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Carla
Call Coordinator
Hello and welcome to the Q1 2024 Revity earnings conference call. My name is Carla and I will be coordinating your call today. During the presentation, you can register to ask a question by pressing star followed by one on your telephone K-pad. If you change your mind, please press star followed by two. I will now hand you over to your host, Steve Willoughby to begin. Steve, please go ahead.
Steve Willoughby
Host
Thank you, operator. Good morning, everyone, and welcome to Revity's first quarter 2024 earnings conference call. On the call with me today are Prahlad Singh, our president and chief executive officer, and Max Gricojak, our senior vice president and chief financial officer. I'd like to remind you of our safe harbor statements outlined in our press release issued earlier this morning, and also those in our SEC filings. Statements or comments made on this call may be forward-looking statements, which may include, but are not necessarily limited to financial projections or other statements of the company's plans, objectives, expectations, or intentions. These matters involve certain risks and uncertainties. The company's actual results may differ significantly from those projected or suggested due to a variety of factors which are discussed in detail in our SEC filings. Any forward-looking statements made today represent our views as of today. We disclaim any obligation to update these forward-looking statements in the future, even if our estimates change. So you should not rely on any of today's statements as represented in our views as of any date after today. During this call, we will be referring to certain non-GAAP financial measures. A reconciliation of the measures we plan to use during this call to the most directly comparable GAAP measures is available as an attachment to our earnings press release. I'll now turn it over to our president and chief executive officer Prahlad Singh. Prahlad?
Prahlad Singh
President and Chief Executive Officer
Thanks, Steve, and good morning, everyone. Following the company's transformation over the last several years, today marks the fourth quarter that we have reported our results as a Revity. And in two weeks, I look forward to celebrating with my colleagues the one-year anniversary of our new company unveiling. I'm proud to look back on all that we have accomplished in such a short period of time, and I'm excited to continue to build on the great progress we have been making towards reaching our ultimate potential. We were extremely active during the first few months of the year as the team hit the ground running on a number of key initiatives on which I thought I would provide some more insight this morning. First, from a market perspective, while we have begun to have more constructive conversations with our pharma and biotech customers over the last 45 to 60 days, their actual spending has not yet begun to meaningfully pick back up. So while it is promising to see continued stability, and there are a couple of potential trends on the horizon which could turn into tailwinds, given we have yet to see a meaningful inflection in actual audit trends, we are currently maintaining our outlook for the remainder of the year. Revity's uniqueness was on display through in the first quarter as our diagnostic businesses have continued to remain strong and perform well. Our immunodiagnostic franchise, which is by far the largest piece of our diagnostic segment, is in the low double digits in the quarter. Our newborn screening business also continued to perform well with -single-digit growth overall, including double-digit growth outside of China. This helped to offset the significant declines that occurred as we had anticipated in our applied genomics business. The combination of these market environments led our performance overall to be better than we had anticipated, with our organic revenue declining 3% ahead of our -single-digit decline expectation. Given the trends we experienced over the last few months of 2023, which continued into this year, we entered 2024, accelerating our efforts to eliminate standard costs from our recent transformation and offset the return of variable expenses which were reduced last year. These cost containment efforts continued through the first quarter and will help us further optimize the organization moving forward. Our newly formed Enterprise Operations team is making good progress on leading a number of initiatives to further streamline our business in the near term, while also setting us up to capitalize on more significant internal opportunities over the coming years, such as footprint consolidation, logistics optimization, vendor consolidation, and several very intriguing insourcing opportunities. Secondly, as part of this concerted effort to reach our full potential as quickly as possible, earlier this month we realigned the management of a few of our business units. As part of these changes, I am pleased to announce that Gene Leigh, the founder of BioLegend, has now become the head of our overall Life Sciences segment. As we have mentioned in the past, we have intentionally taken a more flexible approach to the integration of our acquisitions in order to benefit from the strengths and opportunities each of them uniquely provides. With this change, we have cemented the reverse integration process we have been working through in our Life Sciences business since we acquired BioLegend two years ago. This change in leadership is part of a broader streamlining of my direct organization and builds on the recently completed successful integrations of several acquisitions, including IDS, Oxford Immunotech, and Nexelon. With these changes, we are now poised for tremendous internal collaboration and the company will be in an even stronger position to drive key initiatives going forward, including aggressively bringing new innovations to market, capitalizing on new -to-market opportunities, making consistent progress on our key areas of operational focus, and advantageously deploying new technologies. We are now able to build on the same principles of building and deploying capital both internally and externally. For example, these organizational changes are intended to build an even stronger connection between our Life Sciences, Revity Omics, and Diagnostics businesses. I look forward to continuing the invaluable partnership Gene and I already have built, as well as seeing the further progress that I expect will come from this evolution. From a financial standpoint, a strong focus on expense management during this current period of softer market conditions led our adjusted operating margins in the first quarter to be 25.5%, which is approximately 100 basis points above our expectations. We are making good progress in a number of areas, and I expect our margins in both our Diagnostics and Life Sciences segments will continue to improve over the remainder of the year. The improvement in our Diagnostics margins will be a key factor in the years to come, as we look to achieve our 75 basis points of annual margin expansion once organic revenue growth normalizes. Despite already having near industry-leading operating margins for the company overall, in just our first year as Revity, it has been great to see the successful impact our actions over the last few quarters are already having. I am confident in our ability to drive additional margin improvement over both