Novartis AG

Good morning and good afternoon and welcome to the Novartis Q4 and Fall Year 2021 Results Release Conference Call and Live Webcast. Please note that during the presentation, all participants will be in a listen-only mode and the conference is being recorded. After the presentation, there'll be an opportunity to ask questions by pressing star and one at any time during the conference. A recording of the conference call, including the Q&A session, will be available on our website shortly after the call ends. Should anyone need assistance during the conference call, they may signal the operator by pressing star and zero. With that, I would like to hand over to Mr. Samir Shah, Global Head of Investor Relations. Please go ahead, sir.

Thank you very much, and good morning and good afternoon, everybody. A big thank you for joining us today on our Q421 full year 21 results. The information presented today contains forward-looking statements that involve known and unknown risks, uncertainties, and other factors. These may cause actual results to be materially different from any future results, performance, or achievements expressed or implied by such statements. For a description of some of these factors, please refer to the company's Form 20-F and its most recently quarterly results on Form 6-K BATS respectively were filed with and furnished to the U.S. Securities and Exchange Commission. With that, I now hand it, of course, to Vaibh.

Thank you, Sameer, and thank you, everyone, for joining today's conference call. Moving to slide three, with me today, I have Harry, Mary France, Susanna, John, Richard, Karen, and, of course, you've already heard from Sameer. Now, turning to slide five, and before moving into the quarter, I'd like to just make a few overarching statements about the company, our direction, and our overall profile. We believe we continue to present an attractive profile for investors, a clear strategy as a focused medicines company powered by technology and technology platforms, which we believe will define the future of our sector and the future of medicine, an attractive growth profile where we're confident in the 4% plus sales CAGR that we've guided to, and with the goal to be above pure median beyond 2026, and an aspiration to be in the high 30s IM margin, which we're well on our way towards. A strong mid and late-stage portfolio with over 20 assets with significant peak sales potential, platform leadership, which we continue to work towards across multiple defining platforms in the sector, and a balanced approach to capital allocation, which I'll speak more about in a few slides. Now, moving to slide six, we continue to evolve and sharpen our strategy. We are continuing to look at where to play with a particular focus now on four key therapeutic areas with two additional therapeutic areas we are selectively participating in. Focus on four key geographies while always evaluating our geographic footprint and aspiration to transform Sandoz. Five key priorities on how we win, which we continue to focus on and believe will enable us to outperform the sector over time. And a clear aspiration to be a top three innovator, be in the high 30s in terms of our IM margin and attractive return on invested capital, and continuing to be one of the leaders in material ESG factors in the biopharmaceutical sector. Then moving to slide seven, when you look at our track record on our financial performance, our track record, particularly on IM, has been solid. IM sales in the last four years have grown 7%. IM core operating income has grown 13%, which is amongst the highest in the sector. Our IM core margin has now reached 36.2, and our group free cash flow continues to perform well, and we continue to look at improving our free cash flow generation as a firm. So I think this demonstrates that we are delivering against the goals we set ourselves, and we plan to continue to do that in the years to come. Then moving to slide eight, just as a reminder, over the coming years, we expect to grow at that 4% or better rate, overcoming the estimated $9 billion of potential generic impact that we could have in this period with a series of strong growth drivers, six major assets, which we believe will have multibillion-dollar potential, a strong pipeline, which would then be added on top, leading to that 4%. And, of course, depending on when the Entrusto LOE falls, the potential to do even better. So now turning to Q4 and on slide 9. In Q4, we delivered strong performance across our value drivers. Growth was plus 6% in the quarter with IM reaching 7% of sales productivity, continued with group core operating up 12%, IM core operating income up 15%, demonstrating that productivity power we have within the company. I'll come back to innovation, but we had important innovation milestones in the quarter. And in terms of our progress on ESG, we had improved scores on multiple ESG metrics, including the MSCI, and continued our progress on environment and human rights. So focusing in on growth and turning to slide 10, Our key growth drivers grew 24% in the quarter and now represent more than half of the IM sales. We were pleased with the performance on our growth brand, and Mary France and Susanna will go through that in a bit more detail. And as you can see on the right-hand side of the slide, the steady increase we've had of these growth drivers constituting more and more of our sales, demonstrating the replacement power of our core sales space that we have within the company. Then moving to slide 11, Across the six key brands that we're hyper-focused on, we saw double-digit growth. Cosentix growing 17%, Entrusto at 40%, Dolgen's now 46%, and Cascali at 36%. Cosimta is off to a very strong start on its first full launch year. Mary France will go through that in a bit more detail, but we saw very strong share gains. And Lectio is in a build year this year, and we expect over the course of this year to consistently build momentum towards an inflection point in the 23 and beyond time period. As you can see, and as we highlighted in our R&D day, these brands are protected outside of Entrusto into the late 2020s or into the 2030s, forming a strong foundation for the company, which we can build on with our pipeline assets. Then moving to slide 12, and when you take a geographic view of the business, We had consistent growth across U.S., Europe, and China in innovative medicines, driven by different brands in each case. But in the U.S., we continue to show consistent growth, and we have an aspiration to become a top five player in the U.S. over time. In Europe, we remain the largest pharmaceuticals company and, again, are looking forward now to launching Cosimta and Lectio in the market to continue that growth dynamic. In China, we have been one of the most consistent growing companies in the high teens over recent years. And we are confident that we will get to our goal of over $4 billion in sales in China by 2025. And we'll go through a little bit more on some of the dynamics in China in quarter four. But we've already seen a recovery for some of the slowdown we saw in Q4 due to the buying patterns. NRDL listings and some of the other considerations that we have, and we'll speak more about that in the conference call. Now, moving to slide 13 and turning to innovation, we had multiple milestones in the quarter. The approvals of Semblix in the U.S. and Lecuveo in the U.S., importantly, from an approval standpoint. Additional submissions, including Lou PSMA 617 in Europe. as well as alpalisib in PROS, an opportunity for us to take on a very high unmet need, though small, indication. Our readouts, multiple readouts in the quarter, positive data for placentic and hydradenitis, azucaratevia, as well as with IV administration and psoriatic arthritis. Ligalizumab read out as well, positive versus placebo, non-inferior versus Zola, and we continue to evaluate the path forward for ligalizumab And YTB and PHE, which I'll speak more about as well in terms of our novel CAR-T platform. We began our phase three studies for remibrutinib, both in multiple sclerosis and CSU, as well as with legalizumab in food allergy and cold-induced urticaria. Now moving to the next slide on slide 14, just a few words on some of the data readouts. Ionilumab is an acid we're very excited about. This is our anti-BAF receptor monoclonal antibody. Had very strong data in Sjogren's syndrome in a Phase 2B study. We'll be moving into Sjogren's Phase 3 later this year. We are all planning as well shortly to initiate studies in Phase 3 for lupus nephritis. We're advancing in SLE as well as in autoimmune hepatitis and expect additional data over the coming 12 months on these two indications. And we're also looking to progress within B-cell malignancies, where we believe an antibioperceptor antibody could provide an additional option for these patients. Taken together, we think this asset has the potential to be the quote-unquote pipeline in a single asset, and we look forward to advancing it across a broad range of indications. I already mentioned the Cosentix data in HF. This is a high unmet need area. Hydroxymatis supertiva is a severe debilitating condition. A good efficacy profile, a strong safety profile. We are keeping the study blinded until the 52-week time point. And following that 52-week safety data, we will then be able to move forward with submissions in the U.S. Submissions in the EU are already under preparation, and we would expect them in the first half. And as I mentioned with legalizumab, data demonstrated superiority versus placebo, but not superiority versus Zolaire. And we'll provide a further update on this asset in terms of its progress in CSU shortly. However, we do believe there's potential for the medicine in food allergy and Sindhu, given there is no approved anti-IgE therapy, IgE therapy indications. Then moving to slide 15. Just to say a word about the data we recently presented in December on our T-CHARGE platform, our next generation CAR-T platform, which we're excited about