty, and that is a flat 3% royalty. In terms of royalty rates that you know, for the entire portfolio, we haven't given a specific number, but it's generally in the low to mid single digits. And I would expect, based on kind of as we get out into the future, that that 3% number would go up based on sort of deals that we've signed. That being said, it's going to be a function of sort of what individual deals are that kind of move forward. But in general, I would expect that number Operator, can we go to the next question?
spk09: Your next question comes from from HC Wainwright. Please go ahead.
spk05: Hey, guys. Good morning. Thanks. So I guess I'm going to approach OmniDeep from a marketing standpoint. So whether you get inbounds or whether you're out there marketing your overall platform, how would you say OmniDeep differentiates from other in silico approaches?
spk01: Yeah, thanks, Joe. Really, it starts at our core, I'll say, which is our foundation of biological intelligence and the deep repertoires, the proprietary multi-species antibody databases that we possess that have been built up by doing many, many, many programs over many, many years, and then pairing that with cutting-edge technology. As I said, this is an area that's been woven into throughout our tech stack in pieces for years. But we've leaned into it more over the last 12, 18 months, really leveraged some of the expertise that we've had internally that had been built up over time in some of the organizations that were acquired that formed the foundation of OmniAB. But really what differentiates it is pairing some of these tools and capabilities with our transgenic animal systems and the biological intelligence and capabilities. Again, the term deep is a nod to deep repertoires, the deep screening capabilities that we have, deep sequencing, as well as deep learning elements that we've invested in. And as we launch this next week at PEGS, as I said, Bob Chen, who heads our systems engineering, will be presenting at the PEGS meeting in Boston, also with some case studies around targets where this sort of work has really been able to be highlighted, things like NKP46 and other areas where I think partners will realize, and some partners are already benefiting from these capabilities, kind of the power that this creates within our business model.
spk05: No, that's helpful. Thank you. And then I guess two little questions, housekeeping and expenses for both of you, I guess. Are there any changes the terms or everything sort of status quo with the Seastone announcement? And number two, with regard to OmniDeep or, for example, any key infrastructure investments that need to come from that at this point?
spk01: Yeah, I can comment on Seastone. Yeah, Joe, you're referring to Seastone announced earlier in the week they regained development commercialization rights to Sugamelimab outside of greater China. And yeah, no change at all to uh, to the economics, uh, to us, um, that, you know, obviously assets do change hands from time to time. We've seen that, uh, at times and, uh, there's no change there. Maybe I'll let Kurt, uh, comment on, on expenses.
spk08: Yeah, no, no, no additional, uh, expenses, you know, related to OmniDeep or any of these other programs relative to, you know, we're, we're still sticking with the guidance that we have. So no, no major change to that. Fantastic.
spk05: Thanks for the call guys. Yeah. Thanks, Joe.
spk09: Thank you. Your next question comes from Punit Soda from SVB Securities. Please go ahead.
spk04: Yeah, hi, Matt, Kurt. Thanks for taking the question. So first one on, you know, maybe a broader one, just given what we're hearing in the marketplace and in terms of, you know, small biotechs, emerging biotechs, funding constraints. what are you seeing within the business development pipeline? Maybe can you give us a high-level view there? And then also, you know, within the 260 discovery programs that you have, are you hearing anything in terms of cancellations or, you know, potential for that, you know, sort of in the next two quarters?
spk01: Yeah, thanks, Punit. So, first, I'll just comment on your last question. All the numbers we report are net of attrition, right? So whenever we report our numbers, they're net of attrition. And of course, you do see attrition at any time. That's a natural part of the pharmaceutical business, of course. But your question on the macro environment, obviously, we are students of the industry as well and have been for some time. And we do have, I'll say, a really interesting vantage point on the industry, given our 70 different partners, over 300 programs. But in answering your question, I think I'll first point historically and note that we've been able to grow our number of partners and number of active programs on an annual basis through a variety of macro funding cycles in the industry in those times when raising capital for smaller partners was relatively easy or in times like now where it's viewed as more complex. And I'll speak for our business more specifically and say that the diversity of our partner base with a mix of global big pharmas, with biotechs, with startups who have interesting biology, but that diversity brings a lot of power to the business and I think positions us well to create long-term value for our stakeholders as cycles come and go. Our deeper relationships with partners also informs our innovation. That obviously creates what we call the positive feedback loop and really, I'll say, informs our conviction around continued innovations for our platform. And also, I'll say, I say this to our team a lot internally as well, that when you see cycles in the broader landscape generally, that these are the times when true innovation and true differentiation, but innovation wins, if you will. And partners come to us to help them discover new drugs, to get scientific solutions. That's why they come to us, is for that innovation. So, you know, could some of the things that are seen in the macro landscape, if sustained, influence some of our metrics at some point? Sure, I think it would be odd to say that it absolutely could not, but that said, We do think that our innovation will win out, and we really like how we are positioned because of that. Our business development team remains extremely busy. The vast majority of our deal dialogue and deals have come from inbound interest or scientist migration. That continues to be true. And we are leaning into, I'll say, more conferences. We used to do about a half a dozen or so conferences a year. We're increasing that by about 3x over the next 12 months. So that's hopefully a little bit of color there for you.