the remainder of this year and in the years to come. Now that the majority of our divestiture and rebranding activities are behind us, I was also very pleased to see that our cash generation performance was again quite strong in the first quarter of the year. During the first quarter, we generated over $130 million of free cash flow for the second quarter in a row. While the first quarter of the year is typically the lightest from a cash flow generation standpoint, it was great to see such strong performance this quarter. This is a testament to the keen attention being paid by the team on all things that impact our cash flow, such as purchasing an inventory, improving collections, strong management of our payables, and an otherwise tight focus on our spending. We expect these positive cash flow trends to continue over the remainder of the year and be supplemented by additional meaningful inflows related to the divestiture that are due to us in the coming months. In addition to our better than expected financial performance in the first quarter, we also had an extremely robust first few months from an innovation perspective. Starting in our Revity Signals software business, we launched three new SaaS-based offerings, two of which Signals Clinical and Signals Synergy. These offerings enter us into new adjacent markets for which we have not previously served. Our Signals business is off to a strong start this year by growing a better than expected high single digits in the first quarter and is well positioned to continue to perform well, both from a financial standpoint and an innovation standpoint over the remainder of the year. Also, software related, we launched our Next Generation Sequencing Solution for newborn screening during the first quarter. This new optimized RUO workflow will build on our already strong market leadership position in newborn screening as the technology continues to develop. One initial success story of this offering is our recently announced collaboration with the large nonprofit research institute, RTI, whereby their groundbreaking early check research study for newborn screening will benefit from Gravity's genomic sequencing capabilities starting in May. These are the types of cutting edge collaborations with the world's leading scientists that Revity excels at. Finally, we again had a strong quarter of innovation in our Life Sciences Reagents business. As our GMP Reagent Capacity expansion begins to fully come online, we launched a number of new GMP recombinant proteins in addition to several products incorporating our new Next Generation UV dyes. I am also proud to announce that our BioLegend business was awarded several grants from the Michael J. Fox Foundation to become one of their main partners in helping to commercialize the profound scientific breakthroughs on Parkinson's disease that their impactful work is producing. So in closing, now that we are almost at one year since becoming Revity and having already crossed over the first anniversary of completing our significant divestiture, with those time consuming activities now largely behind us, I see every day how the company is beginning to hit its stride. We are making more profound advancement in our operating structure and our -to-market strategy. This will both enable us to properly weather the current industry environment as well as set us up to accelerate our financial performance as more normalized demand returns, hopefully starting in the second half of this year. I wanted to share that we plan to provide additional insight on our significant potential and the progress we are making at an investor day. We will host this November, both in person and virtually from a BioLegend campus in San Diego. We look forward to being able to provide an even deeper dive on our key operational initiatives and the status of the transformation that has already occurred. We also plan to share more perspective on our new product pipelines and key strategic partnerships, as well as how our capital deployments both internally and externally over the last few years have set up the company for consistent industry leading financial performance in the years to come. We will communicate more details on this event in the coming months, but wanted to put it on everyone's radar screen now. With that, I'll now turn the call over to Max.
Max Gricojak
Senior Vice President and Chief Financial Officer
Thanks Prahlad and good morning everyone. During the first quarter, we continue to execute at a high level despite the continued challenges in the pharma biotech industry. As we face these headwinds, the strength of our immunodiagnostics, newborn and software businesses allowed us to exceed our organic revenue expectations and also overcome some incremental FX pressure. As we've been discussing over the last several quarters, during this period of software pharma and biotech spending, we have had a concerted effort on controlling those items that are more directly within our control, specifically our operational efficiency and our cash flow generation. It was great to see both of these focus areas really performing well in the first quarter, with our adjusted operating margins of 25.5%, being approximately 100 basis points above our expectations, and 132 million of free cash flow being well over 100% of our adjusted net income in the quarter. As I begin to walk through our financials for the quarter, I wanted to remind everyone that 2023 revenues related to COVID were de minimis, and as such, we will no longer be referencing non-COVID revenue. Instead, I will focus my commentary and our disclosed results solely on our organic performance. Overall, the company generated total adjusted revenues of 650 million in the quarter, resulting in a 3% decline in organic revenue, which was above our expectations. FX was a modest -over-year headwind, roughly 100 basis points worse than we had assumed, and we again had no incremental contributions from acquisitions. As it relates to our P&L, we generated .5% adjusted operating margins in the quarter as we continue to focus on controlling our operational costs, while accelerating the elimination of divestiture-related stranded costs, leading to stronger margins this quarter. We incurred a favorable pricing impact of approximately 100 basis points in the quarter, and we continue to expect at least 100 basis points a favorable price annually going forward. Looking below the line, we had adjusted net interest and other expense of 11 million and an adjusted tax rate of 22.2%, both in line with our expectations. With an average diluted share count of 123.5 million for the quarter, this resulted in adjusted EPS in the first quarter of 98 cents, which was 5 cents above the midpoint of our expectations. Moving beyond the P&L, as I mentioned, we generated free cash flow of 132 million in the quarter. I am encouraged by the strong cash performance and diligent execution across all teams. We expect this momentum to continue, given our recent AI-driven cash collection investments and an increased focus on inventory management. In addition to this internally generated cash flow, we are anticipating some divestiture-related outflows from last year to be reversed and returned to us in the coming months, further strengthening our balance sheet. As for capital deployment, we remained active in the first quarter. We repurchased $11 million of shares in the quarter and remained active in evaluating potential inorganic opportunities