given the potential to provide fast access to therapy, hopefully improved rates of response and longer durability, as well as attractive economics in terms of its production and scalability. YTB, which is indicated for DLBCL, in a small study of 16 patients demonstrated a 73% CR rate at month three, and we're looking forward now to reading out the six-month data over the coming months. And we plan to start a phase three trial in DLBCL this summer for this asset. And PHE in multiple myeloma is a BCMA-directed CAR-T. Again, early data, but in the first six patients, 100% ORR. And what's unique about this technology platform is its ability to preserve what's termed as T-cell stemness, the ability of T-cells to regenerate themselves, to hopefully lead to more long and durable responses if a cancer occurrence should occur. Also enables a shortened timeframe for cells to be out of the patient's body. So many things to be excited about early days, but we look forward to taking this forward and hopefully over time bringing additional targets onto the T-CHARGE platform. Then moving to slide 16, in the quarter as well, we signed four additional BDML deals to strengthen the pipeline. We acquired Gyroscope, which has a one-time subretinal phase two gene therapy that has the potential to transform the care of geographic atrophy. In early data in nine patients, rather remarkable results that we saw for this one-time administration. We'll now have to see how those results hold up in larger phase two studies, but at least the potential to address a very large market and a very large patient unmet need with a one-time therapy. We signed an option agreement with Beijing for Osiprolimab, the phase 3 TIGID inhibitor, currently being run by Beijing in global phase 3 studies in solid tumors, particularly in lung cancer, EFCC, and cervical cancer. We are looking forward to working with Beijing to fully build out this program over the course of the year, and then as data continues to materialize, determine if a full opt-in would be warranted. We signed our opt-in agreement with molecular partners for Enzovibep, which has the potential to be a broad-spectrum coronavirus therapeutic for patients in the outpatient setting. It has three – targets the spike protein in three separate binding domains, opportunity for bacterial production, so much higher yield and much more efficient production, also higher scales. We are on track in our discussions with the FDA to complete an emergency use authorization filing, and then it would be determined by a review matter if the FDA would ultimately provide an approval. We also continue to be in discussions with the U.S. government as well as other governments around the world regarding this therapeutic, as well as advancing the phase three trials and subcutaneous formulation. And then lastly, we signed an agreement with UCB for the co-development and co-commercialization of an alpha-synucleon small molecule inhibitor, an opportunity to tackle Parkinson's disease with a small molecule agent against, I think, a very exciting target, early data, early days, but certainly the potential to address a major unmet need. Now, turning to slide 17, slide 17 and the following slide as well give you an overview, one kind of a snapshot of our portfolio in pharmaceuticals and cardiorenal. Things are on track, and you can see some additional progress we've made on the electio outcome studies, and if Tacopan and Pelocarsin also remain on track. In neuroscience, Zolgensma, we've initiated the phase 3 intrathecal study now. Branoplam has also now initiated its phase 2B study in Huntington's disease. I already mentioned remibrutinib and our agent in Parkinson's disease. And across the immunology portfolio, a number of ongoing projects and programs in Phase II and Phase III are largely on track. At the bottom, you see the status of our wildcard programs. Later this year, we would have readouts for QBW and UNR, and we continue to also progress the other agents in that box as well. And turning to slide 18. In oncology, we also are progressing on track in solid tumors and hematology. The Qiskali-Natalie readout is on track for an event-driven readout, but we continue to expect it by the end of 2022 if the event rate changes and it flips into 23. We'll, of course, let the markets know. The Canopy A study also is on track for a readout in the second half of this year. Lew PSMA, importantly, the additional readout for our PSMA-4 study, again, an event-driven study, but we're hopeful to have a readout on that in the earlier lines of prostate cancer by the end of 2022. And the review of Lew PSMA with the FDA is on track, given its action date later this quarter. And we also progressed JDQ with TNO. We look forward to presenting additional data on the combination, we hope, over the coming 12 months. In hematology, the Asiminib first-line approval, third-line approval, we've already achieved, and Susanna will speak more about that. And then I've already mentioned some of the other agents here. Sabatolamab, our anti-SIM3, on track for a PFS readout in the first half of this year, and the various other studies moving towards PFS and OS will come over the coming year as well. So a lot going on. We expect additional readouts, particularly in the back half of this year and heading into 2023. When you look at slide 19, you can see the full list of expected events, regulatory decisions, submissions, submission enabling readouts, additional readouts, and you can also see a large number of pivotal study starts. These studies will be important for us to continue to advance the 20 plus assets that we've been talking about that will drive growth 2025 and beyond. So moving to slide 20, Just to say also a word on Sandoz. We saw Sandoz stabilizing in quarter four. You saw sales grow plus 2% in the quarter, as well as biopharma growing 7% in constant currencies. When we think about the outlook for 2022, we forecast sales to be broadly in line. And Harry will talk a little bit more about the specifics on the guidance. We're assuming here that cough and cold reverts to pre-COVID levels. That biosimilar continues to perform, particularly in Europe, where we have a very strong market position. But we also face continued gross margin headwinds due to the price erosion and unfavorable mix, particularly in the U.S., which we expect to fully bottom out in this year and start to move towards a growth dynamic in the back half of next year. Our biosimilars launches, however, continue to be on track, and we're expecting these launches to drive material growth in the back half of 2023 into 2024 and beyond. There are $80 billion of originator sales, a large opportunity. We have 15-plus assets somewhere in development. So that will be absolutely critical to move Sandoz into a strong growth dynamic looking ahead. Moving to slide 21, a word on our capital allocation strategy. We remain disciplined and shareholder focused and really trying to balance the four elements of our strategy. And this is a shift. We're not ranking them, but rather really showing them as a balanced approach. We invest in organic business. You can see $9 billion in R&D, over a billion dollars in capital investments. We also continue to look at value creating bolt-ons. We've done around $30 billion of acquisitions since 2018. And we also return value to shareholders through our annual dividend, where we propose this year to increase by 3% Swiss francs and 6% U.S. dollars. And as announced in the quarter four, we continue to also return our capital to shareholders where appropriate. Share buybacks of $2.8 billion were executed in 2021, and we're on track with respect to the $15 billion share buyback program that we announced. the back half of last year which we expect given the nature of the swiss second line second trading line cancellations take us until the end of 2023 to fully complete so moving to slide 22 from an esg standpoint we continue to make important progress in sub-saharan africa with respect to our human rights commitments in terms of disability inclusion our environmental targets are on track with 34 scope one and two Reductions excluding offset waste disposal also reduced and on track to be at half by 2025, all on track towards our goal of being carbon neutral across scopes one through three by 2030 and fully net zero by 2040 and as soon as possible is our aspiration. And this is all led to improved scores from an MSCI. We are no longer having an MSCI controversy red flag. ranked number two in the Access to Medicine Index and also favorably ranked in the S&P Global ESG ratings, amongst other ratings that we've had over the course of the year. So in closing on slide 23, I just want to highlight the priorities for the company over the course of this year. The successful launches of Lectio, Cosimta, Lu PSMA, which we believe has the potential to be a very significant asset, And Semblix, where, again, we have the opportunity to build on a third-line approval and hopefully move into earlier lines of therapy. Maintain the growth momentum on our six multibillion-dollar assets that are the assets that we believe will drive the company's base level of growth over the coming years. Progressing the pipeline of 20-plus potential significant sales assets with the opportunity that be approved by 2026. optimize our portfolio with the sandoz review with a plan to have this updated by the end of 2022 and remain disciplined and thoughtful on our bd and m a to build the growth profile of the company but also ensure attractive returns for our shareholders deliver those returns through our productivity initiatives but especially in manufacturing and business services as we move towards the high 30s in our margins as well as an attractive return on invested capital profile and continue to reinforce the foundations of a great company, a strong culture that drives performance, leadership, and data science to drive value across the business and being an ESG leader. So thank you very much. And with that, I'll hand it over to Mary Fromm.

