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Operator
When posing your question, please pick up your handset to allow optimal sound quality. Lastly, if you should require operator assistance, please press star zero. It is now my pleasure to turn the floor over to Steve Frank. Steve, you may begin.
Steve Frank
Thank you. Good morning, everyone, and welcome to the Zoleta Second Quarter 2021 Earnings Call. I am joined today by Kristen Peck, our Chief Executive Officer. and by Wetney Joseph, our Chief Financial Officer. Before we begin, I'll remind you that the slides presented on this call are available on the investor relations section of our website, and that our remarks today will include forward-looking statements, and that actual results could differ materially from those projections. For a list and description of certain factors that could cause results to differ, I refer you to the forward-looking statements in today's press release, and our SEC filings, including but not limited to our annual report on Form 10-K and our reports on Form 10-Q. Our remarks today will also include references to certain financial measures which were not prepared in accordance with generally accepted accounting principles or U.S. GAAP. A reconciliation of these non-GAAP financial measures to the most directly comparable U.S. GAAP measures is included in the financial tables that accompany our earnings press release. and in the company's 8K filing dated today, Thursday, August 5th, 2021. We also cite operational results, which exclude the impact of foreign exchange. With that, I will turn the call over to Kristen.
Kristen Peck
Thank you, Steve, and good morning, everyone. I hope you and your loved ones are all staying healthy and getting vaccinated for COVID-19. I'd like to start the call by welcoming our new Chief Financial Officer, Watney Joseph, who is joining me on the call today. As the former CFO of Catalan, Whitney is a veteran of the biopharma industry and very familiar with many of you in the investment community. Whitney joined us on June 1st and is off to a fast start, learning all about the company and animal health, everything from cattle runs and drought impacts to pet care trends and parasiticide season. I am confident that Whitney will make strong contribution to our ongoing market performance, value creation, and leadership in animal health. I also want to take a moment to thank Glenn David for his partnership and all of his contributions to Zoetis as CFO over the last five years. Glenn has taken on a new role overseeing our international operations and other business units, including Pharmac, BioDevices, and Pumpkin Pet Insurance. I know he will bring his signature leadership qualities, business skills, and industry knowledge to this role and continue driving profitable growth in these areas. Now turning to the second quarter, we achieved strong results once again, with 22% operational growth in revenue and 28% operational growth in adjusted net income. Our companion animal portfolio generated 36% operational revenue growth, driven by our pet care parasiticides, key dermatology products, vaccines, and diagnostics. Meanwhile, livestock product sales were up 3% operationally and remain in line with our expectations for more moderate growth this year. The second quarter results also reflected favorable comparisons to last year's second quarter when the uncertainty of COVID-19 and related lockdowns were most severely felt across the animal health industry. We are raising full-year guidance for revenue and adjusted income again this quarter to reflect our first half performance and confidence in the underlying growth drivers of our business. We remain on track for a very strong year and continue to focus on sustaining our investment in long-term growth opportunities. With a strong cash flow and positive outlook, we are investing internally and externally in innovative new products, market expansion plans, and direct-to-consumer promotions that will support future growth. Our team has been delivering strong growth based on internally developed companion animal parasiticides. led by our Empirica, ProHeart, and Revolution Plus franchises. We've redefined care for the dermatology category with our development of Apoquel and Cytopoint, and we see more growth potential coming from our monoclonal antibodies for osteoarthritis pain, new vector vaccines for poultry, and the industry's first cloud-based diagnostic platform with AI capabilities. In terms of our monoclonal antibodies for alleviation of OA pain in dogs and cats, we continue to anticipate U.S. approval for Labrella and Silencia in 2022. Meanwhile, initial customer response from vets and pet owners in Europe has been excellent, and we recently received approval of Silencia in Canada. I always say with great pride that we have the best field force in the animal health industry, and we will continue to expand their scope, effectiveness, and digital tools in ways that can enhance our customers' experience and support our growth objectives. We've also seen a positive return on our investment in direct-to-consumer promotions for Semperica, Apoquel, and Disease Awareness over the years. And DTHC remains an area of ongoing investment to support our parasiticide and dermatology portfolios. And finally, we continue to look externally for business development opportunities that can complement our portfolio and expand our market presence or capabilities. Yesterday, we announced plans to acquire Jurox, a privately held animal health company based in Australia. Expected to close in the first half of 2022, the acquisition will provide us with growth opportunities, manufacturing capacity, and increased capabilities in Australia, our fifth largest market, and also bring us a range of companion animal and livestock products primed for global expansion. As I wrap up my remarks, our growth story for this year remains very consistent, based on three recurring catalysts. First, our companion animal portfolio, driven by our triple combinations in Perica Trio and other parasiticides, our dermatology treatments, Apical and Cytopoint, new monoclonal antibodies for pain, and our VetScan diagnostic systems. The entire portfolio is benefiting from strong pet care trends in terms of increasing clinic visits, rising spend per visit, and a focus on diagnostics and specialty care, especially among newer and younger generations of pet owners. Recent estimates for market growth in companion animal products are in the high single digits, and Zoetis continues to expect to grow faster than the market. We're gaining share in the approximately $5 billion global parasiticides market for pets, and we're excited by veterinarian and pet owner responses to our new monoclonal antibodies for pain. We also continue to see progress in the early launch of vet scan images, which leads to our second catalyst for growth, diagnostics, which posted 38% operational revenue growth in the second quarter, and access to vet clinics in the U.S. rebounded from the year-ago quarter. Our third growth catalyst is international, where we continue to generate strong operational growth, driven by China and Brazil, which grew at 30% and 40%, respectively. All our catalysts for growth are buoyed by our priority to champion a healthier and more sustainable future through commitments to our communities, animals, and the planet. You can read more about our progress on these ESG goals in our first sustainability report, which was published in June. In closing, we had a great second quarter, and we're focused on delivering a record-setting year. The market dynamics in animal health remain strong, steady, and resilient, even during the challenging times, based on people's unbreakable bond with animals. For the remainder of the year, our diverse portfolio, innovative pet care products, strengthened diagnostics, and expansion in international markets will continue driving our performance. Now, let me hand things off to Wetney.