that are of interest to us. As a reminder, we continue to hold a significant amount of U.S. Treasuries, which are term-matched to the remainder of the $800 million bond we have coming due this September. We finished the quarter with a net debt to adjusted EBITDA leverage ratio of 2.7 times. I will now provide some commentary on our first quarter business trends, which is also included in the quarterly slide presentation on our Investor Relations website. The 3% decline in organic revenue in the quarter was comprised of an 8% decline in our Life Sciences segment and 1% growth in diagnostics. Geographically, we declined in the low single digits in the Americas, declined in the mid-single digits in Europe, and declined low single digits in Asia, with China declining mid-single digits. From a segment perspective, our Life Sciences business generated adjusted revenue of $303 million in the quarter. This was down 8% on both a reported and an organic basis. From a customer perspective, sales to pharma biotech customers declined in the low double digits in the quarter, while sales to academic and government customers declined low single digits. Our Life Sciences instrument revenue was down mid-teens in the quarter, and our reagents, technology licensing, and specialty pharma services revenue declined high single digits. We saw delays in our pharma customers finalizing their budgets for this year, and continued lower overall lab activity levels. As Prahlad mentioned, while we now do have more insight into what customer's budgets look like for this year than we did 90 days ago, and are observing pockets of more favorable trends, we have not yet seen this result in a meaningful improvement in underlying order rates outside of normal seasonality. Our Signal Software business grew high single digits in the quarter, which was a bit ahead of our expectations. We continue to have very strong growth in our SaaS offerings, which bodes well for the long-term potential of this business, especially as we continue to bring new SaaS offerings to market as we have demonstrated with our multiple launches so far this year. In our Diagnostics segment, we generated $347 million of adjusted revenue in the quarter, which was flat on a reported basis and grew 1% on an organic basis. From a business perspective, our Immuno Diagnostics business grew in the low double digits organically during this quarter. This consisted of high teams organic growth in China and high single digit growth outside of China. The strong performance marks another quarter of above market growth, which is driven by the uniqueness of the markets we play in, as well as capitalizing on our strong menu and geographic expansion opportunities. Our Reproductive Health business grew in the low single digits organically in the quarter. This was driven by stabilization in our Rebiddy Omics Lab business, as it has now anniversary the contract completions and new project delays which pressured growth last year. Our Newborn Screening continued to perform well and grew in the mid single digits in the quarter globally. Finally, as we had expected, the pressures our Applied Genomics business experienced in the latter half of 2023 continued into this year, resulting in this business declining in the mid-20s year over year. Critical customers continue to absorb the instrumentation they purchased for COVID testing, and our pharma customer spending remains subdued. We expect our Applied Genomics performance to improve as the year progresses, and we continue to expect a high single digit decline in the business for the full year. As it pertains to China specifically, as mentioned, our revenue in the country overall declined in the mid single digits year over year, which was in line with our expectations. This consisted of a high single digit decline for diagnostics in the quarter, with high teens growth and immunodiagnostics offset by a significant decline in reproductive health. Our Chinese Reproductive Health business faced incremental headwinds as birthrates came under more pressure related to the COVID lockdowns ending and the impact from the reopening wave. Our Life Sciences business in China declined mid single digits, which was slightly better than we had anticipated. While there has been talk regarding additional stimulus which could impact our industry, at this point we have not yet seen this show up in orders. Consequently, while we are ready to capitalize on any opportunities that could arise, we are remaining cautious as it pertains to our assumptions on the potential impact to our business this year. In regards to our outlook for the remainder of the year, we are encouraged by our Q1 results, but are maintaining our full year assumptions which includes organic growth in the -3% range. While feedback from our pharma partners is now more constructive, these insights are leading us to assume that the softer end market environment that we have experienced over the last 6 months will continue. Given how dynamic things have been, we will want to see clearer signs of recovery before potentially making any adjustments to our outlook for the remainder of the year. As a result, we expect the company won't return to positive organic growth until the second half of this year as we expect our organic revenue to decline in the low single digits in the second quarter. Given the increased fluctuation in currency rates over the last few months, we now anticipate effects to have a neutral impact to our revenues this year, down from our previous 1% tailwind assumption. This results in our full year revenue now expected to be in the range of $2.76 to $2.82 billion. Moving down the P&L, we continue to expect to hold our operating margins this year roughly flat at 28% as our recent cost actions are offsetting the return of some variable expenses. We continue to expect our operating margins to be fairly similar in the second and third quarters and slightly below our full year average before improving sequentially in the fourth quarter. Below the operating line, we now expect a few moving pieces which largely offset each other. First, we now expect our net interest and other expenses for the year to be approximately $60 million, down $10 million from our prior outlook. However, this will be offset by a modestly higher than expected tax rate, which we expect to still round to approximately 20%. Our average diluted share count we still assume will be 123.5 million shares this year. For the second quarter specifically, we expect our below the line items to be similar to what we have just reported in the first quarter. This results in our adjusted EPS guidance for the remaining unchanged in the range of $4.55 to $4.75 as the $0.05 outperformance here in the first quarter is largely being offset by the increase in the net interest. This is the increase FX headwinds we are now facing. In closing, the company has performed well over the first several months of 2024 despite a continued challenging end market. We did a great job executing on those items that are more fully in our control, such as managing our expenses and driving strong cash flow. When combined with our success in bringing significant innovations to market, the improvements we have made on both our transformation initiatives and key processes across our organization are positioning us extremely well to deliver differentiated performance in the years to come. With that, Operator, we would now like to open up the call for questions.