So good morning, good afternoon to all. On slide 25, I'm pleased to share the quarter four results of the pharma division with you. Our sales grew 9% this quarter. As you know, we're fully focused on our growth drivers and launches and the rejuvenation of our portfolio. You can expect us to continue to drive this shift in 2022 and beyond. So moving on to slide 26, Cosentix delivered $1.2 billion in revenues and grew 13% in the quarter. We've seen strong demand for Cosentix across geographies. We did see some impact in China due to the year-end budget caps. However, we've already seen a strong rebound in Q1. Our lifecycle program is starting to deliver with a positive readout for Hydra Adenitis Superativa and IV, and we'll start to be a growth driver in 2023. If we look to 2022, our focus is on volume growth in all geographies, especially China. In the U.S., our access position is stable, and we plan to grow with the market. As we will not benefit from the price favorability we saw last year, volume growth for us is key. You can expect to see the typical quarter-over-quarter decline in Q1, followed by continued double-digit growth for the full year, fully on track to deliver on our $7 billion-plus guidance. If I move on to slide 27, Entresta grew 34 percent in the quarter, finishing the year at 3.5 billion in sales. We continue to pull through the first-line recommendations in the U.S. and Europe, and we continue to have good traction with the expanded label in the U.S., which, as you know, includes five out of six patients with heart failure. In China, we renewed our NRDL listing for heart failure, and we are thrilled that hypertension is now listed. The dip that you see in the ex-U.S. sales column is for China, And that is because of the wholesaler compensation for stock given our new price. But again, this is on the back of very good news. Now that we have the listing, we also have access to a much broader population. And if you think about the fact that only 15% of patients in China or hypertensive patients in China are well controlled versus, for example, 52 in the US, you can start to see the potential. For 2022, we are absolutely confident we can maintain and trust those momentum in the US, in Europe, driving broader and earlier adoption, but we're also very excited about our opportunities in Asia. If I move on to slide 28, we're now in our third year in the marketplace with Zolgensma, and we've treated 1,800 babies. Because this is a one-time therapy, you will continue to see volatility in the quarters. as new markets gain access, as we add the bolus, and then move on to an incident population. Our focus is clear. We want to maintain a leading position in the U.S. focusing on the incident population. We want to accelerate newborn screening. We know it's really important to treat SMA as early as possible, and therefore, our plan is to double the rate of newborn screening in Europe. And three, we want to continue on our plan for geographic expansion into emerging markets. In parallel, we're progressing with our IT formulation. We're laying the foundation to bring Zolgensma to patients across the full SMA spectrum. Our STEER study has just opened and just recruited its first patient, and we're also conducting a study in pretreated patients who may benefit from Zolgensma as one-time treatment. If I move on to slide 29, with Casimta, we finished the year strong with 147 million sales in Q4. We maintain a high share of voice, We now reach a critical mass with multiple sclerosis specialists. We continue to onboard new patients, and the majority of those patients continue to be in first line, first switch. There is no question that B-cell therapy is now the gold standard in efficacy. We also know that there have been questions on safety in the context of COVID, and this has been a priority for us to provide relevant answers to our customers. With the reassuring vaccination data that we have, we are building additional confidence in Cosimta's profile and providing further important clinical differentiation in the marketplace. As we drive additional uptake in the U.S. and continue to execute on our launches across the world, you can expect us to continue to do everything to make this Cosimta story even better. Moving on to slide 30. As you know, we've received FDA approval in December for Lexio, and we've been in the field for two weeks. On the system side, we're implementing our strategy. Our focus right now is to support the P&T reviews and the implementation of acquisition or referral processes. We've started onboarding alternative injection centers, and we continue to broaden our network. We've also filed for our permanent J code as we planned. On the healthcare professional side, We're educating on Lecvio's clinical profile, the twice-yearly dosing, and the breadth of the label. We are really excited about the enthusiasm that we're getting from the market on the clinical aspects, but also seeing the high willingness of physicians to discuss the non-clinical support options. As was said before, the first half of the year will be about laying the foundation to drive the uptake in second half of the year and beyond. when some of the larger systems should be ready for buy-in bill, and of course, when our permanent J code should be issued. On a separate note, we've also made significant progress with the NHS on the implementation plan and are awaiting the list on the moratorium of all non-COVID related communication and initiatives to begin the rollout of the agreement. So in summary, on slide 31, 2021 was a strong year for pharma. I want to thank the teams for the focus, the bold thinking, and the diligence around customer obsession and market metrics to deliver exquisite execution. You will see us continue to build on that strong foundation in 2022 with the right investment, not only in our products, but also in new partnerships, customer engagement, and digital tools. So thank you very much, and now let me pass it on to Susanna. Thank you, Marie-France.

And moving to oncology on slide 33, you see that the oncology business grew 4% in 2021, reaching $15.5 billion, with our growth drivers increasing 17% versus prior year. And also Q4 was a solid quarter, growing 3%. As you see, the growth was driven by continued double-digit growth of brands like Kiskali, Promacta, Revelade, Tafenlar, Mekinis, and Shakavi. We are very pleased to see a continued strong portfolio rejuvenation with these growth drivers now representing 54% of the total portfolio. Moving to slide 34, Kiskali. We saw a very strong performance growth of 58% in Q4, reaching now 285 million in sales. We saw increased demand across all regions as a reflection of further penetration in the first-line postmenopausal segment. We continued to gain share in the U.S., with NBRX in the metastatic setting reaching 17% in November 21. And in the international markets, we had an impressive growth of 90%. mostly driven by Europe, where we see sustained leadership in premenopausal setting, but also increased penetration in the largest postmenopausal setting. With the Mona Lisa 2 data presented at ESMO, Kiskali demonstrated the longest median over survival so far in adverse breast cancer, and we now have OS data across all eligible patient populations. And this is why Kiskali is also the only CDK4 inhibitor highlighted in the US and CCN guidelines to demonstrate OS benefit in first line. So we are moving forward with confidence in Kiskali. And in collaboration with the SALT study group, we have initiated the phase three harmonia trial to evaluate Kiskali versus Palvoseklib in advanced breast cancer. In addition, we continue our geographical expansion of Qiskali with reimbursement achievement in Brazil and regulatory submission in China. As you know, our key development program is the Natalie trial, studying Qiskali in adjuvant setting for both high and intermediate risk patients. And this study has fully recruited, and as Vas mentioned, the readout is expected towards the end of 2022. So overall, we are very pleased with the Qiskali performance and expect continued momentum. On slide 35, you see three of our blockbusters, Tafelar Mechanist, Promacta or Revolate, and Chakavisa. These brands continue to deliver double-digit growth driven by strong demand across regions. Tafelar Mechanist was growing 14% with strong contribution from Europe. And just to remind ourselves, this is the first and only targeted therapy to achieve both five-year overall survival in metastatic as well as adjuvant. And TAFLA mechanism continues to sustain leadership in metastatic melanoma as the most used worldwide targeted therapy in the setting. Moving forward, we expect growth will primarily come from adjuvant melanoma and non-small cell lung cancer indication, as well as the increased uptake in China. Also, Promacta Revolut reached very strong growth with 12%. And we saw this growth across all regions with share gains supported by the sustained efficacy and oral administration convenience. And we expect continued growth in ITP and SAA. And finally, ChakaV, reaching 12% growth. This growth was driven by earlier usage in myelofibrosis and polycythema vera. And we continue with our geographical expansion on grass versus whole species launches, and we expect further uptake there as well. So moving to slide 36. Last quarter, as was mentioned, we have launched Semblix in the US, and this is a unique stamp inhibitor with superior clinical profile in late-line CML that could potentially change the standard of care. And you see that Semblix has a very strong clinical profile with a two-fold improvement in major molecular response and a three-time reduction in discontinuation due to aversive lens. So looking at the patient potential for Semblix, that means that approximately 25% to 30% of CML patients may be eligible within the approved Semblix label. And this includes patients experience resistance or intolerance with previously treated two or more TKIs, as well as patients with the T315I mutation. And as you know, we have started a first-line registrational trial with filing expected in the first half of 2025. So leveraging decades of experience in CML, Semblix is off to a solid start in the U.S. with leading share of voice already within the first month. And this is complemented by a robust digital footprint with over 20,000 users and nearly 60,000 patient website visits. We have over 50 patients enrolled in our patient assistant program and have above 150 patients included in our managed access program. SAMBLX is also already included in the N-CNN guidelines. So we are also pursuing global commercialization and the approvals in Europe and Japan remain on track for 2021. Moving to slide 37, with our radial ligand therapy Lutetium PSMA 617, we have another exciting launch upcoming. Lutetium PSMA has the potential to address the high unmet median advanced metastatic castration resistant prostate cancer. And results of the phase three vision trial demonstrated improved radiographic PFS and overall survival. On the commercial side, we are moving forward with launch preparations. We are targeting 435 treatment sites across US and Europe. We are leveraging our Lutathera footprint combined with an incremental field force dedicated to prostate cancer. In the U.S., that field force is fully recruited and trained, and the same is true for Europe where we start building that field force. We don't foresee any hospital capacity constraints for the launch in this vision population. And on the development side, we currently have two ongoing phase C studies in the pre-texane and the hormone-sensitive settings. with the potential to significantly expand the eligible population by up to four times. So in conclusion, moving to slide 38, I would like to conclude with three important messages. First, in 2021, we continue to see solid execution on growth brands and portfolio rejuvenation, with sales from our growth drivers increasing 70% versus prior year. With Kivkali, one of our key brands, we continue to gain share in the CDK4-6 class, and we have strong OS data in metastatic settings, and we are looking forward to the Natalie readout in Ativan. And we keep our focus on launch execution with Semblix and Lutetium PSMA preparation and advancing our next wave of assets. And with that, I'm handing over to Hari.