Steve
Thank you, Kristen, and good morning, everyone. Before I discuss our second quarter performance, I would like to take a moment to express how excited I am to join Zoetis, a company with an exceptional opportunity for meaningful long-term growth, driven by the durability and resiliency of the existing portfolio, a robust product pipeline, and a keen focus on future innovation. I look forward to leading an outstanding finance organization and maintaining the financial principles and investment strategies which position Zoetis as a world leader in animal health. I would also like to express my appreciation to the Zoritis colleagues and the investment community for such a warm and gracious welcome. I had the pleasure of speaking with several of our investors since becoming CFO, and I look forward to connecting with many more in the coming weeks. Now, shifting focus to earnings. This morning, I will provide commentary on our second quarter financial results, contributing factors to our performance, and an update on our improved full year of 2021 guidance. In the second quarter, we generated revenue of $1.9 billion, growing 26% on a reported basis and 22% operationally. Adjusting an income of $566 million was an increase of 33% on a reported basis and 28% operationally. Operational revenue grew 22% with 2% from price and 20% from volume. Volume growth includes 12% from other inline products, 6% from new products, and 2% from key dermatology products. We delivered another strong quarter and remain encouraged by the performance of our business, health of the overall industry, and our outlook for the future. It is worth noting that Q2 2020 is a favorable comparative period due to the impact of COVID-19. The pandemic caused widespread uncertainty last year, which led to clinic closures, supply chain disruptions, and shifts in consumer demand from restaurant and food service to grocery stores. This materially impacted several aspects of our companion animal and livestock businesses. Now let's dive further into the details of the quarter. Companion animal products led the way in terms of species growth, growing 36% operationally, with livestock growing 3% operationally in the quarter. Performance in companion animal was again driven by our parasiticide portfolio led by cells of Semperica Trio and with significant contributions from the broader portfolio. We also continue to see growth in our key dermatology products, Apocryl and Cytopoint, as well as in vaccines and diagnostics. Symbarica Trio has continued to perform exceptionally well, posting revenue of $139 million, representing growth of more than 200% versus the comparable 2020 period. In addition to sales, we are exceeding our other performance measures as well, such as clinic penetration, share within penetrated clinics, and reordering rates. The strength of our entire companion animal parasiticide portfolio was evident again this quarter, growing 50% operationally, with meaningful growth in the ProHeart and Revolution stronghold franchises in addition to the Semperica franchise. Having the broadest and most innovative portfolio within a large and expanding therapeutic area leaves us bullish on future growth in parasiticides. Global sales of our key dermatology portfolio were $280 million in the quarter, growing 22% operationally, Cytopoint had a particularly strong quarter, growing 42% operationally and generating quarterly revenue of $100 million for the first time since launch. New-to-date sales for key dermatology products are $524 million, and our view remains unchanged that sales will exceed $1 billion this year. Our diagnostic portfolio had operational growth of 38% in Q2, led by increases in consumer and instrument revenue, as the business continues to recover from the impact of the pandemic. With our sustained investments in diagnostics, the new technology we are bringing to the market, and the ability to leverage the breadth of our medicines and vaccines portfolio, we are well positioned to grow faster than the diagnostics market, which is expected to grow double digits and outpace the overall animal health market. Livestock growth in the quarter was driven by our cattle and swine businesses. Cattle grew 3% and swine grew 6% operationally, despite price reductions as part of our generic defense strategy and higher input costs weighing on producer profitability in the U.S. Data suggests the food service and restaurant industries continued to recover in the second quarter, which is a crucial dynamic for demand of our premium products. Poultry was the only species to decline in the quarter, which fell 4% as producers in the U.S. extended their use of lower cost alternatives to our products. The decline in poultry partially offset the growth in cattle, swine, and fish products. Now let's discuss the revenue growth by segment for the quarter. U.S. revenue grew 22% with sales of companion animal products growing 34% and livestock product sales declining 8%. U.S. quarterly revenue exceeded $1 billion for the first time in company history. For a companion animal, pet ownership and pet spending trends remain robust. Vet clinic revenue increased double digits in the quarter, and patient visits and spend per visit were up as well. While we expect some of the trends to moderate, our view is they will remain above pre-COVID-19 levels. A meaningful portion of pet acquisitions which occurred during the pandemic were by Millennials and Gen Z. This infuses a solid foundation of younger pet ownership who are willing to spend disproportionately