Carla
Call Coordinator
Thank you. If you'd like to ask a question, please press star followed by 1 on your telephone keypad now. If you change your mind, please press star followed by 2. When preparing to ask your question, please ensure your device is unmuted locally. Our first question comes from Michael Riskin from Bank of America.
Michael Riskin
Analyst at Bank of America
Great. Thanks for taking the question. I want to ask one big picture one sort of qualitative and then I'll follow drill in with a little bit more specific. In terms of how the quarter played out, it seems like there are still a decent number of surprises. You talked about reagents coming out a little worse, farm and biotech being a little bit worse, but then China was a little bit better, Diagnostics was better. It just seems like there was a lot of moving pieces. I know we're still operating in a pretty volatile and market environment, but how do you feel about your confidence in terms of predicting growth going forward in terms of the visibility? Is this something that you anticipate will improve? Is this just is this temporary or is this a little more inherent to the business mix as it is?
Prahlad Singh
President and Chief Executive Officer
Good morning. I think it's a great question. As both myself and Max said in our prepared remarks, you know, overall, I would say that the market has stabilized. You know, obviously, our diagnostics business has done, you know, continues to shine in light of that. But you've got to break it down into pieces. You are right on the reagent side, you know, the life sciences, but we had some licensing calm. Which pressured things, but excluding that, our core reagents were down only with single digits. We did see a slower start to the year as customers delayed their finalizing their budgets and lab activity that continues to have some pockets of volatility. You know, however, given the trends that we have seen now in March and so far here in April, you know, we feel much more optimistic and have not changed our assumption for the full year and continue to expect core reagents to be up in the mid single digits. On the diagnostic side of the business, yes, newborn screening was pressured in China, but outside of China, newborn screening actually grew in the double digits. You know, software business continued to be better than our expectations. So I think all in all, you're right that there are quite a few moving pieces, but I, you know, as you said, at a high level, the differentiation of our portfolio actually shines in markets like this, where there is pressure someplace else, something else picks it up. So overall, we feel pretty good about where we are.
Michael Riskin
Analyst at Bank of America
Okay, thanks. That's helpful. And then the follow up, I do want to drill in exactly into that life science business, the reagents, pharma and biotech. I mean, there's a lot of overlap between that, but it seems like that was an area that was a little bit weaker than you thought. And it sounded like it was a little bit weaker than what we've seen from some of your peers reporting. Your mix is a little bit different there. I mean, biolegend alone is a good chunk of that reagents business. But anything in particular you want to call out there, you know, you talked about the licensing comps. Could you provide some clarity on that? How that's going to phase as you go through the rest of the year? And just what gives you confidence that that business can reaccelerate pharma, biotech and reagents specifically?
Max Gricojak
Senior Vice President and Chief Financial Officer
Thanks. Yeah, hey, Mike. I mean, I don't have too much for that add on to what Pallada already mentioned. I guess if you were to break it down a little bit further, you know, if you look at our performance of the reagents between academic and government and pharma biotech, academic and government still grew in the quarter for us from a reagent business. So, I think from a reagent perspective, which is predominantly the biolegend portfolio, I think when you look at pharma biotech, it really goes back to some of Pallada's comments around it was just a slower overall start for the year. We have seen good progress through March and April, and we're confident in our full year outlook. Okay, thanks.
Carla
Call Coordinator
Our next question comes from Max on Goldman Sachs.
Matt
Analyst at Goldman Sachs
Good morning. Thanks for my questions. Pallada, maybe a big question for you on capital allocation. If you kind of look back to over the past couple years, the acquisitions that you've made, that you're now integrating, given what you know now about the environment, both on capital equipment and just pharma biotech, is there anything you would have done differently in terms of those acquisitions to position the business? Or do you feel like the business position is going to be more of a macro-related issue? I think the acquisition today is just a macro-related issue and that they should start outperforming going forward.
Prahlad Singh
President and Chief Executive Officer
That's a good question, Matt. I mean, I think if you look at the acquisition that we did, majority of our acquisition were in life sciences, reagents related to biomolecules and large molecules and cell and gene therapy. And I think the longer term trend that if you look in the marketplace, that is where a majority of the investment is going to go. As you pointed out, there are some headwinds in the market right now, but we are very confident in our strategy about the acquisitions that we have made. Again, going back, what it has done is it has put us in a place where 80% of our revenue is coming on a recurring basis. Life sciences, software, and even the diagnostics area where we play, we have a portfolio that we feel is very differentiated and I think it is going to serve us well.
Matt
Analyst at Goldman Sachs
Got it. Thank you for that. And then if I could just kind of understand a little bit better the dynamics behind the instruments. I know that in life sciences, mid-teens decline might have been a little bit better than expectations, but could you just characterize instrument demand, whether it is in life sciences or applied genomics, in terms of the stabilization that occurred during Q1 or did things actually incrementally get worse in terms of demand and what is your understanding of that? And then I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question.
Max Gricojak
Senior Vice President and Chief Financial Officer
I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I think that is a good question. I'm interesting because given what we've seen today, what you've seen in the past, what is happening globally, isn't it in accepted as well
Matt
Analyst at Goldman Sachs
as in close distance? Great. Thank you very much.
Carla
Call Coordinator
Our next question comes from Patrick Donnelly from CT.
Patrick Donnelly
Analyst at CT
Hey, guys. Thanks for taking the questions. Perlotte, I just want to follow up on Mike's question there on the reagent piece. Can you talk a little bit more about what you saw in the quarter, how things trended, specifically on biolegends, just what the growth was there, and then what the expectations are on 2Q? I know you called out the licensing headwind in 1Q, just trying to get a sense for what this business could look like 2Q and going forward as we work our way through the year here.