Yeah, thank you very much, Susanne. Good morning and good afternoon, everybody. So I'm now going to walk you through some of the financials for the fourth quarter and the full year, as well as provide you with our 2022 guidance. As always, my comments refer to growth rates and constant currencies, unless I would note it otherwise. Turning to slide 40. Here we compare briefly our results with our latest 2021 guidance. As you can see, overall our full year results were in line with guidance with a particularly strong Innovative Medicines performance. Innovative Medicines grew the top line by 6% and the bottom line even double digit by 10%. We are pleased that despite a challenging business environment during the year, we were able to deliver on our expectations. Next slide, please. We finished the year on a strong quarter with sales and cooperating income growing 6% and 12%, respectively. This resulted in full-year performance of 4% and 6% growth on top and bottom line. Net income of $24 billion benefited, of course, from the one-time gain from the raw stake divestment of $14.6 billion. But even if you exclude that effect and you see that in the lower line, we've followed net income. Net income grew a healthy 15%, mainly due to higher sales and productivity gains. Core EPS grew 7%, mainly from a strong cooperating income growth and was slightly impacted by the Roche divestment in quarter four. Free cash flow was up 14%, reaching $13.3 billion. And I will go a bit into more details about free cash flow a little later. Before we move on, just wanted to highlight that quarter four sales growth includes a positive 1% point impact from a small reclassification effect of contract manufacturing from other revenues to sales. Slide 42, please. This slide shows you the performance by division for the quarter and full year. Clearly, innovative medicines had a strong year driven by our key growth drivers and and the key oncology brands, which also Marie-France and Susanne laid out. The innovative medicine sales grew to 6%, bottom line 10%, and margins reaching 36.2% points, up from 32% in 2018. So an increase over the three-year period of 420 basis points. For the quarter, innovative medicine sales grew seven and cooperating income 15%. As Vas mentioned, Sandoz is still facing some challenges, mainly from pricing pressures, especially in the U.S., and COVID-related demand impacts, although quarter four showed signs of stabilization. Now let's turn to slide 43. Free cash flow of the year was mainly driven by the higher operating income and was up 14% to $13.3 billion. There were also lower payments from legal matters in 2021 compared to what we had in 2020. This was offset, as you can see, by the upfront payment for in-licensing of tyzolizumab from Beijing. On the next slide, I'm very pleased to announce that we will propose our 25th consecutive dividend increase to 3 francs 10 per share from 3 francs last year. This is an increase of 3.3% in Swiss franc and 6% in US dollars. with our dividend reaching 4% and fully aligned with our dividend policy of dividend increases every year in Swiss francs. Now turning to slide 45, where we sum up our guidance on top and bottom line. With the divisions, we expect another year of innovative medicine sales growing mid single digits. and cooperating income to grow mid to high single digits ahead of sales. The expected innovative medicines core margin increase will be driven by the expected good top line momentum and continuation of our productivity programs. For Sandoz, we expect the top line to be broadly in line with prior year and cooperating income to decline low to mid single digit, mainly driven by growth margin pressures due to pricing and product mix. Also on the top line, it's also due to the fact that we do not expect many launches for Zandos in 2022. With respect to the entire group, we expect both the top and the bottom line to grow mid-single digit. The key assumption for this guidance, as you can see in the bottom box here, is that we are continuing to return to normal global healthcare systems including prescription dynamics, and that no misunderstood LER generics would enter in the US in 2022. On slide 46, I would like to add some perspective on other key financial elements of our expected core net income performance. As you can see, we expect core net financial results to be broadly aligned versus 2021. And the 2022 core tax rate is expected to be in the range of 17 to 17.5%. This is higher than the 16% core tax rate range we experienced over the last couple of years. However, as you can see, approximately 1% point of this increase is due to the mathematical impact of the Roche divestment. And there may also be a slight increase due to geographical profit mix changes, which we will monitor throughout the year. Finally, on slide 47, for modeling purposes, we thought it would be very helpful to you to go into some details regarding the currency impact, especially given the recent appreciation of the US dollar. As you saw in quarter four, currency had a negative impact of 2% On net sales, a negative 3% point impact on cooperating income. As the U.S. dollar further strengthened, this currency effect, of course, also impacted the sales of our key growth drivers, XUS, in quarter four. If late January rates prevail for the remainder of 2022, we would expect the full impact of currencies on top line to be a negative 3% points and on bottom line negative 4% points. In quarter one, the impact is a bit more pronounced and sales would be negative four and bottom line negative five points. As currency rates are quite volatile, as we all know, we update this impact estimate every month on our websites. And with this, I will hand it back to Lars.

Perfect. Thank you, Harry. So moving to slide 49 and briefly in closing, In 2021, we delivered on our goal of guidance of mid-single-digit top-line growth, margin expansion, and strong free cash flow. We remain confident in our in-market growth drivers, six major brands that are performing well across geographies, supporting our confidence and our outlook of 4% plus sales carrier to 2026. We continue to deliver important innovation milestones across the portfolio and will work over the coming years 12 to 24 months to deliver important milestones on our 20 plus T assets. And we remain balanced in our capital allocation, continuing to invest in innovation alongside returning capital to our shareholders. And with that, operator, we can open the line for questions. I would ask that each questioner limit themselves to one question, and we'll try to go multiple times through the round as far as we can in the allotted time. Thank you. Thank you.

Thank you very much, sir. Ladies and gentlemen, if you have a question, please press star and 1 on your telephone keypad. Please limit yourself to one question only. Again, that's star and 1 if you have a question. Your first question today comes from the line of Graham Parry, Bank of America. Please go ahead. Your line is open.

Great. Thanks for taking my question. So just regarding the Sandals review, Obviously you're looking there and you're saying all options are still on the table despite there being some recent speculation again about there being some private equity interest. When you're considering a sale versus spin versus keeping the business, how much consideration are you giving to what multiple you think the market would value Sandal at versus what an acquirer might view it at? And secondly, in the scenario of a sale, what uses of cash would you consider given that you're already doing a large buyback. So would the intent there to be to return capital to investors or to put it back into the business through M&A and organic investment? Thank you.