more on all aspects of pet care than prior generations and will be a key growth driver for companion animal medicines, vaccines, and diagnostics moving forward. Our companion animal parasiticide portfolio was the largest contributor to companion animal growth in the U.S., going 59% in the quarter. Keto-dermatology products, vaccines, and diagnostics also contributed to growth. Semperica Trio had an incredibly strong quarter in the U.S., with sales of $120 million, generating the highest revenue by a single product in the U.S. for Q2. The Semperica franchise generated sales of $153 million, growing 96%, and remained the number two brand in the U.S. flea, tick, and hardware market. Key Dermatology sales were $197 million for the quarter, growing 23%, with significant growth for Apoquil and Cytopoint. Diagnostic sales increased 22% in the quarter, with growth in instruments, rapid tests, point-of-care consumables, and reference lab revenue. Direct livestock sales fell 8% in the quarter, driven by declines in cattle and poultry, with swine essentially flat for the quarter. Q2 cattle sales were negatively impacted by a promotional program in the first quarter of this year, which pulled forward a portion of second quarter sales. In addition, Price reductions as part of our generic defense strategy and higher input costs weighing on beef and dairy end markets presented challenges to our cattle business this quarter. Poultry declined in the quarter as producers expanded use of lower cost alternatives to our premium products as a result of higher feed costs and labor wages and smaller flock sizes reducing disease pressure. We also faced generic competition for Zoemix, our alternative to antibiotics and medicated feed additives. To summarize, our U.S. operations delivered another strong quarter, led by our innovative and robust companion animal portfolio. The in-market dynamics for companion animal remain extremely healthy, with pet ownership and pet spending trends driving an environment conducive to sustainable future growth, which is expected to more than offset the near-term weaknesses of U.S. livestock business. Now turning to our international segment. Revenue in our international segment also grew 22% operationally in the quarter, with companion animal revenue growing 41% and livestock revenue growing 10% operationally. The trends fueling strength in our international companion animal business are very similar to those in the U.S. The increasing medicalization rates and centers of care by pet owners, coupled with significant investments in advertising and promotion to support new product launches and key brands, drove growth across our parasiticides, vaccines, diagnostics, and key dermatology portfolios. Diagnostics were 106% operational in the quarter, with consumables and instrument revenue each exceeding 100% operational growth. Librella, our monoclonal antibody for alleviation of OA pain in dogs, launched in the EU in the second quarter. Feedback from the early France trials in Q1 was encouraging, and second quarter sales exceeded our expectations, further supporting our optimism on the long-term blockbuster potential of the product, as well as monoclonal antibodies as a platform for future growth. Our free line monoclonal antibody for alleviation of OA pain, Selencia, began early experience programs in the second quarter with an EU launch following in Q3. As previously mentioned, OA pain in cats is a significant unmet need in animal health, and we're excited to provide pet owners with a novel product in a space that has previously lacked innovation. Meanwhile, our international livestock business had its second with growth across all species. led by strong operational growth in cattle and swine. Cattle growth in the quarter was driven by marketing campaigns, key account penetration, and favorable export market conditions in Brazil and several other emerging markets. Revenue growth in swine is largely distributed to China, which was 38% operational. The themes of growth in swine remain consistent with previous quarters, as large key accounts increase their use of our vaccines and other products, as they continue to expand production as the market shifts from smaller farms to larger-scale modern operations. Our official portfolio continues to perform very well, growing 25% operational. Wealth was driven by strong performance of Oslo Flux in Chile, vaccine volume in Norway, and the 2020 acquisition of FishVet Group. From a market perspective lens, all major markets grew double digits in the second quarter, which declined slightly in Q2. China and Brazil had strong quarters, growing 30% and 40%, respectively, on an operational basis. Growth in companion animal across emerging markets remains a key driver of our international business. And in addition to the growth in China and Brazil, our other emerging markets' companion animal business grew 68% operational. Overall, our international segment delivered strong results, demonstrating the importance of our diversity across species and geography. The livestock business continues to perform well, and increasing pet acquisitions and pet care spending are extremely encouraging trends for long-term growth in companion animal. Now moving on to the rest of the P&L. Adjusted growth margins of 70% is essentially flat on a reported basis compared to the prior year, as favorable product mix and price were offset by higher manufacturing costs and freight. Adjusted operating expenses increased 23% operationally, resulting from increased