spk04: Yeah, no, that's great. On the business model, the way you're offering is, can you talk to us a little bit on sort of how cost effective it is versus the traditional model where the work is being done under sort of one roof and some of your competitors. Can you talk about what sort of leverage you have if the market was to get tougher? How can that offering resonate potentially more with your customers? Thank you.
spk08: Yeah, it's a great question, Puneet. our business is highly scalable in terms of the way we've structured it. So, you know, the deals that we have, you know, when partners come to us, depending on the type of species they use, and we'll use OmniRat as an example, in that case, in many cases, we do very little work for the partner. We ship them the rats. They have the capabilities to, you know, do the inoculations, do the screening themselves, and we really just kind of get quarterly reports on, on the work that they've done. In terms of OmniRAT, that business is almost theoretically infinitely scalable without us adding additional costs. When it comes to OmniChicken, we actually have to go do some of that work ourselves on the front end because we're the only ones that house the chickens. But we sort of pride ourselves in having this flexibility or flexible business model where partners can come pay us to go do all of the work, right? So we can do screening and optimization for them and we'll earn extra service revenue for that. But to the extent that the partner has those capabilities and wants to do that work themselves, that's fine too. And they take over the work and do that. So our business model tends to be much more scalable than others, just in terms of the way that we operate with our partners and the fact that in many, many cases, our partners are doing the majority of the work themselves.
spk04: Got it. Okay, great. Thanks, guys.
spk08: Thanks, Vinit.
spk09: Thank you. Your next question comes from Steven Ma from TV. Please go ahead.
spk07: Great. Thanks for the questions, and congrats on the quarter.
spk00: Thanks.
spk07: Maybe just to follow up on Puneet's question on when you're doing a transgenic animal license, it seems like to me maybe you can confirm on the Scripps licensing deal, that's an OmniRAT license where Scripps is maintaining the colony and doing the work for themselves. Is that right?
spk01: Yeah. deeper specifics around, I'll say, the workflows for certain partners on a specific basis. Maybe I'll just describe it generally. One of the things we have started to focus on over the last year or so is continuing to advance partnerships with leading academic institutions. And Scripps is an example of that. We've got a great network of academics, not only through kind of the history that we've built up of genetic engineering first, but also through our board and others and Scripps is an example of an organization that has a history of innovation and interesting biology. So they want access or take an access to our animals and then from there one of the benefits of these sorts of deals, and we've done these with other academic institutions as well, is that these are ones that also have a history of licensing and or seeding and spinning out innovative companies. And in this instance with the Scripps Institute, the assets that came out of our technology there are now in development at Cessation Therapeutics. Cessation's developing novel immunobiologics to prevent fentanyl overdose and to treat fentanyl addiction using really what is a completely new approach. It's really by sequestering fentanyl before it's able to enter the brain to offer more durable protection for overdose. So kind of an interesting new area of science, but this is an instance where it's a partnership through through a leading academic center who had some interesting novel biology that now then led to assets being moved forward at a company.
spk07: Okay, yeah, I appreciate the color. And if possible, can you give us a sense for the economic structures of like a transgenic animal licensing deal where I mentioned where they maintain the colony themselves and do the work themselves versus... like a full platform deal like the one you signed with Neurocrime in the second quarter?
