Praxis Precision Medicines, Inc.

Good day and thank you for standing by. Welcome to the Praxis Precision Medicines 4Q and FY 2021 Corporate Update Q&A call. At this time, all participants are in a listen-only mode. After the speaker's brief presentation, there will be a question and answer session. To ask a question during a session, you will need to press star 1 on your telephone. If you require any further assistance, please press star 0. I would now like to hand the conference over to Spriggy today Alex Kane, Vice President of Investor Relations and Corporate Communications, for a very brief presentation. Please go ahead.

Thank you. Good morning, everybody, and thank you for joining us today for our fourth quarter and fiscal year 2021 Corporate Update Q&A call. With me on the call is our President and CEO, Marcio Souza, our Chief Medical Officer, Bernard Ravino, and our Chief Financial Officer, Tim Kelly. Following the press release and video update issued earlier this morning, we will focus today's call on your questions to provide additional perspective on the updates provided earlier. We ask that you keep to one question initially, and then please feel free to rejoin the queue for follow-up questions as needed. Before we proceed, I would like to remind you that during today's call, we may make certain statements that are beliefs forward-looking and subject to various risks and uncertainties. For additional detail on forward-looking statements and the risks associated with our business, I encourage you to consult our FCC filings and in particular, our 10K file today. With that, I will now pass the call over to the operator to open up the line for Q&A. Operator?

Thank you. And as a reminder, to ask a question, you need to press star 1 on your telephone. And our first question will come from the line of Yasmin Rahim from Piper Sandler. You may begin.