OmniAb, Inc.

results. These forward-looking statements are qualified by the cautionary statements contained in today's press release and our SEC filings. Importantly, this conference call contains time-sensitive information that is accurate only as of the date of this live broadcast today, August 6, 2025. Except as required by law, OMNIEV undertakes no obligation to revise or update any forward-looking statements to reflect events or circumstances after the date of this call. Joining me on the call today is Matt Foer, OmniApp's President and CEO. And during today's call, we'll provide highlights on the company's business and operations, partner and technology updates, as well as our recent financial results and outlook. And at the conclusion of the prepared remarks, we'll open the call to questions. And with that, let me turn the call over to Matt.

Thanks, Kurt. Good afternoon, everyone, and thanks for joining us today on our Q2 call. I'll start now with slide number four. As I mentioned on our last call, we started the year with strong deal flow, and it continued in the second quarter with a number of new partners added in the first half of the year, setting a pace for one of our strongest years yet. We continue to see a robust pace and quality of deals, and we think this is a testament to our differentiated technology platform, which continues to evolve and expand, and to our team's relentless pursuit of innovation that leverages our unique vantage point in the industry. Our partners are actively advancing programs into human trials with the start of a new clinical stage program during the second quarter and several others that are progressing through development. And on the third highlight here on slide four, the recent launch of our Exploration Partner Access program has been very well received. with a strong response from existing partners and others. Within weeks of launch, we sold and installed an exploration system, and we are managing a robust pipeline of leads and business activity for this new technology that's expected to be accretive to the business and to further diversify our sources of revenue. Our platform is attracting new partners and facilitating the addition of new programs. We continue to drive efficiencies in our business through leveraging our technologies, including exploration, and through the streamlining of our business practices, all with the goal of creating long-term and sustainable value for our stakeholders. We've been realigning our staffing needs and recently reduced some costs in our headcount. This is in addition to the staffing realignment we disclosed back in February related specifically to the small molecule ion channel element of our business. We began 2025 with 114 employees, and our go-forward headcount is at 87 employees. And Kurt will provide some financial details in his remarks. So in summary here, our outlook for 2025 remains very much on track. And we feel we're extremely well positioned to deliver on our strategic goals, to expand the reach of our technologies, and to execute on our current exploration launch and the upcoming new technology launches that we're also very excited about. Additionally, we're constantly seeking further workflow efficiencies and technology innovations in what we see as a highly scalable business. So now I'll review some of our business metrics starting here on slide number five. We ended Q2 with 100 active partners. During the second quarter, we signed an asset deal with Angelini Pharma for a small molecule ion channel modulator that targets KB 7.2, which we discussed on our last call. In addition, we executed multiple license agreements, including new deals with Varaxa Biotech, Duke NUS, the University of Strathclyde, the University of Maryland, A.B. Ray Bio, and an undisclosed global CRO. As you see on the slide, we're also providing some updated detail on the distribution of our active partners by type, including discovery, commercial, and academic, as well as the distribution of our partners on a geographic basis. Although our partners are mostly based here in the U.S., there's been a steady diversification of our partner base as we've been successfully increasing the reach of our platform. Turning to slide six, you can see the number of active programs increased to 381 as of quarter end. We've continued to experience positive momentum with a year-to-date net increase of 18 programs. And we're continuing to see the strength in program additions that started late last year. Attrition is obviously a natural and expected element in drug discovery and development generally, and we do continue to see and expect to see attrition, which can be driven by a variety of factors, including partner therapy area focusing and budget decisions and timing of receipt of reports or updates from our partners. That said, the net addition of 18 programs year to date shows some significant strength and is more than double the number of net additions through the first half of 2024. Slide number seven breaks down our 381 active programs by their license type and summarizes elements of overall contracted downstream economics. Importantly, about 99% of our active programs have potential future economics contractually owed to AMYA. The 1% that don't are generally linked to legacy agreements with prepaid licenses that were signed years ago by companies that we acquired. 