Thanks, Ram, for the question. Let me start with where we are on the process. I think as we guided at the end of last year, The first part of this year is really focused on carving out the financials for Sandoz, being clear on the perimeter, and then being able to provide potential counterparties with the relevant information for them to make concrete formal offers, whether those are private equity or other companies. Alongside that, evaluate the options for a potential spin of the business, and lastly, a potential retention of the business. We are going through the work right now of evaluating those different options, and I expect that to take us to the middle of this year. Before then, we can take the next steps and hopefully come to a decision in the second half of the year. In terms of considerations, we're of course always looking at a few things. One, how to make Sandoz as successful as possible, consistent with the aspiration for Sandoz to become the leading generics company. in the world. Second, what is most value-creating and also tax-efficient for our shareholders? We, I think, have proven with the Alcon spin that we're able to think through those considerations in a way that is beneficial to the shareholders and really making sure we're thinking about these things in a shareholder-friendly way. And I think it's really premature for us to speculate if there were a quote, unquote, sale, how we would use the cash. And I think we're still a long ways away from that point in time. And we would, of course, be able to determine that at that point in time, that we would stay consistent with the balanced capital allocation approach, which I outlined earlier, thinking through investing in the business versus returning value to shareholders. So thanks for the question, Graham. Next question, operator.

Thank you. Your next question comes from the line of Richard Parks, BNP Paribas. Please go ahead. Your line is open.

Hi. Thanks very much for taking my question. I've got a question on capital allocation. I remember on the last call you mentioned that you were engaging with investors around the sort of balance of returning the capital from the Roche stake sale between sort of buybacks and M&A. And I just wondered how your thoughts on M&A and business development had evolved based on that feedback. I'm just wondering if more meaningful bolt-ons have moved up or down the priority list based on that feedback. Thank you.

Yeah, thank you. Thank you, Richard. So I think not much more to say on the feedback. I mean, what I think we can say is that We know that given the strong cash flow that we generate at Novartis, we have the ability to continue to do a bolt on acquisitions like we've done in the past when we find attractive assets that fit with our therapeutic area goals and our platform goals. As we evaluated the situation over the course of December, it became clear that at this point in time, we could return significant capital to shareholders through the buyback while maintaining the ability to also do attractive accretive M&A if it should materialize. So right now, our focus is, of course, first and foremost, on driving the business and then evaluating the various options that are out there over time. But of course, being very patient to ensure we only do deals where we're confident that we can generate significant returns for the company and also fit with our strategic priorities. So, I would say there's nothing imminent, and we're going to continue to evaluate the options and watch how valuations move in the sector, and then look for opportunity as they arise. We're quite happy to continue to do deals like the four deals that we've done in quarter four that enabled us to acquire four mid-stage and or late-stage assets through various deal structures we think have attractive financial terms. Harry, anything else you wanted to add on that?

No, I think one element to see, I think, you know, also feedback on the 15 billion share buyback has been quite positive. And also maybe some analyst investors are not very familiar with the Swiss system where we have to buy these on the second line for cancellation. And that takes then until the middle to the second half of next year. So 23%. Unlike like US situations where you can do this quite quickly. So as we see that can monitor the market, we do as much as we can on this 15 billion share buyback as you go forward. So there's also a bit of time to continue to think about the different ways of capital allocation. And then, of course, we have to see, as Vaz mentioned, would there be a great opportunistic M&A opportunity here? And otherwise, as we laid out, the capital allocation priorities, that's how we're going to allocate continuously our capital.

Thank you, Eric. Next question, operator.

Thank you. Your next question comes from the line of Laura Sutcliffe from UBS. Please go ahead. Your line is open.

Hello. Thanks. A question on Lectio, please. You've talked a lot about the hard work you've done in removing access and reimbursement hurdles in the U.S., but do you think you need any specific guideline inclusions or recommendations to start driving use there? And is there the possibility of sort of trying to protocolize this in any way in your centers of interest to get sales going? Thanks.

I think, Laura. Mary Francis?

Yeah, so the first thing I'd say is that LDL lowering is already widespread across the guidelines and we already have class 1A in Europe. So when you ask your question, the intent philosophically of us going or concentrating on the 200 systems of care is exactly that. It's around how do you protocolize the use or the management of lipid lowering within the system. So how that looks like concretely will probably depend system by system. But as you know, we've just launched a cooperation with the AHA, which is around, it's not necessarily specific to Lectio, but it is around how do you better monitor and control cholesterol lowering for patients. So the intent is there. It's about making sure that we can identify the care pathways and then also support the centers in how they can specifically identify patients to come in when their LDL is not at the level that it should be or not at goal. So you're absolutely right. That's the intent. That's the way we're looking at it. Locally, it's going to look very different country by country, system by system. But that's the goal. And ultimately, we'll change the landscape in ASCVD because today, even though there are medicines on the marketplace, patients are not being treated and they're not at goal. And therefore, you see 18 million deaths worldwide because of ASCVD.

Thanks very much. Thanks, Laura. Next question, operator.

Thank you. Your next question comes from the line of Andrew Brown from Citi. Please go ahead. Your line is open.

Many thanks. Could you just outline for us the differences between this 15,000 Victorian 2P and the Iran 4 trial for Lectio? I'm assuming this is just a sort of marketing-based phase 3 to expand clinician experience, but maybe I've missed something different about the patient populations apart from the subtleties. And maybe if you have a second, perhaps you could comment on the Legalizumab surprise, given how robust the pre-large Phase IIb data was. Is this the ZOLAR-armed is better than expected? If you have any insights, it'd be great to hear. Thank you.

Yeah, thanks, Andrew. John?

Yeah, sure. Thanks for the question, Andrew. Specifically on Lectio, as you know, the study Orion 4, which is being conducted in the UK, is more of a population-based approach to looking at secondary prevention. And that is mostly in the UK with some patients in the US. The V2P is a broader patient population where we're going globally, not only in the US, but across major geographies throughout the world. And we know that there are differences in practice patterns throughout the world. what we intend to do is ensure we follow these patients and make sure that we have a clear understanding of the treatment for secondary prevention for LECVIO. So those are the approaches that we're taking difference of Orion IV versus LECVIO. And back on your question for legalizumab and what we've seen, you know, we started the phase three study on PERL-1 and PERL-2, which were designed against the active comparator, which was omalizumab. These studies were based on primary endpoints that we saw through our Phase IIb study. And that Phase IIb study had 380 patients and 80 patients per arm. And as we've actually demonstrated or showed during the fourth quarter as we shared at the R&D day, We did achieve the primary endpoint of superiority versus placebo, but we did not demonstrate superiority versus omalizumab. We're currently reviewing that data, and we're evaluating the best potential for moving that forward. And as Vas stated earlier, we're advancing the studies in Sindhu and food allergy, and they're continuing as planned.

And maybe, Andrew, just one additional point to John's comments to your specific point. We did see omalizumab perform better in the Phase III study versus the Phase II study. So that is a leading hypothesis we have, but I think still more work to do to fully ascertain why we saw the difference between the Phase IIb in the New England Journal and the result that we saw in Phase III. So as soon as we have a better understanding, we'll, of course, share it. In the meantime, legalizumab continues to develop in food allergy in Sindhu, given the lack of an IgE drug for those indications. Thanks, Sindhu. Next question, operator.

Thank you. Your next question comes from the line of Simon Baker from Redburn. Please go ahead. Your line is open.

Thank you for taking my question. It's a question on the impact of COVID specifically in three areas for you. Firstly, could you give us an update on the dynamic MS market as it affects Cosimta and also recruitment into the Phase 3 remabrutinib study that started in fourth quarter? And also for Lecvio in the UK, Marie-France, you mentioned the NHS non-COVID block is about to be released, but I just wondered how the significant backlogs within the UK healthcare system could potentially impact the rate at which you will accrue the target number of patients over the next few years. Thanks so much.

Thank you, Simon. So first, Mary Fons, on the MS market and Lectio NHS.