compensation-related costs, advertising and promotion expense, and freight. The adjusted effective tax rate for the quarter was 20%, a decrease of 230 basis points driven by the favorable impact of jurisdictional mix of earnings, lower guilty tax, and an increase in favorable discrete items compared to the prior comparable quarter. Adjusted net income and adjusted diluted EPS grew 28% operationally for the quarter, primarily driven by revenue growth. We remain in a very strong liquidity position and continued our share buyback program, repurchasing approximately $165 million worth of shares in the quarter. The strength of a balance sheet and substantial free cash flow generation allows us to make significant investments for future growth while still returning excess cash to shareholders. Before I review our updated guidance, I would like to reiterate a point that has been discussed on prior earnings calls, which is that we expect growth to moderate in the second half of the year as a result of varying comparative periods where pent-up demand created by COVID-19 in the first half of 2020 worked its way through the system in the second half of the year, in addition to the expected increased generic competition for Jackson. Adjusting for the variability in the comparative period due to the pandemic our phasing of top-line growth would be more normalized and consistent quarter to quarter throughout this year. Now moving on to our updated guidance for 2021, which we are raising and narrowing as a result of our second quarter performance, strength of our product portfolio, and favorable market dynamics, which we expect to continue. Please note that our guidance reflects foreign exchange rates as of mid-July. For revenue, we are raising and narrowing our guidance range with projected revenue now between $7.625 and $7.7 billion and operational revenue growth between 12.5% and 13.5% for the full year versus the 10.5% to 12% in our May guidance. adjusted SG&A expense for the year are expected to be between $1.87 and $1.91 billion versus $1.82 and $1.87 billion in our prior guidance. The increased spend represents additional advertising and promotion investments, a significant portion of which will occur in the third quarter, as well as compensation-related costs due to company performance. Adjusted net income is not expected to be in the range of $2.135 and $2.175 billion, representing operational growth of 13% to 15% compared to our prior guidance of 12% to 14%. Adjusted diluted EPS is not expected to be in the range of $4.47 to $4.55, and reported diluted EPS to be in the range of $4 to $4.19. Now to summarize before we move on to Q&A. Our strong performance in the first half of 2021 continues to underscore the value of our diversity, innovation, and durable business model. We again raised and narrowed our full year 2021 guidance and expect to grow faster than the market. We continue to focus on long-term sustainable growth by investing in our pipeline, including infrastructure to support current and future product launches, and remain very positive in our outlook for sustainable growth beyond this year. Now I'll hand things over to the operator to open the line for your questions. Operator.
Operator
And once again, that is start and one if you would like to ask a question. And as a reminder, we do ask that you limit yourself to one question. And we'll take our first question from Michael Ruskin with Bank of America.
Michael Ruskin
Thanks for taking the question, as always, and congrats on another strong quarter. I want to start with, simperica trio just to really break out quarter with 139 million um i mean by our projections something in the in the 450 to 500 range uh isn't out of the picture for the rest of the year so i just want to get a better sense of where you're seeing that incremental growth coming from um i mean we did note a little bit of a tick down in regular simperica in the u.s year over year so i'm just wondering if you could comment a little bit again on on cannibalization just sort of your expectations as you move forward um and then my second question question will be on the operating leverage. Something we've talked about in the past, but definitely saw a notable step up sequentially in SG&A coming in somewhat above my estimates. You mentioned a lot of advertising spend, a lot of competition related expenses. Could you give us a sense of how much this is expected to persist going forward? It's obviously just going to play a big role in the operating leverage in the second half of the year. some of the comps. I want to get a better sense of what goes into that $490 million and how to think about that.
Kristen Peck
Great. Thanks, Mike. I'll take the first question, then I'll let Whitney take the second question on the leverage. Simperica and Simperica Trio did have a phenomenal quarter. Overall, as Whitney mentioned, we had 50% growth in parasiticides. But as you look at the quarter for Trio with $139 million, it was incredibly strong. And I would say Trio is and has been outpacing our expectations. In fact, the Semperica franchise in Q2 was the second largest in the flea tick heartworm space. So we're very excited. You know, we expect to continue to see this product grow. You know, the market itself, as you know, went to over $5 billion. So we remain super excited. We're doing well both on our penetration of clinics as well in reorders. So we see strong momentum that we think will continue into the second half of the year. So I'll let Whitney take your second question.