90% of the programs are linked to what we generally refer to as antibody standard licenses, and 7% are through what we call revenue share license agreements, where we get a defined portion of whatever form of value our discovery partners get, be that equity, cash, or other forms of value. These revenue share deals are mostly with academic institutions that incubate OMNIAB-derived assets prior to planned corporate formation events. Our antibody programs have over $3 billion in total remaining contracted potential milestone payments and an average royalty rate of 3.36%. This 3.36% average is an increase from an average royalty rate of 3.2% that we reported in November of 2023. I think the ability to command strong royalties reflects the value of our technologies and their relevance to the industry. It also speaks to the value our team is creating for our partners and for our stakeholders. Here now on slide eight, we're putting a bit of a spotlight on the continued growth of the post-discovery stage programs in our portfolio, as well as the advancement of these programs into and through development. During the quarter, a number of new programs progressed to the preclinical stage of development, and another one is recruiting for a Phase III clinical trial, which is Immunovans IMVT-1402 for myasthenia gravis. We're really encouraged by the expanding number of post-discovery stage programs, which have experienced 22% growth from the prior year period. The preclinical programs also have nice diversity of indications and include inflammation, fibrosis, renal dermatology, CNS diseases, and others, in addition to the historical strong showing in oncology. Importantly, these 61 programs that are post-discovery stage are associated with approximately $1.3 billion in contracted remaining potential milestones to OMIAD. The total potential milestones associated with the later stage programs have continued to increase, and that increase has been fairly dramatic in the last 8 to 12 months. And you can see here the contribution of $700 million from small molecule ion channel programs that have now moved into preclinical. We think the growth here demonstrates potential value-creating events in the pipeline, the progress in the pipeline overall, as well as our partners' conviction around assets that have been discovered with our technologies. Moving now to slide nine, the number of active clinical programs and approved products was 32 at the end of Q2. A new omni-chicken-derived program entered the clinic in the quarter from Seismic Therapeutics. This marks the third omni-chicken-derived antibody to enter human clinical trials, following programs with Beringer-Ingelheim and Teva. Through Q2, we've had two novel programs initiate first in human clinical trials in 2025. We've seen attrition or stage of development modification in phase one assets with a CN1 program returned from Curon to Wuji that Wuji now characterizes as preclinical and a GenMAP program that entered an initial phase one trial in Q1 and then exited that trial in Q2 As I've said, and as we often say, attrition is a natural part of drug development. Based on dialogue with our partners, we continue to see potential for a total of approximately five to seven new entries into clinical development for novel omniab-derived programs this year. Slide number 10 illustrates our clinical and commercial stage partner pipeline for active programs that carry remaining downstream economics. As you see, this pipeline flows from phase one through to later stages and product approvals from left to right. Placement in this graphic is based on a program's most advanced status in any geography or indication. In the last couple of quarters, it's been great to see the growing number of programs moving to the right on this graphic, the latest of which now includes the recent addition of Immunovance IMVT-1402 shown in Phase 3, as I mentioned. Turning to slide 11, we've highlighted select recent partner updates, including presentations at ASCO from J&J and Merck KGA. The disclosed J&J data for their tri-specific 5322 program is especially notable to us with the 100% response rate that was observed in heavily pretreated multiple myeloma patients. The initial data were described as suggesting a potential paradigm shift for the treatment of these patients. So there's a real opportunity with this program to significantly elevate the standard of care for multiple myeloma. J&J indicated publicly that they look forward to seeing the results from planned Phase II and Phase III studies for the 5322 program. And on their most recent earnings call, they highlighted these data again while saying they are now, quote, closer than ever to their ambition of curing multiple myeloma, unquote. Other highlights shown here include TEVA receiving fast-track designation for TEV408 for the treatment of celiac disease. And I want to note that this program is also in clinical development for vitiligo. TEVA additionally announced a partnership with Fosun for TEV278, which is a partnership established with the goal of accelerating clinical development of the compound that's in clinical trials now for the treatment of various forms of cancer, including melanoma. Now, to conclude my section, here on slide number 12, We've highlighted our recently launched exploration partner access program. Exploration is a high throughput single B cell screening instrument that leverages machine learning and AI. It offers 10 times more single cell screening