Prahlad Singh
President and Chief Executive Officer
Yeah, Patrick. Good morning. I mean, again, starting with, as I said earlier, right, to Mike's question, we expect our core reagents business to be up mid-single digits for the year. And I think also, you know, the trends that we saw in March and April make us optimistic to keep that profile. As I mentioned, you know, we had licensing comms which pressured this, excluding that the reagents were down mid-singles. I think the way I would take it is that, you know, some of the budget finalization that happened with our PharmaBioTech customers, typically they would happen in December. But I think that sort of bled into January, and the release of the budgets happened a little later into the year than as it typically happens. And I think that's where we saw some initial volatility. But again, March and April, it has come back to where we would have expected it to be. Hopefully that gives you a bit of a flavor of how we relate that.
Patrick Donnelly
Analyst at CT
Okay. And just maybe the trend on how to think about it for 2Q in the year.
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, for the second quarter, Patrick, we do expect the core reagents business to return to positive low single digits growth in the second quarter. And then in order to get to the mid-single digits growth for the full year, you can do the math in the back half.
Patrick Donnelly
Analyst at CT
Yep, perfect. And then maybe just quickly on the biopharma conversation, we've seen some firming up in the last two months, viewpoint per lot. Yeah, have you seen this before in the last year and a half? I'm just wondering if you've seen some false starts where things sound good and then they tighten back up, or is this one of the more encouraging signs you've seen over the past few quarters and you feel that visibility is improving? Thank you.
Prahlad Singh
President and Chief Executive Officer
Yeah, Patrick, I think there is more solidity to the conversations, and I think that's a more encouraging trend than what we have seen earlier. But as Max said earlier, I mean, they haven't yet converted into orders, so it's not really at a point where we can say there's an inflection. But I think the discussions are much more solid and much more prolonged. So that's probably a flavor around what the encouragement that we have on the other trend for the life sciences instrument side.
Carla
Call Coordinator
Our next question comes from Andrew Cooper from Raymond James.
Andrew Cooper
Analyst at Raymond James
Hey, everybody. Thanks for the questions. Maybe just first, you had a lot of news in terms of software in the quarter. Maybe just high level, you know, how big do you think that business can get over the next few years and how much of that growth relies on sort of additional new rollouts versus what you've seen in terms of how long out there in the market today in terms of getting to that long-term.
Prahlad Singh
President and Chief Executive Officer
That's a great question, Andrew. I think we are very positive on our software signals business. And as you pointed out, we had several launches in the year. And I think as I've said earlier, the product launches that happen in our software business are a direct correlation of the user group and voice of customer meetings that we have at least twice a year in different continents. So basically it's direct output of what our customers asks are. And that's why there is a solid trend related to it. You know, the expansion that we had with signal clinicals, it takes us outside of the preclinical environment to support customers on the analytics and the data that is generated from clinical trials. In addition, these are SAS only. So that gives a more longer-term certainty around the revenue. And we've seen good initial traction with that. Similarly, on signal synergy, which was launched in mid-April, that connects the data back for our customers between the pharma and the CRO. Again, this is something that I've talked about earlier. There is always one of the biggest needs for our pharma customers is the unstructured form in which the data comes through. This product helps them transfer unstructured data, provide the analytics and visualization that our customers are looking for. So, you know, pretty promising launches. And I think there will continue to be launches that will come through from our signal portfolio simply because we have taken a modular approach as to how to bring our product profile into the customers.
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, I think if you look at it long-term, Andrew, I think we've already come out with the LRP growth assumptions for our software's business. It's high single digits to low double digits growth per year. It's what we are expecting here in 2024. And so depending on how long you're trying to model out, you can get to how big this business is, given that it's, you know, roughly a $200 million business for us today.
Andrew Cooper
Analyst at Raymond James
Fair enough. That's super helpful. Maybe just one kind of on some of the numbers here. You know, you called out free cash flow normally weakest in the first quarter, but obviously pretty strong here. We know there's some divestiture kind of inflows that are a little bit more one-time in terms of not repeating in 25 maybe. But should we think about higher each quarter for the rest of the year from here and maybe on a normalized basis? Is that same seasonality still what we should expect on a go-forward basis as well?
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, look, I mean, from a cash flow perspective, there will always be some quarterly notes to some extent just given business activity. I think as you look at this year, though, you know, the second and third quarter, I would anticipate to be probably lower than the fourth quarter, but we're still maintaining our overall expectation this year to be greater than $475 million of free cash flow conversion. Okay,
Andrew Cooper
Analyst at Raymond James
great. Thanks for the time, Mike. Thanks for the time. I'll stop there.
Carla
Call Coordinator
Our next question comes from Josh Waldman from Cleveland Research.
Josh Waldman
Analyst at Cleveland Research
Morning. Thanks for taking my questions, one for Max and one for Lod. First, Max, can you talk a bit more on the drivers to the out margins coming in better than expected? I mean, it sounds like it was supported by cost efforts and I assume organic upside. I'm curious, you know, how much of the cost benefit was one time in nature? And I guess what would you need to see to start to pull up your margin outlook either for the year or longer term?