spk08: Yeah. In terms of the way the deals are structured, the partnership economics are all built the same, right? So we don't, to the up front, we don't sort of say, hey, if we're going to do a lot of work for you, then that's going to come at a higher royalty rate or higher royalty rate. The idea is that the economics in terms of the upfront and milestone payments and royalties, they're really established upfront. And they're independent of whether or not we tend to do or whether we're going to do a lot of work for the partner on a program or not. Because in some cases, you'll have a partner where they might be set up to do an OmniRAT program where they do all of that work themselves. And then the next program they decide to go do is with Omni Chicken, whereas we're maybe doing a big chunk of that work. The economics in terms of milestones and royalties will be the same, although in the case of the Omni Chicken program, that's where we would earn additional service revenue as we do work. So the basic structure of the deal is sort of the same for all programs that a partner would go do. The difference would be, to the extent that we're doing additional work, is the additional collaboration revenue that we would earn.
spk07: Okay. That's a really helpful color. And last one for me on OmniDeep. Is this something that can be monetized as like a software as a service to others or to, for example, partners that are just doing the transgenic animal license route?
spk01: I think the answer to that is yes. Elements of it potentially could, but you could say that about a lot of elements of our technology stack. We've got proprietary pieces of our technology that one could use the portable word around from a number of perspectives, but generally that's not been how we do it. We have built up a technology offering of a variety of proprietary tools, of which this contains a number as well. But our view would be, no, this would be for partners who sign licenses with us, and we leverage it for them to facilitate their programs moving forward more quickly and efficiently.
spk07: Okay, got it. Perfect. Thanks for the questions.
spk08: Yep. Thanks, Steve.
spk09: Thank you. Ladies and gentlemen, as a reminder, should you have a question, please press star one. Your next question comes from Matt Hewitt from Keck Hallam Capital Group. Please go ahead.
spk06: Good morning. Thank you for taking the questions. And I apologize if I ask one that was already asked. I'm kind of bouncing around between calls. But first up, thank you for providing the update on the number of active programs. Some nice growth there despite some of the questions about funding and whatnot. I'm curious, what is the number of partners that you currently have? Do you have that number that you can break out?
spk01: Yeah, Matt, we're reporting at the end of Q1 70 partners who are leveraging OmniAb technologies and assets.
spk06: That's great. Thank you. And then, you know, congratulations on the pending launch of OmniDeep. But I'm curious, given your strong cash balance and the current environment that is putting some pressure on some smaller companies, would you contemplate or is M&A something that you would consider to kind of add to your tool set? Or is your preference to continue to build those out internally? Thank you.
spk01: Yeah, Matt, thanks. Great question. And obviously, we built what became the foundation of OmniAB through doing six acquisitions in less than six years of technologies that fit very well with one another, that are complementary to one another. I'm proud of the fact that we've kept many of the founders of those companies on board as key members of our science team. And so M&A really is something that is in our DNA, those six acquisitions. all of which have brought us elements of our technology stack that have been important. We're always cautious never to promise deals, right? But we've been quite successful, I think, in tacking on technologies and teams out of the private sector. So these are private companies who have technologies that are validated or in the early stages of validation. So, like I said, we're always cautious never to promise deals, but I certainly wouldn't rule it out. That is something we do think about and are thinking about and are always assessing. That said, we are also excited about our internal investments in technology, like OmniDeep, like the heavy chain-only chicken that will launch in Q4. That investment in our technology is built into our plan, right? It's something we'll continue to do, and we can keep leveraging that. that positive feedback loop that we have from deeper relationships with partners that really inform our conviction around innovation. So a long way to say, yeah, we certainly are always looking at interesting things to bolt on, whether those come out of companies, whether they come out of universities or other academic areas where we think we could add on new technologies or capabilities that will drive growth in partnerships and programs. So hopefully that answers your question.
spk06: Absolutely. Great. Thank you very much.
spk01: Thank you.
spk06: Thank you.
spk09: There are no further questions at this time. You may proceed.
spk01: Great. Thank you, operator. I'd like to thank everyone for participating on this morning's call and for your questions and engagement. We look forward to keeping you updated. on our progress and speaking with you next quarter. I just want to mention also that we'll be out on the road meeting with investors in addition to attending the E.F. Hutton Conference today here in New York. We'll also be attending the B. Reilly Conference in the L.A. area, the Benchmark Virtual Conference, as well as the Craig Hallam Capital Conference that's coming up in Minneapolis. So thanks again all and have a great day.
spk09: Ladies and gentlemen, this concludes your conference call for today. We thank you for participating and ask that you please disconnect your lines.
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