Voyager Therapeutics, Inc.

Good afternoon, and welcome to the Voyager Therapeutics Third Quarter 2024 Financial Results Conference Call. At this time, our participants are in a listen-only mode. There will be a question and answer session at the end of this call. Please note that today's call is being recorded. A replay of today's call will be available on the Investors section of the company website approximately two hours after completion of this call. I would now like to turn the call over to Trista Morrison, Chief Corporate Affairs Officer at Voyager.

Thank you and good afternoon. We issued our third quarter 2024 financial results press release this afternoon. The press release and 10Q are available on our website. Joining me on today's call are Dr. Al Sandrock, our Chief Executive Officer, Dr. Toby Ferguson, our Chief Medical Officer, and Dr. Todd Carter, our Chief Scientific Officer. We will also be joined for the Q&A portion of the call by Nathan Jorgensen, our Chief Financial Officer. Before we get started, I would like to remind everyone that during this call, Voyager representatives may make forward-looking statements, as noted in slide two of today's deck. These statements are based on our current expectations and beliefs. They are subject to risks and uncertainties, and our actual results may differ materially. I encourage you to consult the risk factors discussed in our SEC filings, which are available on our website, for additional detail. Now, I will turn the call over to Al.

Good afternoon, everyone, and thank you for joining us. Please turn to slide three. At Voyager, we are leveraging the power of human genetics to discover and deliver transformative medicines that address the root cause of neurological diseases. Our four pillars of value include, first, our pipeline of four wholly owned and 14 partnered programs. During the third quarter, we completed enrollment and dosing in the single ascending dose trial of VY7523, our anti-Tau antibody for Alzheimer's disease. We also recently saw encouraging third-party clinical data with another anti-Tau antibody for Alzheimer's disease, which Toby will talk about shortly. Our second pillar of value is our industry-leading tracer platform for the discovery of novel AAV capsids to enable CNS gene therapy. These IV-delivered CNS-targeted capsids underlie all of our wholly owned and partnered gene therapy programs, and we expect INDs for three of these programs next year. Third, we have blue chip partnerships with some of the world's experts in neurology and gene therapy, including Neurocrine, Novartis, and Naloxone. We continue to progress these partnerships through the third quarter, with Novartis signing on for a fifth program partnership and Neurocrin nominating a third development candidate. Finally, we continue to explore the potential to leverage receptors we have identified to shuttle non-viral genetic medicines into the brain. Ultimately, we aim to expand from gene therapy and antibodies into other modalities of neurogenetic medicine, broadening our impact. With that, I'll turn the call over to Toby to talk more about our anti-Tau antibody and some of the recent third-party data in the space.