Yeah, so maybe I'll just start off by saying that, you know, we're all getting used to COVID. And I think not only the industry, but also healthcare systems in general, we're sort of learning to become more and more agile. But it is true that there are areas that are disproportionately impacted. And clearly, the dynamic multiple sclerosis market, if you look at it, it is still below pre-COVID levels. And we are also seeing, as you said, a delay in our Lectio launch in the UK, given this moratorium on anything that's not COVID-related. You know, ultimately, yes, it's true. I don't think for Casimta it slowed us down. I can already say, for example, that in the beginning of the year, we already have all of our patients re-verified. We've tried as much as possible to be out there with physicians. Our share of voice is high. We have absolutely doubled down on patient services to make sure that patients are not left out in the cold in this whole sort of pandemic era. So I do think it's almost allowed us to to basically rethink some of the way that we approach the market and do better. However, it's a clear reality on certain areas and not only those. For the UK, as I said this morning, it hasn't really slowed us down on the implementation. I mean, we've been working really diligently in the background on things that we would have had to do anyway, right? NHS guidelines, making sure that the communication is ready to go out, looking at, for example, the patient digital identification. NHS guidelines have already been written. So I think when this moratorium is listed, and of course, you know, remember that this is all in the primary care sector. So our entire plan for the NHS is centered around the primary care physician, and that's where the moratorium is. So We're waiting for that to be listed, but I do want to reassure the audience that we're not at a standstill. We're doing the things that we would have to do anyway and laying the groundwork for the future. And with maybe a last word on Casenta, we're bullish on our ability to double sales in the U.S. We've got approval in 63 countries around the world. We're working through reimbursement. And so, you know, we believe it's going to be a good year for Cosimta despite the local, let's say, lockdowns or pandemic influence that we see across the globe.

And then, John, on remibrutinib recruitment, any insight yet?

Absolutely. Thanks for the question, Simon. You know, the MS space is one that we know very well from our experience and the studies that we conducted across Gilenya. James Moore-Mazin, as well as Kasimta. We announced earlier in the year in 2021 that we were advancing with remibrutinib, which is our selective molecule, BTK inhibitor James Moore-Mazin, in the space. We had discussions in the middle of the year to late in the year with regulatory authorities and we've already started recruiting at the end of the year. And we know the space well. We're confident that we can recruit in the MS space and that we're excited to continue to fulfill the criteria in terms of advancing the recruitment for the MS patients for remifrutinib.

Thanks, John. Thanks, Simon. Next question, operator.

Thank you. Your next question comes from the line of Tim Anderson, Wolf Research. Please go ahead. Your line is open.

Yes, thank you for taking my question. It's Richard Wagner, Wolf Research, for Tim Anderson. My question on M&A, whether you can say definitively that you won't do larger M&A, meaning something that would be, say, $30 billion or larger. Thank you.

Yeah, thanks for the question, Richard. We don't have plans to do, quote unquote, larger M&A. Hard to sign up for specific thresholds given the dynamics in the market. But our focus is not larger M&A. Our focus is bolt-on. Bolt-on deals, most of the deals we've done, as I mentioned earlier, have been sub $1 billion upfront with payouts for the total deal value of less than $2 billion in recent times, including the four deals that we recently announced. Richard K. Dying and we continue to focus our energies, there we look at larger assets valuations are stretched expectations remain high harder to make the numbers work to create. Richard K. Value for shareholders and an attractive profile for for Novartis but we continue to set those let's call the larger bolt on deals and then beyond that we are not looking at large m&a now at this time, so next question operating Thank you Richard.

Thank you. Your next question comes from the line of Kerry Halford from Barenburg. Please go ahead. Your line is open.

Thank you very much. Question, please, on Sandoz. In your presentation, Harry, you're speaking of stabilisation in Q4, but the 2022 guidance for this division is somewhat disappointing. I wonder if you can walk us through the drivers of your guidance for operating profit decline this year Is that predominantly price pressure, more of the same, maybe disruption? Or is there some element of more investment required to see the top line of this division return to growth? I guess specifically I'm looking for what you expect to get more difficult for Sandals this year versus last, given the stabilization signs you mentioned in Q4. And then just a very quick follow-up. Can we assume the contract manufacturer revenue reclassification that you mentioned in the quarter is a one-off event? Please, thanks.

Thanks, Carrie. So maybe first on Sandoz, Richard, you want to start, and then maybe Harry can chime in if anything.

Yeah, sure. Thank you, Vance, and thank you for the question, Carrie. Yeah, as I said, we saw things returning back to a more normal state of affairs and a nice, I guess, solid performance for quarter four. As we go into 2022, I mean, we've seen good growth from the rest of the world. And really, the challenge continues to be the U.S. And that's slowly the impact of price clearly drives the issues in the U.S. We're slowly stabilizing. And so really, I see 2022 as a year where the rate of decline in the U.S. starts to stabilize, but it does drag down the overall business. Price still is a significant impact. And also bear in mind, 2022, we don't see many significant launches. It's still a fairly quiet year in terms of LOE launches. So really, the impact on bottom line is really a mixture of price and mix. And we expect that then to slowly start changing as we come out of 23 into 24 as the biologics pipeline starts to kick in again. and the U.S. continues its stabilized journey, and we see accelerative growth then in Europe and the rest of the world. Thanks, Richard.

And then Harry on contract manufacturing, and if you have any other comments on Sandoz.

You know, I think Richard said it all on Sandoz. In terms, Harry, of contract manufacturing, you know, we have reported relatively small contract manufacturing business within other revenues. And now that we may increase over the next years a little bit, that business, you know, we basically chose to change representation, split up the sales and COGS. And we also transparently show that actually on page 13 of the condensed financial report in established medicines, you see that the contract manufacturing line 108 million in quarter four which is kind of the full year 21 as we decided you know in the year that maybe over the next few years this may increase so that's why we changed that it doesn't change the full year number for the company it changes in the quarter basically by one point on the company and the two divisions and so we will you will see that as we go forward you know how this is developing And from that standpoint, we thought it's a better representation as we go forward.

Thanks, Harry. Thanks, Gary. Next question, operator.

Thank you. Your next question comes from the line of Kaya Parekh from Goldman Sachs. Please go ahead. Your line is open.

Hi. Thank you for taking my questions. Please do, if I may. First, kind of vast in your introductory comments, you spoke about your aspiration to be a top three innovator. I was wondering if you might be able to give us some more details around kind of how do you define a top three innovator? Is that in terms of number of new drugs approved? Is that commercial value of the pipeline? Just your thoughts around kind of how you define that. And then secondly, as we look forward to the phase three study readout for Iptacopan, What should be our kind of expectations around the profile for that? Should we be looking at superiority? Should we be looking at something else? Just kind of your confidence around that and where should our expectations be for that molecule? Thank you.

Yeah, thanks, here on the first one, you know, a few measures on on our minds, you know, one is the replacement power and can be a leader and consistent replacement power of our of our sales. I think replacement power and or freshness index are valuable measures of the the the power of an innovation engine to replace sales within our sector and then ultimately to grow the sales of the company. Second, we're very focused on the value per NME that we are able to deliver. Over the last five years, I've been the leading company in the sector in the number of NMEs approved, but we'd like to be the leader in the value per NME or peak sales per NME, put it another way, that we're delivering to the market. And of course, ultimately, this all leads to long-term sales growth and our ability to have an innovation engine that can drive that sales growth where we want to consistently be. But I would say replacement power and value per annum here, two high measures on our mind. In terms of the phase three profile of Iptacopan, John?

Yeah, thanks, Gare. As we look at the Iptacopan and the way that we're looking at the overall profile, obviously we're looking at the overall unmet needs of the patient. As you know, this is a factor B that is actually targeting the alternative complement pathway. We're looking at both extravascular and intravascular hemolysis for PNH in this specific indication. Also, as we think about the renal indications, we're looking at it from the standpoint of reduction in terms of proteinuria. And it could be in a couple of different ways, as we know that these patients have a significant unmet need as One, that they actually may need something more than what's the current standard of care, which is through ACE inhibitors and ARBs. So this could be a combination approach of moving forward. The second way of looking at this, not only in terms of a medical need, is also the route of administration or in terms of the convenience for the patients. As we think about the approach, many patients actually are requiring the sub-Q administration, which could take up to 60 minutes. And having an oral administration twice a day would be much easier in terms of the approach. And thirdly is evaluating the safety profile as we look moving forward. And we'll find out more about the safety profile as we read out in our studies. So that's the way that we're looking at Atacpan overall across the indications for PNH as well as C3G, IgA, and other renal indications.