throughput versus other instruments, which allows users to screen in a far more efficient fashion. We believe this system has unmatched screening throughput and superior hit recovery, along with exceptional ease of use and reliability. We highlighted Exploration in a presentation at the Boston PEGS Conference in May, where the system was awarded Best of Show honors. Just weeks after launching, we sold and installed Exploration at a global partner, creating a new revenue stream derived from the sale of the instrument, as well as recurring revenue from proprietary single-use consumables and subscription services for software with maintenance. It's still early in the launch, but the response from the market has been extremely positive. And we're building a pipeline of sales leads from our growing roster of partners based on new availability of the platform. And we're also getting inquiries from others who are interested in becoming OmniAd discovery partners specifically to get access to exploration. With exploration, we're able to further empower partners with the latest technologies to improve their probability of success in a really efficient and scalable manner. And that's part of why we see exploration as a nice complement to our current core business, as it supports our mission of enabling the rapid development of innovative therapeutics. The feedback we are getting indicates to us that this is the right time for exploration. as the industry embraces the value of lab automation and instrumentation for big data generation to also leverage AI and ML-aided screening and selection. We're very excited about the prospects of this new offering as it continues to demonstrate our commitment to innovation and to customer service while diversifying our revenue streams. And with that, let me now turn the call back over to Kurt for a discussion of our Q2 financial results. Kurt?

Thanks, Matt. On slide 14, I'll start with a review of our revenue. For the second quarter of 2025, we reported revenue of $3.9 million compared with $7.6 million for the same period in 2024. The decrease was primarily related to lower milestones achieved in the quarter and lower service revenue. service revenue declined primarily due to the discontinuation of a small molecule ion channel program last year, which also resulted in the acceleration of non-cash revenue in that quarter, which overinflated last year's number. The decrease was partially offset by the new exploration revenue this quarter, and this revenue primarily includes the sale of an instrument as well as the sale of various consumables related to the exploration platform. Slide 15 shows our costs and operating expenses for the second quarter of 2025, which decreased to $20.1 million from $23.9 million for the prior year period. We saw decreases in both R&D and G&A expenses relative to last year. And I'll go into some of those details here on the next slide. So turning to slide 16 and focusing on operating expense, You'll see a new line item for the cost associated with the exploration revenue, which were approximately $300,000 this quarter. This represents the cost associated with the manufacturing of the exploration instrument, as well as the related consumables sold in the quarter. Research and development expense was $10.9 million versus $13.9 million a year ago, with the decrease primarily due to lower stock-based compensation, lower headcount, as well as lower external expenses associated with small molecule ion channel programs. GNA expense declined to $7.7 million from $8 million for the same period in 2024, with a decrease primarily due to lower legal fees and lower stock-based compensation expense. The other operating income line includes a gain of $3 million for the sale of the KB7 asset to Angelini. which was partially offset by an increase to our CBR liability associated with this sale. The net loss for the second quarter of 2025 was $15.9 million, or 15 cents per share, which compared with the net loss of $13.6 million, or 13 cents a share, for the same period, 2024. As Matt mentioned, we had a further reduction to our headcount in July. This reduction is expected to have one-time expenses of about $1 million that will occur primarily in the third quarter. We expect that the combination of the actions that we took last February and this one here in July will result in approximately $7 million of annual cash savings going forward. Turning to slide 17, you'll see the balance sheet as of June 30th, 2025. We ended the quarter with $41.6 million in cash And our cash use in the quarter was $2 million. During the quarter, we received milestone payments for GENMABS 1078 and ACASENLMAB, as well as the upfront payment from Angelini related to the sale of the KD7 asset. So let me conclude with slide 18 with a discussion of our 2025 guidance. We continue to expect that 2025 revenue will be between $20 and $25 million, and operating expense will be between $85 and $90 million. As a reminder, approximately 40% of our operating expense is non-cash, mostly due to stock-based compensation and the amortization of intangibles, primarily from historical company or technology acquisitions. We also continue to expect that our cash use in 2025 will be lower than cash used in 2024. And finally, our guidance on the tax rate remains unchanged at approximately 0% due to evaluation allowance. And with that, I'd like to open up the call for questions. Operator.