Steve
Yeah, in terms of SG&A, indeed, the step-up that you see in terms of trend, there is really largely driven by R&D investment. really largely what's driving it. In terms of compensation related costs, these are really more of variable compensation areas that are really in line with the performance of the company there as well.
Operator
And we will take our next question from John Block with Stiefel.
John Block
Great. Thanks, guys. Good morning. Kristen, maybe I'll start on the monoclonals, and I know it's early But how are you seeing Librella being used in these international practices? In other words, is it market expansion? Is it taking share from other solutions or cannibalization or Remedil? You know, any color you have there would be helpful. And then just to shift gears on livestock, it's always choppy and can move around, but is there anything more structural going on in the U.S. market? In regards to generic competition, and maybe on that last point, how is Draxen playing out? You mentioned it. It seems like maybe less impact to date, but is the overall year assumption still unchanged? Thanks, guys.
Kristen Peck
sure thanks john good to hear from you i'll take the first question i'll let um let me take the second question on livestock we have been very excited at the uptick in labrell um you know what we're seeing in your question about how is it really being used we've seen really strong efficacy of the product um the feedback we've gotten through early experience in our first quarter of sales is just, you know, really quick efficacy. So, you know, they're noticing differences pretty quick. It's improving quality of life, better sociability. So we really think, you know, more and more vets are looking at this as a first-line therapy. We do think that there's significant opportunities for Labrella to grow the category. The dog categories we've talked about before currently is 400 million, but we believe by bringing this type of innovation to the market, it's important globally, but bringing this type of innovation from the safety and efficacy profile, we think we have the ability to potentially double that market if you look at how many dogs there are, how many have OA, and how many are treated. So we look at the opportunity to grow this market in a few ways. Certainly, as I talked about, getting more animals, getting more days on treatment and better compliance, and then certainly with prices. This product is priced at a premium to those that are already on the market. So, Whitney, do you want to take the second question on livestock?
Steve
Yeah, sure. Well, in terms of livestock, we don't see a structural change here in terms of your question. And the performance that we're seeing is right in line with our expectations. Livestock grew 3% on the quarter. And as we've said, livestock has tended to grow somewhere around the 4% range in the past where we've technically been low single digits. this year, and really the global growth in that area is driven by our international markets, particularly when you think about emerging markets like China and Brazil, et cetera. In the U.S., with the generic competition for Draxen, we expected to see some headwind there, and it's really playing out in line with our expectations. One more point I'll make is, if you recall, In Q1, we did have some promotions, again, in line with our generic defense strategy that really accelerated some of our revenue into Q1 from Q2. So that's playing out a little bit in terms of what you're seeing in the livestock figures for the U.S. But we expect to see further declines in terms of livestock for the remainder of the year, and all that's factored into the guidance that we raised today as well.
Operator
And we will take our next question from Louise Chen with Cantor.
Louise Chen
Hi. Thanks for taking my question here. Just curious how durable you think this increase in vet visits plus the spend per pet will be over the longer term. Thank you.
Kristen Peck
Thanks, Louise. Great to hear from you. Yes, we're very confident in the durability of the companion animal trends that you've seen throughout 2020 and 2021. So as you look in the quarter, we saw overall clinic revenues up 14%, and that was equally split between vet visits and spend per visit. And, you know, our confidence in the... trends really have to do with a few things. One, there are more pets. You know, we've talked about that for a number of quarters. The other thing is an increase in the standard of care, the expectations of pet owners, greater use across the portfolio, greater use of diagnostics, more people home noticing more about their pets. But the other really important trend that's going to continue to play out is who's adopting a lot more of these pets. And that's a lot of millennials and Gen Z, and they tend to spend more on their pet. They're very engaged in their care. So we see these as durable trends that will continue and will remain a big growth driver for the company over the coming years.
Operator
And we'll take our next question from John Crager with William Blair.
John Crager
Hi, thanks very much. I have a gross margin question. I realize the monoclonals are sort of a new class for you guys. As Salencia and Labrella ramp, do you expect the gross margin on those products to be better or worse than what you see across your traditional product portfolio?
Steve
Yeah, John, look, we certainly, given the safety and efficacy profile of these products, we expect them to be priced at a significant premium to existing therapies, including on Remedil. So I would say it would be above sort of our average gross margin that you see across our portfolio.
John Crager
Great. Thanks, Whitney.
Steve
Thanks, John.
Operator
And we will take our next question from Katie Tai.