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah. Hey, Doug. So, you know, I think if you look back at what we had mentioned, you know, for the outlook for this year, we had mentioned that from a margin profile perspective, our operating expenses for the full year were going to be very similar kind of quarter over quarter off of our Q4 exit. And that's kind of what you saw here in the first quarter. And again, that's just a function of us taking permanent cost reduction actions to offset the variable expenses that we knew would be coming back this year. And so I don't think that outlook has changed. Where the upside was in the first quarter was really more on the gross margin side. Again, as you look at the seasonality or I guess the phasing over the rest of the year, the gross margin rate will uptake as we go throughout the year based on volume, which is what gets you to that then 28% operating margin for the full year. And I think when you look at in terms of what could push us above the 28% for the full year, it's going to be a combination of, you know, just better volume or on the gross margin line. Again, as our operating expenses will be relatively flat over the course of the year.
Josh Waldman
Analyst at Cleveland Research
Got it. Okay. And then, Prahlad, a couple on China. Within the life science segment, you know, curious any trends you've seen positive or negative on the reagent side as the quarter played out and then here into April. And then within the instrument, curious if you've seen any, you know, sign of stimulus showing up in the funnel or customer activity. And then I guess lastly on the diagnostic side, you know, curious if there's any change in how you're thinking about China DX for the year. And then within that, any change to what you're seeing from a pricing dynamics, you know, any anything like VVP or local competition showing up or is pricing in China been fairly stable?
Prahlad Singh
President and Chief Executive Officer
I'll try to remember all four or five of the questions that you had in there, Josh. I think the region side played out. I think the reagent side pretty much played out on the life sciences side as we had expected. And to your second question around the stimulus, you know, as some of our peers have mentioned, there has been talk and discussion about it, but that's not something that we are thinking or assuming in any of our assumptions so far. On the diagnostic side of the business, you know, as we pointed out earlier, you know, we are going to continue to have some volatility related to VVP and the price declines that we have laid out that is assumed in our LRP. On the reproductive health side, you know, as we mentioned that both trades declined more than 20% in the latter half of 2023. So we do expect that softness to continue through QQ. But as most of you know, we expect that to change in the second half of the year, given that it's the year of the dragon in which we have traditionally seen a noticeable increase in the number of babies born. It's run through the first quarter of next year. And, you know, to some extent we have already started seeing some signs of this occurring from our prenatal business in China. So there is an indication that the birth rate trend in China is going to, you know, is going to improve a bit in the second half of the year. I think I caught most of them. Yeah,
Max Gricojak
Senior Vice President and Chief Financial Officer
maybe just one other piece to add just I guess from an overall numbers perspective. Our outlook on China for the full year has not changed. Again, the first quarter was mostly in line with our expectations. And for the full year, we are assuming China to be roughly flat for the full year. So there's no change to that assumption.
Josh Waldman
Analyst at Cleveland Research
Got it. Okay. I appreciate it, guys.
Carla
Call Coordinator
So that's our next question. Our next question comes from Doug. It's Kale-Kale from Wolf Research.
Kale-Kale
Analyst at Wolf Research
Hey, good morning, guys. Thanks for taking my questions. Just a couple quick cleanup questions on guidance. I just want to make sure we understand all the moving parts. So just starting on revenue, you reiterated full year organic revenue guidance and Q2 was guided about as expected. Yet you acknowledged biotech and pharma demand has yet to rebound as maybe hoped. So I think that's a relative bad guy. What's the good guy specifically? What's getting better than what you expected relative to where we started the year? And then turning to margins, coming into the year you had guided Q2 and Q3 operating margin to be about in line with the full year guidance target. I think you actually said Q2 might be even a little bit below that. Just doing the math there, I think it implies Q4 operating margin will be in the low 30s. I get to 31%. Is that math right? And if so, can you just help us with what makes you confident in that type of ramp given we're starting at 25.5 coming out of Q1?
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah. Hey, Doug. So I'll work backwards through your questions there, so maybe starting on the margin one. You know, I mentioned it to Josh's question earlier. But really the margin story or assumptions we had coming into the year are unchanged. Operating expenses are going to be flat, and as we move throughout the year, it is just a volume dynamic moving up our gross margins percentage. In terms of the quarterly phasing that you had mentioned, yeah, that's probably about right if you do modestly lower second and third quarter operating margins. That would imply a fourth quarter. That's around 30.5%, 31% OM. And again, that's kind of consistent with our business practice and our business seasonality as the volume steps up sequentially as you go throughout the year. I think when you look at it on an organic growth perspective, you know, I think to maybe use your own words, yeah, we were, everyone was hoping that, you know, margins had recovered, or no, excuse me, the markets had recovered more strongly here in the first quarter. But that's not what our guidance had assumed. Our guidance had actually assumed that it was a relatively stable, consistent outlook from what we saw in the fourth quarter, which is what played out here in the first quarter and we expect to play out for the rest of the year. So I don't know that it necessarily got worse in terms of what our guidance assumptions were.
Kale-Kale
Analyst at Wolf Research
Okay. That's super helpful. And one I think somewhat related follow-up, applied genomics. I think that accounts for roughly a quarter of diagnostics. Hopefully I'm not too far off there. That was down, I think, mid-20s in the quarter. If it weren't for that headwind, I think that means diagnostics would have grown, you know, 5, 6% mathematically. As we kind of think about things getting better as the year progresses, my guess is that's a big part of the math that makes you feel better about an acceleration in the second half of that business, essentially just annualizing some of the headwinds that you're fighting through right now, specific to applied genomics. Is that right?
