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spk05: The conference will begin shortly. To raise your hand during Q&A, you can dial star 1 1.
spk02: Ladies and gentlemen, thank you for standing by. Welcome to Quantum's SI Third Quarter 2022 Earnings Call. At this time, all participants are in a listen-only mode. After the speaker's presentation, there will be a question and answer session. To ask a question, you will need to press star 1 1 on your telephone. You will then hear an automated message advising your hand is raised. Please be advised today's conference is being recorded. I would now like to turn the conference to Juan Avendano, Head of Investor Relations for QuantumSI. Juan, please go ahead.
spk01: Good evening, everyone. Thank you for joining us. Today, after market close, QuantumSI released financial results for the third quarter ending September 30th, 2022. A copy of the press release is available on the company's website. Joining me today are Dr. Jonathan Rothberg, Founder and Chairman of the Board Jeff Hawkins, our newly appointed Chief Executive Officer, Patrick Schneider, President and Chief Operating Officer, and Claudia Creighton, Chief Financial Officer. Before we begin, I'd like to remind you that management will be making certain forward-looking statements within the meaning of federal securities laws. These statements involve material risks and uncertainties that could cause actual results or events to materially differ from those anticipated. Additional information regarding these risks and uncertainties appears in the section entitled forward-looking statements of our press release. For a more complete list and description of risk factors, please see the company's filings made with the Securities and Exchange Commission. This conference call contains time-sensitive information that is accurate only as of the live broadcast today, November 7, 2022. Except, as required by law, the company claims any intention or obligation to update or revise any forward-looking statements. During this call, we will also be referring to certain financial measures that are not prepared in accordance to U.S. generally accepted accounting principles or GAAP, including a gesta repita, a reconciliation of non-GAAP financial measures to the most directly comparable GAAP financial measures as included in the press release filed earlier today. With that, I will turn the call over to Dr. Jonathan Rothberg.
spk05: As a testament to the promise of our pioneering work, QuantumSI's next-generation single molecule protein sequencing technology was recently published in Science. This is the first paper from any company demonstrating next-generation protein sequencing published in a major peer-reviewed journal. The paper demonstrates the use of QuantumSI's proprietary time domain sequencing method to enable digital, massively parallel protein sequencing at amino acid resolution on a semiconductor chip. By decoding the linear sequence of amino acids and post-translational modifications that make up a protein and determine its function, QuantumSI's next generation protein sequencing technology will unlock a new understanding of health and disease. I was lucky enough to work with a team that brought the world the first next-generation DNA sequencing technology. Earlier this year, I was pleased to see one of my first next-gen collaborators, Svante Paavo, win a Nobel Prize for his work with next-generation DNA sequencing. In a similar manner, I am confident that early adopters of QuantumSI's next generation protein sequencing will make equally transformative advances in the life sciences. While I had a productive eight months at the helm of the company as interim CEO, I am very excited to pass the baton to Jeff Hawkins, our new CEO. Jeff is a proven business leader with 20 years of experience at some of the world's leading life science and diagnostic companies, including Illumina. His experience in scaling up next-generation DNA sequencing and opening up key markets will be a key factor enabling QuantumSI's success. I want to express my sincere gratitude to the team and all who continue to support and invest in QuantumSI. Remaining focused on execution and under Jeff's leadership, I am confident that we can own the fork in history we create. I'll now turn the call over to Jeff to provide a business update.