Katie Tai
Hi, thanks for taking my question. You highlighted the strengths in diagnostics. Can you just speak about some of the advantages and success that you've had with bundling strategies with therapeutics? And can you speak to what you're seeing in terms of competitive placements for instruments? You also called out the new VetScan images platform. I mean, how has that been performing today and how do you expect that to contribute to growth in the business going forward? Thanks.
Kristen Peck
Thanks, Katie. As you look at diagnostics, it was a very strong quarter with 38% operational growth. Diagnostics we've talked about remains a very attractive segment with double-digit growth, and it really is core to the way the vet practice operates. Again, pets cannot tell you exactly how they're feeling, so we continue to see this being a really strong part of our continuum of care strategy. It's critical to the vet practice. We did, you know, incredibly strong growth, as you saw, in the quarter in international, making, you know, significant placements, very strong in the U.S. And we're focused on a few things there. Certainly it's placements, as we've talked about, where we are seeing, you know, good growth there. Stronger in the quarter in international than the U.S., but also really driving consumable use. And we think that remains a big opportunity for us versus competition, you know, getting more consumable use in the placements that we have. And then really adding on to that, the innovation. So if you look... It has done better than our expectations. We continue to see very strong growth there. Right now, the indication for the Vetscan images is in fecal, and that's a large market. It's about $500 million, growing at 7% to 8%. So we see really strong growth there. I don't know what acres anything you'd add.
Steve
No, you've covered it well.
Operator
And we'll take our next question from David Westenberg with Glutenheim Securities.
David Westenberg
Hi. Thank you for taking the question. I'm going to actually continue on that concept. And that was just asked with Katie. Can you help us conceptualize the size of the non-therapeutic revenue for Zoetis on a go-forward basis and whether or not we should see it as a revenue contributor or as maybe a means of driving therapeutic revenue? And, you know, I'm going across the categories with, like, diagnostics, insurance, MBRIX, genomics, etc., And then just a quick clarification question to the answer to John Block's question on the doubling of the pain market. Was that just in dogs and then cat plus beyond that? Or was that $800 million or the doubling of the $400 million just dog and cat? Thank you.
Steve
I'll start and see if Kristen wants to add anything. In terms of non-therapeutics, if you look at diagnostics, for example, where we saw 38% growth this quarter, so roughly $99 million of revenue on the quarter on the base of what we reported for the year. So in relative terms, it's not the largest proportion of our revenue streams, certainly, but we're very much excited about the potential for the future in a very fast-growing market in terms of diagnostics, which we expect to grow faster than the overall animal health space for us. And really, one more point that I'll make is, overall, we expect diagnostics, as Kristen covered earlier, In terms of the impact of continuum of care, we think overall in use of diagnostics as we look to medicalization rates across pets will have a positive effect on overall therapeutics in the long haul. We think that's also an exciting opportunity for the long term.
Kristen Peck
Sharon, I can take your second question with regards to the cat market. Yes, we think that would be incremental. It is a little hard to size the cat market today. There's really not much of an OA pain market in the U.S. There is some international products that are approved. But, you know, as we talked about doubling the dogs from 400 to 800 million, if you Again, it's a little hard to size the cat market. Maybe it's 100. We think you can double that as well. So I think that could be a $200 million market, which would make the OA category for us across dogs and cats potentially a $1 billion market that we can plan. So we think this is, you know, a very exciting space for us.
Operator
And we will take our next question from Balije Prashad with Barclays. Your line is now open.
spk00
Good morning. Thanks for the questions. Just a couple for me. Firstly, on the pesticide market, do you have a sense of relative size of where NexGarden and Breveto were in the quarter? And if TRIO growth came in at the cost of competitors, or is there market expansion? On the same point, you recently got a labor expansion for Simparica. Could you also just describe, take us through the implications for it commercially? And on the guidance side, could you also just take us through what led to a 1% revenue guide change and a 2% increase in SG&A and where those increased expenditures are going to? Thanks.
Kristen Peck
Sure. Thanks, Michelle. I'll take the first question, and I will let Whitney take the second one. As we look, I can't get into what our competitors' product sales are. You know, we remain, you know, quite excited for what Simperic is doing. We did get the additional label claim, you know, that was expected. That was included in the guidance that we had. In the sense of where are we getting some of those sales from, it is an and. We are both growing the market. I think more people are moving back into prescribed products versus some of the over-the-counter, but we're also seeing that we are taking share from many of our competitors as well. It's an exciting opportunity across both dimensions. Whitney, do you want to take his other question?
Steve
Yeah, look, one thing I would add in terms of parasiticides, it's a $5 billion market that's growing around 5%, and we're gaining share in this marketplace. We do think that with the triple combo, it's improving compliance with respect to heartworm, et cetera, and so that will have the opportunity to continue to expand the market as well. So we're very pleased with the performance across our parasiticides portfolio and the share that we're gaining. We'll continue to invest behind behind this product and this portfolio as well.