Thanks, John. Thanks, Kara, for the question. Next question, operator.

Thank you. Your next question comes from Wimal Kapadia from Bernstein. Please go ahead. Your line is open.

Great. Thank you very much for taking my question. I just want to touch on PSMA. So you have an interesting readout, PSMA for potentially late 2022. How should we be thinking about the incremental efficacy versus current benchmarks? And then in particular, how should we be thinking about the pre-taxing setting from a potential perspective versus the post-taxing setting? And then just tied to that, The launch of, you know, from the vision study, is it fair to assume Lutathera trajectory is a fair benchmark, or just given prostate is a larger indication, the trajectory should look a little bit different, you know, with more sustained growth beyond the initial ramp from saturation of clinics with capability?

Thank you. Yes, thanks, Wimol. So maybe Susanna first on the overall story with Lute PSMA and the launch of the vision study, and then I'll hand it to John on the specific question. questions on pre and post-toxin. Susanna? Susanna, are you there?

Sorry, I was on mute. So Latisha has demonstrated very strong data in the metastatic castration-resistant prostate cancer population, as you know, with significant radiographic PFS and OS. So We know in this population there's basically no alternative, and lutetium PSMA has demonstrated superiority versus the standard of care. So we expect there quite big interest, and we have started managed access programs where we already see quite high demand. So therefore, when you ask me about the uptake, It will be probably steadily going up. We don't expect a big bolus. This is fourth-line prostate cancer patients. But, of course, incidence of prostate cancer is much higher than, for example, neuroendocrine tumors. And therefore, I think we see different dynamics in the uptake. Of course, it's a smaller part. It's the last line of prostate cancer. But we expect continued growth and not like a bolus and then stability. It's a very different population than prostate. than GAPNET. And maybe just a comment before I hand over to John on the setting. I mean, the current indication that we have filed for would really be in last line after androgen therapy and taxane chemotherapy. And before, of course, with the profile that we see on lutetium PSMA, we would aim to go earlier. And certainly the pre-taxane setting is one of the settings that is significantly bigger than what we have filed for in the current indication. So with that, Sean, maybe over to you, maybe a few words on PSMA4.

Sure. Happy to talk about PSMA4. Maybe to start off, just to think about prostate cancer. As we know, 80% of prostate cancers actually express PSMA. So that's a starting point in the pathophysiology. What we saw in the third line, as Susanna expressed, is we saw that we had 38% improvement in overall survival and 60% in terms of radiographic progression-free survival, as well as combination of OS. That is the starting point. We know that there are a number of patients that are in need of additional treatments, whether that's in the pre-taxane setting or in the first-line setting, especially given the toxicity of the taxanes and chemotherapy. And what we know is radioligin therapy has less adverse events than compared to chemotherapy. So we've already started recruitment in the pre-taxane study, and we're hoping to read out before the end of the year for the second-line treatment. And then we're also looking at first-line treatment in terms of hormone-sensitive population, and that study is also advancing. And in addition to those studies, we're also looking at studies in terms of – patients who have not had metastases in terms of prostate cancer. So I think this is going to be a very broad program as we move forward for lutetium PSMA.

Great. Thank you. Thank you, John. Thank you, Umal. So we have still quite a few people in the queue, so if we could try to limit ourselves to one question, we'll try to get to as many questions as possible. Next question, operator.

Thank you. Your next question comes from the line of Matt Weston from Credit Suisse. Please go ahead. Your line is open.

Thank you. My question's on Ensovipep. And Harry has asked, I'd be very interested to understand how you've integrated it into guidance. I can see from your slides that you've given it a billion-dollar unprobability-adjusted peak sales potential. And obviously, if you're able to achieve regulatory emergency use authorization, We could see significant bolus orders. And so I'd love to know what you've taken into account when you've set guidance for 2022 too. Thank you.

Yeah, thank you, Matthew. And I can take that. So we've not included in ZOVI-BEP in our guidance, any of the guidance that we've provided today. I think as we understand better, as we move through the emergency use authorization application and review process, ultimately understand FDA's decision and then the potential contracting we would have with the U.S. as well as other interested parties around the world. We've had discussions with a number of other governments around the world around the medicines, but I would say most of those governments have centered their view on how the FDA ultimately views the EUA application if they were going to make emergency orders. We think it's prudent right now not to include it, and then once we understand the dynamics better over the course of Q1, we hope, or into Q2, we would then update accordingly. Thank you. Great. Thank you, Matthew. Thank you, Matthew. Next question, operator.

Thank you. Your next question comes from the line of Richard Foster from JP Morgan. Please go ahead. Your line is open.

Hi, thanks for taking my question. So just a question on price pressure from ex-US governments, etc. I mean, they've been pretty hit by COVID and COVID expenses. After the great financial crisis, we saw some increased pressure on drug prices. You know, are we going to see something like that? Are there any murmurings from governments on pricing pressure generally? Thanks very much.

Well, I can start and say as far as my discussions have gone on with various health officials in Europe, I've heard an increased focus or shift in terms of the support for innovative medicines and enabling medicines that brought access or improved access. Certainly that's a priority for President Macron and his European Commission presidency. But maybe, Mary France, do you have any thoughts or insights on this?

Yeah, I mean, I just think in general, we always have to be prepared. I mean, we do more and more have to make the case or we see limitations on reimbursement in terms of line of therapy, et cetera, et cetera. You know, obviously we have a lot of experience and we're very used to that in the European landscape. You see a lot of tough negotiations happening in China. So I would say it's a little bit Almost like the ticket to entry is making sure that the value of our products is recognized, that we're focused on value-based pricing, which I think is something that Novartis has been very diligent about, and making sure that access is really top of mind on any strategy when it comes to product launch or making sure that more patients can reach products faster.

Terrific. Thanks very much. Thank you, Richard. Next question, Operator?

Thank you. Your next question comes from the line of Emmanuel Papadakis from Deutsche Bank. Please go ahead. Your line is open.

Thank you for taking the question. Maybe I'll take one on Inalimab and Sjogren's and the decision to progress into phase three. I guess a question around design and timing. You've published data that I would say better in patients with less advanced disease. So have you reached any decisions, excuse me, yet about the phase three design? What breadth of enrollment is that likely to include in terms of the patient population and therefore what proportion of the surrogate population, which is pretty large, that phase three trial might apply to? And then just in terms of timing, you told us that the R&D day 2026 was the likely timing for a potential phase three readout. Is there any way that could be accelerated, for example, on interim surrogate or biomarker data, since that would imply a pretty long phase three timeline. Thank you.

Thank you, Emmanuel, all very good questions. John, on Ionilumab phase three design for Sjogren's?

Yeah, as we think about Ionilumab, and as Bas said earlier, we're excited about a number of indications in Sjogren's syndrome, lupus nephritis, and SLE. Specifically, as you ask about Sjogren's syndrome, as you know, we've advanced based on results that we've seen from our Phase II study. These are patients who actually have had high SDI scores, and that's the specific population that we're targeting moving forward in this population. We are going to start recruiting patients in the second half of this year. In terms of advancing, I think the balance here is the largest Sjogren's Syndrome Phase III study that's been conducted actually I should say the largest study, not phase three, but the largest study that's been conducted has been conducted by us. And we want to ensure that there's consistency in terms of these patients that we're recruiting because Sjogren's is a very diverse population of patients. We've guided the results in 2026, and we will update as we find the patients and how recruitment goes. But we are using strict criteria for inclusion to ensure that that we get the best results moving forward. Currently, we are expecting results in 26.

I mean, I think one of the dynamics I've learned is how important it is to have well-trained centers here that really ensure that they apply the SDI and some of the other measures in a consistent way. So I think we want to be appropriately cautious on our timeline. And then, of course, as we learn more, as John said, we'll provide updates on Ionilamab across all of the indications that we take it forward in. Thanks, Emmanuel. Next question, operator.

Thank you. Your next question comes from the line of Mark Purcell from Morgan Stanley. Please go ahead. Your line is open.