spk06: Thank you, Jonathan. Good afternoon, everyone, and thank you for joining us. In today's call, we will provide a business update and present our third quarter financial performance and outlook for 2022. We will then open the line for questions. QuantumSI's mission is to transform life science research and proteomics by becoming the first company to launch next generation protein sequencing. I am pleased to join QuantumSI, an innovative company with deep technical expertise and a disruptive technology on its quest to transform and democratize the field of proteomics. Having spent over 20 years in life sciences and diagnostics, I am keenly aware of the potential for proteomics tools to transform a wide range of markets from research to drug discovery to diagnostics. To fully execute on this transformation, novel technologies like QuantumSI's next-generation protein sequencing are needed. As I assessed the opportunity to join QuantumSI, I was excited about two key aspects of the company's approach. First, a benchtop system that leverages a standard laboratory workflow and includes customer-friendly analysis software will enable more researchers to have the technology in their labs. Enabling a larger number of researchers with a new technology like next-generation protein sequencing will be critical to accelerating the pace of proteomics research globally. Second, the ability to sequence not only amino acids but also post-translational modifications and proteoforms will provide a far richer set of data than existing technologies. This expanded set of data has the potential to significantly improve the research community's ability to study protein function, regulatory mechanisms, and other complex protein interactions. The potential to change the way drug discovery is performed or develop new biomarker tests that better predict response to therapy or diagnose disease could truly transform the future of healthcare. I'm about one month into my role here at QuantumSI. I'm continually impressed by the caliber of people at the company and their sincere commitment to our success. Personally, I'm passionate about new technologies and enjoy the challenges of building companies and creating new markets. With an amazing technical team already in place here at Quantum SI, I can focus more of my time on building out the commercial organization and setting the market development strategy for our next generation protein sequencing technology. Given my experience in next generation DNA sequencing and the reality that next generation protein sequencing could have a similar or even larger impact on both research and clinical markets, We must get this right. Next, I would like to turn to the business and update you on our progress over the past quarter. In October, we published the first next-generation protein sequencing paper in the journal Science. This paper demonstrated the broad capabilities of our novel protein sequencing technology, which the team continues to build upon. Some of the key findings in the paper are the following. QuantumSI's benchtop platform and semiconductor chip-based technology is capable of detecting hundreds of thousands of single molecules in parallel. We demonstrated the ability to sequence peptides from proteins based upon kinetic signatures. Using these kinetic signatures, we showed that we can not only identify amino acids, but also post-translational modifications and proteoforms. The technology demonstrated in the science paper has the potential to unmask critical regulatory mechanisms of protein function and interactions that could advance biomarker discovery, drug development, and lead to the discovery and development of new diagnostic tests. The science paper is just one of many firsts that we will establish in this field over the course of the next several quarters. Turning to the status of our product development program, the team is laser focused on the final steps towards launch, specifically finalizing the customer-facing analysis software, and completing transfer to manufacturing and scale-up activities. We expect to complete the remaining internal activities over the coming weeks. Based upon that timeline, we expect to launch the Platinum instrument and start to take orders before the end of this year and begin shipping product in Q1. We are excited about the upcoming launch of the platinum instrument and look forward to partnering with our customers to demonstrate the capabilities of our next generation protein sequencing technology. Finally, I would like to provide an update with regards to our facilities. Earlier this year, we signed a lease and announced that we would be relocating our headquarters to Winchester Works, a technology and life sciences hub in New Haven, Connecticut. Following a thorough review of our business infrastructure needs, and consistent with our ongoing efforts to optimize our cost structure, we have decided not to move to this facility. Instead, we have identified a new space in Brantford, Connecticut, where we can continue to grow and fulfill our infrastructure needs in a more capital efficient way. As mentioned in our previous earnings calls, our entire team understands that this is the time to get more out of our expenditures for our investors. I would now like to turn the call over to Patrick our President and Chief Operating Officer, to discuss additional business updates. Before doing so, I wanted to thank Patrick for his engagement and support during my time as a candidate, and most recently, as part of my onboarding with QuantumSI. Patrick? Thank you, Jeff.
spk08: Starting with development, we've made good progress on productizing our technology. We're in the last steps of the process, scaling, validating, and finalizing the customer-facing software. We're also continuing to push the technology development forward as we incorporate the new binders that we described the last quarter, giving us even more proteome coverage. I can't be more proud of the team and their accomplishments on all the development fronts. One of the most important components of our technology is the recognizer system. And we have a world-class team working at the intersections of various backgrounds, including molecular biology, computational biology, chemical biology, and protein engineering to develop this key component of the system. This last quarter, we strengthened our development partnership with ESPCI and welcomed new team members in France with unique skills and expertise in directed evolution of proteins to further our advancement. Moving into commercialization, our strategy for the next few quarters is to develop and test the market in a selection of key application areas. which include biologics discovery and protein validation through protein sequencing. We continue to develop our leads and funnel, and we'll prioritize customers for these applications as we start to take orders. Our initial rollout will include the platinum sequencing instrument. The carbon sample prep instrument will go through a beta testing phase in early 2023. We've filled positions in our customer success team to continue to support early adopters and expect to ramp up the commercial team in a metered way as we build momentum for our platform over the next few quarters. In line with our business development plans, we've also ramped up our participation at industry trade shows and academic conferences. In late October, we attended the American Society of Human Genetics annual meeting, where we experienced significant interest in our platinum as the first next-generation protein sequencing system. We gave demonstrations of the instrument, the chips, and the data output. Last week, we also attended the Single Molecule Protein Sequencing Conference in Delft, the Netherlands. This conference brought together leading researchers pioneering the development of single molecule protein sequencing techniques. We were pleased to present our advancements and bring our thought leadership to the topic of single molecule protein sequencing, as we are the first in this new category. From now through the end of the year, we're looking forward to building on our business development efforts at more industry trade shows, including the Society for Neuroscience and the Human Proteome Organization World Conference. On the supply chain front, the team stands ready to support commercialization. We continue to work closely with our contract manufacturers to build up our inventory of platinum instruments. The validation of our chip assembly and packaging capacity ramp up at our Garnet Valley, Pennsylvania facility is in progress according to plan, and we are on track to meet our monthly chip and cartridge production goals. We're also working diligently to incorporate our latest chemistry improvements into our reagent consumables and scaling to meet demand. I will now turn the call over to Claudia to review our financial results.