Kristen Peck
Did you want to take the increasing guidance question?
Steve
Yeah, look, certainly when you look at our guidance, compared to where we started in the year and given the overall market, positive market dynamics that we see, our portfolio is performing very well. Kristen covered some of the trends around vets, visits, and so on. All those are contributing towards optimism. And you've seen the year-to-date performance that we've delivered. And in fact, we've taken our guidance in terms of top-line operational growth up from where we started in the year at 9% to 11% now at 12.5% to 13.5%, so a full three points above where we started the year. So we're very pleased with how we started the year. I think if you look at it from an overall perspective, certainly the first half and the second half of the year, if you look at purely top-line, it's really roughly in line with pretty consistent sort of phasing across the year. The growth rate will moderate based on last year, largely not really a matter of how this year is executing for us. very positive market dynamic with very strong performance across our portfolio. Last year, given the pandemic, there was a bit of variability across the year. There was disruption in the first half of the year given COVID-19, which created more demand that got pent up and caught up in the back half of the year. So that's going to create a dynamic in terms of what the Vs look like in terms of growth rates for SACRA's second half. We're very pleased with where we are, and we are going to continue to invest behind our key portfolios and brands.
Operator
And we will take our next question from Chris Schott with JP Morgan.
Chris Schott
Great. Thanks so much for the questions. I just want to focus a little bit more on U.S. livestock. Can you talk a little bit again about the 2Q dynamics? Because it seems like you were going up against a fairly easy comp. The business was still down about 8%. So I was trying to get a sense of, like, as we think about the rates of decline you're expecting in the business in the second half of the year, just help us conceptualize what type of erosion you're thinking about as we go up against what seems like some tougher comps for those quarters. And then maybe from a longer-term perspective, can you just walk a little bit through about how you're thinking about recovery for U.S. livestock as you think about both poultry and cattle as we get past some of these kind of more challenging near-term dynamics and just think about the longer-term business? Thanks so much.
Kristen Peck
Thanks, Chris. I'll start on more strategic drivers, and I'll let Whitney get into some of the specifics here. You know, LASIK really has performed as we expected. You know, as we talked about going into the year with the LOE of Jackson, we did, you know, expect a decline in general, as we talked about for the last few years. That's generally 20% to 40% over two to three years, and as we said, we thought that would be faster. As you look at the quarter, we did see a 19% decline. overall in Draxen specifically. And I think that is one of the key factors in the U.S. And as what he's mentioned earlier, I think continue. But if you look at broader livestock, historically, it's a, you know, low to mid single digit grower. Certainly, as you saw in 2019 with ASF in China, And 2020 with COVID, it's been lower than what you've historically seen. We do believe, as we said, that overall this will trend back to a market growth in the mid-single digits, call it, you know, around the 4% range, maybe 3 to 5. And then we think the WEDIS will be in line with that. You know, it could be slightly lower over the next few years, as you see this year. And really, the strategic driver of that is that we have a number we have the largest number of products hitting lots of exclusivity as you look at our guidance that's why it is baked in so it wasn't just drax and we also and poultry as you were just referencing um had uh zoemix and bmd as well but again we've got good growth in some of these other species as well as you look at poultry we're really excited at the growth of vector vaccines it's a 300 million dollar market growing 13 we've already launched two of them newcastle and ibd um and that will be a growing portfolio for us but I'll let, you know, Whitney get into some of the more specific numbers, but I do think if you look at livestock just more strategically on a higher level, you know, I think it's going to be a lower-growing companion animal, but we do think it goes back to historical levels. Whitney, if you want to build on that.
Steve
Yeah, look, I mean, if you look at livestock across the world with protein consumption, population growth, income levels rising, et cetera. We expect those to continue to drive growth in livestock for the long term. We delivered 3% on the year, as we said, as expected. And as was covered in the prior, earnings call, we expected declines in the U.S., particularly given the generic entry for Draxen. Now, the first quarter did benefit a bit from two things. One, there was a little bit of a delay in terms of the entry of generic for Draxen, but also we ran a promotion in the first quarter that accelerated some revenue into Q1, taking it out of Q2. So if you take those into consideration, which are exactly in line with our defense strategy, livestock really is performing exactly as we expected. Now, given that the intensification of generic competition, as we expected, just began really into the late first quarter, into the second quarter, we expect those declines to continue. And, again, they're right in line with our expectations here.
Operator
And we will take our next question from Steve Scala with Cowan.
Steve Scala
Thank you. A local paper in Nebraska reported last week that Librella is being manufactured at the Lincoln plant. If that is correct, then is that product ultimately destined for the U.S.? And as the U.S. regulatory process evolves, can you confirm that it is still the case that no new clinical data is required? Thank you.