Yeah, thanks for taking my question. Entresto China, can you help us understand the size, the opportunity, and hypertension, but when the LOE timing is going to kick in, and on the basis of that, you know, the pivot opportunity into the retail pharmacy setting to maintain your momentum in China, and then just to quickly, Vaz, in terms of a clarification in terms of the Sandoz considerations for counterparties. What should we expect next in terms of biosimilar data? And what are the key LOE launches coming up in 23 and beyond?

Yeah, absolutely, Mark. So first on the interest of China, Mary Frantz.

Yeah, so the opportunity certainly from a volume perspective is significant, right? So we're moving the population from 7 to 8 million heart failure patients to about 240 hypertension patients. And as I said before in my comments, hypertensive patients in China are really not well controlled. So there is a big opportunity. Obviously, there was a significant price concession as we listed NRDL, but we do think that it is a worthwhile opportunity. proposition just because there's an opportunity to just expand to such a broad, broad population of patients. So we have broadened our footprint as well. We're making the necessary investments. We also want to make sure that we have the right digital tools in place. As you know, we have a cooperation with Tencent where Um, we're looking at, of course, interest, no independent, but looking at making sure that, that, that, um, heart failure patients can, uh, be more in control of their own monitoring. So there are a lot of activities in this space, as you know, in China, CBD is a major, um, uh, you know, cardiovascular disease is a major problem with the, with the massive costs. And when it comes to, um, the, the, um, patent situation. In China, China is hard to give a definitive answer. We are obviously working to secure RDP in China, and I think that's, you know, an industry-wide initiative. So there are some question marks around until when, and certainly couldn't give you guidance on that here today. But the opportunity is significant. We're thrilled about it. This was as we said, you know, a potential upside for us, and could be up to about a third of our, let's say, growth in Entresto for this year.

Thanks, Mary France. And then on Sandoz Biosimilars' upcoming launches, Richard.

Thanks, guys. Really, the next launchers are really Adalimab and Nacilizumab. coming in, I guess, late 23 into 24. So I think I commented earlier that that's really the start of the next wave of biosimilars that should start accelerating both our top line and clearly the margin expansion from the business. I'm clear as what we'll update as we file and move those products forward.

Thanks, Mark. Thanks, Richard. Thank you, Mark. I think we have time for, I don't know how many more we have in the queue, but let's take the next question and we'll keep going until the mid of the hour.

Thank you. Your next question comes from the line of Florent Cespedes from Societe Generale. Please go ahead. Your line is open.

Good afternoon. Thank you very much for taking my question. A quick follow-up on China, please. Could you Please elaborate on beyond Entresto, which are the growth drivers there and potential risk and how you see the momentum in China. Thank you.

Mary France, you want to take that on pharma China?

Yeah, so we've got three main growth drivers for the pharma business in China, Cosentix, Entresto, and Lucentis. And all three products are showing strong growth. I mean, as we mentioned before, they were all affected in Q4, but Q4 is also normally the lowest quarter in the year for us. So we talked about the budget constraints for Cosentix. We've seen the rebound in Q1 for Entresto, the NRDO listing, and the stock compensation in Lucentis was due to COVID lockdowns. The one thing I'll say about China is that going forward and giving the fact that the country is now so open to innovation, we are now thinking about China as we think about any other country. So when we look forward at our portfolio, whether that's LECVO, we just received the launch or the approval for Cosimta, we are thinking about our portfolio in China in the same way as we're thinking about our portfolio in the U.S. and Europe. So going forward, that's what you can expect. The three growth drivers, maybe the big exception is Lucentis, which continues to be a strong growth driver for us in China. And that's where the focus is. That's where we're investing. And that's where our footprint is working.

Thank you very much. The next we'll go to, I think we have two more first time questions. Next question operator.

Thank you. Your next question comes from Peter Welford from Jefferies. Please go ahead. Your line is open.

Hi, thanks for screening me in. It's one for Harry, really, the outlook for innovative medicines. The outlook for the core operating income, mid to high single digits, is slightly above sales growth. Obviously, this year, you started similar, but you delivered close to 10%. When you can talk a little bit about what we should be thinking about the greater investments, I guess, you're making this year, that if you like, constrain perhaps the margin expansion versus the benefit we saw in 21, the result in that mid to high single digit growth, or is it just conservatism on your part? Thank you.

Thanks, Peter. Yeah, thank you, Peter. So, of course, always a fine balance, right? As we know, in pharma companies, one can get almost any kind of core margin one would like to have, but it's always this very delicate balance between investing and also driving, of course, productivity, as we do. And so, overall, we have made significant strides on the core margin improvement, as Vaas shared in one of his earlier charts. 180 basis points in 2019, 220 basis points in 2020, and then 130 basis points last year. And a part of that was also some restricted investments, if you will, due to the pandemic situation. So we always ensure that we invest appropriately in the R&D line, certainly. and we have to ensure that the launches are getting very well supported, and we have fantastic launches that Marie-Françoise and her teams are driving. So I would expect each of the next years in innovative medicines some good margin improvement, but of course not to the level we have seen over the last two or three years. So it's a balance, and the investments are clear in the pipeline, the launches. Thank you.

Thanks, Terry. And then we have time, please, Peter, last question operator.

Thank you. Your last question today comes from the line of Seamus Fernandez from Guggenheim. Please go ahead. Your line is open.

Oh, great. Thanks for the question. So just wanted a couple of pipeline questions very quickly. Just in terms of the differentiation, what makes inalienamab unique from other April bath compounds that have failed in similar type indications, particularly in lupus. I think we've seen a number of challenges there. And then just separately on ligalizumab versus remibrutinib and CSU, can you just help us understand the decision points, you know, as it relates to ligalizumab for filing? And then, you know, how, if you do launch there, you'll trade off your expectations for remibrutinib in a similar setting. Thanks.

Yeah, I think, John, if you're still there, you want to take the Ionanumab question?

Sure. Absolutely. And thanks for the question, Seamus. As we look at Ionanumab, you know, this is our anti-BAF agent, and we really see two different modes of action with Ionanumab. It's a direct lysis of B cells by ADCC as one path, and the other is BAF receptor blockade that interrupts the BAF-mediated signaling for B cell maturation proliferation and survival. So the difference here is there are dual modes of mechanisms of action versus what has been seen with previous bath receptor blockers. And what we've seen is actually this counterbalance of the two mechanisms that allows us to see. And we've actually seen good responses, as we said earlier, in our phase two studies. And that's why we're moving forward in these various indications. On your second question, I think, in terms of, go ahead, Dr. Bost.

I was just going to chime in on I think some of the competitor of historical molecules only targeted the BAF ligand and then only certain subtypes of the BAF ligand, so not completely comparable to previous results. Go ahead, John, on remibrutinib.

Yeah, so in terms of looking at remibrutinib versus legalizumab, as we look at both combinations, we've seen good results in both. And as you know, for remibrutinib for the BTK selective oral inhibitor, what we've seen is also good results in CSU with an oral compound. So as we're moving forward, we're looking at both approaches and we'll make decisions as we further analyze the results from legalizumab. And then as we move forward with remibrutinib, we'll continue recruitment in these studies.

I think, Seamus, the idea of legalism, I guess the question is there value in getting the medicine on the market ahead of the potential future launches in food allergy and Sindhu, or is that not a sensible strategic approach? And we just haven't come to a determination yet. Our current view is that we, with the superiority of the placebo, it is potentially filable and, of course, a review issue with the FDA. So we're going to make those assessments carefully and then decide what the right approach is. Very good. So thanks, everyone, for joining today's conference call. We hope it was helpful to get a perspective on both the near-term but also the longer-term outlook of the company, the pipeline, the products, and the things we're excited about. We're excited about delivering a strong 2022, and we'll look forward to keeping you up to date through various interactions and then, of course, in our next quarterly conference call. We wish you a great year, and we'll look forward to speaking to you soon. Thank you.

Thank you. That does conclude today's conference call. Thank you for participating. You may all disconnect.