spk00: Thank you, Patrick. Hello, everyone. Let's discuss the details of our Q3 2022 financial performance. Research and development expenses in the third quarter of 2022 were $16.7 million compared to $11.1 million in the third quarter of 2021. The increase was primarily due to higher internal and external product development activities and higher personnel costs as a result of increased headcount. Selling, general, and administrative expenses in the third quarter of 2022 were $11 million compared to $14.1 million in the third quarter of 2021. The decrease was primarily the result of lower stock-based compensation expense associated with the business combination that took place last year, a reduction in consulting services, insurance, and other professional fees, partially offset by an increase in compensation costs as a result of higher headcount. In aggregate, total operating expenses in the third quarter of 2022 were 27.7 million compared to 25.2 million in the third quarter of 2021. Net loss for the quarter was 31.7 million compared to 18.1 million in the third quarter of 2021. Adjusted EBITDA was a loss of 22.9 million compared to a loss of $17.5 million in the third quarter of 2021. A reconciliation table of adjusted EBITDA to GAAP net loss is provided in a press release filed earlier today. As of September 30, 2022, we had $372.1 million in cash and cash equivalents in investments in marketable securities. We believe that this cash position can support our operations through the year 2024. In addition, we continue to increase our efforts to manage costs and improve efficiencies. As a result, we're lowering our operating expense guidance for a second consecutive time. We now expect GAAP operating expenses to go 25 to 30% year over year in 2022 down from a prior expectation of 40 to 50%. I would now like to turn the call back over to Jeff for closing remarks.
spk06: Thank you, Claudia. QuantumSI is hitting an inflection point in terms of progress, and the company is at the cusp of revolutionizing proteomics. I am looking forward to leading this exceptional team as we advance the launch of our revolutionary next generation single molecule protein sequencing platform and work to make it an indispensable tool for life sciences researchers. Operator, please open the line for questions.
spk02: Thank you. As a reminder, to ask a question, you'll need to press star 1 1 on your telephone. Please stand by while we compile the Q&A roster. And our first question comes from the line of Alex Vukasen with Canaccord Genuity. Your line is open.
spk04: Thank you very much. Hi, this is Alex Vukasen on the line for Kyle Mixon. Thank you very much for the great update. I just had a few questions, and I just wanted to elaborate on a few things you just discussed. So I think a good place to start is that we were wondering if you could discuss whether you'll be providing any revenue guidance for 2023 in the immediate to near term. Thanks.
spk06: Yeah, Alex, this is Jeff. I'll take that one. We're not providing any guidance yet for 2023. Obviously, the focus right now is getting the product launched and opening up the order so we can begin to see what that backlog would look like. Guidance for next year I think will be something we'll look to do once we get, you know, the initial read on the uptake.
spk04: Got it. Thank you. And then kind of changing gears a bit here, so additionally, you previously discussed the ability to potentially detect up to 15 out of roughly 20 amino acids. I was wondering if you could update us on things like the target amino acid detection levels as well as any other recent prelaunch updates that will be implemented to the system that will be launched in 4Q. Thanks.
spk06: Yeah, thanks, Alex. We'll let Patrick take that one.
spk08: Hi, Alex. Thank you for that question. So, yeah, so we discussed last quarter five recognizer system that gets us to roughly, you know, 15 amino acids. We're absolutely continuing on the development, you know, process as we look for more binders and more, you know, access to more amino acids. The interesting thing, though, is that with the system that we have now, we can get a lot of information. So we have access to a lot of the proteomes, even with the recognizer system we have now. So we're certainly satisfied with launching. That being said, we're continuing to put our development efforts into accessing even more of the proteome.