Kristen Peck
Sure. I think I mentioned earlier, we do believe we will see approval in the U.S. for both Labrella and Silencia in 2022, with Labrella most likely in the second half. We have long-term strategies from obviously multiple sites. I don't think the U.S. will be manufactured out of La Brella at launch. We certainly are looking at potentially adding sites just given the strength, as I mentioned earlier, of that product. So we have been having ongoing good conversations with regulatory authorities and remain on track for the guidance we previously provided, which is approval for both those products, with Cilentia likely earlier in the year and La Brella later. But you should not probably expect that we'd be producing out of Lincoln, Nebraska at launch for La Brella.
Steve
Look, given our global footprint and presence, you should not read anything into the location of manufacturing in terms of where products are destined to. In particular, we'll continue to leverage both our own footprint as well as third parties in our manufacturing. And so I wouldn't draw any conclusion from that.
Operator
And we'll take our next question from Elliot Wilber with Raymond James.
Elliot Wilber
Hi, guys. This is actually Michael Parallari filling in for Elliot. Thanks for taking my question. So I believe you said in the past that TRIO has had about a 90% uptake on top corporate accounts. Just wondering if you could provide an update, though, on penetration across all targeted accounts. And then in relation to the DTC campaign, I know you said in your prepared remarks that it remains beneficial, but just wondering if you could give an updated timeline on how long you could see it continuing and then also how you see incremental spend really driving ROI here. Thank you.
Kristen Peck
Sure. Thanks, Michael. You know, we continue to be very – we are at or surpass all the clinic penetration that we expected for TRIO. So we're quite pleased with that. And right now we're a little more focused on reorder rates, as I mentioned. We think the important trend for us now is, you know, I think our penetration is where we would expect it and is very broad across the U.S. for TRIO. And we're, you know, really focused on those reorders, which we now have at 80%, and continuing to grow those overall reorder rates. Direct-to-consumer advertising is critical in this category. It is $5 billion. It is a category that, you know, consumers really do go in and ask for brands. We do obviously track our ROI on this. And as you've seen and as Whitney mentioned earlier, we will continue to invest behind this brand. We have seen incredibly strong ROI in doing so. And that is why you're seeing us step up that brand. As we talked about earlier, it is outpaced our expectations. I think that has everything to do with the innovative nature of the product, but it also has to do with the investment we put behind that in direct-to-consumer advertising. in investing with our field force, and we will continue to do that. You should expect this year and next year, certainly, we have a window of opportunity with no competition in the U.S., and we will leverage that opportunity. You know, we still don't know exactly when we'll see competition. At this point, we don't expect any until the second half of 2022 at the earliest, as we mentioned. But as long as we do not have competition, we will invest aggressively behind this brand. And even when we do, we will do it as well, because we've seen very strong ROI in doing that.
Operator
And we will take our next question from Noventai, Le City.
Noventai
Hi, good morning. Could you comment on capital allocation? Shall we expect a continuity of financial policy going forward? And also, following Girox, shall we expect further geographic expansion via bolt-on acquisition in addition to internal investments? Thank you.
Steve
Yeah, sure. So in terms of capital allocation, you should expect consistency in terms of how we manage capital allocation with the focus first and foremost on internal investments. We have opportunities in terms of R&D, investing behind our brands on advertising promotion perspective, CapEx to support our growing pipeline, including monoclonal antibodies, et cetera. That's really our first priority. Of course, we'll take advantage of any opportunities from a business development perspective for NNA that helps to accelerate our growth in various markets and areas as well. So that really follows in terms of investments. And then as we have free cash flow generation, very strong free cash flow generation, we'll look to return cash to our shareholders. We've increased our dividends, as you've seen, typically faster than our revenue. And we re-initiated our share buyback, which we will continue. That remains consistent, I would say, with the past.
Kristen Peck
And then on Jurox, do you want to just comment on the VD Geographic Extension?
Steve
Yeah, so look, certainly Jurox, we're excited to be bringing them. Once we get through the process here for the next six months and close the transaction, we're excited to bring Jurox into the Zoetis family. Australia is our fifth largest market globally, and this is really at our core. It does increase our presence in the therapeutic area globally. product as well. So we're very excited about that opportunity and what it does for us, and we'll continue to look for bolt-on opportunities to bring on both the core as well as other areas of the business, whether it's diagnostics or what have you as well.
Operator
Can this does conclude today's question and answer session? I will now turn the program back over to Kristen Peck for any additional or closing remarks.
Kristen Peck
Great. Thank you, everybody, for your questions today and for your continued interest in Zoetis. We look forward to keeping you updated on our business throughout the remainder of the year and continuing to deliver on our results and innovations that you and our customers expect. So thanks so much for joining us today. Stay safe.
Operator
This does conclude today's program. Thank you for your participation. You may disconnect at any time. And have a wonderful day.
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