Max Gricojak
Senior Vice President and Chief Financial Officer
That's exactly right. And I would say as we get going throughout the rest of the year for applied genomics, it will improve from the first quarter. The fourth quarter will be its worst performance from an overall organic growth perspective. But when you look at multi-year stacks, although it's still improving, you know, in a discrete organic growth for the second through fourth quarters, the multi-year stacks we are actually assuming a little bit slower than the multi-year stack we had in the first quarter, which gives us confidence in terms of the rebound for that business for the rest of the year.
Kale-Kale
Analyst at Wolf Research
Okay. Thanks again, guys.
Carla
Call Coordinator
Our next question comes from Vijay Kumar from Evercore.
Vijay Kumar
Analyst at Evercore
Hey, guys. Thanks for taking my questions. Just on the second quarter, I think you mentioned organic is down low singles. And I think variations are expected to be up. So what drives the low singles, right, if reagents improve sequentially? Is there some kind of VBP impact? Like when is VBP supposed to hit? Did we see any impact in Q1?
Prahlad Singh
President and Chief Executive Officer
You know, Vijay, I think, you know, on the VBP question, what we've said, we've assumed, you know, what single-digit price declines on an annual basis. And that's what we continue to see. So it's not a sudden swing that we are seeing, but we're just seeing a leak on the price, on the pricing. And that's what we've assumed and what we've shared earlier. You know, I think, you know, if the life sciences reagents are going to improve sequentially from the Q1 to Q2, the instrument side of the business is still pressured. And I think that's what's assumed in our low single-digit guidance, and hopefully it will be better.
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, I think maybe just to add more specifics to it, Vijay, in terms of what is changing Q1 to Q2. To your point, reagents will get a little bit better, as will applied genomics for my response to Doug. You know, really what we're not assuming repeats in the second quarter, I think, is the robust growth we saw in both the newborn business and immunodiagnostics outside of China. They both continue to grow, you know, low double digits, mid-teens, respectively. And so I think we're just being a little bit more conservative in the assumptions for those in the second quarter.
Vijay Kumar
Analyst at Evercore
Understood. And then a follow-up to that, Max, on this China down mid-singles in Q1. Sorry, did we see that 500 basis points of pricing pressure in Q1, or is that something that's supposed to come in a back half? And I think your guidance for China is up low singles for the year. So what drives that back half? Is that just a comp issue or perhaps, you know, timing of VVP?
Max Gricojak
Senior Vice President and Chief Financial Officer
No, I mean, I don't think there's discrete quarterly timing around the pricing there, Vijay. It's kind of a consistent pricing headwinds that we face over the course of the year, so I don't think there's anything specifically there to call it from a quarter perspective.
Vijay Kumar
Analyst at Evercore
Understood. Thanks, guys.
Carla
Call Coordinator
Our next question comes from Jack Meehan from Neffron Research.
Jack Meehan
Analyst at Neffron Research
Thank you. Good morning. I wanted to ask about pharma and biotech, maybe to a different lens. I know you're not seeing improvement in orders at this point, but is there any commentary you can share across the different businesses? I'm curious if some of the more production-oriented businesses like parts of Horizon Discovery or Sirion are doing better than the lab-oriented areas.
Prahlad Singh
President and Chief Executive Officer
Good morning, Jack. I think I would say that, you know, we see maybe from a general commentary perspective, the pressure is still more on the higher ticket items, you know, probably not as much on the lower ticket items. So, again, it continues to be a capex story around instrumentation, and I think that's where the pressure was assumed, and that continues to be there.
Andrew Cooper
Analyst at Raymond James
Okay, got it.
Jack Meehan
Analyst at Neffron Research
And then I was just curious, operationally with Spotfire, I know there was some disruption that was caused back in March. How are things going there? I know it's a small business, but just has the customer impact. How's that going?
Prahlad Singh
President and Chief Executive Officer
Yeah, I mean, you know, Jack, as you know, and as we have reported, we quickly got an injunction or received an injunction which essentially maintains the previous status quo as the litigation plays out. You know, to your point, any initial customer inquiries and questions have died down significantly. And, you know, at the end of the day, we still have an agreement in place into the next decades with renewals beyond that.
Jack Meehan
Analyst at Neffron Research
Excellent. Okay, thank you.
Carla
Call Coordinator
Our next question comes from Katherine Schulte from Baird.
Katherine Schulte
Analyst at Baird
Hey, guys, thanks for the questions. Maybe just one more on pharma. Last week Roche mentioned that it had removed about 20% of the molecules in its pipeline over the last three quarters, and that doesn't seem like a dynamic that's been unique to them. So, guys, where do you think we are in this pipeline reprioritization across large pharma, and when do you think the dust settles there?
Prahlad Singh
President and Chief Executive Officer
Yeah, good morning, Katherine. I think the pipeline realignment is happening, and it will continue to happen. I mean, from our perspective, just as we look at preclinical research and discovery both on the small molecules and on the biomolecule side, and as I have pointed out, the funnel has to be broad enough at the beginning for it to narrow down. I think, you know, as they realign their portfolio, they will continue to optimize, you know, cost measures as they go further into development from preclinical research and into clinical. But in order to get into development and clinical, they have to have a broad enough funnel. So I think mid to longer term, we don't see that having much of an impact on our business. I think the key will be how do we continue to help our pharma biotech customers continue to optimize and make it more efficient for them to bring candidates from discovery into development.
Carla
Call Coordinator
Okay,
Katherine Schulte
Analyst at Baird
and then could you just talk through your expectations for pharma and biotech for the second quarter? And when do you think we could see a return to growth in that end market?