spk04: Got it. Thank you very much. And I had one last one for Jeff. So I was just wondering if you could highlight some of the things that attracted you to the business. I know you've discussed it previously. And also, are there any other strategic initiatives that you could discuss in detail perhaps that you hope to lead or address in the near to medium term besides some of the more obvious ones that you've already discussed? Thank you.
spk06: Sure. Thanks, Alex. Well, as I said in my prepared remarks, I think the approach was certainly a draw for me. Benchtop and at the cost points the company was planning for, I think were attractive to get a broader base of users. That should ultimately help with the pace of discovery and also really the depth of the data we're going to get. So I think those two things hold for me. The other thing I liked was You know, I like to look for complimentary opportunities in terms of my skill sets with the team. And I think what I learned in the process was really the quality of the technical team here, not only in what they've done to date to get to what you saw in the science paper, but also just their thinking about what the art of possible could be with this technology over time. And I think, you know, what was missing was, you know, additional capabilities and experience in the go-to-market and the scale-up side, which I brought. So I thought that was a nice compliment to the existing team. Your second question was more around strategic initiatives. I'm one month into the job, so really focused on immersion into the business, focused on supporting Patrick and the team with the launch, focused on helping the commercial team that's here really refine that strategy and be ready to go. I think as we get through this phase and get the product out the door, you know, we'll look to provide more updates on these types of initiatives, you know, at earnings calls coming up in the future.
spk04: Thank you very much. Really appreciate your time.
spk02: And as a reminder, to ask a question, please press star 1 1 on your telephone. One moment, please, for our next question. And our next question comes from Yuan Z with B. Riley. Your line is open.
spk03: Hi, this is Brendan Carney for Yuan. Thanks for taking our questions. Can you talk about the market potential beyond basic research?
spk06: So I'll start and then I'll pass it over to Patrick. You know, I think if we reflect on you know, sort of the next gen DNA sequencing world, right? It started with basic research, people proving out the capabilities, proving out the early applications, you know, and over time, as more people became aware of the capability, more and more applications evolved. I would expect a very similar evolution here. So I think what it looks like on day one, you know, will look very different at year one and year three and so on. In terms of, you know, how large is the market or maybe some specific application interest we're hearing, I'll turn it over to Patrick to provide a little additional color.
spk08: Yeah, thanks, Jeff. And thank you for the question. Certainly, as we're developing the market, we're seeing certain areas, application areas, and interest areas, a lot in the drug discovery and biologics identification and screening, a lot in very basic research. We're also seeing in protein validation, affinity reagent validation, et cetera. And so those are on the research side. But then there's certainly applications, and not just yet, but in the future, applications around the clinical side, right? So you can imagine identifying, you know, characterizing particular proteins in the proteoforms. and then moving that into clinical applications as well. So certainly on our roadmaps, we're continuing to develop those markets, and that's of real interest for us as we drive adoption. But first and foremost is driving that adoption and making sure we get it right, and that we're supporting the early adopters, which will amplify the message, right? you know, the applications that we go into.
spk03: Yep. Thanks. That's helpful. Maybe I'm wondering if you could provide some, for instance, some examples of how protein sequencing can be incorporated into a process that provides, like, diagnosis for clinical applications.
spk06: Yeah, I'll start and again pass to Patrick maybe for a potential example. I think the important thing, you know, today is I think we're, as we said, we're focused in really enabling those, that research community, you know, on sort of day one when we go out to the market. I think a big part of the long-term success of the company will be about engaging with the research community and getting published evidence of the capabilities of the technology and the range of potential applications. I think ultimately the collective intelligence of the research community will be a powerful tool to really fully unlock all the opportunities for the technology. You know, clinical obviously has many flavors. There's the CLIA lab version of clinical where labs could validate their own tests. with our technology. And then, you know, you have the very long term, which is, you know, at some point, does it become a regulated product? But maybe Patrick, do you have anything you'd like to add on?
spk08: Yeah, I mean, that's right, Jeff. And I guess I would maybe just add a little bit of color around, you know, sort of clinical research, right? I mean, there's this, you know, if we identify or it's a researcher identifies a potential biomarker, You know, this could help accelerate getting that biomarker into the clinical research. You know, these are some of the things that we're thinking about and continuing to have discussions around with potential collaborators.
spk03: Okay, thanks. That's helpful. Thanks for taking our questions. You're welcome. Thank you.
spk02: And I'm showing no further questions at this time. I would now like to turn the conference back to Juan Abundano for closing remarks.
spk01: Thank you all for your participation today. We look forward to updating you on our progress in the next quarterly earnings call. Have a good evening.
spk02: And this concludes today's conference call. Thank you for participating. You may now disconnect.
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