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, as a reminder, too, we don't necessarily give outlooks on an end market basis. And so, look, I think as you can hear from our sentence, assuming a general change in the overall end market for pharma biotech as we go throughout the course of this year, so that's probably the best insight I can give you on that question. Great,
Carla
Call Coordinator
thanks. Our next question comes from Don Brennan from TD Colon.
Don Brennan
Analyst at TD Colon
Great, thank you. Thanks for the questions. Maybe just on the immunodiagnostic solid first quarter, again, comps do get more difficult as we go through the year. Can you just walk us through maybe the Q2 expectation and the outlook for the second half and anything we should be considering, anything notable, whether it be new products or pricing that support the outlook?
Max Gricojak
Senior Vice President and Chief Financial Officer
Yeah, I think as we look at the outlook for IDX, to your point, it was another strong first quarter here. We continue to expect the business to continue to perform well, even both in China for the rest of the year as well as outside of China. And so our expectation is that for the business for the full year, it's still going to grow in the high single digits. Its multiyear stacks are still in line with our LRP, and it's really a combination of both the geographic expansion of our immunodiagnostics portfolio, but then also the wave of innovation and menu expansion that we've been driving for the past couple of years.
Prahlad Singh
President and Chief Executive Officer
And just to add to what Max said, the US continues to also be a very good growth driver for us for the immunodiagnostics business. I know we tend to talk about China, but the US for us is probably the fastest grower for our immunodiagnostics business.
Don Brennan
Analyst at TD Colon
Got it. And then maybe just one on costs. You had a lot of comments in the prepared remarks on new programs it sounded like or maybe some emerging programs to take costs out. Talked about stranded costs. Can you just elaborate a little bit? Like it sounds like maybe those impacts are going to come after 24. Maybe we'll learn more at the investor day, but just kind of any impact in 24 baked in from some of these additional focus on costs, and if not, kind of how do we think about the magnitude of upside beyond? Thanks.
Max Gricojak
Senior Vice President and Chief Financial Officer
Yes, a great question. So I would say from a cost perspective and really our operating margin initiatives, there is the short term and the long term bucket. I think when we've talked about short term really for 2024, it's the structural actions we've been taking to remove the stranded costs really in relation to our SG&A functions. And so that has worked, has already mostly been done in the fourth and first quarter here. It's baked into our assumption for the full year. I think then when you look at it long term, you know, it's a lot of the topics that we had mentioned in our prepared remarks this morning really around, you know, insourcing, freight lane optimization, vendor consolidation, rooftop consolidation. And so those will continue to be areas that we're focused on executing over the next couple of years. It's part of our playbook for our LRP operating margin expansions. And so that's really probably the way I would think about those two different cost actions.
Vijay Kumar
Analyst at Evercore
Got it. Thank you.
Carla
Call Coordinator
And our final question comes from Luke. Sarah Gots from Barclays.
Sarah Gots
Analyst at Barclays
Great. Thanks for the question. I just want to follow up a lot on what you just talked about from the US and IDX being the fastest grower. I mean, this has kind of been the long term thesis here on Euro moon in general. And so can you just talk about what's driving the accelerated growth here? You know, how big the US is now as a region for Euro immune? And do you guys think that you are close to the critical mass when thinking about the menu or the menu expansion needs to really start to drive share gain here?
Prahlad Singh
President and Chief Executive Officer
Good morning, Luke. I think, you know, if you look at our immunodiagnostics business in the US, you know, it is grown at a 20% cagger since the acquisition. And I don't think we have, you know, really gone to where we would say that we have reached close to critical mass so that it would plateau out. You know, it's gone from being 5% to nearly 15% of our overall immunodiagnostics business. But there is still a lot of, you know, a lot of growth that we have to cover in the US. And I would say that we are still in the early phases of growth that this business is going to see over the next several years in the US. And it is all a direct correlation of how many products that we can get onto the panel and get through the FDA approval process into the US. And the team is working very hard intelligently on that.
Sarah Gots
Analyst at Barclays
All right. Great. Thanks. And then just another follow-up here on the diagnostic side from, you know, with automated tuberculosis testing. Can you talk about any recent tenders that you have won, any that are coming up throughout the rest of this year? And then I guess, you know, how does the new automated system compare to the quantiferon and the liaison?
Prahlad Singh
President and Chief Executive Officer
That's a great question, Luke. Again, you know, we don't talk on specific tenders, but I'm happy to talk about the launch that we just did and announced that it was even at a current show, at a current show that's going on. It's a complete workflow that has a specialized liquid handler added to it. You know, it builds on the T-spot select, which has added now chemagic extraction and cell counting ability. So I think the workflow that this product uses, the benefit is that it uses all our other offerings, too, including Celica cell counting, the Euroimmune reader, which will eventually connect it also to EuroLabs software in the future. It essentially reduces our hands-on time by 50% versus the current existing T-spot select. And it has a reduction of approximately 80% in technician touch points. So this was one of the major hurdles that T-spot select was facing in the market in terms of hands-on and technician time. And the intent really is to significantly eliminate that. And now if you combine for day one and day two, it essentially has lesser total hands-on time versus the competitors' product offering that you talked about.
Sarah Gots
Analyst at Barclays
Great. Thank you.
Carla
Call Coordinator
We currently have no further questions. We'll hand back to Steve Villarreal for final remarks.
Steve Willoughby
Host
Thank you, Carla. Thanks, everyone, for your time this morning. We look forward to touching base with everyone over the coming weeks. Have a good day.
Carla
Call Coordinator
This concludes today's call. Thank you for joining. You may now disconnect your line.
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